Intestinal dendritic cells

Current Opinion in Gastroenterology

Volumn 31, Issue 2, 2015, Pages 98-103

  Schiavi, Elisa ^a   Smolinska, Sylwia ^a,b,c   O'mahony, Liam ^a,d  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ALL MED Medical Research Institute   (Switzerland)

^c WROCLAW MEDICAL UNIVERSITY   (Poland)

^d SWISS INSTITUTE OF ALLERGY AND ASTHMA RESEARCH SIAF   (Switzerland)

Author keywords

Dendritic cells; Goblet cells; Microbiome; Retinoic acid; Short chain fatty acids

Indexed keywords

MUCIN; ANTIGEN; STOMACH MUCIN;

CELL INTERACTION; DENDRITIC CELL; ENVIRONMENTAL FACTOR; GOBLET CELL; HUMAN; IMMUNE RESPONSE; INTESTINE CELL; INTESTINE FLORA; MICROBIAL METABOLISM; NONHUMAN; POLARIZATION; REVIEW; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASE; INTESTINE MUCOSA; MUCOSAL IMMUNITY; PHENOTYPE;

ANTIGENS; DENDRITIC CELLS; GASTRIC MUCINS; GOBLET CELLS; HUMANS; IMMUNE TOLERANCE; IMMUNITY, MUCOSAL; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; PHENOTYPE;

EID: 84922641635     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0000000000000155     Document Type: Review

References (44)

