Upregulated MiR-1269 in hepatocellular carcinoma and its clinical significance

International Journal of Clinical and Experimental Medicine

Volumn 8, Issue 1, 2015, Pages 714-721

  Gan, Ting Qing ^a   Tang, Rui Xue ^b   He, Rong Quan ^a   Dang, Yi Wu ^b   Xie, You ^b   Chen, Gang ^b  

^a Departments of Medical Oncology   (China)

^b FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma; MiR 1269; Paraffin embedded tissues; RT qPCR; Target prediction

Indexed keywords

ACYLGLYCEROL KINASE; BROMODOMAIN PHD FINGER TRANSCRIPTION FACTOR; DAPPER HOMOLOG 1; MICRORNA; MICRORNA 1269; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; AGAP1 GENE; AGED; AREA UNDER THE CURVE; ARTICLE; BMPER GENE; C16ORF74 GENE; CANCER INFILTRATION; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CLINICAL ASSESSMENT; FEMALE; GENE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIX1L GENE; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; RBMS3 GENE; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SENSITIVITY AND SPECIFICITY; TUMOR CAPSULAR INFILTRATION; UPREGULATION; VASCULAR TUMOR; VERY ELDERLY;

EID: 84923039214     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Phuah NH and Nagoor NH. Regulation of MicroRNAs by Natural Agents: New Strategies in Cancer Therapies. Biomed Res Int 2014; 2014: 804510.
2. Di Leva G, Briskin D and Croce CM. MicroRNA in cancer: new hopes for antineoplastic chemotherapy. Ups J Med Sci 2012; 117: 202-216.
3. Iuliano R, Vismara MF, Dattilo V, Trapasso F, Baudi F and Perrotti N. The role of microRNAs in cancer susceptibility. Biomed Res Int 2013; 2013: 591931.
4. Sun J, Lu H, Wang X and Jin H. MicroRNAs in hepatocellular carcinoma: regulation, function, and clinical implications. Scientific World Journal 2013; 2013: 924206.
5. Fang Y, Xue JL, Shen Q, Chen J and Tian L. MicroRNA-7 inhibit tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma. Hepatology 2012; 55: 1852-1862.
6. Dang Y, Luo D, Rong M and Chen G. Undere-xpression of miR-34a in hepatocellular carcinoma and its contribution towards enhancement of proliferating inhibitory effects of agents targeting c-MET. PLoS One 2013; 8: e61054.
7. Albertini MC, Olivieri F, Lazzarini R, Pilolli F, Galli F, Spada G, Accorsi A, Rippo MR and Pro-copio AD. Predicting microRNA modulation in human prostate cancer using a simple String IDentifier (SID1.0). J Biomed Inform 2011; 44: 615-620.
8. Rong M, He R, Dang Y and Chen G. Expression and clinicopathological significance of miR-146a in hepatocellular carcinoma tissues. Ups J Med Sci 2014; 119: 19-24.
9. Fu Y, Qin W, Cao H, Xu R, Tan Y, Lu T, Wang H, Tong W, Rong X, Li G, Yuan M, Li C, Abe K, Lu L and Chen G. HCV 6a prevalence in Guangdong province had the origin from Vietnam and recent dissemination to other regions of China: phylogeographic analyses. PLoS One 2012; 7: e28006.
10. Rong M, Chen G and Dang Y. Increased miR-221 expression in hepatocellular carcinoma tissues and its role in enhancing cell growth and inhibiting apoptosis in vitro. BMC Cancer 2013; 13: 21.
11. Hamfjord J, Stangeland AM, Hughes T, Skrede ML, Tveit KM, Ikdahl T and Kure EH. Differential expression of miRNAs in colorectal cancer: comparison of paired tumor tissue and adjacent normal mucosa using high-throughput se-quencing. PLoS One 2012; 7: e34150.
12. Dalmasso G, Nguyen HT, Yan Y, Laroui H, Srinivasan S, Sitaraman SV and Merlin D. MicroRNAs determine human intestinal epithelial cell fate. Differentiation 2010; 80: 147-154.
13. Morin RD, O’Connor MD, Griffith M, Kuchen-bauer F, Delaney A, Prabhu AL, Zhao Y, Mc-Donald H, Zeng T, Hirst M, Eaves CJ and Marra MA. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res 2008; 18: 610-621.
14. Zheng J, Li C, Wu X, Yang Y, Hao M, Sheng S, Sun Y, Zhang H, Long J and Hu C. Astrocyte elevated gene-1 is a novel biomarker of epithelial-mesenchymal transition and progression of hepatocellular carcinoma in two China regions. Tumour Biol 2014; 35: 2265-2269.
15. Zhou Z, Deng H, Yan W, Luo M, Tu W, Xia Y, He J, Han P, Fu Y and Tian D. AEG-1 promotes anoikis resistance and orientation chemotaxis in hepatocellular carcinoma cells. PLoS One 2014; 9: e100372.
16. Yau TO, Chan CY, Chan KL, Lee MF, Wong CM, Fan ST and Ng IO. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. Oncogene 2005; 24: 1607-1614.
17. Fritz D and Stefanovic B. RNA-binding protein RBMS3 is expressed in activated hepatic stellate cells and liver fibrosis and increases expression of transcription factor Prx1. J Mol Biol 2007; 371: 585-595.
18. Chen J, Kwong DL, Zhu CL, Chen LL, Dong SS, Zhang LY, Tian J, Qi CB, Cao TT, Wong AM, Kong KL, Li Y, Liu M, Fu L and Guan XY. RBMS3 at 3p24 inhibits nasopharyngeal carcinoma development via inhibiting cell proliferation, angiogenesis, and inducing apoptosis. PLoS One 2012; 7: e44636.
19. Chen X, Ying Z, Lin X, Lin H, Wu J, Li M and Song L. Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells. J Clin Invest 2013; 123: 2576-2589.
20. Wang X, Lin C, Zhao X, Liu A, Zhu J, Li X and Song L. Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor. Mol Cancer 2014; 13: 106.
21. Heinke J, Kerber M, Rahner S, Mnich L, Lass-mann S, Helbing T, Werner M, Patterson C, Bode C and Moser M. Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behavior. Oncogene 2012; 31: 2919-2930.
22. Grinberg-Rashi H, Ofek E, Perelman M, Skarda J, Yaron P, Hajduch M, Jacob-Hirsch J, Amariglio N, Krupsky M, Simansky DA, Ram Z, Pfeffer R, Galernter I, Steinberg DM, Ben-Dov I, Rechavi G and Izraeli S. The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain. Clin Cancer Res 2009; 15: 1755-1761.
23. Buganim Y, Goldstein I, Lipson D, Milyavsky M, Polak-Charcon S, Mardoukh C, Solomon H, Kalo E, Madar S, Brosh R, Perelman M, Navon R, Goldfinger N, Barshack I, Yakhini Z and Ro-tter V. A novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype. PLoS One 2010; 5: e9657.
24. Kim WT, Yun SJ, Park C, Kim IY, Moon SK, Kwon TG, Choi YH and Kim WJ. Identification of C16orf74 as a marker of progression in primary non-muscle invasive bladder cancer. PLoS One 2010; 5: e15260.
25. Colombo J, Fachel AA, De Freitas Calmon M, Cury PM, Fukuyama EE, Tajara EH, Cordeiro JA, Verjovski-Almeida S, Reis EM and Rahal P. Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma. Oncol Rep 2009; 21: 649-663.