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Volumn 11, Issue , 2015, Pages 171-188

Xerostomia induced by radiotherapy: An overview of the physiopathology, clinical evidence, and management of the oral damage

Author keywords

Management strategies; Radiation induced xerostomia; Salivary gland hypofunction

Indexed keywords

CHOLINERGIC RECEPTOR STIMULATING AGENT;

EID: 84922355968     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S70652     Document Type: Review
Times cited : (130)

References (70)
  • 1
    • 0032090264 scopus 로고    scopus 로고
    • A common problem among the elderly
    • Bivona PL. Xerostomia. A common problem among the elderly. N Y State Dent J. 1998;64:46-52
    • (1998) N Y State Dent J , vol.64 , pp. 46-52
    • Bivona, P.L.1
  • 2
    • 2142855158 scopus 로고    scopus 로고
    • Xerostomia: Clinical aspects and treatment
    • Cassolato SF, Turnbull RS. Xerostomia: clinical aspects and treatment. Gerodontology. 2003;20:64-77
    • (2003) Gerodontology , vol.20 , pp. 64-77
    • Cassolato, S.F.1    Turnbull, R.S.2
  • 4
    • 74949101063 scopus 로고    scopus 로고
    • Xerostomia and chronic oral complications among patients treated with haematopoietic stem cell transplantation
    • Brand HS, Bots CP, Raber-Durlacher E. Xerostomia and chronic oral complications among patients treated with haematopoietic stem cell transplantation. Br Dent J. 2009;207:E17
    • (2009) Br Dent J , vol.207 , pp. E17
    • Brand, H.S.1    Bots, C.P.2    Raber-Durlacher, E.3
  • 6
    • 80052246563 scopus 로고    scopus 로고
    • Risk factors and symptoms associated with xerostomia: A cross-sectional study
    • Villa A, Abati S. Risk factors and symptoms associated with xerostomia: a cross-sectional study. Aust Dent J. 2011;56:290-295
    • (2011) Aust Dent J , vol.56 , pp. 290-295
    • Villa, A.1    Abati, S.2
  • 10
    • 77956478456 scopus 로고    scopus 로고
    • Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO). A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Prevalence, severity and impact on quality of life
    • Jensen SB, Pedersen AM, Vissink A, et al; Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO). A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: prevalence, severity and impact on quality of life. Support Care Cancer. 2010;18: 1039-1060
    • (2010) Support Care Cancer , vol.18 , pp. 1039-1060
    • Jensen, S.B.1    Pedersen, A.M.2    Vissink, A.3
  • 11
    • 0023426021 scopus 로고
    • Subjective reports of xerostomia and objective measures of salivary gland performance
    • Fox PC, Bunch KA, Baum BJ. Subjective reports of xerostomia and objective measures of salivary gland performance. J Am Dent Assoc. 1987;115:581-584
    • (1987) J am Dent Assoc , vol.115 , pp. 581-584
    • Fox, P.C.1    Bunch, K.A.2    Baum, B.J.3
  • 13
    • 0032889741 scopus 로고    scopus 로고
    • A prospective study on quality of life of patients with cancer of the oral cavity or oropharynx treated with surgery with or without radiotherapy
    • De Graeff A, De Leeuw JR, Ros WJ, Hordijk GJ, Blijham GH, Winnubst JA. A prospective study on quality of life of patients with cancer of the oral cavity or oropharynx treated with surgery with or without radiotherapy. Oral Oncol. 1999;35:27-32
    • (1999) Oral Oncol , vol.35 , pp. 27-32
    • De Graeff, A.1    De Leeuw, J.R.2    Ros, W.J.3    Hordijk, G.J.4    Blijham, G.H.5    Winnubst, J.A.6
  • 15
    • 84964927386 scopus 로고    scopus 로고
    • Globocan.iarc.fr [homepage on the Internet], [updated January 9, 2014]. Available from, Accessed May 1, 2014
    • Globocan.iarc.fr [homepage on the Internet]. Lyon; International Agency for Research on Cancer; World Health Organization; 2012 [updated January 9, 2014]. Available from: http://globocan.iarc.fr/Default.aspx. Accessed May 1, 2014
