Crystal structure of LGR4-Rspo1 complex: Insights into the divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors (LGRs)

Journal of Biological Chemistry

Volumn 290, Issue 4, 2015, Pages 2455-2465

  Xu, Jin Gen ^a   Huang, Chunfeng ^a   Yang, Zhengfeng ^b   Jin, Mengmeng ^a   Fu, Panhan ^a   Zhang, Ni ^a   Luo, Jian ^b   Li, Dali ^b   Liu, Mingyao ^b   Zhou, Yan ^a   Zhu, Yongqun ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; HYDROPHOBICITY; LIGANDS; PROTEINS; RECOMBINANT PROTEINS;

EXTRACELLULAR DOMAINS; G PROTEIN COUPLED RECEPTORS; HYDROPHOBIC INTERACTIONS; LEUCINE-RICH REPEATS; LIGAND RECOGNITION; MOLECULAR MECHANISM; MULTIPLE INTERFACES; TWO-STEP MECHANISMS;

CRYSTAL STRUCTURE;

G PROTEIN COUPLED RECEPTOR; GROWTH FACTOR; LEUCINE RICH REPEAT G PROTEIN COUPLED RECEPTOR 1; LEUCINE RICH REPEAT G PROTEIN COUPLED RECEPTOR 2; LEUCINE RICH REPEAT G PROTEIN COUPLED RECEPTOR 3; LEUCINE RICH REPEAT G PROTEIN COUPLED RECEPTOR 4; LEUCINE RICH REPEAT G PROTEIN COUPLED RECEPTOR 5; LEUCINE RICH REPEAT G PROTEIN COUPLED RECEPTOR 6; LEUCINE RICH REPEAT G PROTEIN COUPLED RECEPTOR 7; LEUCINE RICH REPEAT G PROTEIN COUPLED RECEPTOR 8; LGR4 RSPO1 COMPLEX; R SPONDIN 1; UNCLASSIFIED DRUG; LEUCINE; LGR4 PROTEIN, HUMAN; LIGAND; PROTEIN BINDING; RECOMBINANT PROTEIN; RSPO1 PROTEIN, HUMAN; THROMBOSPONDIN; WNT PROTEIN;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; LIGAND BINDING; MUTAGENESIS; OLIGOMERIZATION; PROTEIN STRUCTURE; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; CYTOLOGY; DRUG DESIGN; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; MOLECULAR GENETICS; PLASMID; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; STEM CELL; X RAY CRYSTALLOGRAPHY;

HAGFISH;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LEUCINE; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PLASMIDS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STEM CELLS; THROMBOSPONDINS; WNT PROTEINS;

EID: 84922380022     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.599134     Document Type: Article

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