Neonatal levels of inflammatory markers and later risk of schizophrenia

Biological Psychiatry

Volumn 77, Issue 6, 2015, Pages 548-555

  Nielsen, Philip Rising ^a   Agerbo, Esben ^a   Skogstrand, Kristin ^b   Hougaard, David Michael ^b   Meyer, Urs ^c   Mortensen, Preben Bo ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b STATENS SERUM INSTITUT   (Denmark)

^c ETH ZURICH   (Switzerland)

Author keywords

Blood; Cytokines; Denmark; Epidemiology; Etiology; Schizophrenia

Indexed keywords

ADIPONECTIN; BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; C REACTIVE PROTEIN; CYTOKINE; EPIDERMAL GROWTH FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ALPHA; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA; INTERLEUKIN DERIVATIVE;

ADULT; ARTICLE; ASSAY; CASE CONTROL STUDY; CONTROLLED STUDY; DENMARK; DISEASE ASSOCIATION; DRIED BLOOD SPOT TESTING; HUMAN; IMMUNE RESPONSE; INCIDENCE; INFLAMMATION; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; NEWBORN; NEWBORN SCREENING; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RISK; SCHIZOPHRENIA; BLOOD; BLOOD ANALYSIS; FEMALE; IMMUNOLOGY; MALE; REGISTER; STATISTICAL MODEL; YOUNG ADULT;

BLOOD CHEMICAL ANALYSIS; CASE-CONTROL STUDIES; DENMARK; FEMALE; HUMANS; INCIDENCE; INFANT, NEWBORN; INTERLEUKINS; LOGISTIC MODELS; MALE; PRINCIPAL COMPONENT ANALYSIS; REGISTRIES; RISK; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84922939231     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.07.013     Document Type: Article

References (55)