    • (2012) Lyon; International Agency for Research on Cancer; World Health Organization
  • 16
    • 0026003216 scopus 로고
    • Salivary Gland Hypofunction/ Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO). Acute mucositis in the stimulated oral mucosa of patients during radiotherapy for head and neck cancer
    • Maciejewski B, Zajusz A, Pilecki B, et al; Salivary Gland Hypofunction/ Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO). Acute mucositis in the stimulated oral mucosa of patients during radiotherapy for head and neck cancer. Radiother Oncol. 1991;22:7-11
    • (1991) Radiother Oncol , vol.22 , pp. 7-11
    • Maciejewski, B.1    Zajusz, A.2    Pilecki, B.3
  • 18
    • 0034198642 scopus 로고    scopus 로고
    • Saliva in health and disease: An appraisal and update
    • Sreebny LM. Saliva in health and disease: an appraisal and update. Int Dent J. 2000;50:140-161
    • (2000) Int Dent J , vol.50 , pp. 140-161
    • Sreebny, L.M.1
  • 19
    • 0025994429 scopus 로고
    • Acute irradiation effects on morphology and function of rat submandibular glands
    • Vissink A, Kalicharan D, S-Gravenmade EJ, et al. Acute irradiation effects on morphology and function of rat submandibular glands. J Oral Pathol Med. 1991;20:449-456
    • (1991) J Oral Pathol Med , vol.20 , pp. 449-456
    • Vissink, A.1    Kalicharan, D.2    S-Gravenmade, E.J.3
  • 21
    • 0035052119 scopus 로고    scopus 로고
    • Quality of life and oral function in patients treated with radiation therapy for head and neck cancer
    • Epstein JB, Robertson M, Emerton S, Phillips N, Stevenson-Moore P. Quality of life and oral function in patients treated with radiation therapy for head and neck cancer. Head Neck. 2001;23:389-398
    • (2001) Head Neck , vol.23 , pp. 389-398
    • Epstein, J.B.1    Robertson, M.2    Emerton, S.3    Phillips, N.4    Stevenson-Moore, P.5
  • 22
    • 0026568666 scopus 로고
    • Parotid gland function during and following radiotherapy of malignancies in the head and neck. A consecutive study of salivary flow and patient discomfort
    • Franzén L, Funegård U, Ericson T, Henriksson R. Parotid gland function during and following radiotherapy of malignancies in the head and neck. A consecutive study of salivary flow and patient discomfort. Eur J Cancer. 1992;28:457-462
    • (1992) Eur J Cancer , vol.28 , pp. 457-462
    • Franzén, L.1    Funegård, U.2    Ericson, T.3    Henriksson, R.4
  • 25
    • 0017144208 scopus 로고
    • Radiation-induced xerostomia in cancer patients. Effect on salivary and serum electrolytes
    • Dreizen S, Brown LR, Handler S, Levy BM. Radiation-induced xerostomia in cancer patients. Effect on salivary and serum electrolytes. Cancer. 1976;38:273-278
    • (1976) Cancer , vol.38 , pp. 273-278
    • Dreizen, S.1    Brown, L.R.2    Handler, S.3    Levy, B.M.4
  • 27
  • 28
    • 0019614467 scopus 로고
    • The effect of saliva on plaque pH in vivo
    • Abelson DC, Mandel ID. The effect of saliva on plaque pH in vivo. J Dent Res. 1981;60:1634-1638
    • (1981) J Dent Res , vol.60 , pp. 1634-1638
    • Abelson, D.C.1    Mandel, I.D.2
  • 29
    • 0027767219 scopus 로고
    • Plaque pH and oral retention after consumption of starchy snack products at normal and low salivary secretion rate
    • Lingström P, Birkhed D. Plaque pH and oral retention after consumption of starchy snack products at normal and low salivary secretion rate. Acta Odontol Scand. 1993;51:379-388
    • (1993) Acta Odontol Scand , vol.51 , pp. 379-388
    • Lingström, P.1    Birkhed, D.2
  • 30
    • 33845458722 scopus 로고    scopus 로고
    • Minor salivary gland secretion rates and immunoglobulin A in adults and the elderly
    • Eliasson L, Birkhed D, Osterberg T, Carlén A. Minor salivary gland secretion rates and immunoglobulin A in adults and the elderly. Eur J Oral Sci. 2006;114:494-499
