New perspectives for the diagnosis, control, treatment, and prevention of strangles in horses

Veterinary Clinics of North America - Equine Practice

Volumn 30, Issue 3, 2014, Pages 591-607

  Waller, Andrew S ^a  

^a ANIMAL HEALTH TRUST   (United Kingdom)

Author keywords

ELISA; QPCR; Strangles; Streptococcus equi; Vaccine

Indexed keywords

EQUIDAE; STREPTOCOCCUS EQUI;

ABSCESS; ANIMAL; HORSE; HORSE DISEASES; ISOLATION AND PURIFICATION; MICROBIOLOGY; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS EQUI; VETERINARY;

ABSCESS; ANIMALS; HORSE DISEASES; HORSES; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS EQUI;

EID: 84922291248     PISSN: 07490739     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cveq.2014.08.007     Document Type: Review

References (79)

1. Rufus J. De medicina equorum, 1251.
2. Parkinson N.J., Robin C., Newton J.R., et al. Molecular epidemiology of strangles outbreaks in the UK during 2010. Vet Rec 2011, 168:666.
3. Holden M.T., Heather Z., Paillot R., et al. Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens. PLoS Pathog 2009, 5:e1000346.
4. Chalker V.J., Brooks H.W., Brownlie J. The association of Streptococcus equi subsp. zooepidemicus with canine infectious respiratory disease. Vet Microbiol 2003, 95:149-156.
5. Chalker V.J., Waller A., Webb K., et al. Genetic diversity of Streptococcus equi subsp. zooepidemicus and doxycycline resistance in kennelled dogs. JClin Microbiol 2012, 50:2134-2136.
6. Pesavento P.A., Hurley K.F., Bannasch M.J., et al. Aclonal outbreak of acute fatal hemorrhagic pneumonia in intensively housed (shelter) dogs caused by Streptococcus equi subsp. zooepidemicus. Vet Pathol 2008, 45:51-53.
7. Abbott Y., Acke E., Khan S., et al. Zoonotic transmission of Streptococcus equi subsp. zooepidemicus from a dog to a handler. JMed Microbiol 2010, 59:120-123.
8. Bradley S.F., Gordon J.J., Baumgartner D.D., et al. Group C streptococcal bacteremia: analysis of 88 cases. Rev Infect Dis 1991, 13:270-280.
9. Downar J., Willey B.M., Sutherland J.W., et al. Streptococcal meningitis resulting from contact with an infected horse. JClin Microbiol 2001, 39:2358-2359.
10. Hashikawa S., Iinuma Y., Furushita M., et al. Characterization of group C and G streptococcal strains that cause streptococcal toxic shock syndrome. JClin Microbiol 2004, 42:186-192.
11. Hong C.B., Donahue J.M., Giles R.C., et al. Equine abortion and stillbirth in central Kentucky during 1988 and 1989 foaling seasons. JVet Diagn Invest 1993, 5:560-566.
12. Smith K.C., Blunden A.S., Whitwell K.E., et al. Asurvey of equine abortion, stillbirth and neonatal death in the UK from 1988 to 1997. Equine Vet J 2003, 35:496-501.
13. Brooks D.E., Andrew S.E., Biros D.J., et al. Ulcerative keratitis caused by beta-hemolytic Streptococcus equi in 11 horses. Vet Ophthalmol 2000, 3:121-125.
14. Anzai T., Walker J.A., Blair M.B., et al. Comparison of the phenotypes of Streptococcus zooepidemicus isolated from tonsils of healthy horses and specimens obtained from foals and donkeys with pneumonia. Am J Vet Res 2000, 61:162-166.
15. Wood J.L., Newton J.R., Chanter N., et al. Association between respiratory disease and bacterial and viral infections in British racehorses. JClin Microbiol 2005, 43:120-126.
16. Webb K., Jolley K.A., Mitchell Z., et al. Development of an unambiguous and discriminatory multilocus sequence typing scheme for the Streptococcus zooepidemicus group. Microbiology 2008, 154:3016-3024.
