Small-molecule inhibitors of gram-negative lipoprotein trafficking discovered by phenotypic screening

Journal of Bacteriology

Volumn 197, Issue 6, 2015, Pages 1075-1082

  McLeod, Sarah M ^a   Fleming, Paul R ^a   MacCormack, Kathleen ^a   McLaughlin, Robert E ^a   Whiteaker, James D ^a   Narita, Shin ichiro ^b   Mori, Makiko ^b   Tokuda, Hajime ^b   Miller, Alita A ^a  

^a ASTRAZENECA   (United Kingdom)

^b MORIOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER LOLCDE; ANTIBIOTIC AGENT; BACTERIAL PROTEIN; DOXYCYCLINE; IMIDAZOLE DERIVATIVE; LIPOPROTEIN; MEROPENEM; NALIDIXIC ACID; POLYMYXIN B; RIFAMPICIN; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CANDIDA ALBICANS; CONTROLLED STUDY; CROSS RESISTANCE; ESCHERICHIA COLI; GENE DELETION; GRAM NEGATIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; HIGH THROUGHPUT SCREENING; INNER MEMBRANE; MACROMOLECULE; NONHUMAN; OUTER MEMBRANE; PHENOTYPE; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; SPHEROPLAST; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN TRANSPORT;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; LOLA; NEGIBACTERIA;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; GENE EXPRESSION REGULATION, BACTERIAL; GRAM-NEGATIVE BACTERIA; IMIDAZOLES; LIPOPROTEINS; MOLECULAR STRUCTURE; MUTATION; PHENOTYPE; PROTEIN TRANSPORT;

EID: 84923286190     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.02352-14     Document Type: Article

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