    • (2006) Eur J Oral Sci , vol.114 , pp. 494-499
    • Eliasson, L.1    Birkhed, D.2    Osterberg, T.3    Carlén, A.4
  • 31
    • 0033278029 scopus 로고    scopus 로고
    • Oral microflora in subjects with reduced salivary secretion
    • Almståhl A, Wikström M. Oral microflora in subjects with reduced salivary secretion. J Dent Res. 1998;78:1410-1416
    • (1998) J Dent Res , vol.78 , pp. 1410-1416
    • Almståhl, A.1    Wikström, M.2
  • 32
    • 0027464910 scopus 로고
    • Use of pilocarpine during head and neck radiation therapy to reduce xerostomia and salivary dysfunction
    • Valdez IH, Wolff A, Atkinson JC, Macynski AA, Fox PC. Use of pilocarpine during head and neck radiation therapy to reduce xerostomia and salivary dysfunction. Cancer. 1993;71:1848-1851
    • (1993) Cancer , vol.71 , pp. 1848-1851
    • Valdez, I.H.1    Wolff, A.2    Atkinson, J.C.3    Macynski, A.A.4    Fox, P.C.5
  • 33
    • 0022772520 scopus 로고
    • Changes in the protein composition of whole saliva during radiotherapy in patients with oral or pharyngeal cancer
    • Makkonen TA, Tenovuo J, Vilja P, Heimdahl A. Changes in the protein composition of whole saliva during radiotherapy in patients with oral or pharyngeal cancer. Oral Surg Oral Med Oral Pathol. 1986;62:270-275
    • (1986) Oral Surg Oral Med Oral Pathol , vol.62 , pp. 270-275
    • Makkonen, T.A.1    Tenovuo, J.2    Vilja, P.3    Heimdahl, A.4
  • 34
  • 35
    • 0016712073 scopus 로고
    • Effect of radiation induced xerostomia on human oral microflora
    • Brown LR, Dreizen S, Handler S, Johnston DA. Effect of radiation induced xerostomia on human oral microflora. J Dent Res. 1974; 54(4):740-750
    • (1974) J Dent Res , vol.54 , Issue.4 , pp. 740-750
    • Brown, L.R.1    Dreizen, S.2    Handler, S.3    Johnston, D.A.4
  • 36
    • 0019833423 scopus 로고
    • Dental caries and Streptococcus mutans prevalence in cancer patients with irradiation-induced xerostomia: 1-13 years after radiotherapy
    • Keene HJ, Daly T, Brown LR, et al. Dental caries and Streptococcus mutans prevalence in cancer patients with irradiation-induced xerostomia: 1-13 years after radiotherapy. Caries Res. 1981;15: 416-427
    • (1981) Caries Res , vol.15 , pp. 416-427
    • Keene, H.J.1    Daly, T.2    Brown, L.R.3
  • 37
    • 0024149271 scopus 로고
    • Salivary glucose clearance, dry mouth and pH changes in dental plaque in man
    • Hase JC, Birkhed D. Salivary glucose clearance, dry mouth and pH changes in dental plaque in man. Arch Oral Biol. 1988;33: 875-880
    • (1988) Arch Oral Biol , vol.33 , pp. 875-880
    • Hase, J.C.1    Birkhed, D.2
  • 38
    • 0031637406 scopus 로고    scopus 로고
    • Caries and periodontal conditions in patients with primary Sjögren’s syndrome
    • Ravald N, List T. Caries and periodontal conditions in patients with primary Sjögren’s syndrome. Swed Dent J. 1998;22(3):97-103
    • (1998) Swed Dent J , vol.22 , Issue.3 , pp. 97-103
    • Ravald, N.1    List, T.2
  • 39
    • 0035166268 scopus 로고    scopus 로고
    • Lactoferrin, amylase and mucin MUC5B and their relation to the oral microflora in hyposalivation of different origins
    • Almståhl A, Wikström M, Groenink J. Lactoferrin, amylase and mucin MUC5B and their relation to the oral microflora in hyposalivation of different origins. Oral Microbiol Immunol. 2001;16:345-352
    • (2001) Oral Microbiol Immunol , vol.16 , pp. 345-352
    • Almståhl, A.1    Wikström, M.2    Groenink, J.3
  • 40
    • 77649236714 scopus 로고    scopus 로고
    • Lactobacillus species in supragingival plaque in subjects with hyposalivation
    • Almståhl A, Carlén A, Eliasson L, Lingström P. Lactobacillus species in supragingival plaque in subjects with hyposalivation. Arch Oral Biol. 2010;55:255-259
    • (2010) Arch Oral Biol , vol.55 , pp. 255-259
