-
1
-
-
42049096982
-
Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances
-
Besier S., Ludwig A., Zander J., Brade V., Wichelhaus T.A. Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances. Antimicrob Agents Chemother 2008, 52:1570-1572.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 1570-1572
-
-
Besier, S.1
Ludwig, A.2
Zander, J.3
Brade, V.4
Wichelhaus, T.A.5
-
2
-
-
34248215686
-
Dose dependence of emergence of resistance to linezolid in Enterococcus faecalis in vivo
-
Bourgeois-Nicolaos N., Massias L., Couson B., Butel M.J., Andremont A., Doucet-Populaire F. Dose dependence of emergence of resistance to linezolid in Enterococcus faecalis in vivo. J Infect Dis 2007, 195(10):1480-1488.
-
(2007)
J Infect Dis
, vol.195
, Issue.10
, pp. 1480-1488
-
-
Bourgeois-Nicolaos, N.1
Massias, L.2
Couson, B.3
Butel, M.J.4
Andremont, A.5
Doucet-Populaire, F.6
-
3
-
-
77951234516
-
Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges
-
Brown S.D., Traczewski M.M. Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control ranges. Antimicrob Agents Chemother 2010, 54:2063-2069.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 2063-2069
-
-
Brown, S.D.1
Traczewski, M.M.2
-
6
-
-
84870790006
-
ZAAPS Program results for 2010: an activity and spectrum analysis of linezolid using clinical isolates from 75 medical centers in 24 countries
-
Flamm R.K., Farrell D.J., Mendes R.E., Ross J.E., Sader H.S., Jones R.N. ZAAPS Program results for 2010: an activity and spectrum analysis of linezolid using clinical isolates from 75 medical centers in 24 countries. J Chemother 2012, 24:328-337.
-
(2012)
J Chemother
, vol.24
, pp. 328-337
-
-
Flamm, R.K.1
Farrell, D.J.2
Mendes, R.E.3
Ross, J.E.4
Sader, H.S.5
Jones, R.N.6
-
7
-
-
84872867684
-
Linezolid surveillance results for the United States: LEADER surveillance program 2011
-
Flamm R.K., Mendes R.E., Ross J.E., Sader H.S., Jones R.N. Linezolid surveillance results for the United States: LEADER surveillance program 2011. Antimicrob Agents Chemother 2013, 57:1077-1081.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 1077-1081
-
-
Flamm, R.K.1
Mendes, R.E.2
Ross, J.E.3
Sader, H.S.4
Jones, R.N.5
-
8
-
-
79952280648
-
Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent
-
Im W.B., Choi S.H., Park J.Y., Choi S.H., Finn J., Yoon S.H. Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent. Eur J Med Chem 2011, 46(4):1027-1039.
-
(2011)
Eur J Med Chem
, vol.46
, Issue.4
, pp. 1027-1039
-
-
Im, W.B.1
Choi, S.H.2
Park, J.Y.3
Choi, S.H.4
Finn, J.5
Yoon, S.H.6
-
9
-
-
31544471208
-
Oxazolidinone susceptibility patterns in 2004: report from the Zyvox® Annual Appraisal of Potency and Spectrum (ZAAPS) program assessing isolates from 16 nations
-
Jones R.N., Ross J.E., Fritsche T.R., Sader H.S. Oxazolidinone susceptibility patterns in 2004: report from the Zyvox® Annual Appraisal of Potency and Spectrum (ZAAPS) program assessing isolates from 16 nations. J Antimicrob Chemother 2006, 57:279-287.
-
(2006)
J Antimicrob Chemother
, vol.57
, pp. 279-287
-
-
Jones, R.N.1
Ross, J.E.2
Fritsche, T.R.3
Sader, H.S.4
-
10
-
-
77950467121
-
Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria
-
Kaminska K.H., Purta E., Hansen L.H., Bujnicki J.M., Vester B., Long K.S. Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria. Nucleic Acids Res 2010, 38:1652-1663.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 1652-1663
-
-
Kaminska, K.H.1
Purta, E.2
Hansen, L.H.3
Bujnicki, J.M.4
Vester, B.5
Long, K.S.6
-
11
-
-
77955818964
-
Molecular and epidemiologic characteristics of linezolid-resistant coagulase-negative staphylococci at a tertiary care hospital
-
Kosowska-Shick K., Julian K.G., McGhee P.L., Appelbaum P.C., Whitener C.J. Molecular and epidemiologic characteristics of linezolid-resistant coagulase-negative staphylococci at a tertiary care hospital. Diagn Microbiol Infect Dis 2010, 68:34-39.
