Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells

Molecular and Cellular Endocrinology

Volumn 405, Issue , 2015, Pages 74-83

  Qi, Weiwei ^a   Niu, Jianying ^a   Qin, Qiaojing ^a   Qiao, Zhongdong ^b   Gu, Yong ^a,c  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; GA; MAPK pathway; NADPH oxidase; Nox4; Tubulointerstitial fibrosis

Indexed keywords

ACETYLCYSTEINE; ALPHA SMOOTH MUSCLE ACTIN; APOCYNIN; ASTRAGALOSIDE IV; FIBRONECTIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOSYLATED ALBUMIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROCASPASE 3; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; ACETOPHENONE DERIVATIVE; GLYCOSYLATED SERUM ALBUMIN; NOX4 PROTEIN, RAT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SERUM ALBUMIN;

ALPHA SMA GENE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROSIS; FN GENE; GAPDH GENE; GENE; GENE EXPRESSION; IN VITRO STUDY; KIDNEY TUBULE CELL; NONHUMAN; NOX1 GENE; NOX2 GENE; NOX4 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TGF BETA GENE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; ENZYMOLOGY; GENETICS; KIDNEY PROXIMAL TUBULE; METABOLISM; PATHOLOGY; PHYSIOLOGY; RAT;

ACETOPHENONES; ANIMALS; APOPTOSIS; CELL LINE; FIBRONECTINS; FIBROSIS; GENE EXPRESSION; KIDNEY TUBULES, PROXIMAL; MAP KINASE SIGNALING SYSTEM; NADPH OXIDASE; RATS; SERUM ALBUMIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84923253577     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2015.02.007     Document Type: Article

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