Multidisciplinary clinic dedicated to treating youth with pediatric acute-onset neuropsychiatric syndrome: Presenting characteristics of the first 47 consecutive patients

Journal of Child and Adolescent Psychopharmacology

Volumn 25, Issue 1, 2015, Pages 38-47

  Frankovich, Jennifer ^a   Thienemann, Margo ^a   Pearlstein, Jennifer ^a   Crable, Amber ^a   Brown, Kayla ^a   Chang, Kiki ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; IMMUNOGLOBULIN;

ADOLESCENT; ARTHRITIS; ARTICLE; ATTENTION DEFICIT DISORDER; ATTENTION DISTURBANCE; AUTISM; AUTOIMMUNE DISEASE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CLINICAL EVALUATION; CLINICAL FEATURE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DRUG MEGADOSE; FAMILY; FEMALE; GASTROINTESTINAL SYMPTOM; GESTURE; GROUP A STREPTOCOCCAL INFECTION; HOMICIDE; HUMAN; HYPERACTIVITY; IMMUNOGLOBULIN BLOOD LEVEL; INFLAMMATORY DISEASE; JUVENILE; LEARNING DISORDER; MALE; MEDICAL RECORD REVIEW; MENTAL DISEASE; MENTAL PATIENT; MOOD DISORDER; MOTOR DYSFUNCTION; OBSESSIVE COMPULSIVE DISORDER; OCCUPATIONAL THERAPY; PAIN; PARENT; PEDIATRIC ACUTE ONSET NEUROPSYCHIATRIC SYNDROME; PHYSIOTHERAPY; RELAPSE; REMISSION; SCHOOL CHILD; SENSORY DYSFUNCTION; SLEEP DISORDER; STREPTOCOCCUS GROUP A; SUICIDAL BEHAVIOR; SYMPTOM; THINKING; URINARY FREQUENCY; UROGENITAL TRACT DISEASE; ACUTE DISEASE; AUTOIMMUNE DISEASES; COMPLICATION; FEEDING AND EATING DISORDERS; OBSESSIVE-COMPULSIVE DISORDER; OUTPATIENT DEPARTMENT; STREPTOCOCCAL INFECTIONS; SYNDROME; TREATMENT OUTCOME;

ACUTE DISEASE; ADOLESCENT; AMBULATORY CARE FACILITIES; AUTOIMMUNE DISEASES; CHILD; FEEDING AND EATING DISORDERS; FEMALE; HUMANS; MALE; OBSESSIVE-COMPULSIVE DISORDER; STREPTOCOCCAL INFECTIONS; SYNDROME; TREATMENT OUTCOME;

EID: 84923316474     PISSN: 10445463     EISSN: 15578992     Source Type: Journal    
DOI: 10.1089/cap.2014.0081     Document Type: Article

References (55)

