메뉴 건너뛰기




Volumn 8, Issue 2, 2015, Pages 179-188

Can a fixed-ratio combination of insulin degludec and liraglutide help Type 2 diabetes patients to optimize glycemic control across the day?

Author keywords

basal insulin; combination therapy; DUAL study; incretin therapy; insulin degludec; liraglutide; Type 2 diabetes

Indexed keywords

GLUCOSE; INSULIN; INSULIN DEGLUDEC PLUS LIRAGLUTIDE; ANTIDIABETIC AGENT; DRUG COMBINATION; GLUCAGON LIKE PEPTIDE 1; GLUCOSE BLOOD LEVEL; INSULIN DEGLUDEC; LIRAGLUTIDE; LONG ACTING INSULIN;

EID: 84923324208     PISSN: 17512433     EISSN: 17512441     Source Type: Journal    
DOI: 10.1586/17512433.2015.1017562     Document Type: Review
Times cited : (6)

References (39)
  • 1
    • 84923352284 scopus 로고    scopus 로고
    • [Last accessed on June 2014]
    • International Diabetes Federation. Last updated 2012. Diabetes Atlas Update 2012. Available from: www.idf.org/sites/default/ files/attachments/ 5E-IDFAtlasPoster-2012-EN.pdf? utm-medium=email&utm-campaign=IDF %20Diabetes%20Atlas%202012% 20Update&utm-content=IDF%20Diabetes %20Atlas%202012%20Update+Preview +CID-720a5262162f1f585ba9 fc8ca39fef30&utm-source=campaign monitor&utm-term=English [Last accessed on June 2014]
    • Last Updated 2012. Diabetes Atlas Update 2012
  • 2
    • 84874293805 scopus 로고    scopus 로고
    • [Last accessed on June 2014]
    • WHO Fact sheet. Available from: www. who.int/mediacentre/factsheets/fs312/en/ [Last accessed on June 2014]
    • WHO Fact Sheet
  • 3
    • 84957415695 scopus 로고    scopus 로고
    • Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus
    • Hemmingsen B, Lund SS, Gluud C, et al. Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus. Cochrane Database Syst Rev 2013;11:CD008143
    • (2013) Cochrane Database Syst Rev , vol.11
    • Hemmingsen, B.1    Lund, S.S.2    Gluud, C.3
  • 4
    • 84884307733 scopus 로고    scopus 로고
    • Cardiac implications of hypoglycaemia in patients with diabetes - A systematic review
    • Hanefeld M, Duetting E, Bramlage P. Cardiac implications of hypoglycaemia in patients with diabetes - a systematic review. Cardiovasc Diabetol 2013;12:135
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 135
    • Hanefeld, M.1    Duetting, E.2    Bramlage, P.3
  • 5
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012;35(6):1364-79
    • (2012) Diabetes Care , vol.35 , Issue.6 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 6
    • 84888607940 scopus 로고    scopus 로고
    • Combining incretin-based therapies with insulin: Realizing the potential in type 2 diabetes
    • Vora J. Combining incretin-based therapies with insulin: realizing the potential in type 2 diabetes. Diabetes Care 2013; 36(Suppl 2):S226-32
    • (2013) Diabetes Care , vol.36 , pp. S226-S232
    • Vora, J.1
  • 7
    • 33644932611 scopus 로고    scopus 로고
    • Postprandial glucose regulation: New data and new implications
    • Leiter LA, Ceriello A, Davidson JA, et al. Postprandial glucose regulation: new data and new implications. Clin Ther 2005; 27(Suppl B):S42-56
    • (2005) Clin Ther , vol.27 , pp. S42-56
    • Leiter, L.A.1    Ceriello, A.2    Davidson, J.A.3
  • 8
    • 84862686725 scopus 로고    scopus 로고
    • Optimization of insulin therapy in patients with type 2 diabetes mellitus: Beyond basal insulin
    • Blak BT, Smith HT, Hards M, et al. Optimization of insulin therapy in patients with type 2 diabetes mellitus: beyond basal insulin. Diabet Med 2012;29(7):e13-20
    • (2012) Diabet Med , vol.29 , Issue.7 , pp. e13-20
    • Blak, B.T.1    Smith, H.T.2    Hards, M.3
  • 9
    • 84890452549 scopus 로고    scopus 로고
    • Glycemic control among patients with type 2 diabetes who initiate basal insulin: A retrospective cohort study
