Seminal fluid analysis and testicular volume in adults with epilepsy receiving valproate

Journal of Clinical Neuroscience

Volumn 22, Issue 3, 2015, Pages 508-512

  Hamed, Sherifa A ^a   Moussa, Ehab M M ^a   Tohamy, Amal M ^a   Mohamed, Khaled O ^a   Mohamad, Mohamad E ^a   Sherif, Tahra M K ^a   Abdellah, Mostafa M ^a  

^a ASSIUT UNIVERSITY   (Egypt)

Author keywords

Carnitine Epilepsy Seminal fluid Testicular volume Valproate

Indexed keywords

CARBAMAZEPINE; CARNITINE; FOLLITROPIN; LUTEINIZING HORMONE; PROLACTIN; TESTOSTERONE; THYROTROPIN; THYROXINE; VALPROIC ACID; ANTICONVULSIVE AGENT;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE DURATION; FOLLITROPIN BLOOD LEVEL; FREE THYROXINE INDEX; GENERALIZED EPILEPSY; HORMONE DETERMINATION; HUMAN; HUMAN CELL; LONG TERM CARE; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PROLACTIN BLOOD LEVEL; SEMEN ANALYSIS; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; TREATMENT DURATION; BLOOD; COMPARATIVE STUDY; DRUG EFFECTS; EPILEPSY; ORGAN SIZE; SPERM; SPERMATOZOON; TESTIS;

ADULT; ANTICONVULSANTS; EPILEPSY; HUMANS; MALE; ORGAN SIZE; SEMEN; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; TESTIS; TESTOSTERONE; VALPROIC ACID;

EID: 84923067496     PISSN: 09675868     EISSN: 15322653     Source Type: Journal    
DOI: 10.1016/j.jocn.2014.08.029     Document Type: Article

References (33)

1. M.P. Webber, W.A. Hauser, and R. Ottman Fertility in persons with epilepsy: 1935-1974 Epilepsia 27 1986 746 752
2. J. Bauer, S. Blumenthal, and M. Reuber Epilepsy syndrome, focus, location, and treatment choice affect testicular function in men with epilepsy Neurology 62 2004 243 246
3. S.A. Hamed, K.A. Mohamed, and A.M. EL-Taher The sexual and reproductive health in men with generalized epilepsy: a multidisciplinary evaluation Int J Impotence Res 18 2006 287 295
4. J.I. Isojärvi, M. Repro, and A.J. Pakarinen Carbamazepine, phenytoin, sex hormones and sexual function in men with epilepsy Epilepsia 36 1995 366 370
5. A.M. Kanner, and J.C. Nieto Depressive disorders in epilepsy Neurology 53 1999 S26 S32
6. R. Kuba, M. Pohanka, and J. Zakopcan Sexual dysfunctions and blood hormonal profile in men with focal epilepsy Epilepsia 47 2006 2135 2140
7. B.K. Toone, M. Wheeter, and M. Nanjee Sex hormones, sexual activity and plasma anticonvulsant levels in male epileptics J Neurol Neurosurg Psychiatry 46 1983 824 826
8. N. Taneja, K. Kucheria, and S. Jain Effect of phenytoin on semen Epilepsia 35 1994 136 140
9. M.S. Yerby, and G.B. McCoy Male infertility: possible association with valproate exposure Epilepsia 40 1999 520 521
10. L.S. Røste, E. Taubøll, and T.B. Haugen Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy Eur J Neurol 10 2003 501 506
11. T. Hayashi, S. Yoshida, and A. Yoshinaga Improvement of oligoasthenozoospermia in epileptic patients on switching anti-epilepsy medication from sodium valproate to phenytoin Scand J Urol Nephrol 39 2005 431 432
12. T. Hayashi, A. Yoshinaga, and R. Ohno Asthenozoospermia: possible association with long-term exposure to an anti-epileptic drug of carbamazepine Int J Urol 12 2005 113 114
13. X. Xiaotian, Z. Hengzhong, and X. Yao Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy J Clin Neurosci 20 2013 1492 1497
14. L. Sveberg Røste, E. Taubøll, and A. Berner Morphological changes in the testis after long-term valproate treatment in male Wistar rats Seizure 10 2001 559 565
15. L.S. Røste, E. Taubøll, and J.I. Isojarvi Gonadal morphology and sex hormones in male and female Wistar rats after long-term lamotrigine treatment Seizure 12 2003 621 627
16. D. Shechter-Amir, H. Yavetz, and T.Z. Homonnai Semen parameters among epileptic males treated with carbamazepine Isr J Med Sci 29 1993 648 649
17. S. Rajender, M.G. Monica, and L. Walter Thyroid, spermatogenesis, and male infertility Front Biosci (Elite Ed) 3 2011 843 855
18. S.A. Hamed, and M.M. Abdella The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status Epilepsy Res 86 2009 32 41
19. G. Coppola, G. Epifanio, and G. Auricchio Plasma free carnitine in epilepsy children, adolescents and young adults treated with old and new antiepileptic drugs with or without ketogenic diet Brain Dev 28 2006 358 365
20. G. Hug, C.A. McGraw, and S.R. Bates Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbital, valproic acid, phenytoin, and carbamazepine in children J Pediatr 119 1991 799 802
21. P.R. Borum, and S.G. Bennett Carnitine as an essential nutrient J Am Coll Nutr 5 1986 177 182
22. C. Jeulin, and M.L. Lewin Role of free L-carnitine and acetyl L-carnitine in post-gonadal maturation of mammalian spermatozoa Hum Reprod Update 2 1996 87 102
23. Proposal for revised classification of epilepsies and epileptic syndromes: from the commission on classification and Terminology of the International League Against Epilepsy. Epilepsia 1989;30:389-99.
24. World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction 4th ed, Cambridge University Press, 1999.
25. M. Blaivas, and L. Brannam Testicular ultrasound Emerg Med Clin North Am 22 2004 723 748
26. S.S. Chen, M.R. Shen, and T.J. Chen Effects of antiepileptic drugs on sperm motility of normal controls and epileptic patients with long-term therapy Epilepsia 33 1992 149 153
27. A.J. Shetty, and K. Narayana The effects of carbamazepine on sperm morphology in wistar rats Indian J Physiol Pharmacol 51 2007 255 260
28. R.M. Walker, G.S. Smith, and N.J. Barsoum Preclinical toxicology of the anticonvulsant calcium valproate Toxicology 63 1990 137 155
29. F.X. Coude, G. Grimber, and A. Pelet Action of the antiepileptic drug, valproic acid on fatty oxidation in isolated rat hepatocytes Biochem Biophys Res Commun 15 1983 730 736
30. V. Rogiers, Y. Bandenberghe, and A. Vecuysse Inhibition of gluconeogenesis by sodium valproate and its metabolite in isolated rate hepatocytes Xenobiotica 15 1985 759 765
31. M. De Rosa, B. Boggia, and B. Amalfi Correlation between seminal carnitine and functional spermatozoal characteristics in men with semen dysfunction of various origins Drugs R D 6 2005 1 9
32. A. Lenzi, F. Lombardo, and P. Sgrò Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial Fertil Steril 79 2003 292 300
33. K. Singh, and D. Jaiswal Human male infertility: a complex multifactorial phenotype Reprod Sci 18 2011 418 436