메뉴 건너뛰기




Volumn 185, Issue 2, 2015, Pages 314-324

CXCL9 is important for recruiting immune T cells into the brain and inducing an accumulation of the T cells to the areas of tachyzoite proliferation to prevent reactivation of chronic cerebral infection with Toxoplasma gondii

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR9 ANTAGONIST; CXCL9 CHEMOKINE; GAMMA INTERFERON; MESSENGER RNA; SULFADIAZINE; CXCL9 PROTEIN, MOUSE;

EID: 84922335608     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.10.003     Document Type: Article
Times cited : (53)

References (58)
  • 1
    • 0023895411 scopus 로고
    • Interferongamma: The major mediator of resistance against Toxoplasma gondii
    • Suzuki Y, Orellana MA, Schreiber RD, Remington JS: Interferongamma: the major mediator of resistance against Toxoplasma gondii. Science 1988, 240:516-518
    • (1988) Science , vol.240 , pp. 516-518
    • Suzuki, Y.1    Orellana, M.A.2    Schreiber, R.D.3    Remington, J.S.4
  • 2
    • 0026021838 scopus 로고
    • Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine
    • Gazzinelli RT, Hakim FT, Hieny S, Shearer GM, Sher A: Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J Immunol 1991, 146:286-292
    • (1991) J Immunol , vol.146 , pp. 286-292
    • Gazzinelli, R.T.1    Hakim, F.T.2    Hieny, S.3    Shearer, G.M.4    Sher, A.5
  • 3
    • 0034161721 scopus 로고    scopus 로고
    • Decreased resistance of B celldeficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase
    • Kang H, Remington JS, Suzuki Y: Decreased resistance of B celldeficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase. J Immunol 2000, 164:2629-2634
    • (2000) J Immunol , vol.164 , pp. 2629-2634
    • Kang, H.1    Remington, J.S.2    Suzuki, Y.3
  • 4
    • 0019983374 scopus 로고
    • Toxoplasmosis in immunoglobulin M-suppressed mice
    • Frenkel JK, Taylor DW: Toxoplasmosis in immunoglobulin M-suppressed mice. Infect Immun 1982, 38:360-367
    • (1982) Infect Immun , vol.38 , pp. 360-367
    • Frenkel, J.K.1    Taylor, D.W.2
  • 5
    • 0036138364 scopus 로고    scopus 로고
    • Deficient humoral responses underlie susceptibility to Toxoplasma gondii in CD4-deficient mice
    • Johnson LL, Sayles PC: Deficient humoral responses underlie susceptibility to Toxoplasma gondii in CD4-deficient mice. Infect Immun 2002, 70:185-191
    • (2002) Infect Immun , vol.70 , pp. 185-191
    • Johnson, L.L.1    Sayles, P.C.2
  • 6
    • 0031736936 scopus 로고    scopus 로고
    • Regulation and function of T-cellmediated immunity during Toxoplasma gondii infection
    • Denkers EY, Gazzinelli RT: Regulation and function of T-cellmediated immunity during Toxoplasma gondii infection. Clin Microbiol Rev 1998, 11:569-588
    • (1998) Clin Microbiol Rev , vol.11 , pp. 569-588
    • Denkers, E.Y.1    Gazzinelli, R.T.2
  • 8
  • 9
    • 0000837877 scopus 로고
    • Toxoplasmosis in the setting of AIDS
    • Edited by Broder S, Mergan TC Jr, Bolognesi D. Baltimore, Williams & Wikins
    • Wong SY, Remington JS: Toxoplasmosis in the setting of AIDS. Edited by Broder S, Mergan TC Jr, Bolognesi D. Text Book of AIDS Medicine. Baltimore, Williams & Wikins, 1994, pp 223-257
    • (1994) Text Book of AIDS Medicine , pp. 223-257
    • Wong, S.Y.1    Remington, J.S.2
  • 10
    • 0030997436 scopus 로고    scopus 로고
    • Determination of genotypes of Toxoplasma gondii strains isolated from patients with toxoplasmosis
    • Howe DK, Honore S, Derouin F, Sibley LD: Determination of genotypes of Toxoplasma gondii strains isolated from patients with toxoplasmosis. J Clin Microbiol 1997, 35:1411-1414
