Butyrylcholinesterase: K variant, plasma activity, molecular forms and rivastigmine treatment in Alzheimer's disease in a Southern Brazilian population

Neurochemistry International

Volumn 81, Issue , 2015, Pages 57-62

  Bono, G F ^a   Simao Silva D P ^a   Batistela, M S ^a   Josviak, N D ^a   Dias, P F R ^a   Nascimento, G A ^a   Souza, R L R ^a   Piovezan, M R ^a   Souza, R K M ^b   Furtado Alle, L ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b Neurological Institute of Curitiba   (Brazil)

Author keywords

Alzheimer's disease; BChE molecular forms; BChE K; Butyrylcholinesterase; CHE2 locus

Indexed keywords

ALBUMIN; CHOLINESTERASE; DIMER; MEMANTINE; MONOMER; RIVASTIGMINE; TETRAMER; CHOLINESTERASE INHIBITOR;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BRAZILIAN; CASE CONTROL STUDY; CHOLINESTERASE BLOOD LEVEL; CLINICAL DEMENTIA RATING; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; FEEDBACK SYSTEM; FEMALE; GENE INTERACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NEUROPSYCHOLOGICAL TEST; PHENOTYPE; PRIORITY JOURNAL; BLOOD; BRAZIL; CHEMISTRY; ENZYMOLOGY;

ALZHEIMER DISEASE; BRAZIL; BUTYRYLCHOLINESTERASE; CASE-CONTROL STUDIES; CHOLINESTERASE INHIBITORS; DISEASE PROGRESSION; HUMANS; RIVASTIGMINE;

EID: 84922384358     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2014.12.009     Document Type: Article

References (66)

