Clinical and Cost-Effectiveness of Therapist-Guided Internet-Delivered Cognitive Behavior Therapy for Older Adults With Symptoms of Depression: A Randomized Controlled Trial

Behavior Therapy

Volumn 46, Issue 2, 2015, Pages 193-205

  Titov, Nickolai ^a   Dear, Blake F ^a   Ali, Shehzad ^b   Zou, Judy B ^a   Lorian, Carolyn N ^a   Johnston, Luke ^a   Terides, Matthew D ^a   Kayrouz, Rony ^a   Klein, Britt ^c   Gandy, Milena ^a   Fogliati, Vincent J ^a  

^a MACQUARIE UNIVERSITY   (Australia)

^b UNIVERSITY OF YORK   (United Kingdom)

^c UNIVERSITY OF BALLARAT   (Australia)

Author keywords

Cognitive behavior therapy (CBT); Cost effectiveness; Depression; Internet; Older adults

Indexed keywords

ADULT; AGED; ARTICLE; AUSTRALIAN; CLINICAL EFFECTIVENESS; COGNITIVE THERAPY; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DEPRESSION; DISEASE SEVERITY; FEMALE; FOLLOW UP; HEALTH CARE COST; HUMAN; INTERNET DELIVERED COGNITIVE BEHAVIOR THERAPY; MAJOR CLINICAL STUDY; MALE; PATIENT HEALTH QUESTIONNAIRE 9; PATIENT SATISFACTION; QUALITY ADJUSTED LIFE YEAR; RANDOMIZED CONTROLLED TRIAL; SYMPTOM ASSESSMENT; TREATMENT DURATION; TREATMENT OUTCOME; VERY ELDERLY; AUSTRALIA; COST BENEFIT ANALYSIS; ECONOMICS; HEALTH SERVICE; INTERNET; MIDDLE AGED; PROCEDURES; PSYCHOLOGICAL RATING SCALE; TELEMEDICINE;

AGED; AGED, 80 AND OVER; AUSTRALIA; COGNITIVE THERAPY; COST-BENEFIT ANALYSIS; DEPRESSION; FEMALE; FOLLOW-UP STUDIES; HEALTH SERVICES NEEDS AND DEMAND; HUMANS; INTERNET; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; QUALITY-ADJUSTED LIFE YEARS; TELEMEDICINE; TREATMENT OUTCOME;

EID: 84922909112     PISSN: 00057894     EISSN: 18781888     Source Type: Journal    
DOI: 10.1016/j.beth.2014.09.008     Document Type: Article

References (55)

