Adipose-derived mesenchymal stem cells inhibit activation of hepatic stellate cells invitro and ameliorate rat liver fibrosis invivo

Journal of the Formosan Medical Association

Volumn 114, Issue 2, 2015, Pages 130-138

  Yu, Fuxiang ^a   Ji, Shiqiang ^a   Su, Longfeng ^a   Wan, Li ^a   Zhang, Shengchu ^a   Dai, Chunlei ^a   Wang, Yang ^a   Fu, Junhui ^a   Zhang, Qiyu ^a  

^a THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Adipose derived mesenchymal stem cells; Fibrosis; Hepatic stellate cells; Proliferation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CARBON TETRACHLORIDE; COLLAGEN TYPE 3; HYALURONIC ACID; HYDROXYPROLINE; INTERLEUKIN 10; NERVE GROWTH FACTOR; SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA1; ACTIN;

ADIPOSE DERIVED MESENCHYMAL STEM CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL ISOLATION; CELL PROLIFERATION; CELL STRUCTURE; COCULTURE; CONTROLLED STUDY; FIBROGENESIS; IN VITRO STUDY; IN VIVO STUDY; LIVER FIBROSIS; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PORTAL VEIN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; STELLATE CELL; SUBCUTANEOUS FAT; ADIPOSE TISSUE; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; CYTOLOGY; HEPATIC STELLATE CELL; LIVER; LIVER CIRRHOSIS; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ACTINS; ADIPOSE TISSUE; ANIMALS; APOPTOSIS; CARBON TETRACHLORIDE; CELL PROLIFERATION; CELLS, CULTURED; HEPATIC STELLATE CELLS; LIVER; LIVER CIRRHOSIS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84922828487     PISSN: 09296646     EISSN: 18760821     Source Type: Journal    
DOI: 10.1016/j.jfma.2012.12.002     Document Type: Article

References (25)

1. Bataller R., Brenner D.A. Liver fibrosis. J Clin Invest 2005, 115:209-218.
2. Senoo H. Structure and function of hepatic stellate cells. Med Electron Microsc 2004, 37:3-15.
3. Friedman S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000, 275:2247-2250.
4. Friedman S.L. Liver fibrosis-from bench to bedside. J Hepatol 2003, 38(Suppl. 1):S38-S53.
5. Neuberger J., Gimson A., Davies M., Akyol M., O'Grady J., Burroughs A., et al. Selection of patients for liver transplantation and allocation of donated livers in the UK. Gut 2008, 57:252-257.
6. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
7. Fang B.J., Shi M.X., Liao L.M., Yang S.G., Liu Y.H., Zhao R.C.H. Systemic infusion of FLK1(+) mesenchymal stem cells ameliorate carbon tetrachloride induced liver fibrosis in mice. Transplantation 2004, 78:83-88.
8. Hu K.P., Lin N., Lin J.Z., Deng M.H., Tang Z.F., Xiang P., et al. Invitro regulation effect of human bone marrow mesenchymal stem cells on hepatic stellate cells. J Clin Rehab Tissue Engin Res 2009, 13:5257-5260.
9. Wang H.X., Ma J., Duan F.L., Cheng X.P., Mei X., Tang F.A., et al. Treatment of liver cirrhosis by bone marrow mesenchymal stem cell transplantation in rat. Chin J Gastroenterol Hepatol 2006, 15:365-368.
10. Zhao D.C., Lei J.X., Chun R., Zhang X.M., Xu R.Y., Li S.N., et al. Possibility of rat liver fibrogenesis inhibited by bone marrow-derived mesenchymal stem cells: a 7-week observation on survival time of stem cells and activation of hepatic stellate cells in liver of recipients and a survival analysis. Chin J Clin Rehab 2005, 9:52-55.
11. De Ugarte D.A., Morizono K., Elbarbary A., Alfonso Z., Zuk P.A., Zhu M., et al. Comparison of multi-lineage cells from human adipose tissue and bone marrow. Cells Tissues Organs 2003, 174:101-109.
12. Strem B.M., Hicok K.C., Zhu M., Wulur I., Alfonso Z., Schreiber R.E., et al. Multipotential differentiation of adipose tissue-derived stem cells. Keio J Med 2005, 54:132-141.
13. Gimble J.M., Katz A.J., Bunnell B.A. Adipose-derived stem cells for regenerative medicine. Circ Res 2007, 100:1249-1260.
14. Yoshimura H., Muneta T., Nimura A., Yokoyama A., Koga H., Sekiya I. Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle. Cell Tissue Res 2007, 327:449-462.
15. Friedman S.L. Isolation and culture of hepatic nonparenchymal cells. Methods Toxicol 1996, 1A:292-310.
16. Crop M., Baan C., Weimar W., Hoogduijn M. Potential of mesenchymal stem cells as immune therapy in solid-organ transplantation. Transpl Int 2009, 22:365-376.
17. Kania G., Blyszczuk P., Jochheim A., Ott M., Wobus A.M. Generation of glycogen-and albumin-producing hepatocyte-like cells from embryonic stem cells. Biol Chem 2004, 385:943-953.
18. Oyagi S., Hirose M., Kojima M., Okuyama M., Kawase M., Nakamura T., et al. Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats. J Hepatol 2006, 44:742-748.
19. Avital I., Inderbitzin D., Aoki T., Tyan D.B., Cohen A.H., Ferraresso C., et al. Isolation, characterization, and transplantation of bone marrow-derived hepatocyte stem cells. Biochem Biophy Res Commun 2001, 288:156-164.
20. Lagasse E., Connors H., Al-Dhalimy M., Reitsma M., Dohese M., Osborne L., et al. Purified hematopoietic stem cells can differentiate into hepatocytes invivo. Nat Med 2000, 6:1229-1234.
21. Zuk P.A., Zhu M., Mizuno H., Huang J., Futrell J.W., Katz A.J., et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001, 7:211-228.
22. Huang J.I., Beanes S.R., Zhu M., Lorenz H.P., Hedrick M.H., Benhaim P. Rat extramedullary adipose tissue as a source of osteochondrogenic progenitor cells. Plast Reconstr Surg 2002, 109:1033-1041.
23. Rangappa S., Fen C., Lee E.H., Bongso A., Sim E.K. Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. Ann Thorac Surg 2003, 75:775-779.
24. Friedman L.S. Mechanisms of hepatic fibrogenesis. Gastroenterology 2008, 134:1655-1669.
25. Kim W.H., Matsumoto K., Bessho K., Nakamura T. Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol 2005, 166:1017-1028.