1. J. McGrath, A. Brown St, and D. Clair Prevention and schizophrenia - the role of dietary factors Schizophr Bull 37 2011 272 283
2. D. Malaspina, C. Corcoran, K.R. Kleinhaus, M.C. Perrin, S. Fennig, and D. Nahon Acute maternal stress in pregnancy and schizophrenia in offspring: A cohort prospective study BMC Psychiatry 8 2008 71
3. O.J. van, and J.P. Selten Prenatal exposure to maternal stress and subsequent schizophrenia. The May 1940 invasion of The Netherlands Br J Psychiatry 172 1998 324 326
4. A.S. Khashan, K.M. Abel, R. McNamee, M.G. Pedersen, R.T. Webb, and P.N. Baker Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events Arch Gen Psychiatry 65 2008 146 152
5. M. Cannon, P.B. Jones, and R.M. Murray Obstetric complications and schizophrenia: Historical and meta-analytic review Am J Psychiatry 159 2002 1080 1092
6. A.S. Brown, and E.J. Derkits Prenatal infection and schizophrenia: A review of epidemiologic and translational studies Am J Psychiatry 167 2010 261 280
7. C.S. Kronborg, J. Gjedsted, E. Vittinghus, T.K. Hansen, J. Allen, and U.B. Knudsen Longitudinal measurement of cytokines in pre-eclamptic and normotensive pregnancies Acta Obstet Gynecol Scand 90 2011 791 796
8. K. Skogstrand, D.M. Hougaard, D.E. Schendel, N.P. Bent, C. Svaerke, and P. Thorsen Association of preterm birth with sustained postnatal inflammatory response Obstet Gynecol 111 2008 1118 1128
9. L.M. Ellman, R.F. Deicken, S. Vinogradov, W.S. Kremen, J.H. Poole, and D.M. Kern Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8 Schizophr Res 121 2010 46 54
10. U. Meyer, J. Feldon, and B.K. Yee A review of the fetal brain cytokine imbalance hypothesis of schizophrenia Schizophr Bull 35 2009 959 972
11. U. Meyer, and J. Feldon To poly(I:C) or not to poly(I:C): Advancing preclinical schizophrenia research through the use of prenatal immune activation models Neuropharmacology 62 2012 1308 1321
12. P. Boksa Effects of prenatal infection on brain development and behavior: A review of findings from animal models Brain Behav Immun 24 2010 881 897
13. P.H. Patterson Immune involvement in schizophrenia and autism: Etiology, pathology and animal models Behav Brain Res 204 2009 313 321
14. S.L. Buka, M.T. Tsuang, E.F. Torrey, M.A. Klebanoff, R.L. Wagner, and R.H. Yolken Maternal cytokine levels during pregnancy and adult psychosis Brain Behav Immun 15 2001 411 420
15. A.S. Brown, J. Hooton, C.A. Schaefer, H. Zhang, E. Petkova, and V. Babulas Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring Am J Psychiatry 161 2004 889 895
16. T.D. Cannon, R. Yolken, S. Buka, and E.F. Torrey Decreased neurotrophic response to birth hypoxia in the etiology of schizophrenia Biol Psychiatry 64 2008 797 802
17. M.W. Abdallah, N. Larsen, J. Grove, B. Norgaard-Pedersen, P. Thorsen, E.L. Mortensen, and D.M. Hougaard Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders World J Biol Psychiatry 14 2013 528 538
18. M.W. Abdallah, N. Larsen, E.L. Mortensen, H.O. Atladottir, B. Norgaard-Pedersen, and E.C. Bonefeld-Jorgensen Neonatal levels of cytokines and risk of autism spectrum disorders: An exploratory register-based historic birth cohort study utilizing the Danish Newborn Screening Biobank J Neuroimmunol 252 2012 75 82
19. A.S. Brown, A. Sourander, S. Hinkka-Yli-Salomaki, I.W. McKeague, J. Sundvall, and H.M. Surcel Elevated maternal C-reactive protein and autism in a national birth cohort Mol Psychiatry 19 2014 259 264
20. B.J. Miller, P. Buckley, W. Seabolt, A. Mellor, and B. Kirkpatrick Meta-analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects Biol Psychiatry 70 2011 663 671
21. R.M. Gardner, C. Dalman, S. Wicks, B.K. Lee, and H. Karlsson Neonatal levels of acute phase proteins and later risk of non-affective psychosis Transl Psychiatry 3 2013 e228
22. B.E. Deverman, and P.H. Patterson Cytokines and CNS development Neuron 64 2009 61 78
23. S. Ygberg, and A. Nilsson The developing immune system-from foetus to toddler Acta Paediatr 101 2012 120 127
24. U. Meyer Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems Biol Psychiatry 75 2014 307 315
25. H. Nawa, and N. Takei Recent progress in animal modeling of immune inflammatory processes in schizophrenia: Implication of specific cytokines Neurosci Res 56 2006 2 13
26. L. Asp, S. Beraki, K. Kristensson, S.O. Ogren, and H. Karlsson Neonatal infection with neurotropic influenza A virus affects working memory and expression of type III Nrg1 in adult mice Brain Behav Immun 23 2009 733 741
27. X.C. Liu, M. Holtze, S.B. Powell, N. Terrando, M.K. Larsson, and A. Persson Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment-role of brain kynurenic acid Brain Behav Immun 36 2014 80 89
28. Y. Watanabe, T. Someya, and H. Nawa Cytokine hypothesis of schizophrenia pathogenesis: Evidence from human studies and animal models Psychiatry Clin Neurosci 64 2010 217 230
