Healthcare innovation across sectors: Convergences and divergences

The Business of Healthcare Innovation, Second Edition

Volumn , Issue , 2010, Pages 515-563

  Sammut, Stephen M ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Kaiser Foundation Health Plan and Hospitals   (United States)

^c University of Cambridge Local Examinations Syndicate   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84922719297     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9781139176620.008     Document Type: Chapter

References (104)

1. Tamas Bartfai and Graham Lees, Drug Discovery from Bedside to Wall Street (Burlington, MA: Elsevier Academic Press, 2006).
2. James Hookway, “Philippine Price Controls Hamper Rise of Generics,” Wall Street Journal (June 22, 2010): B1, B7;
3. Andrew Jack, “Drug Groups Fear Parallel Trade,” Financial Times(June 7,2010). Available at www.ft.com/intl/cms/s/0/7328ec86-71cb-11df-8eec-00144feabdc0.html-axzz1PphfgLw9. Accessed June 20, 2011.
4. BDO USA, “US Biotech Companies Decrease R&D Spend, Maintain Cash Reserves, BDO USA Study Finds,” press release (July 29,2011). Available at http://bdo.com/news/pr/1768. Accessed Sept. 27, 2011.
5. Robert A. DeGraaff, “Analysis of Corporate Acquisitions by Medical Device Manufacturers,” unpub. dissertation, The Wharton School, 2006.
6. Gautam Ahuja, Curba Lampert, and Vivek Tandon, “Moving Beyond Schumpeter: Management Research on the Determinants of Technological Innovation,” in J. Walsh and A. Brief (eds.), Academy of Management Annals, Vol. 2 (London: Routledge, 2008), pp 1-99.
7. Harbir Singh and Maurizio Zollo, “Creating Value in Post-Acquisition Integration Processes,” working paper #98-33 (Philadelphia, PA: Wharton Financial Institutions Center, Aug. 1998).Available at http://fic.wharton.upenn.edu/fic/papers/98/p9833.html. Accessed June 20, 2011.
8. Louise Lucas and Andrew Jack, “Food and Pharma Prove a Rich Mix,” Financial Times(Oct. 13, 2010): 18.
9. Ellen Byron, “Paired Up: Merger Challenge: Unite Toothbrush, Toothpaste - P&G and Gillette Find Creating Synergy Can Be Harder Than it Looks,” Wall Street Journal (Apr. 24, 2007): A1.
10. Robert M. Grant, Contemporary Strategy Analysis, 5th edn. (Malden, MA: Blackwell, 2005).
11. Rita Gunther McGrath and Ian MacMillan, The Entrepreneurial Mindset (Boston, MA: Harvard Business School Press, 2000).
12. Michael Raynor, The Strategy Paradox (New York: Crown Publishing, 2007).
13. David Olmos, “Wyeth Says it Will Narrow Focus of New Drug Research,” Bloomberg (Oct. 28, 2008);
14. Rita Peters, “Changing Roles: For Drug Discovery and Preclinical Specialties, a CRO Maybe a Good Option,” Drug Discovery and Development, 13(5) (June 2010): 21–28;
15. Andrew Jack, “GSK Deal Reflects New Philosophy on Cutting Costs,” Financial Times(Oct. 5, 2010): 19.
16. Rosabeth Moss Kanter, “Collaborative Advantage: The Art of Alliances,” Harvard Business Review, 72(4) (July–Aug. 1994): 96–107.
17. Andrew C. Inkpen, “Strategic Alliances,” in Michael Hitt, R. Edward Freeman, and Jeffrey S. Harrison (eds.), Handbook of Strategic Management (Oxford: Blackwell, 2001), pp 409–432.
18. Mitchell Lee Marks and Philip H. Mirvis, Joining Forces (San Francisco, CA: Jossey-Bass, 1998).
19. Michael Beer and Nitin Nohria Breaking the Code of Change (Boston, MA: Harvard Business School Press, 1998)
20. Dovev Lavie, Uriel Stettner, and Michael Tushman, “Exploration and Exploitation Within and Across Organizations,” Academy of Management Annals, Vol. 4 (London: Routledge, 2010), pp 109–155.
21. Stefan H. Thomke, Experimentation Matters (Boston, MA: Harvard Business School Press, 2003).
22. Jeffrey Immelt, Vijay Govindarajan, and Chris Trimble, “How GE is Disrupting Itself,” Harvard Business Review, 87(10) (Oct. 2009): 56–65.
