Effects of ayahuasca on the development of ethanol-induced behavioral sensitization and on a post-sensitization treatment in mice

Physiology and Behavior

Volumn 142, Issue , 2015, Pages 28-36

  Oliveira Lima, A J ^a   Santos, R ^b   Hollais, A W ^b   Gerardi Junior, C A ^c   Baldaia, M A ^b   Wuo Silva, R ^b   Yokoyama, T S ^b   Costa, J L ^d   Malpezzi Marinho, E L A ^a   Ribeiro Barbosa, P C ^a   Berro, L F ^b   Frussa Filho, R ^b   Marinho, E A V ^a  

^a DEPARTAMENTO DE CIÊNCIAS BIOLÓGICAS   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c Universidade Braz Cubas   (Brazil)

^d Forensic Toxicology and Chemistry Laboratory Criminalistic Institute of Sao Paulo   (Brazil)

Author keywords

Ayahuasca; Behavioral sensitization; Counter sensitization; Ethanol; Mice; Spontaneous locomotion

Indexed keywords

ALCOHOL; AYAHUASCA; PSYCHEDELIC AGENT; UNCLASSIFIED DRUG; CENTRAL DEPRESSANT AGENT; PLANT MEDICINAL PRODUCT;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; DRUG SELECTIVITY; EXPERIMENTAL HYPERACTIVITY; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; THERAPY EFFECT; AKATHISIA, DRUG-INDUCED; ANIMAL; BANISTERIOPSIS; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; EXPLORATORY BEHAVIOR; MOTOR ACTIVITY; PHYTOTHERAPY;

AKATHISIA, DRUG-INDUCED; ANIMALS; BANISTERIOPSIS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; EXPLORATORY BEHAVIOR; HALLUCINOGENS; MALE; MICE; MOTOR ACTIVITY; PHYTOTHERAPY; PLANT PREPARATIONS;

EID: 84922309083     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2015.01.032     Document Type: Article

References (48)