1. Altamirano C.V., Bartels C.F., and Lockridge O. The butyrylcholinesterase K-variant shows similar cellular protein turnover and quaternary interaction to the wild type enzyme J. Neurochem 74 2000 869 877
2. Alvarez-Arcaya A., Combarros O., and Llorca J. The butyrylcholinesterase K variant is a protective factor for sporadic Alzheimer's disease in women Acta Neurol. Scand 102 2000 350 353
3. Arendt T., Bruckner M., and Lange M. Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development - a study of molecular forms Neurochem. Int 21 1992 381 396
4. Arpagaus M., Kott M., and Vatsis K.P. Structure of the gene for human butyrylcholinesterase. Evidence for a single copy Biochemistry 29 1990 124 131
5. Bartels C.F., Jensen F.S., and Lockridge O. DNA mutation associated with the human butyrylcholinesterase K-variant and its linkage to the atypical variant mutation and other polymorphic sites Am. J. Hum. Genet 50 1992 1086 1103
6. Bertolucci P.H., Brucki S.M., and Campacci S.R. O mini-exame do estado mental em uma população geral: impacto da escolaridade Arq. Neuropsiquiatr 52 1994 1 7
7. Bizzarro A., Guglielmi V., and Lomastro R. BChE K variant is decreased in Alzheimer's disease not in fronto-temporal dementia J. Neural Transm 117 2010 377 383
8. Boberg D., Furtado-Alle L., and Souza R.L.R. Molecular forms of butyrylcholinesterase and obesity Genet. Mol. Biol 33 2010 452 454
9. Brimijoin S., and Hammond P. Butyrylcholinesterase in human brain and acetylcholinesterase in human plasma: trace enzymes measured by two-site immunoassay J. Neurochem 51 1988 1227 1231
10. Bullock R., Bergman H., and Touchon J. Effect of age on response to rivastigmine or donepezil in patients with Alzheimer's disease Curr. Med. Res. Opin 22 2006 483 494
11. Casey D.A., Antimisiaris D., and O'Brien J. Drugs for Alzheimer's disease: are they effective? P T 35 2010 208 211
12. Chatonnet A., and Lockridge O. Comparison of butyrylcholinesterase and acetylcholinesterase Biochem. J. 260 1989 625 634
13. Chautard-Freire-Maia E.A., Primo-Parmo S.L., and Picheth G. C5 isozyme of serum cholinesterase and adult weight Hum. Hered 41 1991 330 339
14. Clump Sham P.C., and Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci Ann. Hum. Genet 59 1995 97 105
15. Darreh-Shori T., and Soininen H. Effects of cholinesterase inhibitors on the activities and protein levels of cholinesterases in the cerebrospinal fluid of patients with Alzheimer's disease: a review of recent clinical studies Curr. Alzheimer Res 7 2010 67 73
16. Darreh-Shori T., Almkvist O., and Guan Z.Z. Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months Neurology 59 2002 563 572
17. Darvesh S., Cash M.K., and Reid G.A. Butyrylcholinesterase is associated with β-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease J. Neuropathol. Exp. Neurol 71 2011 2 14
18. Davies P., and Maloney A.J. Selective loss of central cholinergic neurons in Alzheimer's disease Lancet 2 1976 1403
19. Diamant S., Podoly E., and Friedler A. Butyrylcholinesterase attenuates amyloid fibril formation in vitro Proc. Natl. Acad. Sci. U.S.A. 103 2006 8628 8633
20. Dietz A.A., Rubinstein H.M., and Lubrano T. Improved method for the differentiation of cholinesterase variants Am. J. Genet 24 1972 58 64
21. Evans R.T., and Wroe J. Is serum cholinesterase activity a predictor of succinyl choline sensitivity? An assessment of four methods Clin. Chem 24 1978 1762 1766
22. Ferris S., Karantzoulis S., and Somogyi M. Rivastigmine in moderately severe-to-severe Alzheimer's disease: severe impairment battery factor analysis Alzheimers Res. Ther 5 2013 63
23. Folstein M.F., Folstein S.E., and McHugh P.R. Mini-Mental State: a practical method for grading the cognitive state of patients for clinician J. Psychiatr. Res 12 1975 189 198
24. Giacobini E. Cholinesterase inhibitors: from the Calabar bean to Alzheimer therapy Giacobini E. Cholinesterases and Cholinesterase Inhibitors 2000 Martin Dunitz London 181 226 LIVRO
25. Giacobini E., Spiegel R., and Enz A. Inhibition of acetyl- and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: correlation with cognitive benefit J. Neural Transm 109 2002 1053 1065
26. Gómez-Ramos P., and Morán M.A. Ultrastructural localization of butyrylcholinesterase in senile plaques in the brains of aged and Alzheimer disease patients Mol. Chem. Neuropathol 30 1997 161 173
27. Guillozet A.L., Smiley J.F., and Mash D.C. Butyrylcholinesterase in the life cycle of amyloid plaques Ann. Neurol 42 1997 909 918
28. Hall L.M.C., and Spierer P. The Ace locus of Drosophila melanogaster: structural gene for acetylcholinesterase with an unusual 5′ leader EMBO J. v 5 1986 2949 2954
29. Harris H., Hopkinson D.A., and Robson E.B. Two-dimensional electrophoresis of pseudocholinesterase components in human serum Nature 196 1962 1296 1298
30. Hughes C.P., Berg L., and Danziger W.L. A new clinical scale for the staging of dementia Br. J. Psychiatry 140 1982 566 572
31. Jann M.W., Shirley K.L., and Small G.W. Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors Clin. Pharmacokinet 41 2002 719 739
32. Johnson G., and Moore S.W. Why has butyrylcholinesterase been retained? Structural and functional diversification in a duplicated gene Neurochem. Int 61 2012 783 797
33. Ki C.S., Na D.L., and Kim J.W. No association between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late onset Alzheimer's disease Am. J. Med. Genet 88 1999 113 135