23. David Cassak, “Negative Innovation: Helping Reduce Health Care Technology Costs,” In Vivo, 28(6) (June 2010): 12–13.
24. Mark Pauly, “‘We Aren’t Quite as Good But We Sure are Cheap’: Prospects for Disruptive Innovation in Medical Care and Insurance Markets,” Health Affairs, 27 (2008): 1349–1352.
25. Robert J. Barro and Xavier Sala-i-Martin, “Technological Diffusion, Convergence, and Growth,” Journal of Economic Growth, 2 (1997): 1–27.
26. C. Bores, C. Saurina, and R. Torres, “Technological Convergence: A Strategic Perspective,” Technovation, 23 (2003): 1–13.
27. Gavin Cameron, James Proudman, and Stephen Redding, “Technological Convergence, Research and Development, Trade and Productivity Growth,” European Economic Review, 49 (2005): 775–807;
28. A. Gambardella and S. Torrisi, “Does Technological Convergence Imply Convergence in Markets? Evidence From the Electronics Industry,” Research Policy, 27 (1998): 445–463;
29. David Lei, “Industry Evolution and Competence Development: The Imperatives of Technological Convergence,” International Journal of Technology Management, 19 (2000): 699–738.
30. Nathan Rosenberg, “Technological Change in the Machine Tool Industry, 1840-1910,” Journal of Economic History, 23 (1963): 414–443;
31. Fredrik Hacklin, Vicente Raurich, and Christian Marxt, “How Incremental Innovation Becomes Disruptive: The Case of Technology Convergence,” International Engineering Management Conference, 2004, Proceedings. 2004 IEEE International, Vol. 1 (Oct. 2004), pp 32–36.
32. Sang Lee, David Olson, and Silvana Trimi, “The Impact of Convergence on Organizational Innovation,” Organizational Dynamics, 39 (2010): 218–225.
33. Nathan Cortez, “International Health Care Comparisons: The Benefits and Burdens of Market-Driven Standardization,” Wisconsin International Law Journal, 26 (Apr. 16,2009): 646–704;
34. John Kimberly, Gerard de Pouvourville, and Thomas D’Aunno, The Globalization of Managerial Innovation in Health Care (Cambridge University Press, 2008).
35. United States Food and Drug Administration (FDA), Innovative Systems for Delivery of Drugs and Biologics: Scientific, Clinical, and Regulatory Challenges, USFDA Workshop (Bethesda, MD: July 8, 2003).
36. Navigant Consulting, Combination Products: An Impact Analysis on the Convergence of Medical Devices and Therapeutics (San Mateo, CA: Navigant Consulting, 2003).
37. Navigant Consulting “Convergence: Drug-Device Summit,” Pittsburgh, PA, Mar. 21–23, 2005.
38. Deloitte Life Science and Health Care Practice, Managing Pathways to Convergence in the Life Sciences Industry (Boston, MA: Deloitte, 2007).
39. David Cassak, “Medtronic: Making Convergence Pay,” In Vivo, 24(1) (Jan. 2006): 15–26.
40. Jonathan Kahan, “Regulatory and Legal Challenges for the Developers of Drug Delivery Systems,” Presentation to USFDA Workshop on Innovative Systems for Delivery of Drugs and Biologics, Bethesda, MD, July 8, 2003.
41. Mary Stuart, “Angiotech: Specialty Pharma in the Device World,” In Vivo, 22(8) (Sept.2004):25–33.
42. In Vivo, “The New Math of Drug Device Convergence,” 23(4) (Apr. 2005): 2, 4
43. Lawton R. Burns, The Health Care Value Chain: Producers, Purchasers, and Providers (San Francisco, CA: Jossey-Bass, 2002).
44. David Cassak, “TYRX: Is This the Model for Drug/Device Convergence?” In Vivo, 28(5) (May 2010): 62–71.
45. Sang Lee, David Olson, and Silvana Trimi, “The Impact of Convergence on Organizational Innovation,” Organizational Dynamics, 39(3) (2010): 218–225.
46. Geert Duysters and John Hagedoorn, “Technological Convergence in the IT Industry: The Role of Strategic Technology Alliances and Technological Competencies,” unpub. manuscript, Maastricht University, 1997.
47. Wesley Cohen and Daniel Levinthal, “Absorptive Capacity: A New Perspective on Learning and Innovation,” Administrative Science Quarterly, 35 (1990): 128–152.
