Differences among young adults, adults and elderly chronic myeloid leukemia patients

Annals of Oncology

Volumn 26, Issue 1, 2015, Pages 185-192

  Castagnetti, Fausto ^a   Gugliotta, G ^a   Baccarani, M ^b   Breccia, M ^c   Specchia, G ^d   Levato, L ^e   Abruzzese, E ^f   Rossi, G ^g   Iurlo, A ^h   Martino, B ⁱ   Pregno, P ^j   Stagno, F ^k   Cuneo, A ^l   Bonifacio, M ^m   Gobbi, M ⁿ   Russo, D ^o   Gozzini, A ^p   Tiribelli, M ^q   De Vivo, A ^a   Alimena, G ^c   Cavo, M ^a   Martinelli, G ^a   Pane, F ^r   Saglio, G ^s   Rosti, G ^a   Salvi, F ^t   Pini, M ^t   Leoni, P ^u   Rupoli, S ^u   Galieni, P ^v   Bigazzi, C ^v   Cantore, N ^w   Palmieri, F ^w   Albano, F ^d   Russo Rossi, A ^d   Rambaldi, A ^x   Intermesoli, T ^x   Palandri, F ^b   Testoni, N ^b   Luatti, S ^b   Soverini, S ^b   Iacobucci, I ^b   Bochicchio, M T ^b   Apolinari, M ^b   Fogli, M ^b   Cervello, I ^b   Capucci, A ^g   Malagola, M ^g   Malpignano, A ^y   Girasoli, M ^y   Angelucci, E ^z   Usala, E ^z   Storti, S ^aa   De Biasi, E ^ab   Tagariello, G ^ac   Sartori, R ^ac   Di Raimondo, F ^ad   Vigneri, P ^ad   Impera, S ^ae   Molica, S ^e   Lanza, F ^af   Vigano C ^af   Grasso, M ^ag   Rapezzi, D ^ag   Cavazzini, F ^ah   Bosi, A ^ai   Santini, V ^ai   Capalbo, S F ^aj   Spinosa, G ^aj   Pierri, I ⁿ   Bergamaschi, M ⁿ   Carella, A M ⁿ   Bacigalupo, A ⁿ   De Blasio, A ^ak   Ciccone, F ^ak   Di Renzo, N ^al   Musolino, C ^am   Russo, S ^am   Cortelezzi, A ^h   Morra, E ^an   Pungolino, E M ^an   Luppi, M ^ao   Marasca, R ^ao   Pogliani, E M ^ap   Gambacorti Passerini, C ^ap   Luciano, L ^r   Ferrara, F ^aq   Annunziata, M ^aq   Latte, G ^ar   Noli, D ^ar   Rege Cambrin, G ^s   Fava, C ^s   Semenzato, G ^as   Binotto, G ^as   Fabbiano, F ^at   Turri, D ^at   Siragusa, S ^au   Caracciolo, C ^au   Musso, M ^av   Porretto, F ^av   Aversa, F ^aw   Crugnola, M ^aw   Cazzola, M ^ax   Orlandi, E ^ax   Falini, B ^ay   Falzetti, F ^ay   Visani, G ^az   Isidori, A ^az   Fioritoni, G ^ba   Di Lorenzo, R ^ba   Vallisa, D ^bb   Trabacchi, E ^bb   Petrini, M ^bc   Galimberti, S ^bc   Pizzuti, M ^bd   Zaccaria, A ^be   Salvucci, M ^be   Ronco, F ⁱ   Ielo, D ⁱ   Merli, F ^bf   Avanzini, P ^bf   Tosi, P ^bg   Merli, A ^bg   Musto, P ^bh   De Stefano, V ^bi   Sica, S ^bi   Latagliata, R ^c   De Fabritiis, P ^bj   Trawiska, M ^bj   Majolino, I ^bk   Pacilli, L ^bk   Ronci, B ^ab   Cedrone, M ^ab   Petti, M C ^bl   Pisani, F ^bl   Tafuri, A ^bm   Montefusco, E ^bm   Iuliano, F ^ab   Dore, F ^bn   Pardini, S ^bn   Bocchia, M ^bo   Defina, M ^bo   Liberati, A M ^bp   Luzzi, D ^bp   Boccadoro, M ^bq   Ferrero, D ^bq   Vitolo, U ^j   Gherlinzoni, F ^br   Calistri, E ^br   Fanin, R ^bs   Pizzolo, G ^bt   Meneghini, V ^bt   Rodighiero, F ^bu   D'Emilio, A ^bu   more..