    • Almståhl, A.1    Carlén, A.2    Eliasson, L.3    Lingström, P.4
  • 41
    • 84886442857 scopus 로고    scopus 로고
    • Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia
    • Radvansky LJ, Pace MB, Siddiqui A. Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia. Am J Health Syst Pharm. 2013;70:1025-1032
    • (2013) Am J Health Syst Pharm , vol.70 , pp. 1025-1032
    • Radvansky, L.J.1    Pace, M.B.2    Siddiqui, A.3
  • 42
    • 0036023212 scopus 로고    scopus 로고
    • Patients with head and neck cancer cured by radiation therapy: A survey of the dry mouth syndrome in long-term survivors
    • Wijers OB, Levendag PC, Braaksma MM, Boonzaaijer M, Visch LL, Schmitz PI. Patients with head and neck cancer cured by radiation therapy: a survey of the dry mouth syndrome in long-term survivors. Head Neck. 2002;24:737-747
    • (2002) Head Neck , vol.24 , pp. 737-747
    • Wijers, O.B.1    Levendag, P.C.2    Braaksma, M.M.3    Boonzaaijer, M.4    Visch, L.L.5    Schmitz, P.I.6
  • 43
    • 79960094407 scopus 로고    scopus 로고
    • Efficacy and toxicity of chemo-radiotherapy using intensity-modulated radiotherapy for unknown primary of head and neck
    • Sher DJ, Balboni TA, Haddad RI, et al. Efficacy and toxicity of chemo-radiotherapy using intensity-modulated radiotherapy for unknown primary of head and neck. Int J Radiat Oncol Biol Phys. 2011;80: 1405-1411
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , pp. 1405-1411
    • Sher, D.J.1    Balboni, T.A.2    Haddad, R.I.3
  • 44
    • 83955165992 scopus 로고    scopus 로고
    • Salivary gland tumors treated with adjuvant intensity-modulated radiotherapy with or with-out concurrent chemotherapy
    • Schoenfeld JD, Sher DJ, Norris CM Jr, et al. Salivary gland tumors treated with adjuvant intensity-modulated radiotherapy with or with-out concurrent chemotherapy. Int J Radiat Oncol Biol Phys. 2012; 82:308-314
    • (2012) Int J Radiat Oncol Biol Phys , vol.82 , pp. 308-314
    • Schoenfeld, J.D.1    Sher, D.J.2    Norris, C.M.3
  • 45
    • 0028418945 scopus 로고
    • Salivary gland dysfunction: Causes, symptoms, treatment
    • Atkinson JC, Wu AJ. Salivary gland dysfunction: causes, symptoms, treatment. J Am Dent Assoc. 1994;125:409-416
    • (1994) J am Dent Assoc , vol.125 , pp. 409-416
    • Atkinson, J.C.1    Wu, A.J.2
  • 46
    • 0032223662 scopus 로고    scopus 로고
    • Gustducin and its role in taste
    • Spielman AI. Gustducin and its role in taste. J Dent Res. 1998; 77:539-544
    • (1998) J Dent Res , vol.77 , pp. 539-544
    • Spielman, A.I.1
  • 47
    • 0036093227 scopus 로고    scopus 로고
    • Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion
    • Pedersen AM, Bardow A, Jensen SB, Nauntofte B. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Dis. 2002;8:117-129
    • (2002) Oral Dis , vol.8 , pp. 117-129
    • Pedersen, A.M.1    Bardow, A.2    Jensen, S.B.3    Nauntofte, B.4
  • 49
    • 0016175640 scopus 로고
    • Oral monilia study on patients with head and neck cancer during radiotherapy
    • Chen TY, Webster JH. Oral monilia study on patients with head and neck cancer during radiotherapy. Cancer. 1974;34:246-249
    • (1974) Cancer , vol.34 , pp. 246-249
    • Chen, T.Y.1    Webster, J.H.2
  • 50
    • 0024051789 scopus 로고
    • Oral candidosis: 1. Clinicopathological aspects
    • 230-231
    • Samaranayake LP, Lamey PJ. Oral candidosis: 1. Clinicopathological aspects. Dent Update. 1988;15(6):227-228; 230-231
    • (1988) Dent Update , vol.15 , Issue.6 , pp. 227-228
    • Samaranayake, L.P.1    Lamey, P.J.2
  • 52
    • 79952201695 scopus 로고    scopus 로고
    • Pilocarpine used to treat xerostomia in patients submitted to radioactive iodine therapy: A pilot study
    • Almeida JP, Kowalski LP. Pilocarpine used to treat xerostomia in patients submitted to radioactive iodine therapy: a pilot study. Braz J Otorhinolaryngol. 2010;76(5):659-662