48. Qing Wang and Nick Von Tunzelmann, “Complexity and the Functions of the Firm: Breadth and Depth,” Research Policy, 29 (2000): 805–818.
49. Stefano Brusoni, Andreas Prencipe, and Keith Pavitt, “Knowledge Specialization, Organization Coupling, and the Boundaries of the Firm: Why do Firms Know More than they Make?” Administrative Science Quarterly, 46 (Dec. 2001): 597–621.
50. Nick Von Tunzelmann, “Localised Technological Search and Multitechnology Companies,” Economics of Innovation and New Technology, 6 (1998): 231–255.
51. Brusoni, Prencipe, and Keith Pavitt “Public Law 111-152-Health Care and Education Reconciliation Act of 2010,” US Government Printing Office. Available at www.gpo.gov/fdsys/pkg/PLAW-111publ152/content-detail.html. Accessed Aug. 14, 2010.
52. Brusoni, Prencipe, and Keith Pavitt “National Population Projections, Table 2: Projections of the Population by Selected Age Groups and Sex for the United States: 2010 to 2050,” US Census Bureau. Available at www.census.gov/population/www/projections/files/nation/summary/np2008-t2.xls. Accessed Aug. 14, 2010.
53. Brusoni, Prencipe, and Keith Pavitt “National Population Projections, Table 4: Projections of the Population by Sex, Race, and Hispanic Origin for the United States: 2010 to 2050,” US Census Bureau. Available at www. census.gov/population/www/projections/files/…/np2008-t4.xls. Accessed Aug. 14, 2010.
54. Brusoni, Prencipe, and Keith Pavitt “Chronic Disease and Medical Innovation in an Aging Nation,” The Silver Book. Available at www.silverbook.org/browse.php?id=24#. Accessed Aug. 14, 2010.
55. Senator Tom Harkin, “Health Care, Not Sick Care,” American Journal of Health Promotion, 19(1) (Sept.-Oct. 2004): 1–2.
56. Donna M. Rowell and David J. Kroll, “Complementary and Alternative Medicine Education in United States Pharmacy Schools,” American Journal of Pharmaceutical Education, 62 (winter 1998): 412–419.
57. Committee on Quality of Health Care in America, To Err Is Human: Building a Safer Health System (Washington, DC: National Academies Press, 2000)
58. Committee on Quality of Health Care in America, Crossing the Quality Chasm: A New Health System for the 21st Century (Washington, DC: National Academies Press, 2001).
59. Joseph Loscalzo, “The NIH Budget and the Future of Biomedical Research,” New England Journal of Medicine, 354(16) (Apr. 20, 2006): 1665–1667.
60. Burton Weisbrod, “The Health Care Quadrilemma: An Essay on Technological Change, Insurance, Quality of Care, and Cost Containment,” Journal of Economic Literature, 29 (1991): 523–552.
61. David Cutler, Allison Rosen, and Sandeep Vijan, “The Value of Medical Spending in the United States, 1960–2000,” New England Journal of Medicine, 355 (Aug. 31,2006): 920–927.
62. Rita Mangione-Smith, Marc N. Elliott, Tanya Stivers, et al., “Racial/Ethnic Variation in Parent Expectations for Antibiotics: Implications for Public Health Campaigns,” Pediatrics, 113(5) (May 2004): E385–E394; Committee on Quality of Health Care in America, To Err is Human.
63. Clayton Christensen, Jerome Grossman, and Jason Hwang, The Innovator’s Prescription (New York: McGraw-Hill, 2009).
64. Clayton Christensen, Jerome Grossman, and Jason Hwang “eICU Program Factsheet.” VISICU (2008). Available at http://multivu.prnewswire.com/mnr/visicu/33159/docs/33159-eICUProgram_Fact_Sheet.pdf. Accessed Feb. 17, 2012.
65. Clayton Christensen, Jerome Grossman, and Jason Hwang “Welcome to NightHawk Radiology.” NightHawk Radiology Services. Available at www.onlineservices.nighthawkrad.net/. Accessed Mar. 26, 2009.
66. Center for Studying Health System Change, “Physicians Slow to E-mail Routinely with Patients,” Report No. 134 (Washington, DC: Center for Studying Health System Change, Oct. 2010).
67. Sherry Glied, Jeanne M. Lambrew, and Sarah Little, The Growing Share of Uninsured Workers Employed by Large Firms (New York: Commonwealth Fund, Oct. 2003); New York State Department of Taxation and Finance, Instructions for Form DTF-672: Election to Participate in the Tax Shelter Voluntary Compliance Initiative.