17. Lindahl S.B., Aspan A., Baverud V., et al. Outbreak of upper respiratory disease in horses caused by Streptococcus equi subsp. zooepidemicus ST-24. Vet Microbiol 2013, 166:281-285.
18. Velineni S., Desoutter D., Perchec A.M., et al. Characterization of a mucoid clone of Streptococcus zooepidemicus from an epizootic of equine respiratory disease in New Caledonia. Vet J 2014, 200:82-87.
19. Waller A.S. Equine respiratory disease: a causal role of Streptococcus zooepidemicus. Vet J 2014, 201:3-4.
20. Timoney J.F. Strangles. Vet Clin North Am Equine Pract 1993, 9:365-374.
21. Timoney J.F., Kumar P. Early pathogenesis of equine Streptococcus equi infection (strangles). Equine Vet J 2008, 40:637-642.
22. Artiushin S.C., Timoney J.F., Sheoran A.S., et al. Characterization and immunogenicity of pyrogenic mitogens SePE-H and SePE-I of Streptococcus equi. Microb Pathog 2002, 32:71-85.
23. Paillot R., Robinson C., Steward K., et al. Contribution of each of four superantigens to Streptococcus equi-induced mitogenicity, gamma interferon synthesis, and immunity. Infect Immun 2010, 78:1728-1739.
24. Flanagan J., Collin N., Timoney J., et al. Characterization of the haemolytic activity of Streptococcus equi. Microb Pathog 1998, 24:211-221.
25. Galan J.E., Timoney J.F. Molecular analysis of the M protein of Streptococcus equi and cloning and expression of the M protein gene in Escherichia coli. Infect Immun 1987, 55:3181-3187.
26. Lannergard J., Guss B. IdeE, an IgG-endopeptidase of Streptococcus equi ssp. equi. FEMS Microbiol Lett 2006, 262:230-235.
27. Timoney J.F., Yang J., Liu J., et al. IdeE reduces the bactericidal activity of equine neutrophils for Streptococcus equi. Vet Immunol Immunopathol 2008, 122:76-82.
28. Tiwari R., Qin A., Artiushin S., et al. Se18.9, an anti-phagocytic factor H binding protein of Streptococcus equi. Vet Microbiol 2007, 121:105-115.
29. Turner C.E., Kurupati P., Jones M.D., et al. Emerging role of the interleukin-8 cleaving enzyme SpyCEP in clinical Streptococcus pyogenes infection. JInfect Dis 2009, 200:555-563.
30. Lewis M.J., Meehan M., Owen P., et al. Acommon theme in interaction of bacterial immunoglobulin-binding proteins with immunoglobulins illustrated in the equine system. JBiol Chem 2008, 283:17615-17623.
31. Meehan M., Lewis M.J., Byrne C., et al. Localization of the equine IgG-binding domain in the fibrinogen-binding protein (FgBP) of Streptococcus equi subsp. equi. Microbiology 2009, 155:2583-2592.
32. Meehan M., Lynagh Y., Woods C., et al. The fibrinogen-binding protein (FgBP) of Streptococcus equi subsp. equi additionally binds IgG and contributes to virulence in a mouse model. Microbiology 2001, 147:3311-3322.
33. Boschwitz J.S., Timoney J.F. Inhibition of C3 deposition on Streptococcus equi subsp. equi by M protein: a mechanism for survival in equine blood. Infect Immun 1994, 62:3515-3520.
34. Galan J.E., Timoney J.F. Immunologic and genetic comparison of Streptococcus equi isolates from the United States and Europe. JClin Microbiol 1988, 26:1142-1146.
35. Heather Z., Holden M.T., Steward K.F., et al. Anovel streptococcal integrative conjugative element involved in iron acquisition. Mol Microbiol 2008, 70:1274-1292.
36. Boschwitz J.S., Timoney J.F. Characterization of the antiphagocytic activity of equine fibrinogen for Streptococcus equi subsp. equi. Microb Pathog 1994, 17:121-129.