    • (2010) Braz J Otorhinolaryngol , vol.76 , Issue.5 , pp. 659-662
    • Almeida, J.P.1    Kowalski, L.P.2
  • 53
    • 1542572645 scopus 로고    scopus 로고
    • Salivary flow and its relationship to oral signs and symptoms in patients with dry eyes
    • Koseki M, Maki Y, Matsukubo T, Ohashi Y, Tsubota K. Salivary flow and its relationship to oral signs and symptoms in patients with dry eyes. Oral Dis. 2004;10(2):75-80
    • (2004) Oral Dis , vol.10 , Issue.2 , pp. 75-80
    • Koseki, M.1    Maki, Y.2    Matsukubo, T.3    Ohashi, Y.4    Tsubota, K.5
  • 54
    • 78049324076 scopus 로고    scopus 로고
    • Efficacy and safety of orally administered pilocarpine hydrochloride for patients with juvenile-onset Sjögren’s syndrome
    • Tomiita M, Takei S, Kuwada N, et al. Efficacy and safety of orally administered pilocarpine hydrochloride for patients with juvenile-onset Sjögren’s syndrome. Mod Rheumatol. 2010;20(5):486-490
    • (2010) Mod Rheumatol , vol.20 , Issue.5 , pp. 486-490
    • Tomiita, M.1    Takei, S.2    Kuwada, N.3
  • 55
    • 77955007144 scopus 로고    scopus 로고
    • Treatment of primary Sjögren syndrome: A systematic review
    • Ramos-Casals M, Tzioufas AG, Stone JH, Sisó A, Bosch X. Treatment of primary Sjögren syndrome: a systematic review. JAMA. 2010;304(4):452-460
    • (2010) JAMA , vol.304 , Issue.4 , pp. 452-460
    • Ramos-Casals, M.1    Tzioufas, A.G.2    Stone, J.H.3    Sisó, A.4    Bosch, X.5
  • 56
    • 1942452258 scopus 로고    scopus 로고
    • Pilocarpine toxicity and the treatment of xerostomia
    • Hendrickson RG, Morocco AP, Greenberg MI. Pilocarpine toxicity and the treatment of xerostomia. J Emerg Med. 2004;26(4):429-432
    • (2004) J Emerg Med , vol.26 , Issue.4 , pp. 429-432
    • Hendrickson, R.G.1    Morocco, A.P.2    Greenberg, M.I.3
  • 57
    • 36248957651 scopus 로고    scopus 로고
    • Open-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomia
    • Chambers MS, Jones CU, Biel MA, et al. Open-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomia. Int J Radiat Oncol Biol Phys. 2007;69(5):1369-1376
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , Issue.5 , pp. 1369-1376
    • Chambers, M.S.1    Jones, C.U.2    Biel, M.A.3
  • 58
    • 34447332530 scopus 로고    scopus 로고
    • Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer
    • Chambers MS, Posner M, Jones CU, et al. Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer. Int J Radiat Oncol Biol Phys. 2007;68(4):1102-1109
    • (2007) Int J Radiat Oncol Biol Phys , vol.68 , Issue.4 , pp. 1102-1109
    • Chambers, M.S.1    Posner, M.2    Jones, C.U.3
  • 59
    • 0033499340 scopus 로고    scopus 로고
    • Treatment of xerostomia with the bile secretion-stimulant drug anethole trithione: A clinical trial
    • Hamada T, Nakane T, Kimura T, et al. Treatment of xerostomia with the bile secretion-stimulant drug anethole trithione: a clinical trial. Am J Med Sci. 1999;318:146-151
    • (1999) Am J Med Sci , vol.318 , pp. 146-151
    • Hamada, T.1    Nakane, T.2    Kimura, T.3
  • 60
    • 0030872983 scopus 로고    scopus 로고
    • A comparative study of the effects of yohimbine and anetholtrithione on salivary secretion in depressed patients treated with psychotropic drugs
    • Bagheri H, Schmitt L, Berlan M, Montastruc JL. A comparative study of the effects of yohimbine and anetholtrithione on salivary secretion in depressed patients treated with psychotropic drugs. Eur J Clin Pharmacol. 1997;52:339-342
    • (1997) Eur J Clin Pharmacol , vol.52 , pp. 339-342
    • Bagheri, H.1    Schmitt, L.2    Berlan, M.3    Montastruc, J.L.4
  • 61
    • 84906929868 scopus 로고    scopus 로고
    • Clinical management and review of Sjögren’s syndrome
    • Dyke S. Clinical management and review of Sjögren’s syndrome. Int J Pharm Compd. 2000;4:338-341
