CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system

Journal of Infectious Diseases

Volumn 211, Issue 1, 2015, Pages 40-44

  Marcondes, Maria Cecilia G ^a   Morsey, Brenda ^b   Emanuel, Katy ^b   Lamberty, Benjamin G ^b   Flynn, Claudia T ^a   Fox, Howard S ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

brain; CD8; cerebrospinal; HIV; immune.; SIV

Indexed keywords

CD163 ANTIGEN; GAMMA INTERFERON; GRANZYME B; HLA DR ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFECTION; CD8+ T LYMPHOCYTE; CEREBELLUM; CERVICAL LYMPH NODE; CONTROLLED STUDY; EFFECTOR CELL; FRONTAL LOBE; HIPPOCAMPUS; INGUINAL LYMPH NODE; LYMPHOCYTE COUNT; MACROPHAGE; MEMORY T LYMPHOCYTE; MICROGLIA; NATURAL KILLER CELL; NONHUMAN; OCCIPITAL LOBE; RHESUS MONKEY; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; VIRUS LOAD; ANIMAL; BRAIN; CEREBROSPINAL FLUID; IMMUNOLOGY; SIMIAN IMMUNODEFICIENCY VIRUS; VIROLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN; CD8-POSITIVE T-LYMPHOCYTES; MACACA MULATTA; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 84922434257     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu401     Document Type: Article

References (15)

1. Spudich S, Gisslen M, Hagberg L, et al. Central nervous system immune activation characterizes primary human immunodeficiency virus 1 infection even in participants with minimal cerebrospinal fluid viral burden. J Infect Dis 2011; 204:753-60.
2. Marcondes MC, Burudi EM, Huitron-Resendiz S, et al. Highly activated CD8(+) T cells in the brain correlate with early central nervous system dysfunction in simian immunodeficiency virus infection. J Immunol 2001; 167:5429-38.
3. Petito CK, Torres-Munoz JE, Zielger F, McCarthy M. Brain CD8+ and cytotoxic T lymphocytes are associated with, and may be specific for, human immunodeficiency virus type 1 encephalitis in patients with acquired immunodeficiency syndrome. J Neurovirol 2006; 12:272-83.
4. Clingerman KJ, Spray S, Flynn C, Fox HS. A technique for intracisternal collection and administration in a rhesus macaque. Lab Anim (NY) 2010; 39:307-11.
5. Fox HS, Weed MR, Huitron-Resendiz S, et al. Antiviral treatment normalizes neurophysiological but not movement abnormalities in simian immunodeficiency virus-infected monkeys. J Clin Invest 2000; 106:37-45.
6. Marcondes MC, Burdo TH, Sopper S, et al. Enrichment and persistence of virus-specific CTL in the brain of simian immunodeficiency virusinfected monkeys is associated with a unique cytokine environment. J Immunol 2007; 178:5812-9.
7. von Herrath M, Oldstone MB, Fox HS. Simian immunodeficiency virus (SIV)-specific CTL in cerebrospinal fluid and brains of SIV-infected rhesus macaques. J Immunol 1995; 154:5582-9.
8. Jin X, Bauer DE, Tuttleton SE, et al. Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virusinfected macaques. J Exp Med 1999; 189:991-8.
9. Schmitz JE, Kuroda MJ, Santra S, et al. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 1999; 283:857-60.
10. Chauhan NB, Siegel GJ, Lichtor T. Distribution of intraventricularly administered antiamyloid-beta peptide (Abeta) antibody in the mouse brain. J Neurosci Res 2001; 66:231-5.
11. Roberts ES, Masliah E, Fox HS. CD163 identifies a unique population of ramified microglia in HIV encephalitis (HIVE). J Neuropathol Exp Neurol 2004; 63:1255-64.
12. Joag SV, Adams RJ, Pinson DM, Adany I, Narayan O. Intracerebral infusion of TNF-alpha and IL-6 failed to activate latent SIV infection in the brains of macaques inoculated with macrophage-tropic neuroadapted SIVmac. J Leukoc Biol 1994; 56:353-7.
13. Roberts ES, Zandonatti MA, Watry DD, et al. Induction of pathogenic sets of genes in macrophages and neurons in NeuroAIDS. Am J Pathol 2003; 162:2041-57.
14. Williams K, Westmoreland S, Greco J, et al. Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS. J Clin Invest 2005; 115:2534-45.
15. Heaton RK, Clifford DB, Franklin DR Jr., et al. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology 2010; 75:2087-96.