37. Walker J.A., Timoney J.F. Construction of a stable non-mucoid deletion mutant of the Streptococcus equi Pinnacle vaccine strain. Vet Microbiol 2002, 89:311-321.
38. Sweeney C.R., Timoney J.F., Newton J.R., et al. Streptococcus equi infections in horses: guidelines for treatment, control, and prevention of strangles. JVet Intern Med 2005, 19:123-134.
39. Anzai T., Kuwamoto Y., Wada R., et al. Variation in the N-terminal region of an M-like protein of Streptococcus equi and evaluation of its potential as a tool in epidemiologic studies. Am J Vet Res 2005, 66:2167-2171.
40. Kelly C., Bugg M., Robinson C., et al. Sequence variation of the SeM gene of Streptococcus equi allows discrimination of the source of strangles outbreaks. JClin Microbiol 2006, 44:480-486.
41. Robinson C., Steward K.F., Potts N., et al. Combining two serological assays optimises sensitivity and specificity for the identification of Streptococcus equi subsp. equi exposure. Vet J 2013, 197:188-191.
42. Galan J.E., Timoney J.F. Mucosal nasopharyngeal immune responses of horses to protein antigens of Streptococcus equi. Infect Immun 1985, 47:623-628.
43. Hamlen H.J., Timoney J.F., Bell R.J. Epidemiologic and immunologic characteristics of Streptococcus equi infection in foals. JAm Vet Med Assoc 1994, 204:768-775.
44. Todd A.G. Strangles. JComp Pathol Ther 1910, 23:212-229.
45. Newton J.R., Wood J.L., Dunn K.A., et al. Naturally occurring persistent and asymptomatic infection of the guttural pouches of horses with Streptococcus equi. Vet Rec 1997, 140:84-90.
46. Verheyen K., Newton J.R., Talbot N.C., et al. Elimination of guttural pouch infection and inflammation in asymptomatic carriers of Streptococcus equi. Equine Vet J 2000, 32:527-532.
47. Weese J.S., Jarlot C., Morley P.S. Survival of Streptococcus equi on surfaces in an outdoor environment. Can Vet J 2009, 50:968-970.
48. Pusterla N., Watson J.L., Affolter V.K., et al. Purpura haemorrhagica in 53 horses. Vet Rec 2003, 153:118-121.
49. Sweeney C.R., Whitlock R.H., Meirs D.A., et al. Complications associated with Streptococcus equi infection on a horse farm. JAm Vet Med Assoc 1987, 191:1446-1448.
50. Heath S.E., Geor R.J., Tabel H., et al. Unusual patterns of serum antibodies to Streptococcus equi in two horses with purpura hemorrhagica. JVet Intern Med 1991, 5:263-267.
51. Waller A.S. Strangles: taking steps towards eradication. Vet Microbiol 2013, 167:50-60.
52. Waller A.S., Paillot R., Timoney J.F. Streptococcus equi: a pathogen restricted to one host. JMed Microbiol 2011, 60:1231-1240.
53. Baverud V., Johansson S.K., Aspan A. Real-time PCR for detection and differentiation of Streptococcus equi subsp. equi and Streptococcus equi subsp. zooepidemicus. Vet Microbiol 2007, 124:219-229.
54. Webb K., Barker C., Harrison T., et al. Detection of Streptococcus equi subspecies equi using a triplex qPCR assay. Vet J 2013, 195:300-304.
55. Guss B., Flock M., Frykberg L., et al. Getting to grips with strangles: an effective multi-component recombinant vaccine for the protection of horses from Streptococcus equi infection. PLoS Pathog 2009, 5:e1000584.
56. Bannister M.F., Benson C.E., Sweeney C.R. Rapid species identification of group C streptococci isolated from horses. JClin Microbiol 1985, 21:524-526.
57. Newton J.R., Verheyen K., Talbot N.C., et al. Control of strangles outbreaks by isolation of guttural pouch carriers identified using PCR and culture of Streptococcus equi. Equine Vet J 2000, 32:515-526.
