Emergence of telaprevir-resistant variants detected by ultra-deep sequencing after triple therapy in patients infected with HCV genotype 1

Journal of Medical Virology

Volumn 85, Issue 6, 2013, Pages 1028-1036

  Akuta, Norio ^a   Suzuki, Fumitaka ^a   Seko, Yuya ^a   Kawamura, Yusuke ^a   Sezaki, Hitomi ^a   Suzuki, Yoshiyuki ^a   Hosaka, Tetsuya ^a   Kobayashi, Masahiro ^a   Hara, Tasuku ^a   Kobayashi, Mariko ^a   Saitoh, Satoshi ^a   Arase, Yasuji ^a   Ikeda, Kenji ^a   Kumada, Hiromitsu ^a  

^a TORANOMON HOSPITAL   (Japan)

Author keywords

HCV; Non response; Resistant variants; Telaprevir; Ultra deep sequence

Indexed keywords

ARGININE; GLUTAMINE; INTERLEUKIN 28B; LEUCINE; METHIONINE; MP 424; PEGINTERFERON ALPHA2B; RIBAVIRIN; TELAPREVIR; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO ACID SUBSTITUTION; ANTIVIRAL RESISTANCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG TREATMENT FAILURE; EVENING DOSAGE; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; JAPANESE; MALE; MORNING DOSAGE; NUCLEOTIDE SEQUENCE; POLYPHARMACY; PREDICTIVE VALUE; TREATMENT RESPONSE; ULTRA DEEP SEQUENCING;

ADULT; AGED; AMINO ACID SUBSTITUTION; ANTIVIRAL AGENTS; DNA, VIRAL; DRUG RESISTANCE, VIRAL; DRUG THERAPY, COMBINATION; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; OLIGOPEPTIDES; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; RIBAVIRIN; SEQUENCE ANALYSIS, DNA; TREATMENT OUTCOME;

HEPATITIS C VIRUS;

EID: 84876359593     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.23579     Document Type: Article

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