68. National Academy of Engineering and Institute of Medicine, Building a Better Delivery System: A New Engineering/Health Care Partnership (Washington, DC: National Academies Press, 2005)
69. Yuehwern Yih, Handbook of Healthcare Delivery Systems (Boca Raton, FL: CRC Press, 2010).
70. Yuehwern Yih “At 20, the 401k Reshaped the Way Americans are Saving for Retirement,” Business Wire (Aug. 30, 2001). Available at http://findarticles.com/p/articles/mi_m0EIN/is_2001_Aug. _30/ai_77704677/. Accessed Sept. 1, 2010.
71. Yuehwern Yih “UPDATE 2-HealthGrades to go private in $294 mln deal.” Reuters (July 28, 2010). Available at www.reuters.com/article/idUSSGE66R0JA20100728. Accessed Sept. 1, 2010.
72. Edward Wagner, Brian Austin, and Michael Von Korff, “Organizing Care for Patients with Chronic Illness,” Milbank Quarterly, 74(4) (1996): 511–544.
73. Richard A. Cooper, Thomas E. Getzen, Heather J. McKee, and Prakash Laud, “Economic and Demographic Trends Signal an Impending Physician Shortage,” Health Affairs, 21(1) (2002): 140–154.
74. Richard A. Cooper, Thomas E. Getzen, Heather J. McKee, and Prakash Laud “Total Physicians by Race/Ethnicity - 2006,” American Medical Association. Available at www.ama-assn.org/ama/pub/about-ama/our-people/member-groups-sections/min-ority-affair-section/physician-statistics/total-physicians-raceethnicity.page. Accessed Sept. 1, 2010.
75. Mark Pauly, “‘We Aren’t Quite as Good, but We Sure are Cheap’: Prospects for Disruptive Innovation in Medical Care and Insurance Markets,” Health Affairs, 27(5) (2008): 1349–1352;
76. Lawton R. Burns, Guy David, and Lorens Helmchen, “Strategic Responses by Providers to Specialty Hospitals, Ambulatory Surgery Centers, and Retail Clinics,” Population Health Management, 14(2) (2011): 69–77.
77. Lawton R. Burns, Jeff Goldsmith, and Ralph Muller, “History of Physician-Hospital Collaboration: Obstacles and Opportunities,” in Jay Crosson and Laura Tollen (eds.), Partners in Health (San Francisco, CA: Jossey-Bass, 2010), pp 18–45.
78. Paul Starr, The Social Transformation of American Medicine (New York: Basic Books, 1982).
79. Fred G. Donini-Lenhoff and Hannah L. Hedrick, “Growth of Specialization in Graduate Medical Education,” Journal of the American Medical Association, 284(10) (Sept. 13,2000): 1284–1289.
80. Elliott S. Fisher, Douglas O. Staiger, Julie P. W. Bynum, and Daniel J. Gottlieb, “Creating Accountable Care Organizations: The Extended Hospital Medical Staff,” Health Affairs, 26(1) (Dec. 5, 2006): w44–w57.
81. Edward H. Wagner, Brian T. Austin, and Michael Von Korff, “Organizing Care for Patients with Chronic Illness,” Milbank Quarterly, 74(4) (1996): 511–544
82. David Lawrence, From Chaos to Care: The Promise of Team-based Medicine (Cambridge, MA: Da Capo Press, 2002).
83. G. Ross Baker, Anu MacIntosh-Murray, Christina Porcellato, et al., “Intermountain Healthcare,” High Performing Healthcare Systems: Delivering Quality by Design (Toronto: Longwoods Publishing, 2008), pp 151–177 (chap. 5).
84. John Wennberg and Alan Gittelsohn, “Small Area Variations in Health Care Delivery,” Science, 182 (Dec. 14, 1973): 1102–1108;
85. Elliott Fisher, David Wennberg, Therese Stukel, et al., “The Implications of Regional Variations in Medicare Spending, Part 1: The Content, Quality, and Accessibility of Care,” Annals of Internal Medicine, 138(4) (Feb. 18, 2003): 273-287.
86. Aliza Marcus, “Peabody Pays Mayo Clinic Prices to Save on Health-Care Costs,” Bloomberg (Sept. 26, 2008). Available at www.bloomberg.com/apps/news?pid=newsarchive&refer=home&sid=atHEjVNWVXow. Accessed Sept. 4, 2010.