    • (2000) Int J Pharm Compd , vol.4 , pp. 338-341
    • Dyke, S.1
  • 62
    • 0035370170 scopus 로고    scopus 로고
    • Acupuncture for pilocarpine-resistant xerostomia following radio-therapy for head and neck malignancies
    • Johnstone PA, Peng YP, May BC, Inouye WS, Niemtzow RC. Acupuncture for pilocarpine-resistant xerostomia following radio-therapy for head and neck malignancies. Int J Radiat Oncol Biol Phys. 2001;50:353-357
    • (2001) Int J Radiat Oncol Biol Phys , vol.50 , pp. 353-357
    • Johnstone, P.A.1    Peng, Y.P.2    May, B.C.3    Inouye, W.S.4    Niemtzow, R.C.5
  • 63
    • 58149095587 scopus 로고    scopus 로고
    • Acupuncture as an evidence-based option for symptom control in cancer patients
    • Sagar SM. Acupuncture as an evidence-based option for symptom control in cancer patients. Curr Treat Options Oncol. 2008;9:117-126
    • (2008) Curr Treat Options Oncol , vol.9 , pp. 117-126
    • Sagar, S.M.1
  • 64
    • 20044366946 scopus 로고    scopus 로고
    • Acupuncture in xerostomia a systematic review
    • Jedel E. Acupuncture in xerostomia a systematic review. J Oral Rehabil. 2005;32:392-396
    • (2005) J Oral Rehabil , vol.32 , pp. 392-396
    • Jedel, E.1
  • 65
    • 84755161651 scopus 로고    scopus 로고
    • A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: Management strategies and economic impact
    • Jensen SB, Pedersen AM, Vissink A, et al. A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact. Support Care Cancer. 2010;18(8):1061-1079
    • (2010) Support Care Cancer , vol.18 , Issue.8 , pp. 1061-1079
    • Jensen, S.B.1    Pedersen, A.M.2    Vissink, A.3
  • 66
    • 79551604253 scopus 로고    scopus 로고
    • Clinical effectiveness and safety of acupuncture in the treatment of irradiation-induced xerostomia in patients with head and neck cancer: A systematic review
    • O’Sullivan EM, Higginson IJ. Clinical effectiveness and safety of acupuncture in the treatment of irradiation-induced xerostomia in patients with head and neck cancer: a systematic review. Acupunct Med. 2010;28:191-199
    • (2010) Acupunct Med , vol.28 , pp. 191-199
    • O’Sullivan, E.M.1    Higginson, I.J.2
  • 67
    • 84876569326 scopus 로고    scopus 로고
    • The preventive and therapeutic effect of acupuncture for radiation-induced xerostomia in patients with head and neck cancer: A systematic review
    • Zhuang L, Yang Z, Zeng X, et al. The preventive and therapeutic effect of acupuncture for radiation-induced xerostomia in patients with head and neck cancer: a systematic review. Integr Cancer Ther. 2013;12: 197-205
    • (2013) Integr Cancer Ther , vol.12 , pp. 197-205
    • Zhuang, L.1    Yang, Z.2    Zeng, X.3
  • 68
    • 0036729046 scopus 로고    scopus 로고
    • The impact of saliva on patient care: A literature review
    • Diaz-Arnold AM, Marek CA. The impact of saliva on patient care: a literature review. J Prosthet Dent. 2002;88:337-343
    • (2002) J Prosthet Dent , vol.88 , pp. 337-343
    • Diaz-Arnold, A.M.1    Marek, C.A.2
  • 69
    • 17844372724 scopus 로고    scopus 로고
    • Different saliva substitutes for treatment of xerostomia following radiotherapy. A prospective crossover study
    • Momm F, Volegova-Neher NJ, Schulte-Monting J, Guttenberger R. Different saliva substitutes for treatment of xerostomia following radiotherapy. A prospective crossover study. Strahlenther Onkol. 2005;181:231-236
    • (2005) Strahlenther Onkol , vol.181 , pp. 231-236
    • Momm, F.1    Volegova-Neher, N.J.2    Schulte-Monting, J.3    Guttenberger, R.4
  • 70
    • 0032542854 scopus 로고    scopus 로고
    • Clinically proved treatments for xerostomia were ignored
    • Davies A. Clinically proved treatments for xerostomia were ignored. BMJ. 1998;316:1247
    • (1998) BMJ , vol.316 , pp. 1247
    • Davies, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.