Kinetic and structural requirements for carbapenemase activity in GES-type β-lactamases

Biochemistry

Volumn 54, Issue 2, 2015, Pages 588-597

  Stewart, Nichole K ^a   Smith, Clyde A ^b   Frase, Hilary ^a   Black, D J ^c   Vakulenko, Sergei B ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^c Bio Logic USA ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; AMINO ACIDS; ANTIBIOTICS; COMPLEX NETWORKS; ENZYMES; FUNCTIONAL GROUPS; HYDROGEN BONDS; MOLECULES;

ACYL-ENZYME COMPLEX; BACTERIAL PATHOGENS; CARBAPENEM ANTIBIOTIC; CATALYTIC EFFICIENCIES; HYDROGEN BONDING NETWORK; LIFE-THREATENING INFECTIONS; STRUCTURAL REQUIREMENTS; SUBSTRATE PROFILE;

CRYSTAL STRUCTURE;

BETA LACTAMASE; CARBAPENEM DERIVATIVE; CARBAPENEMASE; DORIPENEM; ERTAPENEM; IMIPENEM; MEROPENEM; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAM; BETA-LACTAMASE GES-2; THIENAMYCIN DERIVATIVE;

ACYLATION; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DEACYLATION; ENZYME ACTIVE SITE; ENZYME METABOLISM; HYDROGEN BOND; HYDROLYSIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; X RAY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; KINETICS; METABOLISM; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS);

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; BETA-LACTAMS; CARBAPENEMS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; THIENAMYCINS;

EID: 84922473867     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501052t     Document Type: Article

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