The effect of chronic administration of safranal on systolic blood pressure in rats

Iranian Journal of Pharmaceutical Research

Volumn 14, Issue 2, 2015, Pages 585-590

  Imenshahidi, Mohsen ^a   Razavi, Bibi Marjan ^b   Faal, Ayyoob ^c   Gholampoor, Ali ^c   Mousavi, Seyed Mehran ^c   Hosseinzadeh, Hossein ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Crocus sativus; Saffron; Safranal; Systolic blood pressure; Tail cuff

Indexed keywords

DEOXYCORTICOSTERONE ACETATE; HERBACEOUS AGENT; SAFRANAL; SPIRONOLACTONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; DRUG EFFECT; EXPERIMENTAL HYPERTENSION; HEART RATE; MALE; NONHUMAN; RAT; SYSTOLIC BLOOD PRESSURE;

EID: 84923062194     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Ríos J, Recio M, Giner R and Manez S. An update review of saffron and its active constituents. Phytother. Res. (1996) 10: 189-193.
2. Rezaee R and Hosseinzadeh H. Safranal: From an aromatic natural product to a rewarding pharmacological agent. Iran. J. Basic. Med. Sci. (2013) 16: 12-26.
3. Assimopoulou AN, Sinakos Z and Papageorgiou VP. Radical scavenging activity of Crocus sativus L extract and its bioactive constituents. Phytother. Res. (2005) 19: 997-1000.
4. Hosseinzadeh H and Talebzadeh F. Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitoterapia (2005) 76: 722-724.
5. Hosseinzadeh H, Karimi G and Niapoor M. Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranal, in mice. J. Med. Plants (2004) 3: 48-58.
6. Hosseinzadeh H and Noraei NB. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytother. Res. (2009) 23: 768-774.
7. Nemati H, Boskabady MH and Ahmadzadef Vostakolaei H. Stimulatory effect of Crocus sativus (saffron) on b2-adrenoceptors of guineapigtrachealchains. Phytomed. (2008) 15: 1038-1045.
8. Amin B and Hosseinzadeh H. Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. Fitoterapia (2012) 83: 888-895.
9. Hosseinzadeh H and Sadeghnia HR. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J. Pharm. Pharm. Sci. (2005) 8: 394-399.
10. Hosseinzadeh H and Ziaei T. Effects of Crocus sativus stigma extract and its constituents, crocin and safranal, on intact memory and scopolamine-induced learning defcits in rats performing the Morris water maze task. J. Med. Plants (2006) 5: 40-50.
11. Hariri A, Moallem S, Mahmoudi M and Hosseinzadeh H. The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomed. (2011) 18: 499-504.
12. Boskabady MH, Shafei MN, Shakiba A and Sang Sefdi H. Effect of aqueous-ethanol extract from Crocus sativus (saffron) on guinea-pig isolated heart. Phytother. Res. (2008) 22: 330-334.
13. Fatehi M, Rashidabady T and Hassanabad ZF. Effects of petals extracts of saffron on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea–pigileum. J. Ethnopharmacol. (2003) 84: 199-203.
14. Imenshahidi M, Hosseinzadeh H and Javadpour Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother. Res. (2010) 24: 990-994.
15. Lorenz JN. A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2002) 282: 1565-1582.
16. Boskabadi IMH and Aslani MR. Relaxant effect of crocus sativus (saffron) on guinea pig tracheal chains and its possible mechanisms. J. Pharm. Pharmacol. (2006) 58: 1385-1390.
17. Hosseinzadeh H, Shakib SS, Sameni AK and Taghiabadi E. Acute and subacute toxicity of safranal, a constituent of saffron, in mice and rats. Iran. J. Pharm. Res. (2013) 12: 93-99.
18. Mirshafa SA, Azadbakht M and Ahangar N. Study of antidepressant and sedative-hypnotic activity of hydroalcoholic extract of Asperugo procumbens L. aerial parts in mice. Iran. J. Pharm. Res. (2013) 12: 529-535.
19. Hosseinzadeh H and Sadeghnia H. Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomed. (2007) 14: 256-262.
20. Nugent M, Artru A and Michenfclder J. Cerebral metabolic vascular and protective effects of midazolam maleate: Comparison to diazepam. Anesthesiol. (1982) 56: 172-176.
21. Lyer A, Chan V and Brown L. The DOCA-Salt hypertensive rat as a model of cardiovascular oxidative and inflammatory stress. Current. Cardiol. Rev. (2010) 6: 291-297.
22. Fatehi-Hassanabad Z, Fatehi M and Imen Shahidi M. Endothelial dysfunction in aortic rings and mesenteric beds isolated from deoxycorticosterone acetate hypertensive rats: possible involvement of protein kinase C. Eur. J. Pharmacol. (2004) 494: 199-204.
23. Cheng S, Suzuki K, Sadee W and Harding B. Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria. Endocrinol. (1974) 99: 1097-1106.