Cytoskeletal changes in podocytes associated with foot process effacement in Masugi nephritis

American Journal of Pathology

Volumn 148, Issue 4, 1996, Pages 1283-1296

  Shirato, Isao ^a,d   Sakai, Tatsuo ^b   Kimura, Kenjiro ^c   Tomino, Yasuhiko ^b   Kriz, Wilhelm ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b JUNTENDO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ALPHA ACTININ; CELL PROTEIN; PROTEIN PP 44; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL CELL; CONTROLLED STUDY; CYTOSKELETON; DENSE BODY; GLOMERULUS CAPILLARY; INTERDIGITATING CELL; MALE; MASUGI NEPHRITIS; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; RAT;

ANIMALS; BASEMENT MEMBRANE; CYTOSKELETON; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; KIDNEY GLOMERULUS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029940563     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Nagata M, Kriz W: Glomerular damage after uninephrectomy in young rats. II. Mechanical stress on podocytes as a pathway to sclerosis. Kidney Int 1992, 42:148-160
2. Davies DJ, Brewer DB, Hardwicke J: Urinary proteins and glomerular morphometry in protein overload proteinuria. Lab Invest 1978, 38:232-243
3. Cho CR, Lumsden CJ, Whiteside CI: Epithelial cell detachment in the nephrotic glomerulus, a receptor cooperativity model J Theor Biol 1993, 160:407-426
4. Kondo Y, Akikusa B: Chronic Masugi nephritis in the rat, an electron microscopic study on evolution and consequences of glomerular capsular adhesions. Acta Pathol Jpn 1982, 32 231-242
5. Sakai T, Kriz W: The structural relationship between mesangial cells and basement membrane of the renal glomerulus. Anat Embryol 1987, 176:373-386
6. Kaissling B, Kriz W Variability of intercellular spaces between macula densa cells: a transmission electron microscopic study in rabbits and rats. Kidney Int 1982, 22(Suppl 12):S9-S17
7. Shirato I, Sakai T, Fukui M, Tomino Y, Koide H: Widening of capillary neck and alteration of extracellular matrix ultrastructure in diabetic rat glomerulus as revealed by computer morphometry and improved tissue processing. Virchows Arch A 1993, 423:121-129
8. Weibel, ER: Stereological Methods. Practical Methods for Biological Morphometry London, Academic Press, 1979
9. Mundel P, Gilbert P, Kriz W: Podocytes in glomerulus of rat kidney express a characteristic 44 kD protein. J Histochem Cytochem 1991, 39:1047-1056
10. Kondo Y, Shigematsu H, Okabayashi A: Cellular aspect of rabbit Masugi nephritis. III. Mesangial changes. Lab Invest 1976, 34 363-371
11. Nahas AME: Masugi nephritis: a model for all seasons Experimental and Genetic Rat Models of Chronic Renal Failure. Edited by N Gretz, M Strauch. Basel, Karger. 1993, pp 49-67
12. Kühn K, Ryan GB, Hein SJ, Galaske RG, Karnovsky MJ: An ultrastructural study of the mechanism of proteinuria in rat nephrotoxic nephritis. Lab Invest 1977, 36:375-387
13. Drenckhahn D, Franke RP: Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man. Lab Invest 1988, 59:673-682
14. Seiler MR, Rennke HG, Venkatachalam MA, Cotran RS: Pathogenesis of polycation-induced alteration (fusion) of glomerular epithelium. Lab Invest 1977, 36:48-61
15. Andrews PM: Cationized ferritin binding to anionic surfaces in normal and aminonucleoside nephrotic kidneys. Am J Anat 1981, 162:89-106
16. Kerjaschki D: Polycation-induced dislocation of slit diaphragms and formation of cell junctions in rat kidney glomeruli the effects of low temperature, divalent cations, colchicine, and cytochalasin B. Lab Invest 1978, 39:430-440
17. Farquhar MG, Palade GE: Glomerular permeability. II. Ferritin transfer across the glomerular capillary wail in nephrotic rats. J Exp Med 1961, 114:699-715
18. Ryan GB, Karnovsky MJ: An ultrastructural study of the mechanisms of proteinuria in aminonucleoside nephrosis Kidney Int 1975, 8:219-232
19. Messina A, Davies DJ, Dillane PC, Ryan GB Glomerular epithelial abnormalities associated with the onset of proteinuria in aminonucleoside nephrosis. Am J Pathol 1987, 126:220-229
20. Heymann W, Hackel DB, Harwood S, Wilson SGF, Hunter JPL: Production of nephrotic syndrome in rats by Freunds adjuvants and rat kidney suspensions. Proc Soc Exp Biol Med 1959, 100 660-664