    • (1997) J Clin Microbiol , vol.35 , pp. 1411-1414
    • Howe, D.K.1    Honore, S.2    Derouin, F.3    Sibley, L.D.4
  • 13
    • 0026328036 scopus 로고
    • A gene(s) within the H-2D region determines the development of toxoplasmic encephalitis in mice
    • Suzuki Y, Joh K, Orellana MA, Conley FK, Remington JS: A gene(s) within the H-2D region determines the development of toxoplasmic encephalitis in mice. Immunology 1991, 74:732-739
    • (1991) Immunology , vol.74 , pp. 732-739
    • Suzuki, Y.1    Joh, K.2    Orellana, M.A.3    Conley, F.K.4    Remington, J.S.5
  • 15
    • 0024438401 scopus 로고
    • Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice
    • Suzuki Y, Conley FK, Remington JS: Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice. J Immunol 1989, 143:2045-2050
    • (1989) J Immunol , vol.143 , pp. 2045-2050
    • Suzuki, Y.1    Conley, F.K.2    Remington, J.S.3
  • 16
    • 0026749880 scopus 로고
    • + T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii
    • + T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol 1992, 149: 175-180
    • (1992) J Immunol , vol.149 , pp. 175-180
    • Gazzinelli, R.1    Xu, Y.2    Hieny, S.3    Cheever, A.4    Sher, A.5
  • 17
    • 0028299215 scopus 로고
    • Human microglial cell defense against Toxoplasma gondii. The role of cytokines
    • Chao CC, Gekker G, Hu S, Peterson PK: Human microglial cell defense against Toxoplasma gondii. The role of cytokines. J Immunol 1994, 152:1246-1252
    • (1994) J Immunol , vol.152 , pp. 1246-1252
    • Chao, C.C.1    Gekker, G.2    Hu, S.3    Peterson, P.K.4
  • 18
    • 0027241256 scopus 로고
    • Effects of cytokines on multiplication of Toxoplasma gondii in microglial cells
    • Chao CC, Hu S, Gekker G, Novick WJ Jr, Remington JS, Peterson PK: Effects of cytokines on multiplication of Toxoplasma gondii in microglial cells. J Immunol 1993, 150:3404-3410
    • (1993) J Immunol , vol.150 , pp. 3404-3410
    • Chao, C.C.1    Hu, S.2    Gekker, G.3    Novick, W.J.4    Remington, J.S.5    Peterson, P.K.6
  • 19
    • 0028873516 scopus 로고
    • Human astrocytes inhibit intracellular multiplication of Toxoplasma gondii by a nitric oxidemediated mechanism
    • Peterson PK, Gekker G, Hu S, Chao CC: Human astrocytes inhibit intracellular multiplication of Toxoplasma gondii by a nitric oxidemediated mechanism. J Infect Dis 1995, 171:516-518
    • (1995) J Infect Dis , vol.171 , pp. 516-518
    • Peterson, P.K.1    Gekker, G.2    Hu, S.3    Chao, C.C.4
  • 20
    • 0030059619 scopus 로고    scopus 로고
    • Anti-parasitic effector mechanisms in human brain tumor cells: Role of interferon-gamma and tumor necrosis factor-alpha
    • Daubener W, Remscheid C, Nockemann S, Pilz K, Seghrouchni S, Mackenzie C, Hadding U: Anti-parasitic effector mechanisms in human brain tumor cells: role of interferon-gamma and tumor necrosis factor-alpha. Eur J Immunol 1996, 26:487-492
    • (1996) Eur J Immunol , vol.26 , pp. 487-492
    • Daubener, W.1    Remscheid, C.2    Nockemann, S.3    Pilz, K.4    Seghrouchni, S.5    MacKenzie, C.6    Hadding, U.7
  • 21
    • 0031662836 scopus 로고    scopus 로고
    • Effect of cytokines on growth of Toxoplasma gondii in murine astrocytes
    • Halonen SK, Chiu F, Weiss LM: Effect of cytokines on growth of Toxoplasma gondii in murine astrocytes. Infect Immun 1998, 66: 4989-4993
    • (1998) Infect Immun , vol.66 , pp. 4989-4993
    • Halonen, S.K.1    Chiu, F.2    Weiss, L.M.3
  • 23
    • 0036942730 scopus 로고    scopus 로고
    • Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-gamma
