Vasoactive intestinal peptide is a local mediator in a gut-brain neural axis activating intestinal gluconeogenesis

Neurogastroenterology and Motility

Volumn 27, Issue 3, 2015, Pages 443-448

  De Vadder, F ^a,b,c   Plessier, F ^a,b,c   Gautier Stein, A ^a,b,c   Mithieux, G ^a,b,c  

^a INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE   (France)

^b UNIVERSITÉ DE LYON   (France)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

Glucose 6 phosphatase; Gut brain axis; Intestinal gluconeogenesis; Vasoactive intestinal peptide

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE 6 PHOSPHATASE; PROPIONIC ACID; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRAIN FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; GASTROINTESTINAL TRACT FUNCTION; GENE ACTIVATION; GLUCONEOGENESIS; GUT BRAIN NEURAL AXIS; IN VIVO STUDY; INTESTINAL GLUCONEOGENESIS; INTESTINE CELL; INTESTINE INNERVATION; JEJUNUM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; INNERVATION; METABOLISM; NERVE CELL; SPRAGUE DAWLEY RAT;

ANIMALS; ENTERIC NERVOUS SYSTEM; GLUCONEOGENESIS; GLUCOSE-6-PHOSPHATASE; JEJUNUM; MALE; NEURONS; RATS, SPRAGUE-DAWLEY; RECEPTORS, VASOACTIVE INTESTINAL POLYPEPTIDE, TYPE I; VASOACTIVE INTESTINAL PEPTIDE;

EID: 84923252963     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12508     Document Type: Article

References (16)

1. Mithieux G, Andreelli F, Magnan C. Intestinal gluconeogenesis: key signal of central control of energy and glucose homeostasis. Curr Opin Clin Nutr Metab Care 2009; 12: 419-23.
2. Mithieux G. Nutrient control of hunger by extrinsic gastrointestinal neurons. Trends Endocrinol Metab 2013; 24: 378-84.
3. Mithieux G, Misery P, Magnan C, Pillot B, Gautier-Stein A, Bernard C, et al. Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein. Cell Metab 2005; 2: 321-9.
4. Duraffourd C, De Vadder F, Goncalves D, Delaere F, Penhoat A, Brusset B, et al. Mu-opioid receptors and dietary protein stimulate a gut-brain neural circuitry limiting food intake. Cell 2012; 150: 377-88.
5. De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, Bäckhed F, Mithieux G. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 2014; 156: 84-96.
6. Furness JB, Jones C, Nurgali K, Clerc N. Intrinsic primary afferent neurons and nerve circuits within the intestine. Prog Neurobiol 2004; 72: 143-64.
7. Zimmerman RP, Gates TS, Mantyh CR, Vigna SR, Welton ML, Passaro EP Jr, Mantyh PW. Vasoactive intestinal polypeptide receptor binding sites in the human gastrointestinal tract: localization by autoradiography. Neuroscience 1989; 31: 771-83.
8. Gautier-Stein A, Zitoun C, Lalli E, Mithieux G, Rajas F. Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha. J Biol Chem 2006; 281: 31268-78.
9. Prieto JC, Laburthe M, Rosselin G. Interaction of vasoactive intestinal peptide with isolated intestinal epithelial cells from rat. 1. Characterization, quantitative aspects and structural requirements of binding sites. Eur J Biochem 1979; 96: 229-37.
10. Croset M, Rajas F, Zitoun C, Hurot JM, Montano S, Mithieux G. Rat small intestine is an insulin-sensitive gluconeogenic organ. Diabetes 2001; 50: 740-6.
11. Gautier-Stein A, Mithieux G, Rajas F. A distal region involving hepatocyte nuclear factor 4alpha and CAAT/enhancer binding protein markedly potentiates the protein kinase A stimulation of the glucose-6-phosphatase promoter. Mol Endocrinol 2005; 19: 163-74.
12. Berthoud HR. Morphological analysis of vagal input to gastrin releasing peptide and vasoactive intestinal peptide containing neurons in the rat glandular stomach. J Comp Neurol 1996; 370: 61-70.
13. Fung C, Unterweger P, Parry LJ, Bornstein JC, Foong JPP. VPAC1 receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum. Am J Physiol Gastrointest Liver Physiol 2014; 306: G748-58.
14. Winzell MS, Ahrén B. Role of VIP and PACAP in islet function. Peptides 2007; 28: 1805-13.
15. Martin B, Shin Y-K, White CM, Ji S, Kim W, Carlson OD, Napora JK, Chadwick W, et al. Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression. Diabetes 2010; 59: 1143-52.
16. Adeghate E, Ponery AS, Sharma AK, El-Sharkawy T, Donáth T. Diabetes mellitus is associated with a decrease in vasoactive intestinal polypeptide content of gastrointestinal tract of rat. Arch Physiol Biochem 2001; 109: 246-51.