-
(2010)
Diagn Microbiol Infect Dis
, vol.68
, pp. 34-39
-
-
Kosowska-Shick, K.1
Julian, K.G.2
McGhee, P.L.3
Appelbaum, P.C.4
Whitener, C.J.5
-
12
-
-
84896447005
-
Investigation of a multiresistance gene cfr that fails to mediate resistance to phenicols and oxazolidinones in Enterococcus faecalis
-
Liu Y., Wang Y., Schwarz S., Wang S., Chen L., Wu C., et al. Investigation of a multiresistance gene cfr that fails to mediate resistance to phenicols and oxazolidinones in Enterococcus faecalis. J Antimicrob Chemother 2014, 69:892-898.
-
(2014)
J Antimicrob Chemother
, vol.69
, pp. 892-898
-
-
Liu, Y.1
Wang, Y.2
Schwarz, S.3
Wang, S.4
Chen, L.5
Wu, C.6
-
13
-
-
71249138911
-
Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700)
-
Locke J.B., Hilgers M., Shaw K.J. Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700). Antimicrob Agents Chemother 2009, 53:5265-5274.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 5265-5274
-
-
Locke, J.B.1
Hilgers, M.2
Shaw, K.J.3
-
14
-
-
71249101537
-
Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin
-
Locke J.B., Hilgers M., Shaw K.J. Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin. Antimicrob Agents Chemother 2009, 53:5275-5278.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 5275-5278
-
-
Locke, J.B.1
Hilgers, M.2
Shaw, K.J.3
-
15
-
-
78649668302
-
Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations
-
Locke J.B., Finn J., Hilgers M., Morales G., Rahawi S., G C K., et al. Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations. Antimicrob Agents Chemother 2010, 54:5337-5343.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 5337-5343
-
-
Locke, J.B.1
Finn, J.2
Hilgers, M.3
Morales, G.4
Rahawi, S.G.C.K.5
-
16
-
-
84922282208
-
Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05
-
Locke J.B., Rahawi S., Lamarre J., Mankin A.S., Shaw K.J. Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05. Antimicrob Agents Chemother 2012, 53:5265-5274.
-
(2012)
Antimicrob Agents Chemother
, vol.53
, pp. 5265-5274
-
-
Locke, J.B.1
Rahawi, S.2
Lamarre, J.3
Mankin, A.S.4
Shaw, K.J.5
-
17
-
-
84856068450
-
Resistance to linezolid caused by modifications at its binding site on the ribosome
-
Long K.S., Vester B. Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob Agents Chemother 2012, 56:603-612.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 603-612
-
-
Long, K.S.1
Vester, B.2
-
18
-
-
33745599646
-
The Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics
-
Long K.S., Poehlsgaard J., Kehrenberg C., Schwarz S., Vester B. The Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics. Antimicrob Agents Chemother 2006, 50:2500-2505.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 2500-2505
-
-
Long, K.S.1
Poehlsgaard, J.2
Kehrenberg, C.3
Schwarz, S.4
Vester, B.5
-
19
-
-
0036783696
-
Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis
-
Marshall S.H., Donskey C.J., Hutton-Thomas R., Salata R.A., Rice L.B. Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis. Antimicrob Agents Chemother 2002, 46:3334-3336.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 3334-3336
-
-
Marshall, S.H.1
Donskey, C.J.2
Hutton-Thomas, R.3
Salata, R.A.4
Rice, L.B.5
-
20
-
-
3242683097
-
Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA
-
Meka V.G., Pillai S.K., Sakoulas G., Wennersten C., Venkataraman L., DeGirolami P.C., et al. Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA. J Infect Dis 2004, 190:311-317.
-
(2004)
J Infect Dis
, vol.190
, pp. 311-317
-
-
Meka, V.G.1
Pillai, S.K.2
Sakoulas, G.3
Wennersten, C.4
Venkataraman, L.5
DeGirolami, P.C.6
-
21
-
-
44449125584
-
First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States
-
Mendes R.E., Deshpande L.M., Castanheira M., DiPersio J., Saubolle M.A., Jones R.N. First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Antimicrob Agents Chemother 2008, 52:2244-2246.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 2244-2246
-
-
Mendes, R.E.1
Deshpande, L.M.2
Castanheira, M.3
DiPersio, J.4
Saubolle, M.A.5
Jones, R.N.6
-
22
-
-
77957873178
-
Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy
-
Mendes R.E., Deshpande L.M., Farrell D.J., Spanu T., Fadda G., Jones R.N. Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy. J Antimicrob Chemother 2010, 65:2329-2335.
