Automated segmentation of the lamina cribrosa using Frangi's filter: A novel approach for rapid identification of tissue volume fraction and beam orientation in a trabeculated structure in the eye

Journal of the Royal Society Interface

Volumn 12, Issue 104, 2015, Pages

  Campbell, Ian C ^a,b   Coudrillier, Baptiste ^a   Mensah, Johanne ^c   Abel, Richard L ^c   Ethier, C Ross ^a,b  

^a Emory University   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Computed tomography; Confocal microscopy; Image processing; Lamina cribrosa; Ocular biomechanics

Indexed keywords

BIOMECHANICS; BIOPHYSICS; COLLAGEN; COMPUTERIZED TOMOGRAPHY; CONFOCAL MICROSCOPY; EYE PROTECTION; HARMONIC GENERATION; IMAGE PROCESSING; IMAGE SEGMENTATION; IMAGING TECHNIQUES; MICROSTRUCTURE; MUSCULOSKELETAL SYSTEM; NONLINEAR OPTICS; OPTICAL DATA PROCESSING; TISSUE; TOMOGRAPHY; VOLUME FRACTION;

AUTOMATED SEGMENTATION; CONNECTIVE TISSUES; LAMINA CRIBROSA; MICRO COMPUTED TOMOGRAPHY (MICRO-CT); OCULAR BIOMECHANICS; RAPID IDENTIFICATION; RETINAL GANGLION CELLS; SECOND HARMONIC GENERATION MICROSCOPIES (SHG);

TISSUE ENGINEERING;

ANIMAL TISSUE; ARTICLE; BIOMECHANICS; CONFOCAL MICROSCOPY; CONNECTIVE TISSUE; CONTRAST ENHANCEMENT; FILTER; FINITE ELEMENT ANALYSIS; FRANGI VESSELNESS FILTER; IMAGE PROCESSING; INTERMETHOD COMPARISON; LAMINA CRIBROSA; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OPTIC NERVE; SECOND HARMONIC GENERATION CONFOCAL MICROSCOPY; SWINE; THREE DIMENSIONAL IMAGING; VISION; ANIMAL; AUTOMATION; BIOPHYSICS; CHEMISTRY; COMPUTER ASSISTED DIAGNOSIS; EYE; GLAUCOMA; MECHANICAL STRESS; METABOLISM; MICROSCOPY; PATHOLOGY; PATHOPHYSIOLOGY; PIG; RADIOGRAPHY; RETINA GANGLION CELL; VISUAL SYSTEM FUNCTION;

SUS;

CONTRAST MEDIUM;

ANIMALS; AUTOMATION; BIOMECHANICAL PHENOMENA; BIOPHYSICAL PHENOMENA; CONNECTIVE TISSUE; CONTRAST MEDIA; EYE; FINITE ELEMENT ANALYSIS; GLAUCOMA; MICROSCOPY; MICROSCOPY, CONFOCAL; OCULAR PHYSIOLOGICAL PHENOMENA; OPTIC NERVE; RADIOGRAPHIC IMAGE INTERPRETATION, COMPUTER-ASSISTED; RETINAL GANGLION CELLS; STRESS, MECHANICAL; SWINE; X-RAY MICROTOMOGRAPHY;

EID: 84923233830     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2014.1009     Document Type: Article

References (36)