21. Kerjaschki D Molecular pathology of membranous nephropathy Kidney Int 1992, 41:1090-1105
22. Dworkin LD, Hostetter TH, Rennke HG, Brenner BM: Hemodynamic basis for glomerular injury in rats with desoxycorticosterone-salt hypertension. J Clin Invest 1984, 73 1448-1461
23. Kretzler M, Koeppen-Hagemann I, Kriz W: Podocyte damage is a critical step in the development of glomerulosclerosis in the uninephrectomised-desoxycorticosterone rat. Virchows Arch A 1994, 452:181-193
24. Shimamura T, Morrison AB: A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats. Am J Pathol 1975, 79 95-106
25. Faraj AH, Morley AR Remnant kidney pathology after five-sixth nephrectomy in rat II. Electron microscopy study. APMIS 1993, 101:83-90
26. Kriz W, Hähnel B, Rösener S, Elger M: Long-term treatment of rats with FGF-2 results in focal segmental glomerulosclerosis Kidney Int 1995, 48:1435-1450
27. Brandis A, Bianchi G, Reale E, Helmchen U, Kuhn K: Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain. Kidney Int 1986, 55:234-243
28. Farquhar MG, Vernier RL, Good RA: An electron microscope study of the glomerulus in nephrosis, glomerulonephritis, and lupus erythematosus. J Exp Med 1957, 106:649-660
29. Olson JL: The nephrotic syndrome Pathology of the Kidney. Edited by RH Heptinstall Boston, Little Brown and Co., 1992, pp 839-844
30. Nadasdy T, Silva FG, Hogg RI: Minimal change nephrotic syndrome focal sclerosis complex Renal Pathology Edited by CC Tisher, BM Brenner. Philadelphia, JB Lippincott, 1994, pp 330-389
31. Ehrenreich T, Churg J: Pathology of membranous nephropathy Pathol Annu 1968, 3:145-186
32. Grishman E, Churg J: Focal glomerular sclerosis in nephrotic patients: an electron microscopic study of glomerular podocytes. Kidney Int 1975, 7 111-122
33. Velosa JA, Donadio JV, Holley KE: Focal sclerosing glomerulonephropathy: a clinicopathologic study Mayo Clin Proc 1975, 50 121-133
34. O'Meara YM, Natori Y, Minto AW, Goldstein DJ, Manning EC, Salant DJ: Nephritogenic antiserum identifies a β1-integrin on rat glomerular epithelial cells. Am J Physiol 1992, 262:F1083-F1091
35. Adler S: Integrin receptors in the glomerulus: potential role in glomerular injury Am J Physiol 1992, 262:F697-F704
36. Olson JL, Heptinstall RH: Biology of disease: nonimmunologic mechanisms of glomerular injury Lab Invest 1988, 59 564-578
37. Fries JW, Sandstrom DJ, Meyer TW, Rennke HG: Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat. Lab Invest 1989, 60 205-218
38. Lemanski L, Paulson D, Hill GS, Davis LA, Riles LC, Lim SS: Immunoelectron microscopic localization of α-actinin on Lowicryl-embedded thin-sectioned tissues. J Histochem Cytochem 1985, 33:515-522
39. Critchley, DR: α-Actinin. Guidebook to the Cytoskeletal and Motor Proteins Edited by T Kreis, R Vale. Oxford, Oxford University Press, 1993, pp 22-23
40. Whiteside CI, Cameron R, Munk S, Levy J: Podocytic cytoskeletal disaggregation and basement-membrane detachment in puromycin aminonucleoside nephrosis Am J Pathol 1993, 142:1641-1653
41. Fox JEB: Transmembrane signaling across the platelet integrin glycoprotein IIb-IIIa. Ann NY Acad Sci 1994, 714:75-87
42. Kriz W, Elger M, Mundel P, Lemley KV: Structure-stabilizing forces in the glomerular tuft. Am J Nephrol 1995, 5:1731-1739
43. Blantz RC, Wilson B: Acute effect of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat. J Clin Invest 1976, 58:899-911
44. Maddox DA, Bennet CM, Deen WM, Glassock RJ, Knutson D, Daugharty TM, Brenner BM: Determinants of glomerular filtration in experimental glomerulonephritis in the rat. J Clin Invest 1975, 55:305-318
45. Drumond MC, Kristal B, Myers BD, Deen WM: Structural basis for reduced glomerular filtration capacity in nephrotic humans J Clin Invest 1994, 94:1187-1195
46. Guasch A, Myers BD: Determinants of glomerular hypofiltration in nephrotic patients with minimal change nephropathy. J Am Soc Nephrol 1994, 4:1571-1581
47. Lemley KV, Elger M, Koeppen-Hagemann I, Kretzler M, Nagata M, Sakai T, Uiker S, Kriz W: The glomerular mesangium: capillary support function and its failure under experimental conditions. Clin Invest 1992, 70: 843-856