1. Bernstein GA, Victor AM, Pipal AJ, Williams KA: Comparison of clinical characteristics of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections and childhood obsessive-compulsive disorder. J Child Adolesc Psychopharmacol 20:333-340, 2010.
2. Brimberg L, Benhar I, Mascaro-Blanco A, Alvarez K, Lotan D, Winter C, Klein J, Moses AE, Somnier FE, Leckman JF, Swedo SE, Cunningham MW, Joel D: Behavioral, pharmacological, and immunological abnormalities after streptococcal exposure: A novel rat model of Sydenham chorea and related neuropsychiatric disorders. Neuropsychopharmacology 37:2076-2087, 2012.
3. Candler PM, Dale RC: Three cases of central nervous system complications associated with Mycoplasma pneumoniae. Pediatr Neurol 31:133-138, 2004.
4. Chang HY, Chang LY, Shao PL, Lee PI, Chen JM, Lee CY, Lu CY, Huang LM: Comparison of real-time polymerase chain reaction and serological tests for the confirmation of Mycoplasma pneumoniae infection in children with clinical diagnosis of atypical pneumonia. J Microbiol Immunol Infect 47: 137-144, 2014.
5. Chang K, Frankovich J, Cooperstock M, Cunningham M, Latimer ME, Murphy TK, Pasternack M, Thienemann M, Williams K, Walter J, Swedo SE: Clinical evaluation of youth with pediatric acute onset neuropsychiatric syndrome (PANS): Recommendations from the 2013 PANS Consensus Conference. J Child Adolesc Psychopharmacol 25:3-13, 2015.
6. Dale RC, Brilot F: Autoimmune basal ganglia disorders. J Child Neurol 27:1470-1481, 2012.
7. Esposito S, Bosis S, Semino M, Rigante D: Infections and systemic lupus erythematosus. Eur J Clin Microbiol Infect Dis 33:1467-1475, 2014.
8. Garvey MA, Perlmutter SJ, Allen AJ, Hamburger S, Lougee L, Leonard HL, Witowski ME, Dubbert B, Swedo SE: A pilot study of penicillin prophylaxis for neuropsychiatric exacerbations triggered by streptococcal infections. Biol Psychiatry 45:1564-1571, 1999.
9. Gesundheit B, Rosenzweig JP, Naor D, Lerer B, Zachor DA, Prochazka V, Melamed M, Kristt DA, Steinberg A, Shulman C, Hwang P, Koren G, Walfisch A, Passweg JR, Snowden JA, Tamouza R, Leboyer M, Farge-Bancel D, Ashwood P: Immunological and autoimmune considerations of autism spectrum disorders. J Autoimmun 44:1-7, 2013.
10. Gomes de Alvarenga P, de Mathis MA, Dominguez Alves AC, do Rosario MC, Fossaluza V, Hounie AG, Miguel EC, Rodrigues Torres A: Clinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study. CNS Spectr 17:87-93, 2012.
11. Hilario MO, Len CA, Roja SC, Terreri MT, Almeida G, Andrade LE: Frequency of antinuclear antibodies in healthy children and adolescents. Clin Pediatr (Phila) 43:637-642, 2004.
12. Hoffman KL, Hornig M, Yaddanapudi K, Jabado O, Lipkin WI: A murine model for neuropsychiatric disorders associated with group A beta-hemolytic streptococcal infection. J Neurosci 24:1780-1791, 2004.
13. Husby G, van de Rijn I, Zabriskie JB, Abdin ZH, Williams RC, Jr.: Antibodies reacting with cytoplasm of subthalamic and caudate nuclei neurons in chorea and acute rheumatic fever. J Exp Med 144:1094-1110, 1976.
14. Kaplan EL, Rothermel CD, Johnson DR: Antistreptolysin O and antideoxyribonuclease B titers: Normal values for children ages 2 to 12 in the United States. Pediatrics 101:86-88, 1998.
15. Kirvan CA, Swedo SE, Heuser JS, Cunningham MW: Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea. Nat Med 9:914-920, 2003.
16. Kirvan CA, Swedo SE, Snider LA, Cunningham MW: Antibodymediated neuronal cell signaling in behavior and movement disorders. J Neuroimmunol 179:173-179, 2006.
17. Kirvan CA, Cox CJ, Swedo SE, Cunningham MW: Tubulin is a neuronal target of autoantibodies in Sydenham's chorea. J Immunol 178:7412-7421, 2007.
18. Leckman JF, Vaccarino FM: Editorial commentary: ''What does immunology have to do with brain development and neuropsychiatric disorders?'' Brain Res 2014 [Epub ahead of print].
