Hepatocellular carcinoma with massive lymphoid infiltration: A regressing phenomenon?

Pathology Research and Practice

Volumn 205, Issue 9, 2009, Pages 648-652

  Park, Ho Sung ^a   Jang, Kyu Yun ^a   Kim, Young Kon ^a   Cho, Baik Hwan ^a   Moon, Woo Sung ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Carcinoma; Hepatocellular; Lymphoid tissue; Regression

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ADULT; ARTICLE; B LYMPHOCYTE; CANCER RECURRENCE; CANCER REGRESSION; CANCER SURVIVAL; CASE REPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL INFILTRATION; COMPUTER ASSISTED TOMOGRAPHY; EPSTEIN BARR VIRUS; FOLLOW UP; HUMAN; HUMAN TISSUE; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; LIVER CELL CARCINOMA; LIVER NODULE; LIVER PARENCHYMA; LIVER RESECTION; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MICROSCOPY; TUMOR CELL; TUMOR VOLUME;

CARCINOMA, HEPATOCELLULAR; HUMANS; LIVER NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEOPLASM REGRESSION, SPONTANEOUS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 67749147101     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2009.01.001     Document Type: Article

References (24)

1. Bortolami M., Venturi C., Giacomelli L., Scalerta R., Bacchetti S., Marino F., Floreani A., Lise M., Naccarato R., and Farinati F. Cytokine, infiltrating macrophage and T cell-mediated response to development of primary and secondary human liver cancer. Dig. Liver Dis. 34 (2002) 794-801
2. Bosch F.X., Ribes J., Cleries R., and Diaz M. Epidemiology of hepatocellular carcinoma. Clin. Liver Dis. 9 (2005) 191-211
3. Canning C., O'Brien M., Hegarty J., and O'Farrelly C. Liver immunity and tumour surveillance. Immunol. Lett. 107 (2006) 83-88
4. Challis G.B., and Stam H.J. The spontaneous regression of cancer. A review of cases from 1900 to 1987. Acta Oncol. 29 (1990) 545-550
5. Emile J.F., Adam R., Sebagh M., Marchadier E., Falissard B., Dussaix E., Bismuth H., and Reynès M. Hepatocellular carcinoma with lymphoid stroma: a tumour with good prognosis after liver transplantation. Histopathology 37 (2000) 523-529
6. Everson T.C., and Cole W.H. Spontaneous Regression of Cancer (1996), WB Saunders, Philadelphia and London
7. Hsu H.C., Chen C.C., Huang G.T., and Lee P.H. Clonal Epstein-Barr virus associated cholangiocarcinoma with lymphoepithelioma-like component. Hum. Pathol. 27 (1996) 848-850
8. Iezzoni J.C., Gaffey M.J., and Weiss L.M. The role of Epstein-Barr virus in lymphoepithelioma-like carcinomas. Am. J. Clin. Pathol. 103 (1995) 308-315
9. Jeng Y.M., Chen C.L., and Hsu H.C. Lymphoepithelioma-like cholangiocarcinoma: an Epstein-Barr virus-associated tumor. Am. J. Surg. Pathol. 25 (2001) 516-520
10. Kasugai H., Kojima J., Tatsuta M., Okuda S., Sasaki Y., Imaoka S., Fujita M., and Ishiguro S. Treatment of hepatocellular carcinoma by transcatheter arterial embolization combined with intraarterial infusion of a mixture of cisplatin and ethiodized oil. Gastroenterology 97 (1989) 965-971
11. Kim Y.B., Park Y.N., Han J.Y., Hong K.C., and Hwang T.S. Biliary lymphoepithelioma-like carcinoma not associated with Epstein-Barr virus. Arch. Pathol. Lab. Med. 123 (1999) 441-443
12. Lin T.J., Liao L.Y., Lin C.L., Shih L.S., Chang T.A., Tu H.Y., Chen R.C., and Wang C.S. Spontaneous regression of hepatocellular carcinoma: a case report and literature review. Hepatogastroenterology 51 (2004) 579-582
13. Ng I.O., Lai E.C., Fan S.T., Ng M.M., and So M.K. Prognostic significance of pathologic features of hepatocellular carcinoma. A multivariate analysis of 278 patients. Cancer 76 (1995) 2443-2448
14. Okuno K., Takagi H., Nakamura T., Nakamura Y., Iwasa Z., and Yasutomi M. Treatment for unresectable hepatoma via selective hepatic arterial infusion of lymphokine-activated killer cells generated from autologous spleen cells. Cancer 58 (1986) 1001-1006
15. Shirabe K., Matsumata T., Maeda T., Sadanaga N., Kuwano H., and Sugimachi K. A long-term surviving patient with hepatocellular carcinoma including lymphocytes infiltration - a clinicopathological study. Hepatogastroenterology 42 (1995) 996-1001
16. Si M.W., Thorson J.A., Lauwers G.Y., DalCin P., and Furman J. Hepatocellular lymphoepithelioma-like carcinoma associated with epstein barr virus: a hitherto unrecognized entity. Diagn. Mol. Pathol. 13 (2004) 183-189
17. Swann J.B., and Smyth M.J. Immune surveillance of tumors. J. Clin. Invest. 117 (2007) 1137-1146
18. Tang Z.Y. Hepatocellular carcinoma-cause, treatment and metastasis. World J. Gastroenterol. 7 (2001) 445-454
19. Tsai S.T., Jin Y.T., Mann R.B., and Ambinder R.F. Epstein-Barr virus detection in nasopharyngeal tissues of patients with suspected nasopharyngeal carcinoma. Cancer 82 (1998) 1449-1453
20. Unitt E., Rushbrook S.M., Marshall A., Davies S., Gibbs P., Morris L.S., Coleman N., and Alexander G.J. Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells. Hepatology 41 (2005) 722-730
21. Vortmeyer A.O., Kingma D.W., Fenton R.G., Curti B.D., Jaffe E.S., and Duray P.H. Hepatobiliary lymphoepithelioma-like carcinoma associated with Epstein-Barr virus. Am. J. Clin. Pathol. 109 (1998) 90-95
22. Wada Y., Nakashima O., Kutami R., Yamamoto O., and Kojiro M. Clinicopathological study on hepatocellular carcinoma with lymphocytic infiltration. Hepatology 27 (1998) 407-414
23. Yin X.Y., Lu M.D., Lai Y.R., Liang L.J., and Huang J.F. Prognostic significances of tumor-infiltrating S-100 positive dendritic cells and lymphocytes in patients with hepatocellular carcinoma. Hepatogastroenterology 50 (2003) 1281-1284
24. Yoong K.F., McNab G., Hübscher S.G., and Adams D.H. Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma. J. Immunol. 160 (1998) 3978-3988