메뉴 건너뛰기




Volumn 23, Issue 10, 2014, Pages 2598-2606

Anti-inflammatory and antiapoptotic effects of mesenchymal stem cells transplantation in rat brain with cerebral ischemia

Author keywords

Apoptosis rat cerebral ischemia and reperfusion; Human mesenchymal stem cells; Inflammation; Kappa B; Nuclear factor

Indexed keywords

BROXURIDINE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; PROTEIN BCL 2; PROTEIN P53; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA; I KAPPA B; I KAPPA B KINASE; NF-KAPPAB INHIBITOR ALPHA; PROTEIN BAX;

EID: 84923309509     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2014.05.032     Document Type: Article
Times cited : (36)

References (42)
  • 1
    • 81255195550 scopus 로고    scopus 로고
    • Ischemia and reperfusion-from mechanism to translation
    • Eltzschig HK, Eckle T. Ischemia and reperfusion-from mechanism to translation. Nat Med 2011; 17: 1391-1401.
    • (2011) Nat Med , vol.17 , pp. 1391-1401
    • Eltzschig, H.K.1    Eckle, T.2
  • 2
    • 79951689820 scopus 로고    scopus 로고
    • TRIM-9 functions in the UNC- 6/UNC-40 pathway to regulate ventral guidance
    • Song S, Ge Q, Wang J, et al. TRIM-9 functions in the UNC- 6/UNC-40 pathway to regulate ventral guidance. J Genet Genomics 2011; 38: 1-11.
    • (2011) J Genet Genomics , vol.38 , pp. 1-11
    • Song, S.1    Ge, Q.2    Wang, J.3
  • 3
    • 0022481133 scopus 로고
    • Multiple nuclear factors interact with the immunoglobulin enhancer sequences
    • 2006
    • Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986; 46: 705-716. 2006.
    • (1986) Cell , vol.46 , pp. 705-716
    • Sen, R.1    Baltimore, D.2
  • 4
    • 0031906550 scopus 로고    scopus 로고
    • Signal transduction through NF-kappa B
    • May MJ, Ghosh S. Signal transduction through NF-kappa B. Immunol Today 1998; 19: 80-88.
    • (1998) Immunol Today , vol.19 , pp. 80-88
    • May, M.J.1    Ghosh, S.2
  • 5
    • 67349192965 scopus 로고    scopus 로고
    • Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action
    • Chen B, Liao WQ, Xu N, et al. Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action. Brain Res 2009; 1273: 129-137.
    • (2009) Brain Res , vol.1273 , pp. 129-137
    • Chen, B.1    Liao, W.Q.2    Xu, N.3
  • 6
    • 74449090257 scopus 로고    scopus 로고
    • Intracellular mechanisms of N-acylethanolamine-mediated neuroprotection in a rat model of stroke
    • Garg P, Duncan RS, Kaja S, et al. Intracellular mechanisms of N-acylethanolamine-mediated neuroprotection in a rat model of stroke. Neuroscience 2010; 166: 252-262.
    • (2010) Neuroscience , vol.166 , pp. 252-262
    • Garg, P.1    Duncan, R.S.2    Kaja, S.3
  • 7
    • 1642546640 scopus 로고    scopus 로고
    • Nuclear factor- (kappa)B modulates the p53 response in neurons exposed to DNA damage
    • Aleyasin H, Cregan SP, Iyirhiaro G, et al. Nuclear factor- (kappa)B modulates the p53 response in neurons exposed to DNA damage. J Neurosci 2004; 24: 2963-2973.
    • (2004) J Neurosci , vol.24 , pp. 2963-2973
    • Aleyasin, H.1    Cregan, S.P.2    Iyirhiaro, G.3
  • 8
    • 0033561799 scopus 로고    scopus 로고
    • Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum
    • Qin ZH, Chen RW, Wang Y, et al. Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum. J Neurosci 1999; 19: 4023-4033.
    • (1999) J Neurosci , vol.19 , pp. 4023-4033
    • Zh, Q.1    Chen, R.W.2    Wang, Y.3
  • 9
    • 0037339636 scopus 로고    scopus 로고
    • Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons
    • Pugazhenthi S, Nesterova A, Jambal P, et al. Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons. J Neurochem 2003; 84: 982-996.
    • (2003) J Neurochem , vol.84 , pp. 982-996
    • Pugazhenthi, S.1    Nesterova, A.2    Jambal, P.3
  • 10
    • 0033237384 scopus 로고    scopus 로고
    • Rel/NF-kappaB represses bcl-2 transcription in pro-B lymphocytes
    • Sohur US, Dixit MN, Chen CL, et al. Rel/NF-kappaB represses bcl-2 transcription in pro-B lymphocytes. Gene Expr 1999; 8: 219-229.
    • (1999) Gene Expr , vol.8 , pp. 219-229
    • Sohur, U.S.1    Dixit, M.N.2    Chen, C.L.3