1. Quigley HA. 1999 Neuronal death in glaucoma. Prog. Retin. Eye Res. 18, 39-57. (doi:10. 1016/S1350-9462(98) 00014-7)
2. Burgoyne CF. 2011 A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma. Exp. Eye Res. 93, 120-132. (doi:10. 1016/j. exer. 2010. 09. 005)
3. Campbell IC, Coudrillier B, Ross Ethier C. 2014 Biomechanics of the posterior eye: a critical role in health and disease. J. Biomech. Eng. 136, 021005. (doi:10. 1115/1. 4026286)
4. Anderson DR, Hendrickson A. 1974 Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve. Invest. Ophthalmol. 13, 771-783.
5. Burgoyne CF, Downs JC, Bellezza AJ, Suh JK, Hart RT. 2005 The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage. Prog. Retinal Eye Res. 24, 39-73. (doi:10. 1016/j. preteyeres. 2004. 06. 001)
6. Fechtner RD, Weinreb RN. 1994 Mechanisms of optic nerve damage in primary open angle glaucoma. Surv. Ophthalmol. 39, 23-42. (doi:10. 1016/S0039-6257(05)80042-6)
7. Son JL, Soto I, Oglesby E, Lopez-Roca T, Pease ME, Quigley HA, Marsh-Armstrong N. 2010 Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss. Glia 58, 780-789. (doi:10. 1002/glia. 20962)
8. Flammer J, Orgul S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Renard J-P, Stefnsson E. 2002 The impact of ocular blood flow in glaucoma. Prog. Retin. Eye Res. 21, 359-393. (doi:10. 1016/S1350-9462(02)00008-3)
9. Su WW, Cheng ST, Ho WJ, Tsay PK, Wu SC, Chang SH. 2008 Glaucoma is associated with peripheral vascular endothelial dysfunction. Ophthalmology 115, 1173-1178. (doi:10. 1016/j. ophtha. 2007. 10. 026)
10. Quigley HA, Dorman-Pease ME, Brown AE. 1991 Quantitative study of collagen and elastin of the optic nerve head and sclera in human and experimental monkey glaucoma. Curr. Eye Res. 10, 877-888. (doi:10. 3109/02713689109013884)
11. Jonas JB, Holbach L. 2005 Central corneal thickness and thickness of the lamina cribrosa in human eyes. Invest. Ophthal. Vis. Sci. 46, 1275-1279. (doi:10. 1167/iovs. 04-0851)
12. Sigal IA, Flanagan JG, Ethier CR. 2005 Factors influencing optic nerve head biomechanics. Invest. Ophthalmol. Vis. Sci. 46, 4189-4199. (doi:10. 1167/ iovs. 05-0541)
13. Dongqi H, Zeqin R. 1999 A biomathematical model for pressure-dependent lamina cribrosa behavior. J. Biomech. 32, 579-584. (doi:10. 1016/S0021-9290(99)00025-1)
14. Edwards ME, Good TA. 2001 Use of a mathematical model to estimate stress and strain during elevated pressure induced lamina cribrosa deformation. Curr. Eye Res. 23, 215-225. (doi:10. 1076/ceyr. 23. 3. 215. 5460)
15. Bellezza AJ, Hart RT, Burgoyne CF. 2000 The optic nerve head as a biomechanical structure: initial finite element modeling. Invest. Ophthalmol. Vis. Sci. 41, 2991-3000.
16. Roberts MD, Liang Y, Sigal IA, Grimm J, Reynaud J, Bellezza A, Burgoyne CF, Downs JC. 2010 Correlation between local stress and strain and lamina cribrosa connective tissue volume fraction in normal monkey eyes. Invest. Ophthalmol. Vis. Sci. 51, 295-307. (doi:10. 1167/iovs. 09-4016)
17. Downs JC, Roberts MD, Burgoyne CF, Hart RT. 2009 Multiscale finite element modeling of the lamina cribrosa microarchitecture in the eye. In Proc. Annual Int. Conf. of the IEEE Engineering in Medicine and Biology Society, pp. 4277-4280. (doi:10. 1109/IEMBS. 2009. 5332755)
18. Yang H, Downs JC, Sigal IA, Roberts MD, Thompson H, Burgoyne CF. 2009 Deformation of the normal monkey optic nerve head connective tissue after acute IOP elevation within 3-D histomorphometric reconstructions. Invest. Ophthalmol. Vis. Sci. 50, 5785-5799. (doi:10. 1167/iovs. 09-3410)