1. Andrade A.L., Abrahao K.P., Goeldner F.O., Souza-Formigoni M.L. Administration of the 5-HT2C receptor antagonist SB-242084 into the nucleus accumbens blocks the expression of ethanol-induced behavioral sensitization in Albino Swiss mice. Neuroscience 2011, 189:178-186.
2. Barbosa P.C., Mizumoto S., Bogenschutz M.P., Strassman R.J. Health status of ayahuasca users. Drug Test. Anal. 2012, 4:601-609.
3. Berglund M. A better widget? Three lessons for improving addiction treatment from a meta-analytical study. Addiction 2005, 100:742-750.
4. Bogenschutz M.P., Pommy J.M. Therapeutic mechanisms of classic hallucinogens in the treatment of addictions: from indirect evidence to testable hypotheses. Drug Test. Anal. 2012, 4:543-555.
5. Brierley D.I., Davidson C. Developments in harmine pharmacology-implications for ayahuasca use and drug-dependence treatment. Prog. Neuropsychopharmacol. Biol. Psychiatry 2012, 39:263-272.
6. Carrera M.P., Carey R.J., Dias F.R., de Mattos L.W. Memory re-consolidation and drug conditioning: an apomorphine conditioned locomotor stimulant response can be enhanced or reversed by a single high versus low apomorphine post-trial treatment. Psychopharmacology (Berlin) 2012, 220:281-291.
7. Carter B.L., Tiffany S.T. Cue-reactivity and the future of addiction research. Addiction 1999, 94:349-351.
8. Castro J.P., Frussa-Filho R., Fukushiro D.F., Silva R.H., Medrano W.A., Ribeiro Rde A., Abilio V.C. Effects of baclofen on reserpine-induced vacuous chewing movements in mice. Brain Res. Bull. 2006, 68:436-441.
9. Chinen C.C., Faria R.R., Frussa-Filho R. Characterization of the rapid-onset type of behavioral sensitization to amphetamine in mice: role of drug-environment conditioning. Neuropsychopharmacology 2006, 31:151-159.
10. de Araujo N.P., Fukushiro D.F., Grassl C., Hipólide D.C., Souza-Formigoni M.L., Tufik S., Frussa-Filho R. Ethanol-induced behavioral sensitization is associated with dopamine receptor changes in the mouse olfactory tubercle. Physiol. Behav. 2009, 96:12-17.
11. Deliganis A.V., Pierce P.A., Peroutka S.J. Differential interactions of dimethyltryptamine (DMT) with 5-HT1A and 5-HT2 receptors. Biochem. Pharmacol. 1991, 41:1739-1744.
12. Doering-Silveira E., Grob C.S., de Rios M.D., Lopez E., Alonso L.K., Tacla C., Da Silveira D.X. Report on psychoactive drug use among adolescents using ayahuasca within a religious context. J. Psychoactive Drugs 2005, 37:141-144.
13. Fabregas J.M., Gonzalez D., Fondevila S., Cutchet M., Fernandez X., Barbosa P.C., Alcazar-Corcoles M.A., Barbanoj M.J., Riba J., Bouso J.C. Assessment of addiction severity among ritual users of ayahuasca. Drug Alcohol Depend. 2010, 111:257-261.
14. Ferraz I.C., Boerngen-Lacerda R. Serotonin 5-HT2 receptor antagonist does not reverse established ethanol-induced sensitization but blocks its development and expression. Pharmacol. Biochem. Behav. 2008, 88:456-464.
15. Fraioli S., Crombag H.S., Badiani A., Robinson T.E. Susceptibility to amphetamine-induced locomotor sensitization is modulated by environmental stimuli. Neuropsychopharmacology 1999, 20:533-541.
16. Frussa-Filho R., Palermo-Neto J. Effects of single and long-term administration of sulpiride on open-field and stereotyped behavior of rats. Braz. J. Med. Biol. Res. 1990, 23:463-472.
17. Fukushiro D.F., Josino F.S., Saito L.P., Berro L.F., Morgado F., Frussa-Filho R. Acute and chronic ethanol differentially modify the emotional significance of a novel environment: implications for addiction. Int. J. Neuropsychopharmacol. 2012, 15:1109-1120.
18. Gable R.S. Risk assessment of ritual use of oral dimethyltryptamine (DMT) and harmala alkaloids. Addiction 2007, 102:24-34.
19. Gallate J.E., McGregor I.S. The motivation for beer in rats: effects of ritanserin, naloxone and SR 141716. Psychopharmacology (Berlin) 1999, 142:302-308.
20. Grob C.S., McKenna D.J., Callaway J.C., Brito G.S., Neves E.S., Oberlaender G., Saide O.L., Labigalini E., Tacla C., Miranda C.T., Strassman R.J., Boone K.B. Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil. J. Nerv. Ment. Dis. 1996, 184:86-94.
21. Halberstadt A.L., Buell M.R., Price D.L., Geyer M.A. Differences in the locomotor-activating effects of indirect serotonin agonists in habituated and non-habituated rats. Pharmacol. Biochem. Behav. 2012, 102:88-94.
22. Halpern J.H., Sherwood A.R., Passie T., Blackwell K.C., Ruttenber A.J. Evidence of health and safety in American members of a religion who use a hallucinogenic sacrament. Med. Sci. Monit. 2008, 14:SR15-SR22.
23. Labate B.C., Macrae EJBdN Ayahuasca, Ritual and Religion in Brazil 2010, Equinox, London; Oakville, Conn.