  • 11
    • 84863012337 scopus 로고    scopus 로고
    • Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats
    • Chang YS, Choi SJ, Sung DK, et al. Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats. Cell Transplant 2011; 20: 1843-1854.
    • (2011) Cell Transplant , vol.20 , pp. 1843-1854
    • Chang, Y.S.1    Choi, S.J.2    Sung, D.K.3
  • 12
    • 72049118713 scopus 로고    scopus 로고
    • Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats
    • Chang YS, Oh W, Choi SJ, et al. Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats. Cell Transplant 2009; 18: 869-886.
    • (2009) Cell Transplant , vol.18 , pp. 869-886
    • Chang, Y.S.1    Oh, W.2    Choi, S.J.3
  • 13
    • 84865327142 scopus 로고    scopus 로고
    • Human umbilical cord blood-derived mesenchymal stem cell transplantation attenuates severe brain injury by permanent middle cerebral artery occlusion in newborn rats
    • Kim ES, Ahn SY, Im GH, et al. Human umbilical cord blood-derived mesenchymal stem cell transplantation attenuates severe brain injury by permanent middle cerebral artery occlusion in newborn rats. Pediatr Res 2012; 72: 277-284.
    • (2012) Pediatr Res , vol.72 , pp. 277-284
    • Kim, E.S.1    Ahn, S.Y.2    Im, G.H.3
  • 14
    • 80051599870 scopus 로고    scopus 로고
    • Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice
    • Kim ES, Chang YS, Choi SJ, et al. Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells attenuates Escherichia coli-induced acute lung injury in mice. Respir Res 2011; 12: 108.
    • (2011) Respir Res , vol.12 , pp. 108
    • Kim, E.S.1    Chang, Y.S.2    Choi, S.J.3
  • 15
    • 37549062215 scopus 로고    scopus 로고
    • Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats
    • Okazaki T, Magaki T, Takeda M, et al. Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats. Neurosci Lett 2008; 430: 109-114.
    • (2008) Neurosci Lett , vol.430 , pp. 109-114
    • Okazaki, T.1    Magaki, T.2    Takeda, M.3
  • 16
    • 0030932288 scopus 로고    scopus 로고
    • Characterizing the target of acute stroke therapy
    • Fisher M. Characterizing the target of acute stroke therapy. Stroke 1997; 28: 866-872.
    • (1997) Stroke , vol.28 , pp. 866-872
    • Fisher, M.1
  • 17
    • 33751001799 scopus 로고    scopus 로고
    • Effects of the novel non-steroidal anti-inflammatory compound [N-(2-thiolethyl)-2-{2-[N'-(2,6-dichlorophenyl) amino] phenyl}acetamide on cytokines and apoptosis in ischaemic rat brain
    • Peroulis N, Kourounakis AP, Yiangou M, et al. Effects of the novel non-steroidal anti-inflammatory compound [N-(2-thiolethyl)-2-{2-[N'-(2,6-dichlorophenyl) amino] phenyl}acetamide on cytokines and apoptosis in ischaemic rat brain. Arzneimittelforschung 2006; 56: 688-694.
    • (2006) Arzneimittelforschung , vol.56 , pp. 688-694
    • Peroulis, N.1    Kourounakis, A.P.2    Yiangou, M.3
  • 18
    • 68349160764 scopus 로고    scopus 로고
    • Therapeutic benefit of human umbilical cord derived mesenchymal stromal cells in intracerebral hemorrhage rat: Implications of antiinflammation and angiogenesis
    • Liao W, Zhong J, Yu J, et al. Therapeutic benefit of human umbilical cord derived mesenchymal stromal cells in intracerebral hemorrhage rat: implications of antiinflammation and angiogenesis. Cell Physiol Biochem 2009; 24: 307-316.
    • (2009) Cell Physiol Biochem , vol.24 , pp. 307-316
    • Liao, W.1    Zhong, J.2    Yu, J.3
  • 19
    • 59749103836 scopus 로고    scopus 로고
    • Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia
    • Toyama K, Honmou O, Harada K, et al. Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia. Exp Neurol 2009; 216: 47-55.
    • (2009) Exp Neurol , vol.216 , pp. 47-55
    • Toyama, K.1    Honmou, O.2    Harada, K.3
  • 20
    • 78649703082 scopus 로고    scopus 로고
    • Human mesenchymal stem cells efficiently manage oxidative stress
    • Valle-Prieto A, Conget PA. Human mesenchymal stem cells efficiently manage oxidative stress. Stem Cells Dev 2010; 19: 1885-1893.
    • (2010) Stem Cells Dev , vol.19 , pp. 1885-1893