    • Strack A, Asensio VC, Campbell IL, Schluter D, Deckert M: Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-gamma. Acta Neuropathol 2002, 103:458-468
    • (2002) Acta Neuropathol , vol.103 , pp. 458-468
    • Strack, A.1    Asensio, V.C.2    Campbell, I.L.3    Schluter, D.4    Deckert, M.5
  • 24
    • 84903181053 scopus 로고    scopus 로고
    • VCAM-1/alpha4-beta1 integrin interaction is crucial for prompt recruitment of immune T cells into the brain during the early stage of reactivation of chronic infection with Toxoplasma gondii to prevent toxoplasmic encephalitis
    • Sa Q, Ochiai E, Sengoku T, Wilson ME, Brogli M, Crutcher S, Michie SA, Xu B, Payne L, Wang X, Suzuki Y: VCAM-1/alpha4-beta1 integrin interaction is crucial for prompt recruitment of immune T cells into the brain during the early stage of reactivation of chronic infection with Toxoplasma gondii to prevent toxoplasmic encephalitis. Infect Immun 2014, 82:2826-2839
    • (2014) Infect Immun , vol.82 , pp. 2826-2839
    • Sa, Q.1    Ochiai, E.2    Sengoku, T.3    Wilson, M.E.4    Brogli, M.5    Crutcher, S.6    Michie, S.A.7    Xu, B.8    Payne, L.9    Wang, X.10    Suzuki, Y.11
  • 25
    • 0032509889 scopus 로고    scopus 로고
    • Chemokinese chemotactic cytokines that mediate inflammation
    • Luster AD: Chemokinese chemotactic cytokines that mediate inflammation. N Engl J Med 1998, 338:436-445
    • (1998) N Engl J Med , vol.338 , pp. 436-445
    • Luster, A.D.1
  • 27
    • 77956583188 scopus 로고    scopus 로고
    • Predominant interferon-gamma-mediated expression of CXCL9, CXCL10, and CCL5 proteins in the brain during chronic infection with Toxoplasma gondii in BALB/c mice resistant to development of toxoplasmic encephalitis
    • Wen X, Kudo T, Payne L, Wang X, Rodgers L, Suzuki Y: Predominant interferon-gamma-mediated expression of CXCL9, CXCL10, and CCL5 proteins in the brain during chronic infection with Toxoplasma gondii in BALB/c mice resistant to development of toxoplasmic encephalitis. J Interferon Cytokine Res 2010, 30:653-660
    • (2010) J Interferon Cytokine Res , vol.30 , pp. 653-660
    • Wen, X.1    Kudo, T.2    Payne, L.3    Wang, X.4    Rodgers, L.5    Suzuki, Y.6
  • 28
    • 0346949034 scopus 로고    scopus 로고
    • Regulation of the kinetics of intracerebral chemokine gene expression in murine Toxoplasma encephalitis: Impact of host genetic factors
    • Strack A, Schluter D, Asensio VC, Campbell IL, Deckert M: Regulation of the kinetics of intracerebral chemokine gene expression in murine Toxoplasma encephalitis: impact of host genetic factors. Glia 2002, 40:372-377
    • (2002) Glia , vol.40 , pp. 372-377
    • Strack, A.1    Schluter, D.2    Asensio, V.C.3    Campbell, I.L.4    Deckert, M.5
  • 29
    • 0035061706 scopus 로고    scopus 로고
    • Requirement of non-T cells that produce gamma interferon for prevention of reactivation of Toxoplasma gondii infection in the brain
    • Kang H, Suzuki Y: Requirement of non-T cells that produce gamma interferon for prevention of reactivation of Toxoplasma gondii infection in the brain. Infect Immun 2001, 69:2920-2927
    • (2001) Infect Immun , vol.69 , pp. 2920-2927
    • Kang, H.1    Suzuki, Y.2
  • 30
    • 0027246025 scopus 로고
    • Susceptibility to chronic infection with Toxoplasma gondii does not correlate with susceptibility to acute infection in mice
    • Suzuki Y, Orellana MA, Wong SY, Conley FK, Remington JS: Susceptibility to chronic infection with Toxoplasma gondii does not correlate with susceptibility to acute infection in mice. Infect Immun 1993, 61:2284-2288