87. Hoangmai Pham, Paul Ginsburg, Kelly McKenzie, and Arnold Milstein, “Redesigning Care Delivery in Response to a High-Performance Network: The Virginia Mason Medical Center,” Health Affairs, 26(4) (2007): w532–w544.
88. Ashish K. Jha, Jonathan B. Perlin, Kenneth W. Kizer, and R. Adams Dudley, “Effect of the Transformation of the Veterans Affairs Health Care System on the Quality of Care,” New England Journal of Medicine, 348(22) (May 29, 2003): 2218–2227.
89. Lawton R. Burns, “Comparative Effectiveness Research (CER): What it Means, What it Means for Hospitals,” Economic Outlook (Fall 2011): 14–18.
90. Michael G. Housman, “Organizational Form and Niche Overlap: The Dynamics of Surgery Center Entry and Exit,” Ph.D. dissertation, The Wharton School, University of Pennsylvania, 2009.
91. Lawton R. Burns and Ralph W. Muller, “Hospital-Physician Collaboration: Landscape of Economic Integration and Impact on Clinical Integration,” Milbank Quarterly, 86(3) (2008): 375–434.
92. Regina Herzlinger, Consumer-Driven Health Care: Implications for Providers, Payers, and Policymakers (San Francisco: Jossey-Bass, 2004).
93. Pham, Ruth Bader Ginsburg McKenzie, and Milstein “Families Drive Change in Surgery Waiting Renovation,” Cincinnati Children’s.Available at http://web.archive.org/web/20040908093308/http://www.cincinnatichildrens.org/about/fcc/family/success/surgical-waiting-room.htm?view=content. Accessed Sept. 2, 2010.
94. Ronald C. Kessler, Roger B. Davis, David F. Foster, et al., “Long-Term Trends in the Use of Complementary and Alternative Medical Therapies in the United States,” Annals of Internal Medicine, 135 (2001): 262–268.
95. David M. Eisenberg, Roger B. Davis, Susan L. Ettner, et al., “Trends in Alternative Medicine Use in the United States, 1990–1997,” Journal of the American Medical Association, 280 (Nov. 11, 1998): 1569–1575.
96. Richard Nahin, Patricia Barnes, Barbara Stussman, and Barbara Bloom, “Costs of Complementary and Alternative Medicine (CAM) and Frequency of Visits to CAM Providers: United States, 2007,” National Health Statistics Report, no. 18 (Hyattsville, MD: Centers for Disease Control and Prevention, US DHHS, July 30, 2009).
97. Tilman Ehrbeck, Nicolaus Henke, and Thomas Kibasi, “The Emerging Market in Health Care Innovation,” McKinsey Quarterly (May 2010). Available at www.mckinseyquar terly.com/The_emerging_market_in_health_care_innovation_2584. Accessed Sept. 28, 2011.
98. Paul Fronstin, The Impact of the Recession on Employment-Based Health, Employee Benefit Research Institute, no. 342 (May 2010). Available at www.ebri.org/pdf/briefspdf/EBRI_IB_05-2010_No342_Recssn-HlthBens.pdf. Accessed Sept. 4, 2010.
99. Paul Fronstin “Employer Health Benefits 2010 Annual Survey,” Kaiser Family Foundation and Health Research and Educational Trust (2010). Available at http://ehbs.kff.org/pdf/2010/8085.pdf. Accessed Sept. 4, 2010.
100. Paul Fronstin “NHE Tables,” Centers for Medicare and Medicaid Services. Available at www.cms.gov/NationalHealthExpendData/downloads/tables.pdf. Accessed Sept. 4, 2010.
101. John MacDonald, “Fast Facts: Health Plan Differences: Fully-Insured vs. Self-Insured,” Employee Benefit Research Institute no. 114 (Feb. 11, 2009). Available at www.ebri.org/pdf/FFE114.11Feb09.Final.pdf. Accessed Sept. 4, 2010.
102. Pamela Lewis Dolan, “Walgreens Enters Work-site Clinic Market,” American Medical News (Apr. 28, 2008). Available at www.ama-assn.org/amednews/2008/04/28/bisb0428.htm. Accessed Sept. 4, 2010.
103. Clayton Christensen, The Innovator’s Dilemma (Cambridge, MA: Harvard Business School Press, 1997).
104. Clayton M. Christensen, Richard Bohmer, and John Kenagy, “Will Disruptive Innovations Cure Health Care?” Harvard Business Review, 78 (Sept.-Oct. 2000): 102–112.