    • Curtis B, Lage MJ. Glycemic control among patients with type 2 diabetes who initiate basal insulin: a retrospective cohort study. J Med Econ 2014;17(1):21-31
    • (2014) J Med Econ , vol.17 , Issue.1 , pp. 21-31
    • Curtis, B.1    Lage, M.J.2
  • 10
    • 84859842346 scopus 로고    scopus 로고
    • Insulin adherence behaviours and barriers in the multinational Global Attitudes of Patients and Physicians in Insulin Therapy study
    • Peyrot M, Barnett AH, Meneghini LF, Schumm-Draeger PM. Insulin adherence behaviours and barriers in the multinational Global Attitudes of Patients and Physicians in Insulin Therapy study. Diabet Med 2012;29(5):682-9
    • (2012) Diabet Med , vol.29 , Issue.5 , pp. 682-689
    • Peyrot, M.1    Barnett, A.H.2    Meneghini, L.F.3    Schumm-Draeger, P.M.4
  • 11
    • 79952063907 scopus 로고    scopus 로고
    • Type 2 diabetes care and insulin intensification: Is a more multidisciplinary approach needed? Results from the MODIFY survey
    • Cuddihy RM, Philis-Tsimikas A, Nazeri A. Type 2 diabetes care and insulin intensification: is a more multidisciplinary approach needed? Results from the MODIFY survey. Diabetes Educ 2011; 37(1):111-23
    • (2011) Diabetes Educ , vol.37 , Issue.1 , pp. 111-123
    • Cuddihy, R.M.1    Philis-Tsimikas, A.2    Nazeri, A.3
  • 12
    • 73349087520 scopus 로고    scopus 로고
    • Barriers to insulin initiation and intensification and how to overcome them
    • Kunt T, Snoek FJ. Barriers to insulin initiation and intensification and how to overcome them. Int J Clin Pract Suppl 2009;164:6-10
    • (2009) Int J Clin Pract Suppl , vol.164 , pp. 6-10
    • Kunt, T.1    Snoek, F.J.2
  • 13
    • 84901745922 scopus 로고    scopus 로고
    • Patterns and trends in insulin intensification among patients with type 2 diabetes: A systematic review
    • Polinski JM, Connolly JG, Curtis BH, et al. Patterns and trends in insulin intensification among patients with type 2 diabetes: a systematic review. Prim Care Diabetes 2014;8(2):101-9
    • (2014) Prim Care Diabetes , vol.8 , Issue.2 , pp. 101-109
    • Polinski, J.M.1    Connolly, J.G.2    Curtis, B.H.3
  • 14
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulindependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, et al. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulindependent) diabetic patients. Diabetologia 1993;36(8):741-4
    • (1993) Diabetologia , vol.36 , Issue.8 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3
  • 15
    • 0030667056 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
    • Nauck MA, Niedereichholz U, Ettler R, et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 1997;273(5 Pt 1):E981-8
    • (1997) Am J Physiol , vol.273 , Issue.5 , pp. E981-E988
    • Nauck, M.A.1    Niedereichholz, U.2    Ettler, R.3
  • 16
    • 84883754628 scopus 로고    scopus 로고
    • Incretin hormones and the satiation signal
    • Holst JJ. Incretin hormones and the satiation signal. Int J Obes 2013;37(9): 1161-8
    • (2013) Int J Obes , vol.37 , Issue.9 , pp. 1161-1168
    • Holst, J.J.1
  • 17
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M, Stöckmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 1986;29(1):46-52
    • (1986) Diabetologia , vol.29 , Issue.1 , pp. 46-52
    • Nauck, M.1    Stöckmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 18
    • 84901593760 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: Differences and similarities
    • Lund A, Knop FK, Vilsbøll T. Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: differences and similarities. Eur J Intern Med 2014;25:407-14
    • (2014) Eur J Intern Med , vol.25 , pp. 407-414
    • Lund, A.1    Knop, F.K.2    Vilsbøll, T.3
  • 19
    • 79551615182 scopus 로고    scopus 로고
