New case of azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation in Belgium

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 12, 2014, Pages 3439-3440

  Montesinos, Isabel ^a   Dodemont, Magali ^a   Lagrou, Katrien ^b   Jacobs, Frederique ^a   Etienne, Isabelle ^a   Denis, Olivier ^a  

^a ERASME HOSPITAL   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

cyp51A genotyping; Invasive aspergillosis; Voriconazole high resistance

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; CASPOFUNGIN; GALACTOMANNAN; ITRACONAZOLE; POSACONAZOLE; VORICONAZOLE; ANTIFUNGAL AGENT; CYTOCHROME P-450 CYP51A, ASPERGILLUS; CYTOCHROME P450; FUNGAL PROTEIN; PYRROLE DERIVATIVE;

ACUTE GRAFT VERSUS HOST DISEASE; ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ANTIMICROBIAL THERAPY; ASPERGILLUS FUMIGATUS; BELGIUM; CASE REPORT; CYP51A GENE; FUNGUS MUTATION; GENE MUTATION; GENE SEQUENCE; GENERAL CONDITION DETERIORATION; HOME CARE; HUMAN; IMMUNOCOMPROMISED PATIENT; LETTER; LIVER DISEASE; LUNG ASPERGILLOSIS; LUNG INFARCTION; MINIMUM INHIBITORY CONCENTRATION; MUTATOR GENE; NONHUMAN; PALLIATIVE THERAPY; RESPIRATORY FAILURE; ASPERGILLOSIS; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGY; MISSENSE MUTATION;

ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; AZOLES; BELGIUM; CYTOCHROME P-450 ENZYME SYSTEM; DRUG RESISTANCE, FUNGAL; FUNGAL PROTEINS; HUMANS; MUTATION, MISSENSE;

EID: 84923258961     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dku289     Document Type: Letter

References (11)

1. Van der Linden JW, Camps SM, Kampinga GA et al. Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles. Clin Infect Dis 2013; 57:513-20.
2. Vermeulen E, Maertens J, Schoemans H et al. Azole-resistant Aspergillus fumigatus due to TR46/Y121F/T289A mutation emerging in Belgium, July 2012. Euro Surveill 2012; 17: pii=20326.
3. Fischer J, van Koningsbruggen-Rietschel S, Rietschel E et al. Prevalence and molecular characterization of azole resistance in Aspergillus spp. isolates from German cystic fibrosis patients. J Antimicrob Chemother 2014; 69:1533-6.
4. Clinical and Laboratory Standards Institute. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi: Approved Standard M38-A2. CLSI, Wayne, PA, USA, 2008.
5. Snelders E, Karawajczyk A, Schaftenaar G et al. Azole resistance profile of amino acid changes in Aspergillus fumigatus CYP51A based on protein homology modelling. Antimicrob Agents Chemother 2010; 54:2425-30.
6. Alanio A, Sitterie E, Liance M et al. Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies. J Antimicrob Chemother 2011; 66:371-4.
7. Arendrup MC, Cuenca-Estrella M, Lass-Flörl C et al. Technical note on Aspergillus and amphotericin B, itraconazole, and posaconazole. Clin Microbiol Infect 2012; 18: E248-50.
8. Camps SM, van der Linden JW, Li Y et al. Rapid induction of multiple resistance mechanisms in Aspergillus fumigatus during azole therapy: a case study and review of the literature. Antimicrob Agents Chemother 2012; 56:10-6.
9. Howard SJ, Cerar D, Anderson MJ et al. Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure. Emerg Infect Dis 2009; 15:1068-76.
10. Verweij PE, Snelders E, Kema GH et al. Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use? Lancet Infect Dis 2009; 9:789-95.
11. Chowdhary A, Sharma C, Kathuria S et al. Azole-resistant Aspergillus fumigatus with the environmental TR46/Y121F/T289A mutation in India. J Antimicrob Chemother 2014; 69:555-71.