1. Andersson G., Cuijpers P. Internet-based and other computerized psychological treatments for adult depression: A meta-analysis. Cognitive Behaviour Therapy 2009, 38:196-205.
2. Andrews G., Cuijpers P., Craske M.G., McEvoy P., Titov N. Computer therapy for the anxiety and depressive disorders is effective, acceptable and practical health care: A meta-analysis. PLoS One 2010, 5:e13196.
3. Australian Government Department of Health Medicare benefits schedule book 2013.
4. Australian Government Department of Health Pharmaceutical benefits schedule 2013, Updated December 1, 2013. Retrieved December 3, 2013, from http://www.pbs.gov.au/pbs/home.
5. Ayers C.R., Sorrell J.T., Thorp S.R., Wetherell J.L. Evidence-based psychological treatments for late-life anxiety. Psychology and Aging 2007, 22:8-17.
6. Barlow D., Allen L., Choate M. Toward a unified treatment for emotional disorders. Behavior Therapy 2004, 35:205-230.
7. Beekman A.T., Geerlings S.W., Deeg D.J., Smit J.H., Schoevers R.S., de Beurs E.,., van Tilburg W. The natural history of late-life depression: A 6-year prospective study in the community. Archives of General Psychiatry 2002, 59:605-611.
8. Brazier J. Measuring and valuing health benefits for economic evaluation 2007, Oxford University Press, New York.
9. Brenes G.A., Penninx B.W., Judd P.H., Rockwell E., Sewell D.D., Wetherell J.L. Anxiety, depression and disability across the lifespan. Aging and Mental Health 2008, 12:158-163.
10. Byers A.L., Yaffe K., Covinsky K.E., Friedman M.B., Bruce M.L. High occurrence of mood and anxiety disorders among older adults: The National Comorbidity Survey Replication. Archives of General Psychiatry 2010, 67:489-496.
11. Crabb R.M., Cavanagh K., Proudfoot J., Learmonth D., Rafie S., Weingradt K.R. Is computerized cognitive-behavioural therapy a treatment option for depression in late-life? A systematic review. British Journal of Clinical Psychology 2012, 51:459-464.
12. Cockayne N.L., Glozier N., Naismith S.L., Christensen H., Neal B., Hickie I.B. Internet-based treatment for older adults with depression and co-morbid cardiovascular disease: Protocol for a randomised, double-blind, placebo controlled trial. BMC Psychiatry 2011, 11:10.
13. Cuijpers P., Donker T., van Straten A., Li J., Andersson G. Is guided self-help as effective as face-to-face psychotherapy for depression and anxiety disorders? A systematic review and meta-analysis of comparative outcome studies. Psychological Medicine 2010, 40:1943-1957.
14. Cuijpers P., Marks I.M., van Straten A., Cavanagh K., Gega L., Andersson G. Computer-aided psychotherapy for anxiety disorders: A meta-analytic review. Cognitive Behaviour Therapy 2009, 38:66-82.
15. Dear B.F., Titov N., Schwencke G., Andrews G., Johnston L., Craske M.G., McEvoy P. An open trial of a brief transdiagnostic internet treatment for anxiety and depression. Behaviour Research and Therapy 2011, 49:830-837.
16. Dear B.F., Titov N., Sunderland M., McMillan D., Anderson T., Lorian C., Robinson E. Psychometric comparison of the Generalized Anxiety Disorder Scale-7 and the Penn State Worry Questionnaire for measuring response during treatment of generalised anxiety disorder. Cognitive Behaviour Therapy 2011, 40:216-227.
17. Dear B.F., Zou J., Titov N., Lorian C., Johnston L., Spence J.,., Knight R.G. Internet-delivered cognitive behavioural therapy for depression: a feasibility open trial for older adults. Australian and New Zealand Journal of Psychiatry 2013, 47:169-176.
18. Dear, B. F., Zou, J., Ali, S., Lorian, C., Johnston, L., Terides, M. D.,. Titov, N. (submitted). Examining self-guided internet-delivered cognitive behaviour therapy for older adults with anxiety and depression: Two feasibility open trials. Manuscript submitted for publication.
19. Ewing S., Thomas J. CCi Digital Futures 2012: The Internet in Australia 2012, ARC Centre of Excellence for Creative Industries and Innovation, Kelvin Grove, QLD.
20. Fenwick E., O'Brien B., Briggs A. Cost-effectiveness acceptability curves- Facts, fallacies and frequently asked questions. Health Economics 2004, 13:11.
21. Glick H. Economic evaluation in clinical trials 2007, Oxford University Press, Oxford.
22. Gould R.L., Coulson M.C., Howard R.J. Efficacy of cognitive behavioral therapy for anxiety disorders in older people: A meta-analysis and meta-regression of randomized controlled trials. Journal of the American Geriatrics Society 2012, 60:218-229.
23. Grek A. Clinical management of suicidality in the elderly: An opportunity for involvement in the lives of older patients. Canadian Journal of Psychiatry 2007, 52(Suppl. 1):47S-57S.
24. Gum A.M., King-Kallimanis B., Kohn R. Prevalence of mood, anxiety, and substance-abuse disorders for older Americans in the National Comorbidity Survey-Replication. American Journal of Geriatric Psychiatry 2009, 17:769-781.
25. Gyani A., Shafran R., Layard R., Clark D.M. Enhancing recovery rates: Lessons from one year of IAPT. Behavior Research and Therapy 2013, 51:597-606.
26. Hedman E., Ljotsson B., Lindfors N. Cognitive behaviour therapy via the internet: A systematic review of applications, clinical efficacy and cost-effectiveness. Expert Review of Pharmacoeconics and Outcomes Research 2012, 12:745-764.
27. Hedman E., Ljotsson B., Ruck C., Furmark T., Carlbring P., Lindefors N., Andersson G. Internet administration of self-report measures commonly used in research on social anxiety disorder: A psychometric evaluation. Computers in Human Behaviour 2010, 26:736-740.
