Ginseng total saponin modulates the changes of α-actinin-4 in podocytes induced by diabetic conditions

Journal of Ginseng Research

Volumn 38, Issue 4, 2014, Pages 233-238

  Ha, Tae Sun ^a   Choi, Ji Young ^a   Park, Hye Young ^a   Nam, Ja Ae ^a   Seong, Su Bin ^a  

^a Chungbuk National University College of Medicine   (South Korea)

Author keywords

Diabetic nephropathy; Ginseng total saponin; Panax ginseng; Podocyte; actinin 4

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALPHA ACTININ 4; ANTIDIABETIC AGENT; F ACTIN; GINSENG TOTAL SAPONIN; GLUCOSE; SAPONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DIABETES MELLITUS; GINSENG; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; UPREGULATION;

EID: 84922463914     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jgr.2014.05.004     Document Type: Article

References (29)

1. Parving HH, Mauer M, Fioretto P, Rossing P, Ritz E. Diabetic nephropathy. In: Brenner BM, editor. The kidney. Philadelphia:WBSaunders; 2011. pp. 1411-54
2. Kanwar YS, Wada J, Sun L, Xie P, Wallner EI, Chen S, Chugh S, Danesh FR. Diabetic nephropathy: mechanisms of renal disease progression. Exp Biol Med (Maywood) 2008;233:4-11
3. Sharma K, Ziyadeh FN. Biochemical events and cytokine interactions linking glucose metabolism to the development of diabetic nephropathy. Semin Nephrol 1997;17:80-92
4. Vlassara H. Protein glycation in the kidney: role in diabetes and aging. Kidney Int 1996;49:1795-804
5. Tripathi YB, Yadav D. Diabetic nephropathy: causes and managements. Recent Pat Endocr Metab Immune Drug Discov 2013;7:57-64
6. Mundel P, Kriz W. Structure and function of podocytes: an update. Anat Embryol (Berl) 1995;192:385-97
7. Asanuma K, Mundel P. The role of podocytes in glomerular pathobiology. Clin Exp Nephrol 2003;7:255-9
8. Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 2003;83:253-307
9. Ha TS. Roles of adaptor proteins in podocyte biology. World J Nephrol 2013;2: 1-10
10. Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P. Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 2007;17:428-37
11. Welsh GI, Saleem MA. The podocyte cytoskeleton-key to a functioning glomerulus in health and disease. Nat Rev Nephrol 2011;8:14-21
12. Ha TS. High glucose and advanced glycosylated end-products affect the expression of a-actinin-4 in glomerular epithelial cells. Nephrology (Carlton) 2006;11:435-41
13. Kaplan JM, Kim SH, North KN, Kaplan JM, Kim SH, North KN, Rennke H, Correia LA, Tong HQ, Mathis BJ, et al. Mutations in ACTN4, encoding alphaactinin- 4, cause familial focal segmental glomerulosclerosis. Nature Genet 2000;24:251-6
14. Kang KS, Kim HY, Yamabe N, Nagai R, Yokozawa T. Protective effect of sun ginseng against diabetic renal damage. Biol Pharm Bull 2006;29:1678-84
15. Kim HY, Kang KS, Yamabe N, Nagai R, Yokozawa T. Protective effect of heatprocessed American ginseng against diabetic renal damage in rats. J Agric Food Chem 2007;55:8491-7
16. Kang KS, Yamabe N, Kim HY, Park JH, Yokozawa T. Therapeutic potential of 20(S)-ginsenoside Rg(3) against streptozotocin-induced diabetic renal damage in rats. Eur J Pharmacol 2008;591:266-72
17. Quan HY, Kim DY, Chung SH. Korean red ginseng extract alleviates advanced glycation end product-mediated renal injury. J Ginseng Res 2013; 37:187-93
18. Kang KS, Yamabe N, Kim HY, Park JH, Yokozawa T. Effects of heat-processed ginseng and its active component ginsenoside 20(S)-Rg3 on the progression of renal damage and dysfunction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty rats. Biol Pharm Bull 2010;33:1077-81
19. Ha TS, Choi JY, Park HY, Lee JS. Ginseng total saponin improves podocyte hyperpermeability induced by high glucose and advanced glycosylation endproducts. J Korean Med Sci 2011;26:1316-21
20. Ha TS, Lee JS, Choi JY, Park HY. Ginseng total saponin modulates podocyte p130Cas in diabetic condition. J Ginseng Res 2013;37:94-9
21. Lee JS, Ha TS, Park HY, Choi JY, Nam JA. Ginseng total saponin regulates podocyte P-cadherin/b-catenin unit in diabetic condition. J Biomed Res 2012;13:249-54
22. Mundel P, Reiser J, Zuniga Mejía Borja A, Pavenstadt H, Davidson GR, Kriz W, Zeller R. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 1997;236:248-58
23. Ha TS, Song CJ, Lee JH. Effects of advanced glycosylation endproducts on perlecan core protein of glomerular epithelium. Pediatr Nephrol 2004;19: 1219-24
24. Cortes P, Méndez M, Riser BL, Guérin CJ, Rodríguez-Barbero A, Hassett C, Yee J. F-actin fiber distribution in glomerular cells: structural and functional implications. Kidney Int 2000;58:2452-61
25. Shirato I, Sakai T, Kimura K, Tomino Y, Kriz W. Cytoskeletal changes in podocytes associated with foot process effacement in Masugi nephritis. Am J Pathol 1996;148:1283-96
26. Lachapelle M, Bendayan M. Contractile proteins in podocytes. Immunocytochemical localization of actin and alpha-actinin in normal and nephrotic rat kidneys. Virchows Arch B Cell Pathol 1991;60:105-11
27. Kos CH, Le TC, Sinha S, Henderson JM, Kim SH, Sugimoto H, Kalluri R, Gerszten RE, Pollak MR. Mice deficient in a-actinin-4 have severe glomerular disease. J Clin Invest 2003;111:1683-90
28. Michaud JL, Lemieux LI, Dube M, Vanderhyden BC, Robertson SJ, Kennedy CR. Focal and segmental glomerulosclerosis in mice with podocyte- specific expression of mutant a-actinin-4. J Am Soc Nephrol 2003;14: 1200-11
29. Zhang LN, Xie XS, Zuo C, Fan JM. Effect of ginsenoside Rgl on the expression of TNF-alpha and MCP-1 in rats with diabetic nephropathy. Sichuan Da Xue Xue Bao Yi Xue Ban 2009;40:466-71.