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Volumn 20, Issue 2, 2015, Pages 167-169

How many times should we screen a chemical library to discover an anticancer drug?

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; MOLECULAR LIBRARY;

EID: 84922918064     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2014.12.006     Document Type: Editorial
Times cited : (35)

References (8)
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    • High drug attrition rates - Where are we going wrong?
    • L. Hutchinson, and R. Kirk High drug attrition rates - where are we going wrong? Nat. Rev. Clin. Oncol. 8 2011 189 190
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 189-190
    • Hutchinson, L.1    Kirk, R.2
  • 2
    • 84859169880 scopus 로고    scopus 로고
    • Drug development: Raise standards for preclinical cancer research
    • C.G. Begley, and L.M. Ellis Drug development: raise standards for preclinical cancer research Nature 483 2012 531 533
    • (2012) Nature , vol.483 , pp. 531-533
    • Begley, C.G.1    Ellis, L.M.2
  • 3
    • 84874732406 scopus 로고    scopus 로고
    • Is poor research the cause of the declining productivity of the pharmaceutical industry? An industry in need of a paradigm shift
    • F. Sams-Dodd Is poor research the cause of the declining productivity of the pharmaceutical industry? An industry in need of a paradigm shift Drug Discov. Today 18 2013 211 217
    • (2013) Drug Discov. Today , vol.18 , pp. 211-217
    • Sams-Dodd, F.1
  • 4
    • 84905496728 scopus 로고    scopus 로고
    • Phenotypic screening in cancer drug discovery - Past, present and future
    • J.G. Moffat Phenotypic screening in cancer drug discovery - past, present and future Nat. Rev. Drug Discov. 13 2014 588 602
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 588-602
    • Moffat, J.G.1
  • 5
    • 84892805731 scopus 로고    scopus 로고
    • Cancer statistics, 2014
    • R. Siegel Cancer statistics, 2014 CA Cancer J. Clin. 64 2014 9 29
    • (2014) CA Cancer J. Clin. , vol.64 , pp. 9-29
    • Siegel, R.1
  • 8
    • 84901845122 scopus 로고    scopus 로고
    • The in vivo antitumor activity of cardiac glycosides in mice xenografted with human cancer cells is probably an experimental artifact
    • J.M. Calderon-Montano The in vivo antitumor activity of cardiac glycosides in mice xenografted with human cancer cells is probably an experimental artifact Oncogene 33 2014 2947 2948
    • (2014) Oncogene , vol.33 , pp. 2947-2948
    • Calderon-Montano, J.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.