58. Timoney J.F., Artiushin S.C. Detection of Streptococcus equi in equine nasal swabs and washes by DNA amplification. Vet Rec 1997, 141:446-447.
59. Chanter N., Talbot N.C., Newton J.R., et al. Streptococcus equi with truncated M-proteins isolated from outwardly healthy horses. Microbiology 2000, 146(Pt6):1361-1369.
60. Waller A.S., Jolley K.A. Getting a grip on strangles: recent progress towards improved diagnostics and vaccines. Vet J 2007, 173:492-501.
61. Davidson A., Traub-Dargatz J.L., Magnuson R., et al. Lack of correlation between antibody titers to fibrinogen-binding protein of Streptococcus equi and persistent carriers of strangles. JVet Diagn Invest 2008, 20:457-462.
62. Ling A.S., Upjohn M.M., Webb K., et al. Seroprevalence of Streptococcus equi in working horses in Lesotho. Vet Rec 2011, 169:72.
63. Walshe N., Johnston J., MacCarthy E., et al. "Strangles" in less regulated sectors of the Irish horse industry. JEquine Vet Sci 2012, 32:S3-S95.
64. Knowles E.J., Mair T.S., Butcher N., et al. Use of a novel serological test for exposure to Streptococcus equi subspecies equi in hospitalised horses. Vet Rec 2010, 166:294-297.
65. Bazeley P.L. Studies with equine streptococci 1. Aust Vet J 1940, 16:140-146.
66. Bazeley P.L. Studies with equine streptococci 2. Aust Vet J 1940, 16:243-259.
67. Bazeley P.L. Studies with equine streptococci 3. Aust Vet J 1942, 18:141-155.
68. Bazeley P.L. Studies with equine streptococci 4. Aust Vet J 1942, 18:189-194.
69. Bazeley P.L. Studies with equine streptococci 5. Aust Vet J 1943, 19:62-85.
70. Hoffman A.M., Staempfli H.R., Prescott J.F., et al. Field evaluation of a commercial M-protein vaccine against Streptococcus equi infection in foals. Am J Vet Res 1991, 52:589-592.
71. Jacobs A.A., Goovaerts D., Nuijten P.J., et al. Investigations towards an efficacious and safe strangles vaccine: submucosal vaccination with a live attenuated Streptococcus equi. Vet Rec 2000, 147:563-567.
72. Kemp-Symonds J., Kemble T., Waller A. Modified live Streptococcus equi ('strangles') vaccination followed by clinically adverse reactions associated with bacterial replication. Equine Vet J 2007, 39:284-286.
73. Borst L.B., Patterson S.K., Lanka S., et al. Evaluation of a commercially available modified-live Streptococcus equi subsp equi vaccine in ponies. Am J Vet Res 2011, 72:1130-1138.
74. Patty O., Cursons R. The molecular identification of Streptococcus equi subsp. equi strains isolated within New Zealand. NZ Vet J 2014, 62:63-67.
75. Ivens P.A., Matthews D., Webb K., et al. Molecular characterisation of 'strangles' outbreaks in the UK: the use of M-protein typing of Streptococcus equi ssp. equi. Equine Vet J 2011, 43:359-364.
76. Meehan M., Nowlan P., Owen P. Affinity purification and characterization of a fibrinogen-binding protein complex which protects mice against lethal challenge with Streptococcus equi subsp. equi. Microbiology 1998, 144:993-1003.
77. Sheoran A.S., Artiushin S., Timoney J.F. Nasal mucosal immunogenicity for the horse of a SeM peptide of Streptococcus equi genetically coupled to cholera toxin. Vaccine 2002, 20:1653-1659.
78. Timoney J.F., Qin A., Muthupalani S., et al. Vaccine potential of novel surface exposed and secreted proteins of Streptococcus equi. Vaccine 2007, 25:5583-5590.
79. Flock M., Karlstrom A., Lannergard J., et al. Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse. Vaccine 2006, 24:4144-4151.