    • (1993) Infect Immun , vol.61 , pp. 2284-2288
    • Suzuki, Y.1    Orellana, M.A.2    Wong, S.Y.3    Conley, F.K.4    Remington, J.S.5
  • 31
    • 21344472566 scopus 로고    scopus 로고
    • Importance of CD8(+) Vbeta8(+) T Cells in IFN-gamma-mediated prevention of toxoplasmic encephalitis in genetically resistant BALB/c mice
    • Wang X, Claflin J, Kang H, Suzuki Y: Importance of CD8(+) Vbeta8(+) T Cells in IFN-gamma-mediated prevention of toxoplasmic encephalitis in genetically resistant BALB/c mice. J Interferon Cytokine Res 2005, 25:338-344
    • (2005) J Interferon Cytokine Res , vol.25 , pp. 338-344
    • Wang, X.1    Claflin, J.2    Kang, H.3    Suzuki, Y.4
  • 32
    • 3343018958 scopus 로고    scopus 로고
    • Gamma interferon production, but not perforin-mediated cytolytic activity, of T cells is required for prevention of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease
    • Wang X, Kang H, Kikuchi T, Suzuki Y: Gamma interferon production, but not perforin-mediated cytolytic activity, of T cells is required for prevention of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease. Infect Immun 2004, 72: 4432-4438
    • (2004) Infect Immun , vol.72 , pp. 4432-4438
    • Wang, X.1    Kang, H.2    Kikuchi, T.3    Suzuki, Y.4
  • 33
    • 0032528446 scopus 로고    scopus 로고
    • The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor
    • Tannenbaum CS, Tubbs R, Armstrong D, Finke JH, Bukowski RM, Hamilton TA: The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor. J Immunol 1998, 161:927-932
    • (1998) J Immunol , vol.161 , pp. 927-932
    • Tannenbaum, C.S.1    Tubbs, R.2    Armstrong, D.3    Finke, J.H.4    Bukowski, R.M.5    Hamilton, T.A.6
  • 34
    • 0035253737 scopus 로고    scopus 로고
    • Expression of Mig (monokine induced by interferon-gamma) is important in T lymphocyte recruitment and host defense following viral infection of the central nervous system
    • Liu MT, Armstrong D, Hamilton TA, Lane TE: Expression of Mig (monokine induced by interferon-gamma) is important in T lymphocyte recruitment and host defense following viral infection of the central nervous system. J Immunol 2001, 166:1790-1795
    • (2001) J Immunol , vol.166 , pp. 1790-1795
    • Liu, M.T.1    Armstrong, D.2    Hamilton, T.A.3    Lane, T.E.4
  • 35
    • 26444493233 scopus 로고    scopus 로고
    • Neutralization of chemokines RANTES and MIG increases virus antigen expression and spinal cord pathology during Theiler's virus infection
    • Ure DR, Lane TE, Liu MT, Rodriguez M: Neutralization of chemokines RANTES and MIG increases virus antigen expression and spinal cord pathology during Theiler's virus infection. Int Immunol 2005, 17:569-579
    • (2005) Int Immunol , vol.17 , pp. 569-579
    • Ure, D.R.1    Lane, T.E.2    Liu, M.T.3    Rodriguez, M.4
  • 37
    • 0037446524 scopus 로고    scopus 로고
    • TCR v beta 8+ T cells prevent development of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease
    • Kang H, Liesenfeld O, Remington JS, Claflin J, Wang X, Suzuki Y: TCR V beta 8+ T cells prevent development of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease. J Immunol 2003, 170:4254-4259
    • (2003) J Immunol , vol.170 , pp. 4254-4259
    • Kang, H.1    Liesenfeld, O.2    Remington, J.S.3    Claflin, J.4    Wang, X.5    Suzuki, Y.6
  • 38
    • 0026576247 scopus 로고
    • Isolation of toxoplasma gondii from a naturally infected beef cow
    • Dubey JP: Isolation of Toxoplasma gondii from a naturally infected beef cow. J Parasitol 1992, 78:151-153
    • (1992) J Parasitol , vol.78 , pp. 151-153
