Anti-inflammatory, antiangiogenic, and apoptosis-inducing activity of DLBS1442, a bioactive fraction of phaleria macrocarpa, in a RL95-2 cell line as a molecular model of endometriosis

International Journal of Women's Health

Volumn 7, Issue , 2015, Pages 161-169

  Tandrasasmita, Olivia M ^a   Sutanto, Adeline M ^a   Arifin, Poppy F ^a   Tjandrawinata, Raymond R ^a  

^a Dexa Medica Group   (Indonesia)

Author keywords

Anti inflammatory; Eicosanoid pathway; Estrogen receptor; Progesterone receptor

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIINFLAMMATORY AGENT; APOPTOSIS INDUCING FACTOR; CASPASE 8; DLBS 1442; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR BETA; ICOSANOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; PLANT MEDICINAL PRODUCT; PROCASPASE 9; PROGESTERONE RECEPTOR; PROGESTERONE RECEPTOR B; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG POTENCY; ENDOMETRIOSIS; ENDOMETRIUM CELL; ENZYME INHIBITION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MARKER GENE; MEDICINAL PLANT; MIGRATION INHIBITION; MOLECULAR MODEL; PHALERIA MACROCARPA; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; RL95 2 CELL LINE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 84922342256     PISSN: None     EISSN: 11791411     Source Type: Journal    
DOI: 10.2147/IJWH.S74552     Document Type: Article

References (28)

1. Bulun SE. Endometriosis. N Engl J Med. 2009;360:268-279.
2. Gupta S, Goldberg JM, Aziz N, Goldberg E, Krajcir N, Agarwal A. Pathogenic mechanisms in endometriosis-associated infertility. Fertil Steril. 2008;90:247-257.
3. Tandrasasmita OM, Lee JS, Baek SH, Tjandrawinata RR. Induction of cellular apoptosis in human breast cancer by DLBS1425, a Phaleria macrocarpa compound extract, via downregulation of P13-kinase/AKT pathway. Cancer Biol Ther. 2010;10:814-823.
4. Tjandrawinata RR, Arifin PF, Tandrasasmita OM, Rahmi D, Aripin A. DLBS1425, a Phaleria macrocarpa (Scheff.) Boerl. extract confers anti proliferative and proapoptosis effects via eicosanoid pathway. J Exp Ther Oncol. 2010;8:187-201.
5. Tjandrawinata RR, Nofiarny D, Susanto LW, Hendri P, Clarissa C. Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea with DLBS1442, a bioactive extract of Phaleria macrocarpa. Int J Gen Med. 2011;4:465-476.
6. Rocha AL, Reis FM, Taylor RN. Angiogenesis and endometriosis. Obstet Gynecol Int. 2013;2013:859619.
7. Banu SK, Lee J, Speights VO Jr, Starzinski-Powitz A, Arosh JA. Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms. J Endocrinol. 2008;149:1180-1189.
8. Takenaka Y, Taniguchi F, Miyakoda H, Takai E, Terakawa N, Harada T. Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression. Fertil Steril. 2010;93:325-327.
9. Machado DE, Berardo PT, Landgraf RG, et al. A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an anti-angiogenic effect in a rat model. Fertil Steril. 2010;93:2674-2679.
10. Ota H, Igarashi S, Sasaki M, Tanaka T. Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis. Hum Reprod. 2001;16:561-566.
11. Chishima F, Hayakawa S, Sugita K. Increased expression of cyclooxygenase-2 in local lesions of endometriosis patients. Am J Reprod Immunol. 2002;48:50-56.
12. Matsuzaki S, Canis M, Pouly JL, Wattiez A, Okamura K, Mage G. Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium. Fertil Steril. 2004;82:1309-1315.
13. Buchweitz O, Staebler A, Wulfing P, Hauzman E, Greb R, Kiesel L. COX-2 overexpression in peritoneal lesions is correlated with nonmenstrual chronic pelvic pain. Eur J Obstet Gynecol Reprod Biol. 2006;124:216-221.
14. McLaren J, Prentice A, Charnock-Jones DS, et al. Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. J Clin Invest. 1996;98:482-489.
15. Wieser F, Vigne JL, Ryan I, Hornung D, Djalali S, Taylor RN. Sulindac suppresses nuclear factor-kappaB activation and RANTES gene and protein expression in endometrial stromal cells from women with endometriosis. J Clin Endocrinol Metab. 2005;90:6441-6447.
16. González-Ramos R, Donnez J, Defrere S, et al. Nuclear factor-kappaB is constitutively activated in peritoneal endometriosis. Mol Hum Reprod. 2007;13:503-509.
17. Lousse JC, Van Langendonckt A, Gonzalez-Ramos R, Defrere S, Renkin E, Donnez J. Increased activation of nuclear factor-kappaB (NF-kappaB) in isolated peritoneal macrophages of patients with endometriosis. Fertil Steril. 2008;90:217-220.
18. Lin CC, Lin WN, Wang WJ, et al. Functional coupling expression of COX-2 and cPLA2 induced by ATP in rat vascular smooth muscle cells: role of ERK1/2, p38 MAPK, and NF-κβ. Cardiovasc Res. 2009;8:522-531.
19. Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol. 2002;29(6 Suppl 16):15-18.
20. Ikeda E, Achen MG, Breier G, Risau W. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem. 1995;270:19761-19766.
21. Bulun SE, Cheng YH, Yin P, et al. Progesterone resistance in endometriosis: link to failure to metabolize estradiol. Mol Cell Endocrinol. 2006;248:94-103.
22. Harada T, Kaponis A, Iwabe T, et al. Apoptosis in human endometrium and endometriosis. Hum Reprod Update. 2004;10:29-38.
23. Garcia-Velasco JA, Arici A. Apoptosis and the pathogenesis of endometriosis. Semin Reprod Med. 2003;21:165-172.
24. González-Ramos R, Defrère S, Devoto L. Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology. Fertil Steril. 2012;98:520-528.
25. Vercellini P, Vigano P, Somigliana E, Fedele L. Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol. 2014;10:261-275.
26. Gustafsson JA. Estrogen receptor beta-a new dimension in estrogen mechanism of action. J Endocrinol. 1999;163:379-383.
27. Taylor AH, Al-Azzawi F. Immunolocalisation of oestrogen receptor beta in human tissues. J Mol Endocrinol. 2000;24:145-155.
28. Ito K, Utsunomiya H, Yaegashi N, Sasano H. Biological roles of estrogen and progesterone in human endometrial carcinoma-new development in potential endocrine therapy for endometrial cancer. Endocr J. 2007;54:667-679.