19. Yang H, Downs JC, Girkin C, Sakata L, Bellezza A, Thompson H, Burgoyne CF. 2007 3-D histomorphometry of the normal and early glaucomatous monkey optic nerve head: lamina cribrosa and peripapillary scleral position and thickness. Invest. Ophthalmol. Vis. Sci. 48, 4597-4607. (doi:10. 1167/iovs. 07-0349)
20. Frangi AF, Niessen WJ, Vincken KL, Viergever MA. 1998 Multiscale vessel enhancement filtering. In Medical image computing and computer-assisted intervention (eds WM Wells, A Colchester, S Delp). Lecture Notes in Computer Science, vol. 1496, pp. 130-137. Berlin, Germany: Springer. (doi:10. 1007/BFb0056195)
21. Antiga L. 2007 Generalizing vesselness with respect to dimensionality and shape. Insight J. See http:// hdl. handle. net/1926/576.
22. Metscher BD. 2009 MicroCT for comparative morphology: simple staining methods allow highcontrast 3D imaging of diverse non-mineralized animal tissues. BMC Physiol. 9, 11. (doi:10. 1186/ 1472-6793-9-11)
23. Kroon D-J. 2010 Hessian based Frangi vesselness filter. 02 Mar 2010 ed. See http://www. mathworks. com/matlabcentral/fileexchange/24409-hessianbased-frangi-vesselness-filter.
24. Geuzaine C, Remacle J-F. 2009 Gmsh: A 3-D finite element mesh generator with built-in pre-and post-processing facilities. Int. J. Numer. Methods Eng. 79, 1309-1331. (doi:10. 1002/nme. 2579)
25. Pijanka JK, Coudrillier B, Ziegler K, Sorensen T, Meek KM, Nguyen TD, Quigley HA, Boote C. 2012 Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae. Invest. Ophthalmol. Vis. Sci. 53, 5258-5270. (doi:10. 1167/iovs. 12-9705)
26. Sigal IA et al. 2014 Order in the chaos: regions of highly aligned radial collagen fibers in the peripapillary sclera (PPS). Orlando, FL: Association for Research in Vision and Ophthalmology, ARVO.
27. Maas SA, Ellis BJ, Ateshian GA, Weiss JA. 2012 FEBio: finite elements for biomechanics. J. Biomech. Eng. 134, 011005. (doi:10. 1115/1. 4005694)
28. Gouget CL, Girard MJ, Ethier CR. 2012 A constrained von Mises distribution to describe fiber organization in thin soft tissues. Biomech. Model. Mechanobiol. 11, 475-482. (doi:10. 1007/s10237-011-0326-y)
29. Coudrillier B, Boote C, Quigley HA, Nguyen TD. 2013 Scleral anisotropy and its effects on the mechanical response of the optic nerve head. Biomech. Model. Mechanobiol. 12, 941-963. (doi:10. 1007/s10237-012-0455-y)
30. Brooks DE, Arellano E, Kubilis PS, Komaromy AM. 1998 Histomorphometry of the porcine scleral lamina cribrosa surface. Vet. Ophthalmol. 1, 129-135. (doi:10. 1046/j. 1463-5224. 1998. 00029. x)
31. Sander EA, Barocas VH. 2009 Comparison of 2D fiber network orientation measurement methods. J. Biomed. Mater. Res. A 88, 322-331. (doi:10. 1002/jbm. a. 31847)
32. Dandona L, Quigley HA, Brown AE, Enger C. 1990 Quantitative regional structure of the normal human lamina cribrosa. A racial comparison. Arch. Ophthalmol. 108, 393-398. (doi:10. 1001/archopht. 1990. 01070050091039)
33. McBrien NA, Cornell LM, Gentle A. 2001 Structural and ultrastructural changes to the sclera in a mammalian model of high myopia. Invest. Ophthalmol. Vis. Sci. 42, 2179-2187.
34. Girard MJ et al. 2011 Quantitative mapping of scleral fiber orientation in normal rat eyes. Invest. Ophthalmol. Vis. Sci. 52, 9684-9693. (doi:10. 1167/ iovs. 11-7894)
35. Danford FL, Yan D, Dreier RA, Cahir TM, Girkin CA, Vande Geest JP. 2013 Differences in the region-and depth-dependent microstructural organization in normal versus glaucomatous human posterior sclerae. Invest. Ophthalmol. Vis. Sci. 54, 7922-7932. (doi:10. 1167/iovs. 13-12262)
36. Roberts MD, Sigal IA, Liang Y, Burgoyne CF, Downs JC. 2010 Changes in the biomechanical response of the optic nerve head in early experimental glaucoma. Invest. Ophthalmol. Vis. Sci. 51, 5675-5684. (doi:10. 1167/iovs. 10-5411)