-
(2010)
J Antimicrob Chemother
, vol.65
, pp. 2329-2335
-
-
Mendes, R.E.1
Deshpande, L.M.2
Farrell, D.J.3
Spanu, T.4
Fadda, G.5
Jones, R.N.6
-
23
-
-
84893458897
-
Summary of linezolid activity and resistance mechanisms detected during the 2012 LEADER surveillance program for the United States
-
Mendes R.E., Flamm R.K., Hogan P.A., Ross J.E., Jones R.N. Summary of linezolid activity and resistance mechanisms detected during the 2012 LEADER surveillance program for the United States. Antimicrob Agents Chemother 2014, 58:1243-1247.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 1243-1247
-
-
Mendes, R.E.1
Flamm, R.K.2
Hogan, P.A.3
Ross, J.E.4
Jones, R.N.5
-
24
-
-
84902541725
-
Zyvox® Annual Appraisal of Potency and Spectrum (ZAAPS) Program: report of linezolid activity over 9 years (2004-12)
-
Mendes R.E., Hogan P.A., Streit J.M., Jones R.N., Flamm R.K. Zyvox® Annual Appraisal of Potency and Spectrum (ZAAPS) Program: report of linezolid activity over 9 years (2004-12). J Antimicrob Chemother 2014, 69(6):1582-1588.
-
(2014)
J Antimicrob Chemother
, vol.69
, Issue.6
, pp. 1582-1588
-
-
Mendes, R.E.1
Hogan, P.A.2
Streit, J.M.3
Jones, R.N.4
Flamm, R.K.5
-
25
-
-
84904718296
-
Once-daily tedizolid for 6 days versus twice-daily linezolid for 10 days in acute bacterial skin and skin structure infections: results from a randomised controlled trial using an intravenous-to-oral switch strategy (ESTABLISH-2 study)
-
Moran G.J., Fang E., Corey G.R., Das A.F., De Anda C., Prokocimer P. Once-daily tedizolid for 6 days versus twice-daily linezolid for 10 days in acute bacterial skin and skin structure infections: results from a randomised controlled trial using an intravenous-to-oral switch strategy (ESTABLISH-2 study). Lancet Infect Dis 2014, 14(8):696-705.
-
(2014)
Lancet Infect Dis
, vol.14
, Issue.8
, pp. 696-705
-
-
Moran, G.J.1
Fang, E.2
Corey, G.R.3
Das, A.F.4
De Anda, C.5
Prokocimer, P.6
-
26
-
-
84922278071
-
Absolute bioavailability and intravenous pharmacokinetics of torezolid phosphate in healthy subjects
-
Muñoz K.A., Bien P., Bethune C., Wright R., Prokocimer P. Absolute bioavailability and intravenous pharmacokinetics of torezolid phosphate in healthy subjects. Poster presented at the 20th European Congress of Clinical Microbiology and Infectious Diseases. Vienna, Austria. April 10-13, 2013. Abstract 813 2013.
-
(2013)
Poster presented at the 20th European Congress of Clinical Microbiology and Infectious Diseases. Vienna, Austria. April 10-13, 2013. Abstract 813
-
-
Muñoz, K.A.1
Bien, P.2
Bethune, C.3
Wright, R.4
Prokocimer, P.5
-
27
-
-
0036890601
-
Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype
-
Pillai S.K., Sakoulas G., Wennersten C., Eliopoulos G.M., Moellering R.C., Ferraro M.J., et al. Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype. J Infect Dis 2002, 186:1603-1607.
-
(2002)
J Infect Dis
, vol.186
, pp. 1603-1607
-
-
Pillai, S.K.1
Sakoulas, G.2
Wennersten, C.3
Eliopoulos, G.M.4
Moellering, R.C.5
Ferraro, M.J.6
-
28
-
-
78751689284
-
Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections
-
Prokocimer P., Bien P., Surber J., Mehra P., DeAnda C., Bulitta J.B., et al. Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections. Antimicrob Agents Chemother 2011, 55:583-592.
