Persistent severe hypereosinophilic asthma is not associated with airway remodeling

Respiratory Medicine

Volumn 109, Issue 2, 2015, Pages 180-187

  Alagha, Khuder ^a   Jarjour, Baihas ^b   Bommart, Sebastien ^c,f   Aviles, Berta ^d   Varrin, Muriel ^c   Gamez, Anne Sophie ^b   Molinari, Nicolas ^c   Vachier, Isabelle ^b   Paganin, Fabrice ^d,e   Chanez, Pascal ^a,e   Bourdin, Arnaud ^b,f  

^a ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE   (France)

^b HÔPITAL ARNAUD DE VILLENEUVE   (France)

^c MONTPELLIER UNIVERSITY HOSPITAL   (France)

^d Department of Respiratory Disease ^*  (France)

^e AIX MARSEILLE UNIVERSITY   (France)

^f UNIVERSITY OF MONTPELLIER   (France)

Author keywords

Airway remodeling; Asthma outcomes; Asthma phenotypes; Eosinophils; Severe asthma

Indexed keywords

ADULT; AIRWAY REMODELING; ARTICLE; ASTHMA CONTROL QUESTIONNAIRE; BASEMENT MEMBRANE THICKNESS; BRONCHUS BIOPSY; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; EOSINOPHIL COUNT; EOSINOPHILIA; FEMALE; FOLLOW UP; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN TISSUE; HYPEREOSINOPHILIC ASTHMA; LUNG VOLUME; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PHENOTYPE; PRICK TEST; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; QUESTIONNAIRE; RESPIRATORY AIRFLOW; RESPIRATORY TRACT PARAMETERS; RISK FACTOR; SEVERE PERSISTENT ASTHMA; SMOKING; SUBMUCOSA; AGED; ASTHMA; BLOOD; LOEFFLER PNEUMONIA; PATHOPHYSIOLOGY; PHYSIOLOGY; RADIOGRAPHY;

ADULT; AGED; AIRWAY REMODELING; ASTHMA; EOSINOPHILIA; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PULMONARY EOSINOPHILIA; RISK FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84923071694     PISSN: 09546111     EISSN: 15323064     Source Type: Journal    
DOI: 10.1016/j.rmed.2014.12.008     Document Type: Article

References (47)

