Safety study of 38 503 intravitreal ranibizumab injections performed mainly by physicians in training and nurses in a hospital setting

Acta Ophthalmologica

Volumn 93, Issue 2, 2015, Pages 122-125

  Hasler, Pascal W ^a   Brandi Bloch, Sara ^b,c   Villumsen, Jørgen ^b,c   Fuchs, Josefine ^b,c,d   Lund Andersen, Henrik ^b,c   Larsen, Michael ^b,c,d  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d JOHN F KENNEDY INSTITUTE   (Denmark)

Author keywords

case series; non comparative; observational; retrospective

Indexed keywords

ANTIBIOTIC AGENT; RANIBIZUMAB; ANGIOGENESIS INHIBITOR; MONOCLONAL ANTIBODY; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ABNORMAL NEEDLE OUTFLOW RESISTANCE; ABNORMAL SENSATION; AGE RELATED MACULAR DEGENERATION; ARTICLE; BACTERIUM CULTURE; CENTRAL RETINA VEIN OCCLUSION; CENTRAL SEROUS RETINOPATHY; CLINICAL PRACTICE; CLINICAL PROTOCOL; COMPARATIVE EFFECTIVENESS; COMPARATIVE STUDY; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; DENMARK; DIABETIC RETINOPATHY; DOCTOR NURSE RELATION; DRUG SAFETY; ENDOPHTHALMITIS; EYE CARE; FOLLOW UP; HOSPITAL; HUMAN; INTERVENTION STUDY; INTRAVITREAL DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; NEEDLE; OPERATING ROOM; OPHTHALMOLOGY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RESIDENT; RETINA; RETINA DETACHMENT; RETINA TEAR; RETROSPECTIVE STUDY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STREPTOCOCCUS PNEUMONIAE; SURGEON; TRAINING; TRAUMATIC CATARACT; TREATMENT DURATION; UVEITIS; VISUAL ACUITY; VITREORETINAL; ADVERSE EFFECTS; ANTAGONISTS AND INHIBITORS; CATARACT; EDUCATION; EYE HEMORRHAGE; MEDICAL EDUCATION; NURSE; PEROPERATIVE COMPLICATION; RETINAL DETACHMENT; RETINAL DISEASES;

ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; CATARACT; ENDOPHTHALMITIS; EYE HEMORRHAGE; HUMANS; INTERNSHIP AND RESIDENCY; INTERVENTION STUDIES; INTRAOPERATIVE COMPLICATIONS; INTRAVITREAL INJECTIONS; NURSES; OPHTHALMOLOGY; RETINAL DETACHMENT; RETINAL DISEASES; RETROSPECTIVE STUDIES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84923229310     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/aos.12589     Document Type: Article

References (23)

1. Abell RG, Kerr NM, Allen P, &, Vote BJ, (2012): Intravitreal injections: is there benefit for a theatre setting? Br J Ophthalmol 96: 1474-1478.
2. Bhatt SS, Stepien KE, &, Joshi K, (2011): Prophylactic antibiotic use after intravitreal injection: effect on endophthalmitis rate. Retina 31: 2032-2036.
3. Brown DM, Kaiser PK, Michels M, et al. (2006): Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 355: 1432-1444.
4. Campochiaro PA, Heier JS, Feiner L, et al. (2010): Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology 117: 1102-1112.e1.
5. Comert E, Sullu Y, &, Birinci H, (2013): Retinal pigment epithelium tears following intravitreal ranibizumab injection for neovascular age-related macular degeneration. Acta Ophthalmol 91: e414-e415.
6. Diago T, McCannel CA, Bakri SJ, Pulido JS, Edwards AO, &, Pach JM, (2009): Infectious endophthalmitis after intravitreal injection of antiangiogenic agents. Retina 29: 601-605.
7. Fintak DR, Shah GK, Blinder KJ, et al. (2008): Incidence of endophthalmitis related to intravitreal injection of bevacizumab and ranibizumab. Retina 28: 1395-1399.
8. Gragoudas ES, Adamis AP, Cunningham ET, Feinsod M, &, Guyer DR, (2004): Pegaptanib for neovascular age-related macular degeneration. N Engl J Med 351: 2805-2816.
9. Heier JS, Campochiaro Pa, Yau L, et al. (2012): Ranibizumab for macular edema due to retinal vein occlusions long-term follow-up in the HORIZON trial. Ophthalmology 119: 802-809.
10. Klein KS, Walsh MK, Hassan TS, et al. (2009): Endophthalmitis after anti-VEGF injections. Ophthalmology 116: 1225.e1.
11. Mason JO, White MF, Feist RM, et al. (2008): Incidence of acute onset endophthalmitis following intravitreal bevacizumab (Avastin) injection. Retina 28: 564-567.
12. Mezad-Koursh D, Goldstein M, Heilwail G, Zayit-Soudry S, Loewenstein A, &, Barak A, (2010): Clinical characteristics of endophthalmitis after an injection of intravitreal antivascular endothelial growth factor. Retina 30: 1051-1057.
13. Moshfeghi AA, (2011): Endophthalmitis following intravitreal anti-vascular endothelial growth factor injections for neovascular age-related macular degeneration. Semin Ophthalmol 26: 139-148.
14. Moss JM, Sanislo SR, &, Ta CN, (2009): A prospective randomized evaluation of topical gatifloxacin on conjunctival flora in patients undergoing intravitreal injections. Ophthalmology 116: 1498-1501.
15. Nguyen QD, Brown DM, Marcus DM, et al. (2012): Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology 119: 789-801.
16. Pilli S, Kotsolis A, Spaide RF, et al. (2008): Endophthalmitis associated with intravitreal anti-vascular endothelial growth factor therapy injections in an office setting. Am J Ophthalmol 145: 879-882.
17. Ristau T, Kirchhof B, &, Fauser S, (2014): Antisepsis with polyhexanide is effective against endophthalmitis after intravitreal injections. Acta Ophthalmol 92: e494-e496.
18. Rosenfeld PJ, Brown DM, Heier JS, et al. (2006): Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355: 1419-1431.
19. Ruiz-Moreno JM, Arias L, Montero JA, Carneiro A, &, Silva R, (2013): Intravitreal anti-VEGF therapy for choroidal neovascularisation secondary to pathological myopia: 4-year outcome. Br J Ophthalmol 97: 1447-1450.
20. Simcock P, Kingett B, Mann N, Reddy V, &, Park J, (2014): A safety audit of the first 10-000 intravitreal ranibizumab injections performed by nurse practitioners. Eye (Lond) 28: 1161-1164.
21. Speaker MG, &, Menikoff JA, (1991): Prophylaxis of endophthalmitis with topical povidone-iodine. Ophthalmology 98: 1769-1775.
22. Storey P, Dollin M, Pitcher J, et al. (2014): The role of topical antibiotic prophylaxis to prevent endophthalmitis after intravitreal injection. Ophthalmology 121: 283-289.
23. Wykoff CC, Flynn HW, &, Rosenfeld PJ, (2011): Prophylaxis for endophthalmitis following intravitreal injection: antisepsis and antibiotics. Am J Ophthalmol 152: 717-719.e2.