    • Valle-Prieto, A.1    Conget, P.A.2
  • 21
    • 33644923533 scopus 로고    scopus 로고
    • Differentiation of human bone marrow stem cells into cells with a neural phenotype: Diverse effects of two specific treatments
    • Scintu F, Reali C, Pillai R, et al. Differentiation of human bone marrow stem cells into cells with a neural phenotype: diverse effects of two specific treatments. BMC Neurosci 2006; 7: 14.
    • (2006) BMC Neurosci , vol.7 , pp. 14
    • Scintu, F.1    Reali, C.2    Pillai, R.3
  • 22
    • 84864339379 scopus 로고    scopus 로고
    • The immunomodulatory and neuroprotective effects of mesenchymal stem cells (MSCs) in experimental autoimmune encephalomyelitis (EAE): A model of multiple sclerosis (MS)
    • Al Jumah MA, Abumaree MH. The immunomodulatory and neuroprotective effects of mesenchymal stem cells (MSCs) in experimental autoimmune encephalomyelitis (EAE): a model of multiple sclerosis (MS). Int J Mol Sci 2012; 13: 9298-9331.
    • (2012) Int J Mol Sci , vol.13 , pp. 9298-9331
    • Al Jumah, M.A.1    Abumaree, M.H.2
  • 23
    • 0035122043 scopus 로고    scopus 로고
    • SOD1 downregulates NF-kappaB and c-Myc expression in mice after transient focal cerebral ischemia
    • Huang CY, Fujimura M, Noshita N, et al. SOD1 downregulates NF-kappaB and c-Myc expression in mice after transient focal cerebral ischemia. J Cereb Blood Flow Metab 2001; 21: 163-173.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 163-173
    • Huang, C.Y.1    Fujimura, M.2    Noshita, N.3
  • 24
    • 84923307080 scopus 로고    scopus 로고
    • Shuanghuanglian injection downregulates nuclear factor-kappa B expression in mice with viral encephalitis
    • Gu NB, Tian Y, ZL D. Shuanghuanglian injection downregulates nuclear factor-kappa B expression in mice with viral encephalitis. Neural Regeneration Research 2012; 7: 8.
    • (2012) Neural Regeneration Research , vol.7 , pp. 8
    • Gu, N.B.1    Tian, Y.2    Zl, D.3
  • 25
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • Iadecola C, Anrather J. The immunology of stroke: from mechanisms to translation. Nat Med 2011; 17: 796-808.
    • (2011) Nat Med , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 26
    • 33746424373 scopus 로고    scopus 로고
    • Mesenchymal stem cells as trophic mediators
    • Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006; 98: 1076-1084.
    • (2006) J Cell Biochem , vol.98 , pp. 1076-1084
    • Caplan, A.I.1    Dennis, J.E.2
  • 27
    • 0347600715 scopus 로고    scopus 로고
    • Immunomodulatory effects of fetal and adult mesenchymal stem cells
    • Le Blanc K. Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy 2003; 5: 485-489.
    • (2003) Cytotherapy , vol.5 , pp. 485-489
    • Le Blanc, K.1
  • 28
    • 0038204193 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific Tcells to their cognate peptide
    • Krampera M, Glennie S, Dyson J, et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific Tcells to their cognate peptide. Blood 2003; 101: 3722-3729.
    • (2003) Blood , vol.101 , pp. 3722-3729
    • Krampera, M.1    Glennie, S.2    Dyson, J.3
  • 29
    • 84884711775 scopus 로고    scopus 로고
    • Human mesenchymal stem cell transplantation changes proinflammatory gene expression through a nuclear factorkappaB- dependent pathway in a rat focal cerebral ischemic model
    • Wang H, Nagai A, Sheikh AM, et al. Human mesenchymal stem cell transplantation changes proinflammatory gene expression through a nuclear factorkappaB- dependent pathway in a rat focal cerebral ischemic model. J Neurosci Res 2013; 91: 1440-1449.
    • (2013) J Neurosci Res , vol.91 , pp. 1440-1449
    • Wang, H.1    Nagai, A.2    Sheikh, A.M.3
  • 30
    • 44249112092 scopus 로고    scopus 로고
    • Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow
    • Nagai A, Kim WK, Lee HJ, et al. Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow. PLoS One 2007; 2: e1272.
    • (2007) PLoS One , vol.2 , pp. e1272
    • Nagai, A.1    Kim, W.K.2    Lee, H.J.3
  • 31
    • 71849093751 scopus 로고    scopus 로고
    • Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia
    • Niizuma K, Yoshioka H, Chen H, et al. Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Biochim Biophys Acta 2010; 1802: 92-99.
    • (2010) Biochim Biophys Acta , vol.1802 , pp. 92-99
    • Niizuma, K.1    Yoshioka, H.2    Chen, H.3
  • 32
    • 78649704141 scopus 로고    scopus 로고
    • A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia
    • e15
    • Peters CJ, Rees JR, Hardwick RH, et al. A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardia. Gastroenterology 2010; 139: 1995-2004.e15.
    • (2010) Gastroenterology , vol.139 , pp. 1995-2004
    • Peters, C.J.1    Rees, J.R.2    Hardwick, R.H.3
  • 33
    • 67249139255 scopus 로고    scopus 로고
    • Delayed treatment with a p53 inhibitor enhances recovery in stroke brain
    • Luo Y, Kuo CC, Shen H, et al. Delayed treatment with a p53 inhibitor enhances recovery in stroke brain. Ann Neurol 2009; 65: 520-530.
    • (2009) Ann Neurol , vol.65 , pp. 520-530
    • Luo, Y.1    Kuo, C.C.2    Shen, H.3
  • 34
    • 80051547771 scopus 로고    scopus 로고
    • Targeting the p53 pathway to protect the neonatal ischemic brain
    • Nijboer CH, Heijnen CJ, van der Kooij MA, et al. Targeting the p53 pathway to protect the neonatal ischemic brain. Ann Neurol 2011; 70: 255-264.
    • (2011) Ann Neurol , vol.70 , pp. 255-264
    • Nijboer, C.H.1    Heijnen, C.J.2    Van Der Kooij, M.A.3
  • 35
    • 72949091020 scopus 로고    scopus 로고
    • P53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms
    • Wang Y, Dong XX, Cao Y, et al. p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms. Eur J Neurosci 2009; 30: 2258-2270.
    • (2009) Eur J Neurosci , vol.30 , pp. 2258-2270
    • Wang, Y.1    Dong, X.X.2    Cao, Y.3
  • 36
    • 76749165731 scopus 로고    scopus 로고
    • Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB
    • Meunier J, Hayashi T. Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB. J Pharmacol Exp Ther 2010; 332: 388-397.
    • (2010) J Pharmacol Exp Ther , vol.332 , pp. 388-397
    • Meunier, J.1    Hayashi, T.2
  • 38
    • 0024494427 scopus 로고
    • Reversible middle cerebral artery occlusion without craniectomy in rats
    • Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989; 20: 84-91.
    • (1989) Stroke , vol.20 , pp. 84-91
    • Longa, E.Z.1    Weinstein, P.R.2    Carlson, S.3
  • 39
    • 48049121741 scopus 로고    scopus 로고
    • Effectiveness of a new modified intraluminal suture for temporary middle cerebral artery occlusion in rats of various weight
    • Lourbopoulos A, Karacostas D, Artemis N, et al. Effectiveness of a new modified intraluminal suture for temporary middle cerebral artery occlusion in rats of various weight. J Neurosci Methods 2008; 173: 225-234.
    • (2008) J Neurosci Methods , vol.173 , pp. 225-234
    • Lourbopoulos, A.1    Karacostas, D.2    Artemis, N.3
  • 40
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(- Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(- Delta Delta C(T)) method. Methods 2001; 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 41
    • 0037230778 scopus 로고    scopus 로고
    • Quantitative realtime PCR method for detection of B-lymphocyte monoclonality by comparison of kappa and lambda immunoglobulin light chain expression
    • Stahlberg A, Aman P, Ridell B, et al. Quantitative realtime PCR method for detection of B-lymphocyte monoclonality by comparison of kappa and lambda immunoglobulin light chain expression. Clin Chem 2003; 49: 51-59.
    • (2003) Clin Chem , vol.49 , pp. 51-59
    • Stahlberg, A.1    Aman, P.2    Ridell, B.3
  • 42
    • 36549078060 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide dynamics in rat dorsal root ganglia and spinal cord following different sciatic nerve injuries
    • Zheng LF, Wang R, Xu YZ, et al. Calcitonin gene-related peptide dynamics in rat dorsal root ganglia and spinal cord following different sciatic nerve injuries. Brain Res 2008; 1187: 20-32.
    • (2008) Brain Res , vol.1187 , pp. 20-32
    • Zheng, L.F.1    Wang, R.2    Xu, Y.Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.