Recombinant factor VIIa enhances platelet deposition from flowing haemophilic blood but requires the contact pathway to promote fibrin deposition

Haemophilia

Volumn 21, Issue 2, 2015, Pages 266-274

  Li, R ^a   Panckeri, K A ^b   Fogarty, P F ^b   Diamond, S L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Fibrin; Haemophilia; Haemostasis; Microfluidics; Platelets; Recombinant factor VIIa

Indexed keywords

COLLAGEN; CORN TRYPSIN INHIBITOR; FIBRIN; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBIN; THROMBOPLASTIN; TRYPSIN INHIBITOR; UNCLASSIFIED DRUG; BLOOD CLOTTING FACTOR 7A; PROTEIN BINDING; RECOMBINANT FVIIA; RECOMBINANT PROTEIN;

ARTICLE; BLOOD CLOTTING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG POTENCY; FIBRIN DEPOSITION; FIBRIN POLYMERIZATION; HEMOPHILIA A; HUMAN; PRIORITY JOURNAL; SHEAR RATE; SIGNAL TRANSDUCTION; THROMBOCYTE ADHESION; VEIN WALL; BLOOD; BLOOD CLOTTING FACTOR 11 DEFICIENCY; BLOOD CLOTTING TEST; CASE CONTROL STUDY; DRUG EFFECTS; HEMOPHILIA B; METABOLISM; MICROFLUIDIC ANALYSIS; THROMBOCYTE; THROMBOCYTE ACTIVATION;

BLOOD COAGULATION; BLOOD COAGULATION TESTS; BLOOD PLATELETS; CASE-CONTROL STUDIES; COLLAGEN; FACTOR VIIA; FACTOR XI DEFICIENCY; FIBRIN; HEMOPHILIA A; HEMOPHILIA B; HUMANS; MICROFLUIDIC ANALYTICAL TECHNIQUES; PLATELET ACTIVATION; PLATELET ADHESIVENESS; PROTEIN BINDING; RECOMBINANT PROTEINS;

EID: 84923093342     PISSN: 13518216     EISSN: 13652516     Source Type: Journal    
DOI: 10.1111/hae.12558     Document Type: Article

References (25)

1. Mannucci PM, Tuddenham EGD. The hemophilias-from royal genes to gene therapy. N Engl J Med 2001; 344: 1773-9.
2. Seligsohn U. Factor XI in haemostasis and thrombosis: Past, present and future. Thromb Haemost 2007; 98: 84-9.
3. Astermark J, Donfield SM, DiMichele DM et al. A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: The FEIBA NovoSeven Comparative (FENOC) Study. Blood 2007; 109: 546-51.
4. Sorensen B, Ingerslev J. Whole blood clot formation phenotypes in hemophilia A and rare coagulation disorders. Patterns of response to recombinant factor VIIa. J Thromb Haemost 2004; 2: 102-10.
5. Lisman T, Moschatsis S, Adelmeijer J. Nieuswenhuis HK, deGroot PG. Recombinant factor VIIa enhances deposition of platelets with congenital or acquired alpha IIb beta 3 deficiency to endothelial cell matrix and collagen under flow conditions of via tissue factor-independent thrombin generation. Blood 2003; 101: 1864-70.
6. Onasoga-Jarvis AA, Leiderman K, Folgeson AL et al. The effect of factor VII deficiencies and replacement and bypass therapies on thrombus formation under venous flow conditions in microfluidic and computational models. PLoS ONE 2013; 8: e78732.
7. Li R, Fries S, Li X, Grosser T, Diamond SL. Microfluidic assay of platelet deposition on collagen by perfusion of whole blood from healthy individuals taking aspirin. Clin Chem 2013; 59: 1195-204.
8. 12, using a whole blood microfluidic flow assay. Thromb Res 2013; 2: 203-10.
9. Colace T, Fogarty PF, Panckeri KA, Li R, Diamond SL. Microfluidic assay of hemophiliac blood clotting: Distinct deficits in platelet and fibrin deposition at low factor levels. J Thromb Haemost 2014; 12: 147-58.
10. Hojima Y, Pierce JV, Pisano JJ. Hageman factor fragment inhibitor in corn seeds: Purification and characterization. Thromb Res 1980; 20: 149-62.
11. Chatterjee MS, Denney WS, Jing H, Diamond SL. Systems biology of coagulation initiation: Kinetics of thrombin generation in resting and activated human blood. PLoS Comput Biol 2010; 6: e1000950.
12. Colace TV, Muthard RW, Diamond SL. Thrombus growth and embolism on tissue factor-bearing collagen surfaces under flow: Role of thrombin with and without fibrin. Arterioscler Thromb Vasc Biol 2012; 32: 1466-76.
13. Colace TV, Jobson J, Diamond SL. Relipidated tissue factor linked to collagen surfaces potentiates platelet adhesion and fibrin formation in a microfluidic model of vessel injury. Bioconjugate Chem 2011; 22: 2104-9.
14. 1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions. Integr Biol (Camb) 2010; 2: 183-92.
15. Neeves KB, Maloney SF, Fong KP et al. Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates. J Thrombo Haemost 2008; 6: 2193-201.
16. Monroe DM, Hoffman M, Oliver JA, Roberts HR. A possible mechanism of activated factor VII independent of tissue factor. Blood Coagul Fibrinolysis 1998; 9: S15-20.
17. Monroe DM, Hoffman M, Olivier JA, Roberts HR. Platelet activity of high-dose factor VIIa is independent of tissue factor. Br J Haematol 1997; 99: 542-7.
18. Biere-Rafi S, Baarslag MA, Peters M et al. Cardiovascular risk assessment in haemophilia patients. Thromb Haemost 2011; 105: 274-8.
19. Konkle BA. Clinical challenges within the aging hemophilia population. Thromb Res 2011; 127: S10-3.
20. Mackman N. Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol 2004; 24: 1015-22.
21. Cheng Q, Tucker EI, Pine MS et al. A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood 2010; 116: 3981-9.
22. van der Meijden PE, Munnix IC, Auger JM et al. Dual role for collagen in factor XII-dependent thrombus formation. Blood 2009; 114: 881-90.
23. Walsh PN, Griffin JH. Contributions of human platelets to the proteolytic activation of blood coagulation factors XII and XI. Blood 1981; 57: 106-18.
24. Fuchs TA, Brill A, Duerschmied D et al. Extracelluar DNA traps promote thrombosis. Proc Natl Acad Sci U S A 2010; 107: 15880-5.
25. Girolami A, Scandellari R, Zanon E, Sartori R, Girolami B. Non-catheter associated venous thrombosis in hemophilia A and B. A critical review of all reported cases. J Thromb Thrombolysis 2006; 21: 279-84.