Evolution of simeprevir-resistant variants in virological non-responders infected with HCV genotype 1b

Journal of Medical Virology

Volumn 87, Issue 4, 2015, Pages 609-618

  Akuta, Norio ^a   Suzuki, Fumitaka ^a   Sezaki, Hitomi ^a   Hosaka, Tetsuya ^a   Kobayashi, Masahiro ^a   Suzuki, Yoshiyuki ^a   Saitoh, Satoshi ^a   Kobayashi, Mariko ^a   Ikeda, Kenji ^a   Kumada, Hiromitsu ^a  

^a TORANOMON HOSPITAL   (Japan)

Author keywords

Absolute non response; HCV; Resistant variants; Simeprevir; Ultra deep sequence; Virological non response

Indexed keywords

AMINO ACID; INTERLEUKIN 28B; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN; RNA; SIMEPREVIR; ALPHA INTERFERON; ANTIVIRUS AGENT; FUSED HETEROCYCLIC RINGS; NS3 PROTEIN, HEPATITIS C VIRUS; SULFONAMIDE; VIRUS PROTEIN; VIRUS RNA;

ADULT; AGED; AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ANTIVIRAL THERAPY; ARTICLE; CLINICAL ASSESSMENT; CLINICAL PROTOCOL; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; DRUG RESPONSE; DRUG WITHDRAWAL; FEMALE; GENE SEQUENCE; GENETIC IDENTIFICATION; HEPATITIS C; HEPATITIS C VIRUS SUBTYPE 1B; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOLECULAR EVOLUTION; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); SENESCENCE; SEQUENCE ANALYSIS; TREATMENT RESPONSE; VIROLOGY; VIRUS RESISTANCE; ANTIVIRAL RESISTANCE; DNA SEQUENCE; DRUG EFFECTS; GENETICS; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HIGH THROUGHPUT SEQUENCING; ISOLATION AND PURIFICATION; MISSENSE MUTATION; TIME; TREATMENT FAILURE; VERY ELDERLY;

HEPATITIS C VIRUS;

ADULT; AGED; AGED, 80 AND OVER; ANTIVIRAL AGENTS; DRUG RESISTANCE, VIRAL; EVOLUTION, MOLECULAR; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HETEROCYCLIC COMPOUNDS, 3-RING; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; MUTATION, MISSENSE; RIBAVIRIN; RNA, VIRAL; SEQUENCE ANALYSIS, DNA; SULFONAMIDES; TIME FACTORS; TREATMENT FAILURE; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84922825071     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.24113     Document Type: Article

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