1. Persson EK, Scott CL, Mowat AM, Agace WW. Dendritic cell subsets in the intestinal lamina propria: ontogeny and function. Eur J Immunol 2013; 43:3098-3107.
2. Chang SY, Ko HJ, Kweon MN. Mucosal dendritic cells shape mucosal immunity. Exp Mol Med 2014; 46:e84.
3. Bates JM, Flanagan K, Mo L, et al. Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis. Mucosal Immunol 2014.
4. Kalinski P, Hilkens CMU, Wierenga EA, Kapsenberg ML. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today 1999; 20:561-567.
5. Akdis M, Burgler S, Crameri R, et al. Interleukins, from 1 to 37, and interferong: receptors, functions, and roles in diseases. J Allergy Clin Immunol 2011; 127:701-721.
6. Coombes JL, Siddiqui KR, Arancibia-Cá rcamo CV, et al. A functionally specialized population of mucosal CD103† DCs induces Foxp3† regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 2007; 204:1757-1764.
7. Bekiaris V, Persson EK, Agace WW. Intestinal dendritic cells in the regulation of mucosal immunity. Immunol Rev 2014; 260:86-101.
8. Denning TL, Norris BA, Medina-Contreras O, et al. Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization. J Immunol 2011; 187:733-747.
9. Watchmaker PB, Lahl K, Lee M, et al. Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat Immunol 2014; 15:98-108.
10. Scott CL, Tfp ZM, Beckham KS, et al. Signal regulatory protein alpha (SIRPa) regulates the homeostasis of CD103† CD11b† DCs in the intestinal lamina propria. Eur J Immunol 2014; 44:3658-3668.
11. Kourepini E, Aggelakopoulou M, Alissafi T, et al. Osteopontin expression by CD103- dendritic cells drives intestinal inflammation. Proc Natl Acad Sci USA 2014; 111:E856-865.
12. Sommer F, Bäckhed F. The gut microbiota - masters of host development and physiology. Nat Rev Microbiol 2013; 11:227-238.
13. McDermott AJ, Huffnagle GB. The microbiome and regulation of mucosal immunity. Immunology 2014; 142:24-31.
14. Bakdash G, Vogelpoel LT, van Capel TM, et al. Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells. Mucosal Immunol 2014.
15. Konieczna P, Ferstl R, Ziegler M, et al. Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms. PLoS One 2013; 8:e62617.
16. Konieczna P, Groeger D, Ziegler M, et al. Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells. Gut 2012; 61:354-366.
17. Bimczok D, Kao JY, Zhang M, et al. Human gastric epithelial cells contribute to gastric immune regulation by providing retinoic acid to dendritic cells. Mucosal Immunol 2014.
18. Karimi K, Kandiah N, Chau J, et al. A Lactobacillus rhamnosus strain induces a heme oxygenase dependent increase in Foxp3 † regulatory T cells. PLoS One 2012; 7:e47556.
19. Frei R, Lauener RP, Crameri R, O'Mahony L. Microbiota and dietary interactions: an update to the hygiene hypothesis? Allergy 2012; 67:451-461.
20. Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 2014; 20:159-166.
21. Maslowski KM, Vieira AT, Ng A, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 2009; 461: 1282-1286.
22. An D, Oh SF, Olszak T, et al. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell 2014; 156:123-133.
23. Atarashi K, Tanoue T, Oshima K, et al. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature 2013;500:232-236
24. Goto Y, Panea C, Nakato G, et al. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity 2014; 40:594-607.
25. Dasgupta S, Erturk-Hasdemir D, Ochoa-Reparaz J, et al. Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms. Cell Host Microbe 2014; 15:413-423.
26. Wang Y, Telesford KM, Ochoa-Repáraz J, et al. An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling. Nat Commun 2014; 5:4432.
27. Bloem K, Garciá-Vallejo JJ, Vuist IM, et al. Interaction of the capsular polysaccharide A from Bacteroides fragilis with DC-SIGN on human dendritic cells is necessary for its processing and presentation to T cells. Front Immunol 2013; 4:103.
28. Jones SE, Paynich ML, Kearns DB, Knight KL. Protection from intestinal inflammation by bacterial exopolysaccharides. J Immunol 2014; 192:4813- 4820. This study demonstrates that bacterial exopolysaccharides prevent colitis in a TLR4-dependent manner, which requires myeloid cells.
29. Karumuthil-Melethil S, Gudi R, Johnson BM, et al. Fungal b-glucan, a dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response. J Immunol 2014; 193:3308-3321.
30. De Jesus M, Ostroff GR, Levitz SM, et al. A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling b-glucan microparticles. PLoS One 2014; 9:e91002.
31. Yonekawa A, Saijo S, Hoshino Y, et al. Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria. Immunity 2014; 41: 402-413.
32. Kurakevich E, Hennet T, Hausmann M, et al. Milk oligosaccharide sialyl (a2,3)lactose activates intestinal CD11c† cells through TLR4. Proc Natl Acad Sci USA 2013; 110:17444-17449.
33. Tan J, McKenzie C, Potamitis M, et al. The role of short-chain fatty acids in health and disease. Adv Immunol 2014; 121:91-119.
34. Thorburn AN, Macia L, Mackay CR. Diet, metabolites, and 'western-lifestyle' inflammatory diseases. Immunity 2014; 40:833-842.
35. Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature 2013; 504:451-455.
36. Chang PV, Hao L, Offermanns S, Medzhitov R. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci USA 2014; 111:2247-2252.
37. Singh N, Gurav A, Sivaprakasam S, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity 2014; 40:128-139.
38. Smolinska S, Jutel M, Crameri R, O'Mahony L. Histamine and gut mucosal immune regulation. Allergy 2014; 69:273-281.
39. Frei R, Ferstl R, Konieczna P, et al. Histamine receptor 2 modifies dendritic cell responses to microbial ligands. J Allergy Clin Immunol 2013; 132:194-204.
40. Ferstl R, Frei R,Schiavi E, et al. Histamine receptor 2 is a key influence inimmune responses to intestinal histamine-secreting microbes. J Allergy Clin Immunol 2014; 134:744-746. This report highlights the immunoregulatory role for histamine secreted by gut microbes.
41. Pelaseyed T, Bergström JH, Gustafsson JK, et al. The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol Rev 2014; 260:8-20.
42. McDole JR, Wheeler LW, McDonald KG, et al. Goblet cells deliver luminal antigen to CD103† dendritic cells in the small intestine. Nature 2012; 483:345-349.
43. Knoop KA, McDonald KG, McCrate S, et al. Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon. Mucosal Immunol 2015; 8:198-210.
44. Shan M, Gentile M, Yeiser JR, et al. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 2013; 342:447-453.