24. Marinho E.A., Oliveira-Lima A.J., Santos R., Hollais A.W., Baldaia M.A., Wuo-Silva R., Yokoyama T.S., Takatsu-Coleman A.L., Patti C.L., Longo B.M., Berro L.F., Frussa-Filho R. Effects of rimonabant on the development of single dose-induced behavioral sensitization to ethanol, morphine and cocaine in mice. Prog. Neuropsychopharmacol. Biol. Psychiatry 2015, 58:22-31.
25. Marinho E.A., Oliveira-Lima A.J., Wuo-Silva R., Santos R., Baldaia M.A., Hollais A.W., Longo B.M., Berro L.F., Frussa-Filho R. Selective action of an atypical neuroleptic on the mechanisms related to the development of cocaine addiction: a pre-clinical behavioural study. Int. J. Neuropsychopharmacol. 2013, 17:1-11.
26. McKenna D.J., Towers G.H., Abbott F. Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and beta-carboline constituents of ayahuasca. J. Ethnopharmacol. 1984, 10:195-223.
27. Mittman S.M., Geyer M.A. Dissociation of multiple effects of acute LSD on exploratory behavior in rats by ritanserin and propranolol. Psychopharmacology (Berlin) 1991, 105:69-76.
28. Morse R.M., Flavin D.K. The definition of alcoholism. The Joint Committee of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism. JAMA 1992, 268:1012-1014.
29. Niaura R.S., Rohsenow D.J., Binkoff J.A., Monti P.M., Pedraza M., Abrams D.B. Relevance of cue reactivity to understanding alcohol and smoking relapse. J. Abnorm. Psychol. 1988, 97:133-152.
30. Rezayof A., Sharifi K., Zarrindast M.R., Rassouli Y. Modulation of ethanol state-dependent learning by dorsal hippocampal NMDA receptors in mice. Alcohol 2008, 42:667-674.
31. Riba J., Rodriguez-Fornells A., Strassman R.J., Barbanoj M.J. Psychometric assessment of the hallucinogen rating scale. Drug Alcohol Depend. 2001, 62:215-223.
32. Robinson T.E., Becker J.B. Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res. 1986, 396:157-198.
33. Robinson T.E., Berridge K.C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res. Brain Res. Rev. 1993, 18:247-291.
34. Sanday L., Patti C.L., Zanin K.A., Fernandes-Santos L., Oliveira L.C., Kameda S.R., Tufik S., Frussa-Filho R. Ethanol-induced memory impairment in a discriminative avoidance task is state-dependent. Alcohol. Clin. Exp. Res. 2013, 37(Suppl. 1):E30-E39.
35. Schmidt A.W., Lebel L.A., Howard H.R., Zorn S.H. Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. Eur. J. Pharmacol. 2001, 425:197-201.
36. Smith R.L., Canton H., Barrett R.J., Sanders-Bush E. Agonist properties of N, N-dimethyltryptamine at serotonin 5-HT2A and 5-HT2C receptors. Pharmacol. Biochem. Behav. 1998, 61:323-330.
37. Stewart J., Badiani A. Tolerance and sensitization to the behavioral effects of drugs. Behav. Pharmacol. 1993, 4:289-312.
38. The World Health Report 2008, World Health Organization, Geneva.
39. Thomas G., Lucas P., Capler N.R., Tupper K.W., Martin G. Ayahuasca-assisted therapy for addiction: results from a preliminary observational study in Canada. Curr. Drug Abuse Rev. 2013, 6:30-42.
40. Tupper K.W. The globalization of ayahuasca: harm reduction or benefit maximization?. Int. J. Drug Policy 2008, 19:297-303.
41. Umathe S.N., Bhutada P.S., Raut V.S., Jain N.S., Mundhada Y.R. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav. Pharmacol. 2009, 20:78-83.
42. Vanderschuren L.J., De Vries T.J., Wardeh G., Hogenboom F.A., Schoffelmeer A.N. A single exposure to morphine induces long-lasting behavioural and neurochemical sensitization in rats. Eur. J. Neurosci. 2001, 14:1533-1538.
43. Vanderschuren L.J., Schmidt E.D., De Vries T.J., Van Moorsel C.A., Tilders F.J., Schoffelmeer A.N. A single exposure to amphetamine is sufficient to induce long-term behavioral, neuroendocrine, and neurochemical sensitization in rats. J. Neurosci. 1999, 19:9579-9586.
44. Vanderschuren L.J., Tjon G.H., Nestby P., Mulder A.H., Schoffelmeer A.N., De Vries T.J. Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen. Psychopharmacology (Berlin) 1997, 131:115-122.
45. Winkelman M., Roberts T.B. Psychedelic Medicine: New Evidence for Hallucinogenic Substances as Treatments 2007, Praeger Publishers, Westport, Conn.
46. Callaway J.C., Raymon L.P., Hearn W.L., McKenna D.J., Grob C.S., Brito G.S., Mash D.C. Quantitation of N, N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with ayahuasca. J. Anal. Toxicol. 1996, 20:492-497.
47. Giumanini A.G., Casalini C. Mass spectrometry of the metabolites of 2-ethyl-2,3-dihydro-5-benzofuranylacetic acid. Biomed. Mass. Spectrom. 1980, 7:236-241.
48. Pires A.P., De Oliveira C.D., Moura S., Dörr F.A., Silva W.A., Yonamine M. Gas chromatographic analysis of dimethyltryptamine and beta-carboline alkaloids in ayahuasca, an Amazonian psychoactive plant beverage. Phytochem. Anal. 2009, 20:149-153.