    • Use of twice-daily exenatide in Basal insulin treated patients with type 2 diabetes: A randomized controlled trial
    • Buse JB, Bergenstal RM, Glass LC, et al. Use of twice-daily exenatide in Basal insulin treated patients with type 2 diabetes: a randomized, controlled trial. Ann Intern Med 2011;154(2):103-12
    • (2011) Ann Intern Med , vol.154 , Issue.2 , pp. 103-112
    • Buse, J.B.1    Bergenstal, R.M.2    Glass, L.C.3
  • 20
    • 84862903186 scopus 로고    scopus 로고
    • Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets
    • DeVries JH, Bain SC, Rodbard HW, et al. Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets. Diabetes Care 2012;35(7):1446-54
    • (2012) Diabetes Care , vol.35 , Issue.7 , pp. 1446-1454
    • Devries, J.H.1    Bain, S.C.2    Rodbard, H.W.3
  • 21
    • 84907351456 scopus 로고    scopus 로고
    • Insulin plus incretin: A glucose-lowering strategy for type 2-diabetes
    • Ahrén B. Insulin plus incretin: a glucose-lowering strategy for type 2-diabetes. World J Diabetes 2014; 5(1):40-51
    • (2014) World J Diabetes , vol.5 , Issue.1 , pp. 40-51
    • Ahrén, B.1
  • 22
    • 84864460325 scopus 로고    scopus 로고
    • Design of the novel protraction mechanism of insulin degludec an ultra-long-acting basal insulin
    • Jonassen I, Havelund S, Hoeg-Jensen T, et al. Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin. Pharm Res 2012;29(8):2104-14
    • (2012) Pharm Res , vol.29 , Issue.8 , pp. 2104-2114
    • Jonassen, I.1    Havelund, S.2    Hoeg-Jensen, T.3
  • 23
    • 84874326976 scopus 로고    scopus 로고
    • Insulin degludec: Overview of a novel ultra long-acting basal insulin
    • Gough SC, Harris S, Woo V, Davies M. Insulin degludec: overview of a novel ultra long-acting basal insulin. Diabetes Obes Metab 2013;15(4):301-9
    • (2013) Diabetes Obes Metab , vol.15 , Issue.4 , pp. 301-309
    • Gough, S.C.1    Harris, S.2    Woo, V.3    Davies, M.4
  • 24
    • 84897827073 scopus 로고    scopus 로고
    • Comparative effectiveness of liraglutide in the treatment of type 2 diabetes
    • Rigato M, Fadini GP. Comparative effectiveness of liraglutide in the treatment of type 2 diabetes. Diabetes Metab Syndr Obes 2014;7:107-20
    • (2014) Diabetes Metab Syndr Obes , vol.7 , pp. 107-120
    • Rigato, M.1    Fadini, G.P.2
  • 25
    • 84871937855 scopus 로고    scopus 로고
    • Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: A pre-planned meta-analysis of phase 3 trials
    • Ratner RE, Gough SC, Mathieu C, et al. Hypoglycaemia risk with insulin degludec compared with insulin glargine in type 2 and type 1 diabetes: a pre-planned meta-analysis of phase 3 trials. Diabetes Obes Metab 2013;15(2):175-84
    • (2013) Diabetes Obes Metab , vol.15 , Issue.2 , pp. 175-184
    • Ratner, R.E.1    Gough, S.C.2    Mathieu, C.3
  • 26
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009; 374(9683):39-47
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 27
    • 84872084453 scopus 로고    scopus 로고
    • Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): A randomised open-label study
    • Buse JB, Nauck M, Forst T, et al. Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study. Lancet 2013;81(9861):117-24
    • (2013) Lancet , vol.81 , Issue.9861 , pp. 117-124
    • Buse, J.B.1    Nauck, M.2    Forst, T.3
  • 28
    • 84878863716 scopus 로고    scopus 로고
    • Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin
    • Kapitza C, Forst T, Coester HV, et al. Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin. Diabetes Obes Metab 2013;15(7):642-9
    • (2013) Diabetes Obes Metab , vol.15 , Issue.7 , pp. 642-649
    • Kapitza, C.1    Forst, T.2    Coester, H.V.3
  • 29
    • 84908177336 scopus 로고    scopus 로고
    • Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): A randomised open-label phase 3 non-inferiority trial
    • Dungan KM, Povedano ST, Forst T, et al. Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial. Lancet 2014; 384(9951):1349-57
    • (2014) Lancet , vol.384 , Issue.9951 , pp. 1349-1357
    • Dungan, K.M.1    Povedano, S.T.2    Forst, T.3
  • 30
    • 84903121563 scopus 로고    scopus 로고
    • A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjects with type 2 diabetes (BEGIN: VICTOZA ADD-ON)
    • Mathieu C, Rodbard HW, Cariou B, et al. A comparison of adding liraglutide versus a single daily dose of insulin aspart to insulin degludec in subjects with type 2 diabetes (BEGIN: VICTOZA ADD-ON). Diabetes Obes Metab 2014;16(7):636-44
    • (2014) Diabetes Obes Metab , vol.16 , Issue.7 , pp. 636-644
    • Mathieu, C.1    Rodbard, H.W.2    Cariou, B.3
  • 31
    • 84922519772 scopus 로고    scopus 로고
    • Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: Results of a phase 3 open-label randomised 26-week treat-to-target trial in insulin-naive patients with type 2 diabetes
    • Gough SC, Bode B, Woo V, et al. Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes. Lancet Diabetes Endocrinol 2014;2(11):885-93
    • (2014) Lancet Diabetes Endocrinol , vol.2 , Issue.11 , pp. 885-893
    • Gough, S.C.1    Bode, B.2    Woo, V.3
  • 32
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009;373(9662):473-81
    • (2009) Lancet , vol.373 , Issue.9662 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 33
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brändle M, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabet Med 2009;26:268-78
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3
  • 34
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (liraglutide effect and action in diabetes)-2 study
    • Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care 2009;32(1):84-90
    • (2009) Diabetes Care , vol.32 , Issue.1 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 35
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial
    • Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia 2009;52(10): 2046-55
    • (2009) Diabetologia , vol.52 , Issue.10 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 36
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse JB, et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 2009;32(7): 1224-30
    • (2009) Diabetes Care , vol.32 , Issue.7 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3
  • 37
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week randomised parallel-group open-label trial
    • Pratley RE, Nauck M, Bailey T, et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet 2010;375(9724): 1447-56
    • (2010) Lancet , vol.375 , Issue.9724 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3
  • 38
    • 84923346908 scopus 로고    scopus 로고
    • One-year efficacy and safety of IDegLira in patients with type 2 diabetes
    • Abstract 65-OR
    • Gough SCL, Buse JB, Woo VC, et al. One-year efficacy and safety of IDegLira in patients with type 2 diabetes. Diabetes 2014;63(Suppl 1):A17:Abstract 65-OR
    • (2014) Diabetes , vol.63 , pp. A17
    • Gough, S.C.L.1    Buse, J.B.2    Woo, V.C.3
  • 39
    • 84910049684 scopus 로고    scopus 로고
    • Contribution of liraglutide in the fixed-ratio combination of insulin degludec and liraglutide (IDegLira)
    • Buse JB, Vilsbøll T, Thurman J, et al. Contribution of liraglutide in the fixed-ratio combination of insulin degludec and liraglutide (IDegLira). Diabetes Care 2014; 37(11):2926-33
    • (2014) Diabetes Care , vol.37 , Issue.11 , pp. 2926-2933
    • Buse, J.B.1    Vilsbøll, T.2    Thurman, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.