19. Leonard HL, Swedo SE: Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Int J Neuropsychopharmacol 4:191-198, 2001.
20. Lotan D, Benhar I, Alvarez K, Mascaro-Blanco A, Brimberg L, Frenkel D, Cunningham MW, Joel D: Behavioral and neural effects of intra-striatal infusion of anti-streptococcal antibodies in rats. Brain Behav Immun 38:249-262, 2014.
21. Mahmud FH, Lteif AN, Renaud DL, Reed AM, Brands CK: Steroidresponsive encephalopathy associated with Hashimoto's thyroiditis in an adolescent with chronic hallucinations and depression: Case report and review. Pediatrics 112:686-690, 2003.
22. Malleson PN, Mackinnon MJ, Sailer-Hoeck M, Spencer CH: Review for the generalist: The antinuclear antibody test in children-When to use it and what to do with a positive titer. Pediatr Rheumatol Online J 8:27, 2010.
23. Masters SL, Simon A, Aksentijevich I, Kastner DL: Horror autoinflammaticus: The molecular pathophysiology of autoinflammatory disease (∗). Annu Rev Immunol 27:621-668, 2009.
24. Mercadante MT, Busatto GF, Lombroso PJ, Prado L, Rosario-Campos MC, do Valle R, Marques-Dias MJ, Kiss MH, Leckman JF, Miguel EC: The psychiatric symptoms of rheumatic fever. Am J Psychiatry 157:2036-2038, 2000.
25. Morer A, Lazaro L, Sabater L, Massana J, Castro J, Graus F: Antineuronal antibodies in a group of children with obsessive-compulsive disorder and Tourette syndrome. J Psychiatr Res 42:64-68, 2008.
26. Murphy TK, Snider LA, Mutch PJ, Harden E, Zaytoun A, Edge PJ, Storch EA, Yang MC, Mann G, Goodman WK, Swedo SE: Relationship of movements and behaviors to Group A Streptococcus infections in elementary school children. Biol Psychiatry 61:279-284, 2007.
27. Murphy TK, Storch EA, Turner A, Reid JM, Tan J, Lewin AB: Maternal history of autoimmune disease in children presenting with tics and/or obsessive-compulsive disorder. J Neuroimmunol 229: 243-247, 2010.
28. Murphy TK, Storch EA, Lewin AB, Edge PJ, Goodman WK: Clinical factors associated with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Pediatr 160: 314-319, 2012.
29. Murphy TK, Gerardi DM, Leckman JF: Pediatric acute-onset neuropsychiatric syndrome. Psychiatr Clin North Am 37:353-374, 2014.
30. Murphy TK, Patel PD, McGuire JF, Kennel A, Mutch PJ, Athill EP, Hanks CE, Lewin AB, Storch EA, Toufexis MD, Dadlani GH, Rodriguez CA: Characterization of the pediatric acute-onset neuropsychiatric syndrome phenotype. J Child Adolesc Psychopharmacol 25:14-25, 2015.
31. Nelson P, Rylance P, Roden D, Trela M, Tugnet N: Viruses as potential pathogenic agents in systemic lupus erythematosus. Lupus 23:596-605, 2014.
32. Novak M, Guest C: Application of a multidimensional caregiver burden inventory. Gerontologist 29:798-803, 1989.
33. O'Rourke JA, Scharf JM, Platko J, Stewart SE, Illmann C, Geller DA, King RA, Leckman JF, Pauls DL: The familial association of tourette's disorder and ADHD: The impact of OCD symptoms. Am J Med Genet B Neuropsychiatr Genet 156B:553-560, 2011.
34. Perlmutter SJ, Leitman SF, Garvey MA, Hamburger S, Feldman E, Leonard HL, Swedo SE: Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood. Lancet 354:1153-1158, 1999.
35. Peterson BS, Pine DS, Cohen P, Brook JS: Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit/hyperactivity disorders in an epidemiological sample. J Am Acad Child Adolesc Psychiatry 40:685-695, 2001.
36. Postal M, Appenzeller S: The importance of cytokines and autoantibodies in depression. Autoimmun Rev 14:30-35, 2014.
37. Sanders JS, Stassen PM, van Rossum AP, Kallenberg CG, Stegeman CA: Risk factors for relapse in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis: Tools for treatment decisions? Clin Exp Rheumatol 22:S94-101, 2004.
