High frequency of DQB1*05 and absolute absence of DRB1*13 in muscle-specific tyrosine kinase positive myasthenia gravis

European Journal of Neurology

Volumn 22, Issue 1, 2015, Pages 59-63

  Nikolic, A V ^a,b   Andric, Z P ^c   Simonovic, R B ^c   Rakocevic Stojanovic, V M ^a,b   Basta, I Z ^a,b   Bojic, S D ^b   Lavrnic, D V ^a,b  

^a CLINICAL CENTER OF SERBIA   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c Blood Transfusion Institute of Serbia   (Serbia)

Author keywords

Human leukocyte antigens; Muscle specific tyrosine kinase; Myasthenia gravis

Indexed keywords

HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; MUSK PROTEIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; CHOLINERGIC RECEPTOR; HLA ANTIGEN CLASS 1; HLA DQ ANTIGEN; HLA-DQB1 ANTIGEN; MUSK PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPING TECHNIQUE; HAPLOTYPE; HLA TYPING; HUMAN; MALE; MYASTHENIA GRAVIS; OLIGONUCLEOTIDE PROBE; ONSET AGE; PRIORITY JOURNAL; RISK ASSESSMENT; THYMECTOMY; THYMUS ATROPHY; COHORT ANALYSIS; GENETICS; IMMUNOLOGY; MIDDLE AGED; SERBIA; YOUNG ADULT;

ADULT; AGED; COHORT STUDIES; FEMALE; GENE FREQUENCY; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-DQ BETA-CHAINS; HLA-DRB1 CHAINS; HUMANS; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CHOLINERGIC; SERBIA; YOUNG ADULT;

EID: 84923071866     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/ene.12525     Document Type: Article

References (14)

1. Compston DA, Vincent A, Newsom-Davis J, et al. Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain 1980; 103: 579-590.
2. Giraud M, Beaurain G, Yamamoto AM, et al. Linkage of HLA to myasthenia gravis and genetic heterogeneity depending on anti-titin antibodies. Neurology 2001; 57: 1555-1560.
3. Giraud M, Vandiedonck C, Garchon HJ. Genetic factors in autoimmune myasthenia gravis. Ann N Y Acad Sci 2008; 1132: 180-192.
4. Chen WH, Chiu HC, Hseih RP. Association of HLA-Bw46DR9 combination with juvenile myasthenia in Chinese. J Neurol Neurosurg Psychiatry 1993; 56: 382-385.
5. Matsuki K, Juji T, Tokunaga K, et al. HLA antigens in Japanese patients with myasthenia gravis. J Clin Investig 1990; 86: 392-399.
6. Lavrnic D, Losen M, Vujic A, et al. The features of myasthenia gravis with autoantibodies to MuSK. J Neurol Neurosurg Psychiatry 2005; 76: 1099-1102.
7. Jeretzki A 3rd, Barohn RJ, Ernstoff RM, et al. Myasthenia gravis: recommendations for clinical research standards. Task force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. [Review]. Neurology 2000; 55: 16-23.
8. Andric Z, Popadic D, Jovanovic B, et al. HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in the Serbian population. Hum Immunol 2014; 75: 218-226.
9. Purcell S, Cherny SS, Sham PC. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003; 19: 149-150.
10. Niks EH, Kuks JBM, Roep BO, et al. Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5. Neurology 2006; 66: 1772-1774.
11. Bartoccioni E, Scuderi F, Augugliaro A, et al. HLA class II allele analysis in MuSK positive myasthenia gravis suggests a role for DQ5. Neurology 2009; 72: 195-197.
12. Alahgholi-Hajibehzad M, Yilmaz V, Gulsen-Parman Y, et al. Association of HLA-DRB1*14, -DRB1*16 and -DQB1*05 with MuSK-myasthenia gravis in patients from Turkey. Hum Immunol 2013; 74: 1633-1635.
13. Testi M, Terracciano C, Guagnano A, et al. Association of HLA-DQB1*05:02 and DRB1*16 alleles with late-onset, nonthymomatous, AChR-Ab-positive myasthenia gravis. Autoimmune Dis 2012; 2012: 541760.
14. Lavrnic D, Nikolic A, De Baets M, et al. Familial occurrence of autoimmune myasthenia gravis with different antibody specificity. Neurology 2008; 70: 2011-2013.