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF BARI   (Italy)

^e PUGLIESE CIACCIO HOSPITAL   (Italy)

^f S EUGENIO HOSPITAL   (Italy)

^g SPEDALI CIVILI   (Italy)

^h FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

ⁱ BIANCHI MELACRINO MORELLI HOSPITAL   (Italy)

^j CITTÀ DELLA SALUTE E DELLA SCIENZA HOSPITAL   (Italy)

^k UNIVERSITY OF CATANIA   (Italy)

^l UNIVERSITY HOSPITAL OF FERRARA   (Italy)

^m UNIVERSITY OF VERONA   (Italy)

ⁿ UNIVERSITY OF GENOA   (Italy)

^o UNIVERSITY OF BRESCIA   (Italy)

^p CAREGGI UNIVERSITY HOSPITAL   (Italy)

^q SANTA MARIA DELLA MISERICORDIA UNIVERSITY HOSPITAL   (Italy)

^r UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^s SAN LUIGI GONZAGA UNIVERSITY HOSPITAL   (Italy)

^t Ospedale Civile   (Italy)

^u Ospedale Regionale Torrette   (Italy)

^v Hematology   (Italy)

^w Ospedale Civile 'San Giuseppe Moscati'   (Italy)

^x OSPEDALI RIUNITI   (Italy)

^y Ospedale 'Perrino'   (Italy)

^z Ospedale Oncologico A Businco   (Italy)

^aa CATHOLIC UNIVERSITY   (Italy)

^ab Hematology   (Italy)

^ac San Giacomo Hospital   (Italy)

^ad Ospedale 'Ferrarotto'   (Italy)

^ae Garibaldi Nesima Hospital   (Italy)

^af CREMONA HOSPITAL   (Italy)

^ag S CROCE E CARLE HOSPITAL   (Italy)

^ah UNIVERSITY OF FERRARA   (Italy)

^ai UNIVERSITY OF FLORENCE   (Italy)

^aj OSPEDALI RIUNITI   (Italy)

^ak Ospedale Civile   (Italy)

^al VITO FAZZI HOSPITAL   (Italy)

^am UNIVERSITY OF MESSINA   (Italy)

^an OSPEDALE NIGUARDA CA GRANDA   (Italy)

^ao UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^ap SAN GERARDO HOSPITAL   (Italy)

^aq CARDARELLI HOSPITAL   (Italy)

^ar SAN FRANCESCO HOSPITAL   (Italy)

^as UNIVERSITY OF PADOVA   (Italy)

^at VILLA SOFIA CERVELLO HOSPITAL   (Italy)

^au UNIVERSITY OF PALERMO   (Italy)

^av LA MADDALENA CANCER CENTER   (Italy)

^aw UNIVERSITY OF PARMA   (Italy)

^ax FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^ay POLICLINICO MONTELUCE   (Italy)

^az SAN SALVATORE HOSPITAL   (Italy)

^ba SPIRITO SANTO HOSPITAL   (Italy)

^bb GUGLIELMO DA SALICETO HOSPITAL   (Italy)

^bc UNIVERSITY HOSPITAL OF PISA   (Italy)

^bd SAN CARLO HOSPITAL   (Italy)

^be SANTA MARIA DELLE CROCI HOSPITAL   (Italy)

^bf S MARIA NUOVA HOSPITAL   (Italy)

^bg Ospedale Infermi Azienda Unità Sanitaria   (Italy)

^bh REFERRAL CANCER CENTER OF BASILICATA   (Italy)

^bi CATHOLIC UNIVERSITY   (Italy)

^bj UNIVERSITY OF ROME TOR VERGATA   (Italy)

^bk SAN CAMILLO FORLANINI HOSPITAL   (Italy)

^bl REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^bm SAPIENZA UNIVERSITY OF ROME   (Italy)

^bn UNIVERSITY OF SASSARI   (Italy)

^bo UNIVERSITY OF SIENA   (Italy)

^bp S MARIA HOSPITAL   (Italy)

^bq UNIVERSITY OF TURIN   (Italy)

^br 'Ca' Foncello' Hospital   (Italy)

^bs UNIVERSITY OF UDINE   (Italy)

^bt UNIVERSITY OF VERONA   (Italy)

^bu Divisione di Cardiologia   (Italy)

more..

Author keywords

BCR ABL; Chronic myeloid leukemia; Prognosis; Tyrosine kinase inhibitors; Young adults

Indexed keywords

ANTINEOPLASTIC AGENT; IMATINIB; NILOTINIB; PROTEIN TYROSINE KINASE INHIBITOR; RECOMBINANT ALPHA INTERFERON; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

ADULT; AGE DISTRIBUTION; AGED; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; BASOPHIL; BLAST CELL; CANCER GROWTH; CANCER INCIDENCE; CANCER MORTALITY; CANCER REGISTRY; CANCER SURVIVAL; CHROMOSOME BANDING PATTERN; CHRONIC MYELOID LEUKEMIA; COHORT ANALYSIS; CONTROLLED STUDY; CYTOGENETICS; EOSINOPHIL COUNT; EUTOS SCORE; FEMALE; HIGH RISK PATIENT; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MAJOR MOLECULAR RESPONSE; MALE; MALIGNANT TRANSFORMATION; MIDDLE AGED; OVERALL SURVIVAL; PROBABILITY; RATING SCALE; SCORING SYSTEM; SEX DIFFERENCE; SPLEEN SIZE; SPLENOMEGALY; SURVIVAL TIME; THROMBOCYTE COUNT; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR INVASION; VERY ELDERLY; YOUNG ADULT; AGE; ANTAGONISTS AND INHIBITORS; CLINICAL TRIAL; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MULTICENTER STUDY; PATHOLOGY; PROSPECTIVE STUDY; SPLEEN;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS; FEMALE; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SPLEEN; SPLENOMEGALY; YOUNG ADULT;