    • Dubey, J.P.1
  • 39
    • 78649870765 scopus 로고    scopus 로고
    • Toxoplasma IgG and IgA, but not IgM, antibody titers increase in sera of immunocompetent mice in association with proliferation of tachyzoites in the brain during the chronic stage of infection
    • Singh J, Graniello C, Ni Y, Payne L, Sa Q, Hester J, Shelton BJ, Suzuki Y: Toxoplasma IgG and IgA, but not IgM, antibody titers increase in sera of immunocompetent mice in association with proliferation of tachyzoites in the brain during the chronic stage of infection. Microbes Infect 2010, 12:1252-1257
    • (2010) Microbes Infect , vol.12 , pp. 1252-1257
    • Singh, J.1    Graniello, C.2    Ni, Y.3    Payne, L.4    Sa, Q.5    Hester, J.6    Shelton, B.J.7    Suzuki, Y.8
  • 40
    • 84867612888 scopus 로고    scopus 로고
    • Toxoplasma gondii antigens recognized by IgG antibodies differ between mice with and without active proliferation of tachyzoites in the brain during the chronic stage of infection
    • Hester J, Mullins J, Sa Q, Payne L, Mercier C, Cesbron-Delauw MF, Suzuki Y: Toxoplasma gondii antigens recognized by IgG antibodies differ between mice with and without active proliferation of tachyzoites in the brain during the chronic stage of infection. Infect Immun 2012, 80:3611-3620
    • (2012) Infect Immun , vol.80 , pp. 3611-3620
    • Hester, J.1    Mullins, J.2    Sa, Q.3    Payne, L.4    Mercier, C.5    Cesbron-Delauw, M.F.6    Suzuki, Y.7
  • 41
    • 21344450407 scopus 로고    scopus 로고
    • Microglia and macrophages as innate producers of interferon-gamma in the brain following infection with Toxoplasma gondii
    • Suzuki Y, Claflin J, Wang X, Lengi A, Kikuchi T: Microglia and macrophages as innate producers of interferon-gamma in the brain following infection with Toxoplasma gondii. Int J Parasitol 2005, 35: 83-90
    • (2005) Int J Parasitol , vol.35 , pp. 83-90
    • Suzuki, Y.1    Claflin, J.2    Wang, X.3    Lengi, A.4    Kikuchi, T.5
  • 42
    • 34547201936 scopus 로고    scopus 로고
    • Microglia produce IFN-gamma independently from T cells during acute toxoplasmosis in the brain
    • Wang X, Suzuki Y: Microglia produce IFN-gamma independently from T cells during acute toxoplasmosis in the brain. J Interferon Cytokine Res 2007, 27:599-605
    • (2007) J Interferon Cytokine Res , vol.27 , pp. 599-605
    • Wang, X.1    Suzuki, Y.2
  • 43
    • 0030967209 scopus 로고    scopus 로고
    • Mig and IP-10: CXC chemokines that target lymphocytes
    • Farber JM: Mig and IP-10: CXC chemokines that target lymphocytes. J Leukoc Biol 1997, 61:246-257
    • (1997) J Leukoc Biol , vol.61 , pp. 246-257
    • Farber, J.M.1
  • 45
    • 0344321889 scopus 로고    scopus 로고
    • Expression of chemokines and their receptors in human and simian astrocytes: Evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation
    • Croitoru-Lamoury J, Guillemin GJ, Boussin FD, Mognetti B, Gigout LI, Cheret A, Vaslin B, Le Grand R, Brew BJ, Dormont D: Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation. Glia 2003, 41:354-370
    • (2003) Glia , vol.41 , pp. 354-370
    • Croitoru-Lamoury, J.1    Guillemin, G.J.2    Boussin, F.D.3    Mognetti, B.4    Gigout, L.I.5    Cheret, A.6    Vaslin, B.7    Le Grand, R.8    Brew, B.J.9    Dormont, D.10
  • 47
    • 0031930433 scopus 로고    scopus 로고
    • The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig
    • Piali L, Weber C, LaRosa G, Mackay CR, Springer TA, Clark-Lewis I, Moser B: The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig. Eur J Immunol 1998, 28: 961-972
    • (1998) Eur J Immunol , vol.28 , pp. 961-972