34. Ladner C.J., and Lee J.M. Pharmacological treatment of Alzheimer disease: the cholinergic hypothesis revisited J. Neuropathol. Exp. Neurol 57 1998 719 731
35. Lahiri D.K., and Nurnberger J.L. Jr. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies Nucleic Acids Res 19 1991 5444
36. Lampón N., Hermida-Cadahia E.F., and Riveiro A. Association between butyrylcholinesterase activity and low-grade systemic inflammation Ann. Hepatol 11 2012 356 363
37. Lehmann D.J., Johnston C., and Smith A.D. Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease Hum. Mol. Genet 6 1997 1933 1936
38. Li B., Stribley J.A., and Ticu A. Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse J. Neurochem 75 2000 1320 1331
39. Manoharan I., Boopathy R., and Darvesh S. A medial health report on individuals with silent butyrylcholinesterase in Vysya community of India Clin. Chim. Acta 378 2007 128 135
40. Masson P. Formes moleculaires multiples de la butyrylcholinesterase du plasma humain Biochim. Biophys. Acta 578 1979 493 504
41. McIlroy S.P., Crawford V.L., and Dynan K.B. Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland J. Med. Genet 37 2000 182 185
42. McKhann G.M., Knopman D.S., and Chertkow H. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging and Alzheimer's Association workgroup Alzheimers Dement 7 2011 263 269
43. Mesulam M.M., Guillozet A., Shaw P., Levey A., Duysen E.G., and Lockridge O. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyse acetylcholine Neuroscience 110 2002 627 639
44. Michaelis M.L. Drugs targeting Alzheimer's disease: some things old and some things new J. Pharmacol. Exp. Ther 304 2003 897 904
45. Morris J. The Clinical Dementia Rating (CDR): current version and scoring rules Neurology 43 1993 2412 2414
46. Ofek K., and Soreq H. Cholinergic involvement and manipulation approaches in multiple system disorders Chem. Biol. Interact 203 2013 113 119
47. Perry E., McKeith I., and Ballard C. Butyrylcholinesterase and progression of cognitive deficits in dementia with Lewy bodies Neurology 60 2003 1852 1853
48. Perry E.K., Perry R.H., and Blessed G. Changes in brain cholinesterases in senile dementia of Alzheimer type Neuropathol. Appl. Neurobiol 4 1978 273 277
49. Podoly E., Shalev D.E., and Shenhar-Tsarfaty S. The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology J. Biol. Chem 284 2009 17170 17179
50. Podoly E., Hanin G., and Soreq H. Alanine-to-threonine substitutions and amyloid diseases: butyrylcholinesterase as a case study Chem. Biol. Interact 187 2010 64 71
51. Pohanka M. Cholinesterases, a target of pharmacology and toxicology Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech. Repub 155 2011 219 230
52. Pritchard D., Brown A., and Toutant J.-P. The molecular forms of acetylcholinesterase from Neceuor americanus (Nematoda), a hookworm parasite of the human intestine Eur. J. Biochem 219 1994 317 323
53. Qaseem A., Snow V., and Cross J.T. Jr. Current pharmacologic treatment of Dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians Ann. Intern. Med 148 2008 370 378
54. Raygani A.V., Zahrai M., and Soltanzadeh A. Analysis of association between Butyrylcholinesterase K variant and apolipoprotein E genotypes in Alzheimer's disease Neurosci. Lett 371 2004 142 146
55. Roberson M., and Harrell L.E. Cholinergic activity and amyloid precursor protein metabolism Brain Res. Rev 25 1997 50 69
56. Rubinstein H.M., Dietz A.A., and Lubrano T. Ek1 another quantitative variant at cholinesterase locus 1 J. Med. Genet 15 1978 27 29
57. Silva I.M.W., Leite N., and Boberg D. Effects of physical exercise on butyrylcholinesterase in obese adolescents Genet. Mol. Biol 35 2012 4
58. Silver A. The Biology of Cholinesterases 1974 Elsevier Agricultural Research Council Institute New York 426 447
59. Simão-Silva D.P., Bertolucci P.H., and Labio R.W. Association analysis between K and -116A variants of butyrylcholinesterase and Alzheimer's disease in a Brazilian population Chem. Biol. Interact 203 2013 358 360
60. Singleton A.B., Smith G., and Gibson A.M. No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer's disease Hum. Mol. Genet 7 1998 937 939
61. Souza R.L.R., Mikami L.R., and Maegawa R.O.B. Four new mutations in the BCHE gene of human butyrylcholinesterase in a Brazilian blood donor sample Mol. Genet. Metab 84 2005 349 353
62. Tilley L., Morgan K., and Grainger J. Evaluation of polymorphisms in the presenilin- 1 gene and the butyrylcholinesterase gene as risk factors in sporadic Alzheimer's disease Eur. J. Hum. Genet 7 1999 659 663
63. Toutant J.-P. Insect acetylcholinesterase: catalytic properties, tissue distribution and molecular forms Prog. Neurobiol 32 1989 423 446
64. Van Ros G., and Vervoot T. Frequencies of the "atypical" and C5 variants of serum cholinesterase in Zairians and Belgians. Detection of the C5 variant by agar gel electrophoresis with an acid buffer Ann. Soc. Belg. Med. Trop 53 1973 633 644
65. Wescoe W.C., Hunt C.H., and Riker W.F. Regeneration rates of serum cholinesterase in normal individuals and in patients with liver damage Am. J. Physiol 149 1947 549 551
66. Wiebusch H., Poirier J., and Sevigny P. Further evidence for a synergistic association between APOE ε4 and BCHE-K in confirmed Alzheimer's disease Hum. Genet 104 1999 158 163