Patient selection based on treatment duration and liver biochemistry increases success rates after treatment withdrawal in autoimmune hepatitis

Journal of Hepatology

Volumn 62, Issue 3, 2015, Pages 642-646

  Hartl, Johannes ^a   Ehlken, Hanno ^a   Weiler Normann, Christina ^a   Sebode, Marcial ^a   Kreuels, Benno ^a,b   Pannicke, Nadine ^a   Zenouzi, Roman ^a   Glaubke, Claudia ^a   Lohse, Ansgar W ^a   Schramm, Christoph ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

Autoimmune hepatitis; Drug withdrawal; Immunosuppressive therapy; Loss of remission; Predictors for relapse; Relapse; Remission; Treatment duration

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; AZATHIOPRINE; BUDESONIDE; IMMUNOGLOBULIN G; MERCAPTOPURINE; PREDNISOLONE; IMMUNOSUPPRESSIVE AGENT;

ADOLESCENT; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOIMMUNE HEPATITIS; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOSUPPRESSIVE TREATMENT; LIVER BIOPSY; LIVER HISTOLOGY; MAINTENANCE DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; OUTCOME ASSESSMENT; PATIENT SELECTION; PRIORITY JOURNAL; RECURRENCE RISK; RELAPSE; REMISSION; TREATMENT DURATION; TREATMENT WITHDRAWAL; BLOOD; HEPATITIS, AUTOIMMUNE; IMMUNOLOGY; LIVER; METABOLISM; MIDDLE AGED; RECURRENT DISEASE; TIME; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ALANINE TRANSAMINASE; CHILD; FEMALE; HEPATITIS, AUTOIMMUNE; HUMANS; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; LIVER; MALE; MIDDLE AGED; PATIENT SELECTION; RECURRENCE; REMISSION INDUCTION; TIME FACTORS; WITHHOLDING TREATMENT; YOUNG ADULT;

EID: 84923029650     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.10.018     Document Type: Article

References (25)

1. E.L. Krawitt Autoimmune hepatitis N Engl J Med 354 2006 54
2. A.W. Lohse, and G. Mieli-Vergani Autoimmune hepatitis J Hepatol 55 2011 171 182
3. M.A. Heneghan, A.D. Yeoman, S. Verma, A.D. Smith, and M.S. Longhi Autoimmune hepatitis Lancet 382 2013 1433 1444
4. M.P. Manns, A.J. Czaja, J.D. Gorha, E.L. Krawitt, G. Mieli-Vergani, and D. Vergani Diagnosis and management of autoimmune hepatitis Hepatology 51 2010 2193 2213
5. D. Gleeson, and M.A. Heneghan British Society of Gastroenterology (BSG) guidelines for management of autoimmune hepatitis Gut 60 2011 1611 1629
6. S.K. Roberts, T.M. Therneau, and A.J. Czaja Prognosis of histological cirrhosis in type 1 autoimmune hepatitis Gastroenterology 110 1996 848
7. B. Hoeroldt, E. McFarlane, A. Dube, P. Basumani, M. Karajeh, and M.J. Campell Long-term outcomes of patients with autoimmune hepatitis managed at a nontransplant center Gastroenterology 140 2011 1980 1989
8. N.M. van Gerven, B.J. Verwer, B.I. Witte, B.V. Hoek, M.J. Coenraad, and K.J. van Erpecum Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission J Hepatol 58 2013 141 147
9. R.D. Soloway, W.H. Summerskill, A.H. Baggenstoss, M.G. Geall, G.L. Gitnick, and I.R. Elveback Clinical, biochemical, and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis Gastroenterology 63 1972 820 833
10. A.J. Czaja, H.V. Ammon, and W.H. Summerskill Clinical features and prognosis of severe chronic active liver diseases (CALD) after corticosteroid-induced remission Gastroenterology 78 1980 518 523
11. J.E. Hegarty, Nouri Aria, T. Kayhan, B. Portmann, A.L. Eddleston, and R. Williams Relapse following treatment withdrawal in patients with autoimmune chronic active hepatitis Hepatology 5 1983 685 689
12. A.J. Czaja, J. Ludwig, A.H. Baggenstoss, and A. Wolf Corticosteroid-treated chronic active hepatitis in remission: uncertain prognosis of chronic persistent hepatitis N Engl J Med 304 1981 5 9
13. S. Kanzler, G. Gerken, H. Löhr, P.R. Galle, K.H. Meyer zum Büschenfelde, and A.W. Lohse Duration of immunosuppressive therapy in autoimmune hepatitis J Hepatol 34 2001 354
14. A.J. Montano-Loza, H.A. Carpenter, and A.J. Czaja Improving the end point of corticosteroid therapy in type 1 autoimmune hepatitis to reduce the frequency of relapse Am J Gastroenterol 102 2007 1005 1012
15. S. Lüth, J. Herkel, S. Kanzler, C. Frenzel, P.R. Galle, and H.P. Dienes Serologic markers compared with liver biopsy for monitoring disease activity in autoimmune hepatitis J Clin Gastroenterol 42 2008 926 930
16. E.M. Hennes, M. Zeniya, A.J. Czaja, A. Parés, G.N. Dalekos, and E.L. Krawitt Simplified criteria for the diagnosis of autoimmune hepatitis Hepatology 48 2008 169 176
17. C. Weiler-Normann, and A.W. Lohse Autoimmune hepatitis: a life-long disease J Hepatol 58 2013 5 7
18. A. Montano-Loza, H. Carpenter, and A. Czaja Consequences of treatment withdrawal in type 1 autoimmune hepatitis Liver Int 27 2007 507 515
19. L. Muratori, P. Muratori, G. Lanzoni, S. Ferri, and M. Lenzi Application of the 2010 American Association for the study of liver diseases criteria of remission to a cohort of Italian patients with autoimmune hepatitis Hepatology 52 2010 1857
20. D. Prati, E. Taioli, A. Zanella, E. Della Torre, S. Butelli, and E. Del Vecchio Updated definitions of healthy ranges for serum alanine aminotransferase levels Ann Intern Med 137 2002 1 10
21. S. Verma, B. Gunuwan, M. Mendler, S. Govindrajan, and A. Redeker Factors predicting relapse and poor outcome in type I autoimmune hepatitis: role of cirrhosis development, patterns of transaminases during remission and plasma cell activity in the liver biopsy Am J Gastroenterol 99 2004 1510 1516
22. A.J. Czaja, A.M. Wolf, and A.H. Baggenstoss Laboratory assessment of severe chronic active liver disease during and after corticosteroid therapy: correlation of serum transaminase and gamma globulin levels with histologic features Gastroenterology 80 1998 687 692
23. A.J. Czaja, and H.A. Carpenter Histological features associated with relapse after corticosteroid withdrawal in type 1 autoimmune hepatitis Liver Int 23 2003 116
24. A.J. Czaja Review article: the management of autoimmune hepatitis beyond consensus guidelines Aliment Pharmacol Ther 38 2013 343 364
25. A.J. Czaja Late relapse of type 1 autoimmune hepatitis after corticosteroid withdrawal Dig Dis Sci 55 2010 1761 1769