STAT3 inhibitor NSC74859 radiosensitizes esophageal cancer via the downregulation of HIF-1α

Tumor Biology

Volumn 35, Issue 10, 2014, Pages 9793-9799

  Zhang, Chi ^a   Yang, Xi ^a   Zhang, Qu ^b   Guo, Qing ^c   He, Jia ^d   Qin, Qin ^a   Zhu, Hongcheng ^a   Liu, Jia ^a   Zhan, Liangliang ^a   Lu, Jing ^a   Liu, Zheming ^a   Xu, Liping ^a   Ma, Jianxin ^b   Dai, Shengbin ^c   Cheng, Hongyan ^a   Sun, Xinchen ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b The Second People s Hospital of Lianyungang   (China)

^c TAIZHOU PEOPLE S HOSPITAL   (China)

^d JIANGYIN PEOPLE S HOSPITAL   (China)

Author keywords

Esophageal squamous cell carcinoma; HIF 1 ; NSC74859; Radiotherapy; STAT3

Indexed keywords

4 [[(4 METHYLPHENYL)SULFONYLOXY]ACETAMIDO]SALICYLIC ACID; AMINOSALICYLIC ACID DERIVATIVE; BENZENESULFONIC ACID DERIVATIVE; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; RADIOSENSITIZING AGENT; STAT3 PROTEIN;

ANIMAL; ANTAGONISTS AND INHIBITORS; DOWN REGULATION; DRUG EFFECTS; DRUG SCREENING; ESOPHAGUS TUMOR; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; NUDE MOUSE; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE; WESTERN BLOTTING;

AMINOSALICYLIC ACIDS; ANIMALS; BENZENESULFONATES; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DOWN-REGULATION; ESOPHAGEAL NEOPLASMS; FEMALE; FLOW CYTOMETRY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MICE; MICE, NUDE; RADIATION-SENSITIZING AGENTS; STAT3 TRANSCRIPTION FACTOR; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84922393500     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1007/s13277-014-2207-3     Document Type: Article

References (21)

1. Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci. 2012;33:207–14.
2. Moeller BJDM, Dewhirst MW. HIF-1 and tumour radiosensitivity. Br J Cancer. 2006;95:1–5.
3. Albini ATF, Li VW, Noonan DM, et al. Cancer prevention by targeting angiogenesis. Nat Rev Clin Oncol. 2012;9:498–509.
4. Zhu GH, Huang C, Feng ZZ, Lv XH, Qiu ZJ. Hypoxia-induced snail expression through transcriptional regulation by HIF-1α in pancreatic cancer cells. Dig Dis Sci. 2013;58:3503–15.
5. Niu GBJ, Deng J, Ma Y, et al. Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells. Mol Cancer Res. 2008;6:1099–105.
6. Jung JELH, Cho IH, Chung DH, et al. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB J. 2005;19:1296–8.
7. Lin LHB, Li PK, Ball S, et al. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. Neoplasia. 2010;12:39–50.
8. Wei C, Xuning S, Xuefeng X, et al. NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma. Liver Int. 2012;32(1):70–77.
9. Zhang X, Yue P, Fletcher S, et al. A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes. Biochem Pharmacol. 2010;79(10):1398–409. 15.
10. Siddiquee KZS, Guida WC, Blaskovich MA, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening induces antitumor activity. Proc Natl Acad Sci USA. 2007;104(18):7391–6.
11. Lin L. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling. Oncogene. 2009;28(7):961–72.
12. Dal MM. Hypoxia effects on proangiogenic factors in human umbilical vein endothelial cells: functional role of the peptide somatostatin. Naunyn Schmiedebergs Arch Pharmacol. 2011;383(6):593–612.
13. Yang X, Yang B, Cai J, et al. Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo. Cancer Biol Ther. 2013;14(11):1068–73.
14. Zhang C, Yang X, Zhang Q, et al. Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression. Acta Otolaryngol. 2014;134(2):185–92.
15. Zhang Q, Zhang C, Yang X, et al. Berberine inhibits the expression of hypoxia induction factor-1alpha and increases the radiosensitivity of prostate cancer. Diagn Pathol. 2014;9(1):98. 27.
16. Real PJ, Sierra A, De Juan A, et al. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene. 2002;21:7611–8.
17. Wang T, Niu G, Kortylewski M, et al. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med. 2004;10:48–54.
18. Timme S, Ihde S, Fichter CD, et al. STAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and Barrett's adenocarcinomas. Oncogene. 2013. doi:10.1038/onc.2013.298.
19. You ZXD, Ji J, et al. JAK/STAT signal pathway activation promotes progression and survival of human oesophageal squamous cell carcinoma. Clin Transl Oncol. 2012;14(2):143–9.
20. Pan Y, Zhou F, Zhang R, et al. Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma. PLoS ONE. 2013;8(1):e54565.
21. Adachi M, Cui C, Dodge CT, et al. Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma. Oral Oncol. 2012;48:1220–6.