-
(2011)
Antimicrob Agents Chemother
, vol.55
, pp. 583-592
-
-
Prokocimer, P.1
Bien, P.2
Surber, J.3
Mehra, P.4
DeAnda, C.5
Bulitta, J.B.6
-
29
-
-
84865432225
-
In vitro activity and microbiological efficacy of tedizolid (TR-700) against Gram-positive clinical isolates from a phase 2 study of oral tedizolid phosphate (TR-701) in patients with complicated skin and skin structure infections
-
Prokocimer P., Bien P., DeAnda C., Pillar C.M., Bartizal K. In vitro activity and microbiological efficacy of tedizolid (TR-700) against Gram-positive clinical isolates from a phase 2 study of oral tedizolid phosphate (TR-701) in patients with complicated skin and skin structure infections. Antimicrob Agents Chemother 2012, 56:4608-4613.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 4608-4613
-
-
Prokocimer, P.1
Bien, P.2
DeAnda, C.3
Pillar, C.M.4
Bartizal, K.5
-
30
-
-
84873642637
-
Tedizolid phosphate vs linezolid for treatment of acute bacterial skin and skin structure infections: the ESTABLISH-1 randomized trial
-
Prokocimer P., De Anda C., Fang E., Mehra P., Das A. Tedizolid phosphate vs linezolid for treatment of acute bacterial skin and skin structure infections: the ESTABLISH-1 randomized trial. JAMA 2013, 309:559-569.
-
(2013)
JAMA
, vol.309
, pp. 559-569
-
-
Prokocimer, P.1
De Anda, C.2
Fang, E.3
Mehra, P.4
Das, A.5
-
31
-
-
0034962929
-
Resistance to linezolid: character of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci
-
Prystowsky J., Siddiqui F., Chosay J., Shinabarger D.L., Millichap J., Peterson L.R., et al. Resistance to linezolid: character of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci. Antimicrob Agents Chemother 2001, 45:2154-2156.
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 2154-2156
-
-
Prystowsky, J.1
Siddiqui, F.2
Chosay, J.3
Shinabarger, D.L.4
Millichap, J.5
Peterson, L.R.6
-
32
-
-
67749127546
-
In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent
-
Schaadt R., Sweeney D., Shinabarger D., Zurenko G. In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agent. Antimicrob Agents Chemother 2009, 53:3236-3239.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 3236-3239
-
-
Schaadt, R.1
Sweeney, D.2
Shinabarger, D.3
Zurenko, G.4
-
33
-
-
57049089598
-
In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains
-
Shaw K.J., Poppe S., Schaadt R., Brown-Driver V., Finn J., Pillar C.M., et al. In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains. Antimicrob Agents Chemother 2008, 52:4442-4447.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 4442-4447
-
-
Shaw, K.J.1
Poppe, S.2
Schaadt, R.3
Brown-Driver, V.4
Finn, J.5
Pillar, C.M.6
-
34
-
-
42949115806
-
Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors
-
Smith L.K., Mankin A.S. Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors. Antimicrob Agents Chemother 2008, 52:1703-1712.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 1703-1712
-
-
Smith, L.K.1
Mankin, A.S.2
-
35
-
-
34250028674
-
Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid
-
Toh S.M., Xiong L., Arias C.A., Villegas M.V., Lolans K., Quinn J., et al. Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. Mol Microbiol 2007, 64:1506-1514.
-
(2007)
Mol Microbiol
, vol.64
, pp. 1506-1514
-
-
Toh, S.M.1
Xiong, L.2
Arias, C.A.3
Villegas, M.V.4
Lolans, K.5
Quinn, J.6
-
36
-
-
0035928419
-
Linezolid resistance in a clinical isolate of Staphylococcus aureus
-
Tsiodras S., Gold H.S., Sakoulas G., Eliopoulos G.M., Wennersten C., Venkataraman L., et al. Linezolid resistance in a clinical isolate of Staphylococcus aureus. Lancet 2001, 358:207-208.
-
(2001)
Lancet
, vol.358
, pp. 207-208
-
-
Tsiodras, S.1
Gold, H.S.2
Sakoulas, G.3
Eliopoulos, G.M.4
Wennersten, C.5
Venkataraman, L.6
-
37
-
-
23044470241
-
Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus
-
Wolter N., Smith A.M., Farrell D.J., Schaffner W., Moore M., Whitney C.G., et al. Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus. Antimicrob Agents Chemother 2005, 49:3554-3557.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 3554-3557
-
-
Wolter, N.1
Smith, A.M.2
Farrell, D.J.3
Schaffner, W.4
Moore, M.5
Whitney, C.G.6
-
38
-
-
75749112863
-
Polyphyletic emergence of linezolid-resistant staphylococci in the United States
-
Wong A., Reddy S.P., Smyth D.S., Aguero-Rosenfeld M.E., Sakoulas G., Robinson D.A. Polyphyletic emergence of linezolid-resistant staphylococci in the United States. Antimicrob Agents Chemother 2010, 54:742-748.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 742-748
-
-
Wong, A.1
Reddy, S.P.2
Smyth, D.S.3
Aguero-Rosenfeld, M.E.4
Sakoulas, G.5
Robinson, D.A.6
|