Immunochip-based analysis: High-density genotyping of immune-related loci sheds further light on the autoimmune genetic architecture of alopecia areata

Journal of Investigative Dermatology

Volumn 135, Issue 3, 2015, Pages 919-921

  Redler, Silke ^a   Angisch, Marina ^a   Heilmann, Stefanie ^a   Wolf, Sabrina ^b   Barth, Sandra ^a   Basmanav, Buket F ^a   Giehl, Kathrin A ^b   Hanneken, Sandra ^c   Eigelshoven, Sibylle ^c   Mangold, Elisabeth ^a   Kruse, Roland ^d   Blaumeiser, Bettina ^e   Böhm, Markus ^f   Knapp, Michael ^a   Garcia Bartels, Natalie ^g   Lutz, Gerhard ^h   Wolff, Hans ^b   Blume Peytavi, Ulrike ^g   Nöthen, Markus M ^a   Becker, Tim ^a,i   Betz, Regina C ^a   more..

^a UNIVERSITY OF BONN   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d Dermatological Practice   (Germany)

^e ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^f UNIVERSITY OF MÜNSTER   (Germany)

^g CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^h Hair and Nail   (Germany)

ⁱ GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FAS LIGAND; HLA ANTIGEN CLASS 2; HLA C ANTIGEN; HLA DQA2 ANTIGEN; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; OX40 LIGAND; UNCLASSIFIED DRUG; HLA ANTIGEN;

ADAPTIVE IMMUNITY; ALOPECIA AREATA; APOPTOSIS; AUTOIMMUNITY; BLOOD SAMPLING; CELL GROWTH; CHROMOSOME 6P; CROHN DISEASE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; IMMUNOASSAY; IMMUNOCHIP BASED ANALYSIS; IMMUNOMODULATION; INNATE IMMUNITY; LETTER; META ANALYSIS (TOPIC); PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE; THYROID ADENOMA; ADOLESCENT; ADULT; AGED; ALLELE; AUTOIMMUNE DISEASE; CASE CONTROL STUDY; CAUCASIAN; CHILD; FEMALE; GENETICS; MALE; MIDDLE AGED; PRESCHOOL CHILD; PROTEIN MICROARRAY; STATISTICAL MODEL; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ALLELES; ALOPECIA AREATA; AUTOIMMUNE DISEASES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC LOCI; GENOTYPE; HLA ANTIGENS; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN ARRAY ANALYSIS; YOUNG ADULT;

EID: 84922622982     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2014.459     Document Type: Article

References (15)

1. Al-Shamkhani A, Mallett S, Brown MH et al. (1997) Affinity and kinetics of the interaction between soluble trimeric OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells. J Biol Chem 272:5275-82
2. Barahmani N, de Andrade M, Slusser JP et al. (2008) Human leukocyte antigen class II alleles are associated with risk of alopecia areata. J Invest Dermatol 128:240-3
3. Croft M, So T, DuanWet al. (2009) The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol Rev 229:173-91
4. Entz P, Blaumeiser B, Betz RC et al. (2006) Investigation of the HLA-DRB1 locus in alopecia areata. Eur J Dermatol 16:363-7
5. Franke A, McGovern DP, Barrett JC et al. (2010) Genome-wide meta-Analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 42:1118-25
6. Goh C, Finkel M, Christos PJ et al. (2006) Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. J Eur Acad Dermatol Venereol 20:1055-60
7. Higgins LM, McDonald SA, Whittle N et al. (1999) Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand-IgG fusion protein. J Immunol 162:486-93
8. Jagielska D, Redler S, Brockschmidt FF et al. (2012) Follow-up study of the first genome-wide association scan in alopecia areata: IL13 and KIAA0350 as susceptibility loci supported with genome-wide significance. J Invest Dermatol 132:2192-7
9. John KK, Brockschmidt FF, Redler S et al. (2011) Genetic variants in CTLA4 are strongly associated with alopecia areata. J Invest Dermatol 131:1169-72
10. Niederkorn JY (2006) See no evil, hear no evil, do no evil: the lessons of immune privilege. Nat Immunol 7:354-9
11. Patsopoulos NA, Esposito F, Reischl J et al. (2011) Genome-wide meta-Analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol 70:897-912
12. Petukhova L, Duvic M, Hordinsky M et al. (2010) Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature 466:113-7
13. Redler S, Albert F, Brockschmidt FF et al. (2012) Investigation of selected cytokine genes suggests that IL2RA and the TNF/LTA locus are risk factors for severe alopecia areata. Br J Dermatol 167:1360-5
14. So T, Choi H, Croft M (2011) OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling. J Immunol 186:3547-55
15. Trynka G, Hunt KA, Bockett NA et al. (2011) Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet 43:1193-201