    • Piali, L.1    Weber, C.2    Larosa, G.3    MacKay, C.R.4    Springer, T.A.5    Clark-Lewis, I.6    Moser, B.7
  • 48
    • 45549098590 scopus 로고    scopus 로고
    • The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor
    • Meiser A, Mueller A, Wise EL, McDonagh EM, Petit SJ, Saran N, Clark PC, Williams TJ, Pease JE: The chemokine receptor CXCR3 is degraded following internalization and is replenished at the cell surface by de novo synthesis of receptor. J Immunol 2008, 180: 6713-6724
    • (2008) J Immunol , vol.180 , pp. 6713-6724
    • Meiser, A.1    Mueller, A.2    Wise, E.L.3    McDonagh, E.M.4    Petit, S.J.5    Saran, N.6    Clark, P.C.7    Williams, T.J.8    Pease, J.E.9
  • 49
    • 79952537603 scopus 로고    scopus 로고
    • Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes
    • Korniejewska A, McKnight AJ, Johnson Z, Watson ML, Ward SG: Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes. Immunology 2011, 132:503-515
    • (2011) Immunology , vol.132 , pp. 503-515
    • Korniejewska, A.1    McKnight, A.J.2    Johnson, Z.3    Watson, M.L.4    Ward, S.G.5
  • 51
    • 40449131101 scopus 로고    scopus 로고
    • CXCL9 and CXCL10 expression are critical for control of genital herpes simplex virus type 2 infection through mobilization of HSV-specific CTL and NK cells to the nervous system
    • Thapa M, Welner RS, Pelayo R, Carr DJ: CXCL9 and CXCL10 expression are critical for control of genital herpes simplex virus type 2 infection through mobilization of HSV-specific CTL and NK cells to the nervous system. J Immunol 2008, 180: 1098-1106
    • (2008) J Immunol , vol.180 , pp. 1098-1106
    • Thapa, M.1    Welner, R.S.2    Pelayo, R.3    Carr, D.J.4
  • 53
    • 0030588706 scopus 로고    scopus 로고
    • Genes for chemokines MuMig and Crg-2 are induced in protozoan and viral infections in response to IFN-gamma with patterns of tissue expression that suggest nonredundant roles in vivo
    • Amichay D, Gazzinelli RT, Karupiah G, Moench TR, Sher A, Farber JM: Genes for chemokines MuMig and Crg-2 are induced in protozoan and viral infections in response to IFN-gamma with patterns of tissue expression that suggest nonredundant roles in vivo. J Immunol 1996, 157:4511-4520
    • (1996) J Immunol , vol.157 , pp. 4511-4520
    • Amichay, D.1    Gazzinelli, R.T.2    Karupiah, G.3    Moench, T.R.4    Sher, A.5    Farber, J.M.6
  • 55
    • 84887282184 scopus 로고    scopus 로고
    • CXCR3-dependent CD4(+) T cells are required to activate inflammatory monocytes for defense against intestinal infection
    • Cohen SB, Maurer KJ, Egan CE, Oghumu S, Satoskar AR, Denkers EY: CXCR3-dependent CD4(+) T cells are required to activate inflammatory monocytes for defense against intestinal infection. PLoS Pathog 2013, 9:e1003706
    • (2013) PLoS Pathog , vol.9 , pp. e1003706
    • Cohen, S.B.1    Maurer, K.J.2    Egan, C.E.3    Oghumu, S.4    Satoskar, A.R.5    Denkers, E.Y.6
  • 57
    • 51349107422 scopus 로고    scopus 로고
    • CCR2 receptor is essential to activate microbicidal mechanisms to control Toxoplasma gondii infection in the central nervous system
    • Benevides L, Milanezi CM, Yamauchi LM, Benjamim CF, Silva JS, Silva NM: CCR2 receptor is essential to activate microbicidal mechanisms to control Toxoplasma gondii infection in the central nervous system. Am J Pathol 2008, 173:741-751
    • (2008) Am J Pathol , vol.173 , pp. 741-751
    • Benevides, L.1    Milanezi, C.M.2    Yamauchi, L.M.3    Benjamim, C.F.4    Silva, J.S.5    Silva, N.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.