28. Herdman M., Gudex C., Lloyd A., Janssen M., Kind P., Parkin D., Bonsel G., Badia X. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Quality of Life Research 2011, 20:1727-1736.
29. Jacobson N.S., Truax P. Clinical significance: A statistical approach to defining meaningful change in psychotherapy research. Psychology 1991, 59:12-19.
30. Janssen M.F., Pickard A.,S., Golicki D., Gudex C., Niewada M., Scalone L., Swinburn P., Busschbach J. Measurement properties of the EQ-5D-5L compared with the EQ-5D-3L across eight patient groups: A multi-country study. Quality of Life Research 2013, 22:1717-1727.
31. Kiropoulos L., Klein B., Austin D.W., Gilson K., Pier C., Mitchell J., Ciechomski L. Is internet-based CBT for panic disorder and agoraphobia as effective as face-to-face?. Journal of Anxiety Disorders 2008, 22:1273-1284.
32. Kroenke K., Spitzer R.L., Williams J.B. The PHQ-9: Validity of a brief depression severity measure. Journal of General Internal Medicine 2001, 16:606-613.
33. Kroenke K., Spitzer R.L., Williams J.B., Löwe B. The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales: A systematic review. General Hospital Psychiatry 2010, 32:345-359.
34. Kroenke K., Spitzer R.L., Williams J.B., Monahan P.O., Löwe B. Anxiety disorders in primary care: Prevalence, impairment, comorbidity, and detection. Annals of Internal Medicine 2007, 146(5):317-325.
35. Löwe B., Decker O., Müller S., Brähler E., Schellberg D., Herzog W., Herzberg P.Y. Validation and standardization of the Generalized Anxiety Disorder Screener (GAD-7) in the general population. Medical Care 2008, 46:266-274.
36. McCabe C., Claxton K., Culyer A.J. The NICE Cost-Effectiveness Threshold: What it is and what that means. PharmacoEconomics 2008, 26(9):12.
37. Nordhus I.H., Pallesen S. Psychological treatment of late-life anxiety: An empirical review. Journal of Consulting and Clinical Psychology 2003, 71:643-651.
38. Norman R., Cronin P.A., Viney R.C. A pilot discrete choice experiment to explore preferences for EQ-5D-5L health states. Applied Health Economics and Health Policy 2013, 11:287-298.
39. Phelan E., Williams B., Meeker K., Bonn K., Frederick J., Logerfo J., Snowden M. A study of the diagnostic accuracy of the PHQ-9 in primary care elderly. BMC Family Practice 2010, 11:63.
40. Pirkis J., Pfaff J., Williamson M., Tyson O., Stocks N., Goldney R.,., Almeida O.P. The community prevalence of depression in older Australians. Journal of Affective Disorders 2009, 115:54-61.
41. Rohde P., Lewinsohn P.M., Seeley J.R. Comparability of telephone and face-to-face interviews in assessing axis I and II disorders. American Journal of Psychiatry 1997, 154:1593-1598.
42. Scogin F., Welsh D., Hanson A., Stump J., Coates A. Evidence-based psychotherapies for depression in older adults. Clinical Psychology: Science and Practice 2005, 12:222-237.
43. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E.,., Dunbar G.C. The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 1998, 59(Suppl. 20):22-33.
44. Spek V., Nyklicek I., Smits N., Cuijpers P., Riper H., Keyzer J. Internet-based cognitive behaviour therapy for subthreshold depression in people over 50years old: A randomiszed controlled trial. Psychological Medicine 2007, 37:1797-1806.
45. Spitzer R., Kroenke K., Williams J.B., Löwe B. A brief measure for assessing generalized anxiety disorder: The GAD-7. Archives of Internal Medicine 2006, 166:1092-1097.
46. Titov N. Internet-delivered psychotherapy for depression in adults. Current Opinion in Psychiatry 2011, 24:18-23.
47. Titov N., Dear B.F., Johnston L., Lorian C., Zou J., Wootton B., McEvoy P.M., Rapee R.M. Improving adherence and clinical outcomes in self-guided internet treatment for anxiety and depression: randomised controlled trial. PLoS One 2013, 262873.
48. Titov N., Dear B.F., Johnston L., McEvoy P.M., Wootton B., Terides M.D.,., Rapee R.M. Improving adherence and clinical outcomes in self-guided internet treatment for anxiety and depression: A 12month follow-up of a randomised controlled trial. PLoS One 2014, e89591.
49. Titov N., Dear B.F., Johnston L., Terides M.D. Transdiagnostic internet treatment for anxiety and depression. Spanish Journal of Clinical Psychology 2012, 17:237-260.
50. Titov N., Dear B.F., McMillan D., Anderson T., Zou J., Sunderland M. Psychometric comparison of the PHQ-9 and BDI-II for measuring response during treatment of depression. Cognitive Behaviour Therapy 2011, 40:126-136.
51. Titov N., Dear B.F., Schwencke G., Andews G., Johnston L., Craske M.G., McEvoy P. Transdiagnostic treatment for anxiety and depression: A randomised Controlled trial. Behaviour Research and Therapy 2011, 49:331-452.
52. Wetherell J.L., Lenze E.J., Stanley M.A. Evidence-based treatment of geriatric anxiety disorders. Psychiatric Clinics of North America 2005, 28:871-896.
53. Wild, B., Eckl, A., Herzog, W., Niehoff, D., Lechner, S., Maatouk, I.,. Löwe, B. (in press). Assessing generalized anxiety disorder in elderly people using the GAD-7 and GAD-2 scales: Results of a validation study. American Journal of Geriatric Psychiatry.
54. World Health Organization Composite International Diagnostic Interview, Version 1.0 1990, World Health Organization, Geneva.
55. Zou J.B., Dear B.F., Titov N., Lorian C.N., Johnston L., Spence J.,., Sachdev P. Brief internet-delivered cognitive behavioural therapy for anxiety in older adults: A feasibility trial. The Journal of Affective Disorders 2012, 26:650-655.