Is poor research the cause of the declining productivity of the pharmaceutical industry? An industry in need of a paradigm shift

Drug Discovery Today

Volumn 18, Issue 5-6, 2013, Pages 211-217

  Sams Dodd, Frank ^a,b  

^a Willingsford Ltd   (United Kingdom)

^b Asclepios Bioresearch (UK) Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEIN; CLOZAPINE; DOPAMINE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; GLUTAMATE RECEPTOR ANTAGONIST; SEROTONIN UPTAKE INHIBITOR;

ALZHEIMER DISEASE; CEREBROVASCULAR ACCIDENT; COGNITIVE DEFECT; DEPRESSION; DRUG DEVELOPMENT; DRUG EFFICACY; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG RESEARCH; DRUG RESPONSE; DRUG SCREENING; DRUG TARGETING; DRUG TREATMENT FAILURE; GENETIC ENGINEERING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERACTIVITY; MEDICAL DECISION MAKING; MEDICAL RESEARCH; MOLECULAR BIOLOGY; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; REPRODUCIBILITY; REVIEW; RISK ASSESSMENT; SCHIZOPHRENIA; SOCIAL ISOLATION; THEORETICAL STUDY; THINKING;

EID: 84874732406     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.10.010     Document Type: Short Survey

References (22)

1. I. Kola, and J. Landis Opinion: can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3 2004 711 716
2. F. Sams-Dodd Target-based drug discovery: is something wrong? Drug Discov. Today 10 2005 139 147
3. D.C. Swinney, and J. Anthony How were new medicines discovered? Nat. Rev. Drug Discov. 10 2011 507 519
4. F. Sams-Dodd Research & market strategy: how choice of drug discovery approach can affect market position Drug Discov. Today 12 2007 314 318
5. F. Pammolli The productivity crisis in pharmaceutical R&D Nat. Rev. Drug Discov. 10 2011 428 438
6. J. Arrowsmith Trial watch: Phase II failures: 2008-2010 Nat. Rev. Drug Discov. 10 2011 328 329
7. T.C. Merigan Treatment of AIDS with combinations of antiretroviral agents Am. J. Med. 90 1991 8S 17S
8. D. Fabbro Targeting cancer with small-molecular-weight kinase inhibitors Methods Mol. Biol. 795 2012 1 34
9. R.B. Silverman From basic science to blockbuster drug: the discovery of Lyrica Angew. Chem. Int. Ed. Engl. 47 2008 3500 3504
10. M. Garcia-Alloza Cerebrovascular lesions induce transient β-amyloid deposition Brain 134 2011 3697 3707
11. D.T. Stephenson Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat Brain Res. 593 1992 128 135
12. J. Clarke Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats Eur. J. Neurosci. 26 2007 1845 1852
13. J.J. Legos Pharmacological interventions for stroke: failures and futures Expert Opin. Investig. Drugs 11 2002 603 614
14. Stroke Therapy Academic Industry Roundtable (STAIR) Recommendations for standards regarding preclinical neuroprotective and restorative drug development Stroke 30 1999 2752 2758
15. K. Calkins, and L. Wess Stroke: never say die BioCentury 11 2003 A1 A7
16. J.N. Joyce D2 but not D3 receptors are elevated after 9 or 11 months chronic haloperidol treatment: influence of withdrawal period Synapse 40 2001 137 144
17. Y. Chertkow Dopamine and serotonin metabolism in response to chronic administration of fluvoxamine and haloperidol combined treatment J. Neural Transm. 114 2007 1443 1454
18. M.H. Pang A series of case studies: practical methodology for identifying antinociceptive multi-target drugs Drug Discov. Today 17 2012 425 434
19. F. Sams-Dodd Phencyclidine-induced stereotyped behaviour and social isolation in rats: a possible animal model of schizophrenia Behav. Pharmacol. 7 1996 3 23
20. F. Sams-Dodd A test of the predictive validity of animal models of schizophrenia based on phencyclidine and d-amphetamine Neuropsychopharmacology 18 1998 293 304
21. I.A. Cree Efficacy of anti-cancer agents in cell lines versus human primary tumour tissue Curr. Opin. Pharmacol. 10 2010 375 379
22. E. Koros The selective mGlu5 receptor antagonist MTEP, similar to NMDA receptor antagonists, induces social isolation in rats Neuropsychopharmacology 32 2007 562 576