Firmly tilting the balance of clinical transplant immunity toward tolerance

American Journal of Transplantation

Volumn 15, Issue 3, 2015, Pages 583-584

  Thornley, T B ^a   Strom, Terry B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

bone marrow hematopoietic stem cell transplantation; clinical research practice; editorial personal viewpoint; immunosuppression immune modulation; tolerance; tolerance: chimerism; tolerance: depletion

Indexed keywords

CD34 ANTIGEN; HLA ANTIGEN; IMMUNOSUPPRESSIVE AGENT; THYMOCYTE ANTIBODY;

CHIMERA; EDITORIAL; EFFECTOR CELL; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HAPLOTYPE; HEMATOPOIETIC STEM CELL; HISTOCOMPATIBILITY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; LONG TERM SURVIVAL; LYMPH NODE IRRADIATION; LYMPHOCYTE COUNT; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TRANSPLANTATION TOLERANCE; ADAPTATION; ADULT; BONE MARROW; CLINICAL RESEARCH; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOMODULATION; ORGAN TRANSPLANTATION; TILTING;

ADAPTATION, PHYSIOLOGICAL; HUMANS; TRANSPLANTATION IMMUNOLOGY;

EID: 84923263140     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.13094     Document Type: Editorial

References (13)

1. Spitzer TR, Sykes M, Tolkoff-Rubin N, et al. Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease. Transplantation 2011; 91: 672-676.
2. Kawai T, Sachs DH, Sykes M, Cosimi AB, Immune Tolerance N., HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2013; 368: 1850-1852.
3. Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358: 353-361.
4. Leventhal J, Abecassis M, Miller J, et al. Tolerance induction in HLA disparate living donor kidney transplantation by donor stem cell infusion: Durable chimerism predicts outcome. Transplantation 2013; 95: 169-176.
5. Leventhal J, Abecassis M, Miller J, et al. Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. Sci Transl Med 2012; 4: 124ra128.
6. Scandling JD, Busque S, Shizuru JA, Engleman EG, Strober S., Induced immune tolerance for kidney transplantation. N Engl J Med 2011; 365: 1359-1360.
7. Scandling JD, Busque S, Dejbakhsh-Jones S, et al. Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants. Am J Transplant 2012; 12: 1133-1145.
8. Scandling JD, Busque S, Dejbakhsh-Jones S, et al. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med 2008; 358: 362-368.
9. Scandling JD, Busque S, Shizuru JA, et al. Chimerism, graft survival, and withdrawal of immunosuppressive drugs in HLA matched and mismatched patients after living donor kidney and hematopoietic cell transplantation. Am J Transplant 2015; 15: 695-704.
10. Sykes M, Sachs DH., Mixed allogeneic chimerism as an approach to transplantation tolerance. Immunol Today 1988; 9: 23-27.
11. Sayegh MH, Fine NA, Smith JL, Rennke HG, Milford EL, Tilney NL., Immunologic tolerance to renal allografts after bone marrow transplants from the same donors. Ann Intern Med 1991; 114: 954-955.
12. Starzl TE, Demetris AJ, Trucco M, et al. Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance. Hepatology 1993; 17: 1127-1152.
13. Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB., Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999; 5: 1298-1302.