EID: 84922503933     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdu490     Document Type: Article

References (24)

1. Hehlmann R, Hochhaus A, Baccarani M. Chronic myeloid leukemia. Lancet 2007; 370: 342-350.
2. Kantarjian H, O'Brien S, Jabbour E et al. Improved survival in chronic myeloid leukemia since the introduction of imatinib therapy: a single-institution historical experience. Blood 2012; 119: 1981-1987.
3. Baccarani M, Saglio G, Goldman J et al. Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2006; 108: 1809-1820.
4. Baccarani M, Cortes J, Pane F et al. Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNet. J Clin Oncol 2009; 27: 6041-6051.
5. Baccarani M, Deininger MW, Rosti G et al. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 2013; 122: 872-884.
6. Sokal JE, Cox EB, Baccarani M et al. Prognostic discrimination in "good-risk" chronic granulocytic leukemia. Blood 1984; 63: 789-799.
7. Hasford J, Pfirmann M, Hehlmann R et al. A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. J Natl Cancer Inst 1998; 90: 850-858.
8. Hasford J, Baccarani M, Hoffmann V et al. Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score. Blood 2011; 118: 686-692.
9. Gugliotta G, Castagnetti F, Palandri F et al. Frontline imatinib treatment of chronic myeloid leukemia: no impact of age on outcome, a survey by the GIMEMA CML working party. Blood 2011; 117: 5591-5599.
10. Millot F, Traore P, Guilhot J et al. Clinical and biological features at diagnosis in 40 children with chronic myeloid leukemia. Pediatrics 2005; 116: 140-143.
11. Hasan SK, Sazawal S, Kumar B et al. Childhood CML in India: b2a2 transcript is more common than b3a2. Cancer Gen Cytogen 2006; 169: 76-77.
12. Andolina JR, Neudorf SM, Corey SJ. How I treat childhood CML. Blood 2012; 119: 1821-1830.
13. Millot F, Suttorp M, Guilhot J et al. The international registry for chronic myeloid leukemia in children and adolescents (I-CML-Ped-Study): objectives and preliminary results. Blood 2012; 120: abstract 3741.
14. Kalmanti L, Saussele S, Lauseker M et al. Younger patients with chronic myeloid leukemia do well in spite of poor prognostic indicators: results from the randomized CML study IV. Ann Hematol 2014; 93: 71-80.
15. Chapman WC, Newman M. Disorders of the spleen. In: Wintrobe's, Clinical Hematology, 10th edition. Philadelphia, PA: Williams & Wilkins 1999; 1969-1989.
16. Baccarani M, Zaccaria A, Santucci MA et al. A simultaneous study of bone marrow, spleen and liver in chronic myeloid leukemia. Evidence for differences in cell composition and karyotypes. Ser Haemat 1975; 8: 81-112.
17. Sjogren U, Brandt L. Different composition and mitotic activity of the hemopoietic tissue in bone marrow, spleen, and liver, in chronic myeloid leukaemia. Acta Haematol 1976; 55: 73-80.
18. Muller-Bérat CN, Wantzin GL, Philip P et al. Agar culture studies of bone marrow, spleen and liver in chronic myeloid leukemia. Leukemia Res 1977; 1: 123-131.
19. Pfirrmann M, Hochhaus A, Lauseker M et al. Recommendations to meet statistical challenges arising from endpoints beyond overall survival in clinical trials of chronic myeloid leukemia. Leukemia 2011; 25: 1433-1438.
20. Guilhot J, Baccarani M, Clark RE et al. Definitions, methodological and statistical issues for phase 3 clinical trials in chronic myeloid leukemia: a proposal by the European LeukemiaNet. Blood 2012; 119: 5963-5971.
21. Medical Research Council's Working Party for Therapeutic Trials in Leukaemia. Chronic granulocytic leukaemia: comparison of radiotherapy and busulfan therapy. Brit Med J 1968; 1: 201-207.
22. Monfardini S, Gee T, Fried J, Clarkson B. Survival in chronic myelogenous leukemia: influence of treatment and extent of disease at diagnosis. Cancer 1973; 31: 492-501.
23. Pemmaraju N, Kantarjian H, Shan J et al. Analysis of outcomes in adolescents and young adults with chronic myelogenous leukemia treated with upfront tyrosine kinase inhibitor therapy. Haematologica 2012; 97: 1029-1035.
24. O'Brien S, Radich JP, Abboud CN et al. Chronic Myelogenous Leukemia, Version 1.2014. J Natl Compr Canc Netw 2013; 11: 1327-1340.