1. S.T. Holgate, G. Roberts, H.S. Arshad, P.H. Howarth, and D.E. Davies The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis Proc Am Thorac Soc 6 2009 655 659
2. P. Chanez Severe asthma is an epithelial disease Eur Respir J 25 2005 945 946
3. A. Bourdin, D. Neveu, I. Vachier, F. Paganin, P. Godard, and P. Chanez Specificity of basement membrane thickening in severe asthma J Allergy Clin Immunol 119 2007 1367 1374
4. J. Bousquet, P. Chanez, J.Y. Lacoste, G. Barneon, N. Ghavanian, and I. Enander Eosinophilic inflammation in asthma N Engl J Med 323 1990 1033 1039
5. Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet; 380:651-659.
6. T. Adachi, S. Motojima, A. Hirata, T. Fukuda, and S. Makino Eosinophil viability-enhancing activity in sputum from patients with bronchial asthma, contributions of interleukin-5 and granulocyte/macrophage colony-stimulating factor Am J Respir Crit Care Med 151 1995 618 623
7. N.W. Lukacs Role of chemokines in the pathogenesis of asthma Nat Rev Immunol 1 2001 108 116
8. Coleman JM, Naik C, Holguin F, Ray A, Ray P, Trudeau JB, et al. Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset. Thorax.
9. S. Suissa, P. Ernst, S. Benayoun, M. Baltzan, and B. Cai Low-dose inhaled corticosteroids and the prevention of death from asthma N Engl J Med 343 2000 332 336
10. P. Haldar, I.D. Pavord, D.E. Shaw, M.A. Berry, M. Thomas, and C.E. Brightling Cluster analysis and clinical asthma phenotypes Am J Respir Crit Care Med 178 2008 218 224
11. L. Benayoun, A. Druilhe, M.C. Dombret, M. Aubier, and M. Pretolani Airway structural alterations selectively associated with severe asthma Am J Respir Crit Care Med 167 2003 1360 1368
12. Bourdin A, Kleis S, Chakra M, Vachier I, Paganin F, Godard P, et al. Limited short-term steroid responsiveness is associated with thickening of bronchial basement membrane in severe asthma. Chest; 141:1504-1511.
13. A.M. Vignola, J. Kips, and J. Bousquet Tissue remodeling as a feature of persistent asthma J Allergy Clin Immunol 105 2000 1041 1053
14. P.T. Flood-Page, A.N. Menzies-Gow, A.B. Kay, and D.S. Robinson Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway Am J Respir Crit Care Med 167 2003 199 204
15. P. Flood-Page, A. Menzies-Gow, S. Phipps, S. Ying, A. Wangoo, and M.S. Ludwig Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics J Clin Invest 112 2003 1029 1036
16. P. Flood-Page, C. Swenson, I. Faiferman, J. Matthews, M. Williams, and L. Brannick A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma Am J Respir Crit Care Med 176 2007 1062 1071
17. P.G. Woodruff, B. Modrek, D.F. Choy, G. Jia, A.R. Abbas, and A. Ellwanger T-helper type 2-driven inflammation defines major subphenotypes of asthma Am J Respir Crit Care Med 180 2009 388 395
18. R.H. Green, C.E. Brightling, S. McKenna, B. Hargadon, D. Parker, and P. Bradding Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial Lancet 360 2002 1715 1721
19. Bourdin A, Humbert M, Chanez P. Immunologic therapeutic interventions in asthma: impact on natural history. Clin Chest Med; 33:585-597.
20. Y. Yamada, M.E. Rothenberg, A.W. Lee, H.S. Akei, E.B. Brandt, and D.A. Williams The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease Blood 107 2006 4071 4079
21. K.F. Chung, P. Godard, E. Adelroth, J. Ayres, N. Barnes, and P. Barnes Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society Eur Respir J 13 1999 1198 1208
22. P. Chanez, S.E. Wenzel, G.P. Anderson, J.M. Anto, E.H. Bel, and L.P. Boulet Severe asthma in adults: what are the important questions? J Allergy Clin Immunol 119 2007 1337 1348
23. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. American Thoracic Society Am J Respir Crit Care Med 162 2000 2341 2351
24. E.H. Bel, A. Sousa, L. Fleming, A. Bush, K.F. Chung, and J. Versnel Diagnosis and definition of severe refractory asthma: an international consensus statement from the innovative medicine initiative (IMI) Thorax 66 2011 910 917
25. Y. Nakano, N.L. Muller, G.G. King, A. Niimi, S.E. Kalloger, and M. Mishima Quantitative assessment of airway remodeling using high-resolution CT Chest 122 2002 271S 275S
26. M. Takemura, A. Niimi, M. Minakuchi, H. Matsumoto, T. Ueda, and K. Chin Bronchial dilatation in asthma: relation to clinical and sputum indices Chest 125 2004 1352 1358
27. F. Paganin, E. Seneterre, P. Chanez, J.P. Daures, J.M. Bruel, and F.B. Michel Computed tomography of the lungs in asthma: influence of disease severity and etiology Am J Respir Crit Care Med 153 1996 110 114
28. J.W. Wilson, and X. Li The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway Clin Exp Allergy 27 1997 363 371
29. C. Ordonez, R. Ferrando, D.M. Hyde, H.H. Wong, and J.V. Fahy Epithelial desquamation in asthma: artifact or pathology? Am J Respir Crit Care Med 162 2000 2324 2329
30. GINA Global initiative for asthma 2012
31. R.M. Pascual, and S.P. Peters The irreversible component of persistent asthma J Allergy Clin Immunol 124 2009 883 890 [quiz 91-2]
32. P.C. Tai, S.J. Ackerman, C.J. Spry, S. Dunnette, E.G. Olsen, and G.J. Gleich Deposits of eosinophil granule proteins in cardiac tissues of patients with eosinophilic endomyocardial disease Lancet 1 1987 643 647
33. P. Lange, J. Parner, J. Vestbo, P. Schnohr, and G. Jensen A 15-year follow-up study of ventilatory function in adults with asthma N Engl J Med 339 1998 1194 1200
34. R.H. Brown, and W. Mitzner Understanding airway pathophysiology with computed tomograpy J Appl Physiol 95 2003 854 862
35. Gupta S, Siddiqui S, Haldar P, Entwisle JJ, Mawby D, Wardlaw AJ, et al. Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes. Thorax; 65:775-781.
36. Y.M. Lee, J.S. Park, J.H. Hwang, S.W. Park, S.T. Uh, and Y.H. Kim High-resolution CT findings in patients with near-fatal asthma: comparison of patients with mild-to-severe asthma and normal control subjects and changes in airway abnormalities following steroid treatment Chest 126 2004 1840 1848
37. J.M. Tunon-de-Lara, F. Laurent, V. Giraud, T. Perez, B. Aguilaniu, and H. Meziane Air trapping in mild and moderate asthma: effect of inhaled corticosteroids J Allergy Clin Immunol 119 2007 583 590
38. A.L. James, P.S. Maxwell, G. Pearce-Pinto, J.G. Elliot, and N.G. Carroll The relationship of reticular basement membrane thickness to airway wall remodeling in asthma Am J Respir Crit Care Med 166 2002 1590 1595
39. A. Bourdin, I. Vachier, P. Godard, and P. Chanez Airway wall structural remodeling from endobronchial biopsies: what does it really mean? J Allergy Clin Immunol 123 2009 711 712 [author reply 2]
40. C.L. Grainge, L.C. Lau, J.A. Ward, V. Dulay, G. Lahiff, and S. Wilson Effect of bronchoconstriction on airway remodeling in asthma N Engl J Med 364 2011 2006 2015
41. W.C. Moore, D.A. Meyers, S.E. Wenzel, W.G. Teague, H. Li, and X. Li Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program Am J Respir Crit Care Med 181 2010 Feb 315 323
42. S. Saglani, D.N. Payne, J. Zhu, Z. Wang, A.G. Nicholson, and A. Bush Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers Am J Respir Crit Care Med 176 2007 858 864
43. T.B. Kim, A.S. Jang, H.S. Kwon, J.S. Park, Y.S. Chang, and S.H. Cho Identification of asthma clusters in two independent Korean adult asthma cohorts Eur Respir J 41 6 2013 Jun 1308 1314
44. J. Bousquet, P. Chanez, J.Y. Lacoste, R. White, P. Vic, P. Godard, and F.B. Michel Asthma: a disease remodeling the airways Allergy 47 1992 3 11
45. J. Bousquet, P.K. Jeffery, W.W. Busse, M. Johnson, and A.M. Vignola Asthma. From bronchoconstriction to airways inflammation and remodeling Am J Respir Crit Care Med 161 2000 1720 1745
46. C.S. Ulrik, V. Backer, and A. Dirksen A 10 year follow up of 180 adults with bronchial asthma: factors important for the decline in lung function Thorax 47 1992 14 18
47. T.R. Bai, J.M. Vonk, D.S. Postma, and H.M. Boezen Severe exacerbations predict excess lung function decline in asthma Eur Respir J 30 2007 452 456