29. G. King, and L. Zeng Estimating risk and rate levels, ratios and differences in case-control studies Stat Med 21 2002 1409 1427
30. O. Mors, G.P. Perto, and P.B. Mortensen The Danish Psychiatric Central Research Register Scand J Public Health 39 2011 54 57
31. C.B. Pedersen, H. Gotzsche, J.O. Moller, and P.B. Mortensen The Danish Civil Registration System. A cohort of eight million persons Dan Med Bull 53 2006 441 449
32. L.B. Knudsen, and J. Olsen The Danish Medical Birth Registry Dan Med Bull 45 1998 320 323
33. B. Norgaard-Pedersen, and D.M. Hougaard Storage policies and use of the Danish Newborn Screening Biobank J Inherit Metab Dis 30 2007 530 536
34. K. Skogstrand, P. Thorsen, B. Norgaard-Pedersen, D.E. Schendel, L.C. Sorensen, and D.M. Hougaard Simultaneous measurement of 25 inflammatory markers and neurotrophins in neonatal dried blood spots by immunoassay with xMAP technology Clin Chem 51 2005 1854 1866
35. G. Natarajan, S. Shankaran, S.A. McDonald, A. Das, B.J. Stoll, and R.D. Higgins Circulating beta chemokine and MMP 9 as markers of oxidative injury in extremely low birth weight infants Pediatr Res 67 2010 77 82
36. R.L. Schelonka, A. Maheshwari, W.A. Carlo, S. Taylor, N.I. Hansen, and D.E. Schendel T cell cytokines and the risk of blood stream infection in extremely low birth weight infants Cytokine 53 2011 249 255
37. B.G. Sood, S. Shankaran, R.L. Schelonka, S. Saha, D.K. Benjamin Jr, and P.J. Sanchez Cytokine profiles of preterm neonates with fungal and bacterial sepsis Pediatr Res 72 2012 212 220
38. J.V. Mei, J.R. Alexander, B.W. Adam, and W.H. Hannon Use of filter paper for the collection and analysis of human whole blood specimens J Nutr 131 2001 1631S 1636S
39. K. Skogstrand Multiplex assays of inflammatory markers, a description of methods and discussion of precautions-Our experience through the last ten years Methods 56 2012 204 212
40. U. Meyer Anti-inflammatory signaling in schizophrenia Brain Behav Immun 25 2011 1507 1518
41. B.J. Miller, N. Culpepper, and M.H. Rapaport C-reactive protein levels in schizophrenia: A review and meta-analysis Clin Schizophr Relat Psychoses 7 2014 223 230
42. M. Byrne, E. Agerbo, B. Bennedsen, W.W. Eaton, and P.B. Mortensen Obstetric conditions and risk of first admission with schizophrenia: A Danish national register based study Schizophr Res 97 2007 51 59
43. A.M. Fineberg, and L.M. Ellman Inflammatory cytokines and neurological and neurocognitive alterations in the course of schizophrenia Biol Psychiatry 73 2013 951 966
44. P.A. Garay, E.Y. Hsiao, P.H. Patterson, and A.K. McAllister Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development Brain Behav Immun 31 2013 54 68
45. U. Meyer, B.K. Yee, and J. Feldon The neurodevelopmental impact of prenatal infections at different times of pregnancy: The earlier the worse? Neuroscientist 13 2007 241 256
46. A.S. Brown, M.D. Begg, S. Gravenstein, C.A. Schaefer, R.J. Wyatt, and M. Bresnahan Serologic evidence of prenatal influenza in the etiology of schizophrenia Arch Gen Psychiatry 61 2004 774 780
47. H.J. Sorensen, E.L. Mortensen, J.M. Reinisch, and S.A. Mednick Association between prenatal exposure to bacterial infection and risk of schizophrenia Schizophr Bull 35 2009 631 637
48. J.H. Curfs, J.F. Meis, and J.A. Hoogkamp-Korstanje A primer on cytokines: Sources, receptors, effects, and inducers Clin Microbiol Rev 10 1997 742 780
49. A. Abu-Maziad, K. Schaa, E.F. Bell, J.M. Dagle, M. Cooper, M.L. Marazita, and J.C. Murray Role of polymorphic variants as genetic modulators of infection in neonatal sepsis Pediatr Res 68 2010 323 329
50. P. Uggerby, S.D. Ostergaard, R. Roge, C.U. Correll, and J. Nielsen The validity of the schizophrenia diagnosis in the Danish Psychiatric Central Research Register is good Dan Med J 60 2013 A4578
51. S. Lusyati, C.V. Hulzebos, J. Zandvoort, and P.J. Sauer Levels of 25 cytokines in the first seven days of life in newborn infants BMC Res Notes 6 2013 547
52. D. Rizos, E. Protonotariou, A. Malamitsi-Puchner, A. Sarandakou, E. Trakakis, and E. Salamalekis Cytokine concentrations during the first days of life Eur J Obstet Gynecol Reprod Biol 131 2007 32 35
53. S.E. Sullivan, S.L. Staba, J.A. Gersting, A.D. Hutson, D. Theriaque, R.D. Christensen, and D.A. Calhoun Circulating concentrations of chemokines in cord blood, neonates, and adults Pediatr Res 51 2002 653 657
54. N. Matoba, Y. Yu, K. Mestan, C. Pearson, K. Ortiz, and N. Porta Differential patterns of 27 cord blood immune biomarkers across gestational age Pediatrics 123 2009 1320 1328
55. L. Paulesu, J. Bhattacharjee, N. Bechi, R. Romagnoli, S. Jantra, and F. Ietta Pro-inflammatory cytokines in animal and human gestation Curr Pharm Des 16 2010 3601 3615