38. Satoh M, Chan EK, Ho LA, Rose KM, Parks CG, Cohn RD, Jusko TA, Walker NJ, Germolec DR, Whitt IZ, Crockett PW, Pauley BA, Chan JY, Ross SJ, Birnbaum LS, Zeldin DC, Miller FW: Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. Arthritis Rheum 64:2319-2327, 2012.
39. Selles RR, Storch EA, Lewin AB: Variations in symptom prevalence and clinical correlates in younger versus older youth with obsessive-compulsive disorder. Child Psychiatry Hum Dev 45:666-674, 2014.
40. Shet A, Kaplan EL, Johnson DR, Cleary PP: Immune response to group A streptococcal C5a peptidase in children: Implications for vaccine development. J Infect Dis 188:809-817, 2003.
41. Sieper J, van der Heijde D, Landewe R, Brandt J, Burgos-Vagas R, Collantes-Estevez E, Dijkmans B, Dougados M, Khan MA, Leirisalo-Repo M, van der Linden S, Maksymowych WP, Mielants H, Olivieri I, Rudwaleit M: New criteria for inflammatory back pain in patients with chronic back pain: A real patient exercise by experts from the Assessment of SpondyloArthritis international Society (ASAS). Ann Rheum Dis 68:784-788, 2009.
42. Singer HS, Loiselle CR, Lee O, Minzer K, Swedo S, Grus FH: Antibasal ganglia antibodies in PANDAS. Mov Disord 19:406-415, 2004.
43. Slattery MJ, Dubbert BK, Allen AJ, Leonard HL, Swedo SE, Gourley MF: Prevalence of obsessive-compulsive disorder in patients with systemic lupus erythematosus. J Clin Psychiatry 65:301-306, 2004.
44. Snider LA, Lougee L, Slattery M, Grant P, Swedo SE: Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders. Biol Psychiatry 57:788-792, 2005.
45. Sperotto F, Cuffaro G, Brachi S, Seguso M, Zulian F: Prevalence of antinuclear antibodies in schoolchildren during puberty and possible relationship with musculoskeletal pain: A longitudinal study. J Rheumatol 41:1405-1408, 2014.
46. Stagi S, Rigante D, Lepri G, Bertini F, Matucci-Cerinic M, Falcini F: Evaluation of autoimmune phenomena in patients with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS). Autoimmun Rev 13:1236-1240, 2014.
47. Stringer S, Kahn RS, de Witte LD, Ophoff RA, Derks EM: Genetic liability for schizophrenia predicts risk of immune disorders. Schizophr Res 159:347-352, 2014.
48. Swedo SE, Rapoport JL, Cheslow DL, Leonard HL, Ayoub EM, Hosier DM, Wald ER: High prevalence of obsessive-compulsive symptoms in patients with Sydenham's chorea. Am J Psychiatry 146:246-249, 1989.
49. Swedo SE, Leonard HL, Schapiro MB, Casey BJ, Mannheim GB, Lenane MC, Rettew DC: Sydenham's chorea: Physical and psychological symptoms of St Vitus dance. Pediatrics 91:706-713, 1993.
50. Swedo SE, Leonard HL, Garvey M, Mittleman B, Allen AJ, Perlmutter S, Lougee L, Dow S, Zamkoff J, Dubbert BK: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases. Am J Psychiatry 155: 264-271, 1998.
51. Swedo SE, Schrag A, Gilbert R, Giovannoni G, Robertson MM, Metcalfe C, Ben-Shlomo Y, Gilbert DL: Streptococcal infection, Tourette syndrome, and OCD: Is there a connection? PANDAS: horse or zebra? Neurology 74: 13971399, 2010.
52. Swedo SE, Leckman JF, Rose NR: From research subgroup to clinical syndrome: Modifying the PANDAS criteria to describe PANS (pediatric acute-onset neuropsychiatric syndrome). Pediatr Ther 2, 2012.
53. Toufexis MD, Hommer R, Gerardi DM, Grant P, Rothschild L, D'Souza P, Williams K, Leckman J, Swedo SE, Murphy TK: Disordered eating and food restrictions in children with PANDAS/PANS. J Child Adolesc Psychopharmacol, 25: 48-56, 2015.
54. Williams KA, Swedo SE: Post-infectious autoimmune disorders: Sydenham's chorea, PANDAS and beyond. Brain Res, 2014 [Epub ahead of print].
55. Yaddanapudi K, Hornig M, Serge R, De Miranda J, Baghban A, Villar G, Lipkin WI: Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection. Mol Psychiatry 15:712-726, 2010.