Virion-independent transfer of replication-competent hepatitis C virus RNA between permissive cells

Journal of Virology

Volumn 89, Issue 5, 2015, Pages 2956-2961

  Longatti, Andrea ^a,b   Boyd, Bryan ^a,c   Chisari, Francis V ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b MEDIMMUNE   (United States)

^c Abide Therapeutics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

ARTICLE; CELL CONTACT; CELL FUSION; CELL VIABILITY; CONTROLLED STUDY; DNA TRANSFER; EXOSOME; FLOW CYTOMETRY; HEPATITIS C VIRUS; NONHUMAN; POLYPLOIDY; REPLICON CELL; RNA TRANSPORT; VIRION; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS TRANSMISSION; CELL LINE; GENETICS; HEPACIVIRUS; HUMAN; LIVER CELL; METABOLISM; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; VIROLOGY;

HEPATITIS C VIRUS;

BIOLOGICAL TRANSPORT; CELL LINE; EXOSOMES; HEPACIVIRUS; HEPATOCYTES; HUMANS; RNA, VIRAL; VIRUS REPLICATION;

EID: 84923051057     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02721-14     Document Type: Article

References (21)

1. Takahashi K, Asabe S, Wieland S, Garaigorta U, Gastaminza P, Isogawa M, Chisari FV. 2010. Plasmacytoid dendritic cells sense hepatitis C virusinfected cells, produce interferon, and inhibit infection. Proc Natl Acad Sci USA 107:7431-7436. http://dx.doi.org/10.1073/pnas.1002301107.
2. Bobrie A, Colombo M, Raposo G, Thery C. 2011. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 12:1659-1668. http://dx.doi.org/10.1111/j.1600-0854.2011.01225.x.
3. Dreux M, Garaigorta U, Boyd B, Decembre E, Chung J, Whitten-Bauer C, Wieland S, Chisari FV. 2012. Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity. Cell Host Microbe 12:558-570. http://dx.doi.org/10.1016/j.chom.2012.08.010.
4. Ramakrishnaiah V, Thumann C, Fofana I, Habersetzer F, Pan Q, de Ruiter PE, Willemsen R, Demmers JA, Stalin Raj V, Jenster G, Kwekkeboom J, Tilanus HW, Haagmans BL, Baumert TF, van der Laan LJ. 2013. Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells. Proc Natl Acad Sci USA 110:13109-13113. http://dx.doi.org/10.1073/pnas.1221899110.
5. Bradley D, McCaustland K, Krawczynski K, Spelbring J, Humphrey C, Cook EH. 1991. Hepatitis C virus: buoyant density of the factor VIIIderived isolate in sucrose. J Med Virol 34:206-208. http://dx.doi.org/10.1002/jmv.1890340315.
6. Gastaminza P, Cheng G, Wieland S, Zhong J, Liao W, Chisari FV. 2008. Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion. J Virol 82:2120-2129. http://dx.doi.org/10.1128/JVI.02053-07.
7. Gastaminza P, Kapadia SB, Chisari FV. 2006. Differential biophysical properties of infectious intracellular and secreted hepatitis C virus particles. J Virol 80:11074-11081. http://dx.doi.org/10.1128/JVI.01150-06.
8. Meckes DG, Jr, Raab-Traub N. 2011. Microvesicles and viral infection. J Virol 85:12844-12854. http://dx.doi.org/10.1128/JVI.05853-11.
9. Pumeechockchai W, Bevitt D, Agarwal K, Petropoulou T, Langer BC, Belohradsky B, Bassendine MF, Toms GL. 2002. Hepatitis C virus particles of different density in the blood of chronically infected immunocompetent and immunodeficient patients: implications for virus clearance by antibody. J Med Virol 68:335-342. http://dx.doi.org/10.1002/jmv.10208.
10. Kato T, Date T, Miyamoto M, Furusaka A, Tokushige K, Mizokami M, Wakita T. 2003. Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon. Gastroenterology 125:1808-1817. http://dx.doi.org/10.1053/j.gastro.2003.09.023.
11. Pietschmann T, Lohmann V, Kaul A, Krieger N, Rinck G, Rutter G, Strand D, Bartenschlager R. 2002. Persistent and transient replication of full-length hepatitisCvirus genomes in cell culture. J Virol 76:4008-4021. http://dx.doi.org/10.1128/JVI.76.8.4008-4021.2002.
12. Dreux M, Dao Thi VL, Fresquet J, Guerin M, Julia Z, Verney G, Durantel D, Zoulim F, Lavillette D, Cosset FL, Bartosch B. 2009. Receptor complementation and mutagenesis reveal SR-BI as an essential HCV entry factor and functionally imply its intra-and extra-cellular domains. PLoS Pathog 5:e1000310. http://dx.doi.org/10.1371/journal.ppat.1000310.
13. Zhong J, Gastaminza P, Cheng G, Kapadia S, Kato T, Burton DR, Wieland SF, Uprichard SL, Wakita T, Chisari FV. 2005. Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci USA 102:9294-9299. http://dx.doi.org/10.1073/pnas.0503596102.
14. Chairoungdua A, Smith DL, Pochard P, Hull M, Caplan MJ. 2010. Exosome release of beta-catenin: a novel mechanism that antagonizes Wnt signaling. J Cell Biol 190:1079-1091. http://dx.doi.org/10.1083/jcb.201002049.
15. Kogure T, Lin WL, Yan IK, Braconi C, Patel T. 2011. Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth. Hepatology 54:1237-1248. http://dx.doi.org/10.1002/hep.24504.
16. Kosaka N, Iguchi H, Yoshioka Y, Hagiwara K, Takeshita F, Ochiya T. 2012. Competitive interactions of cancer cells and normal cells via secretory microRNAs. J Biol Chem 287:1397-1405. http://dx.doi.org/10.1074/jbc.M111.288662.
17. Kosaka N, Iguchi H, Yoshioka Y, Takeshita F, Matsuki Y, Ochiya T. 2010. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 285:17442-17452. http://dx.doi.org/10.1074/jbc.M110.107821.
18. Trajkovic K, Hsu C, Chiantia S, Rajendran L, Wenzel D, Wieland F, Schwille P, Brugger B, Simons M. 2008. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319:1244-1247. http://dx.doi.org/10.1126/science.1153124.
19. Yuyama K, Sun H, Mitsutake S, Igarashi Y. 2012. Sphingolipid-modulated exosome secretion promotes clearance of amyloid-beta by microglia. J Biol Chem 287:10977-10989. http://dx.doi.org/10.1074/jbc.M111.324616.
20. Bukong TN, Momen-Heravi F, Kodys K, Bala S, Szabo G. 2014. Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90. PLoS Pathog 10:e1004424. http://dx.doi.org/10.1371/journal.ppat.1004424.
21. Thery C, Amigorena S, Raposo G, Clayton A. 2006. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol Chapter 3:Unit 3.22. http://dx.doi.org/10.1002/0471143030.cb0322s30.