Immunoglobulin light-chain amyloidosis shares genetic susceptibility with multiple myeloma

Leukemia

Volumn 28, Issue 11, 2014, Pages 2254-2256

  Weinhold, N ^a   Forsti A ^b,c   da Silva Filho, M I ^b   Nickel, J ^a   Campo, C ^b   Hoffmann, P ^d,e   Nothen M M ^d   Hose, D ^a,f   Goldschmidt, H ^a,f   Jauch, A ^a   Langer, C ^g   Hegenbart, U ^a   Schonland S O ^a   Hemminki, K ^b,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c LUND UNIVERSITY   (Sweden)

^d UNIVERSITY OF BONN   (Germany)

^e UNIVERSITY OF BASEL   (Switzerland)

^f Department of Medical Oncology   (Germany)

^g UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN;

AGED; AMYLOIDOSIS; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN; MALE; MIDDLE AGED; MULTIPLE MYELOMA; PATHOLOGY;

AGED; AMYLOIDOSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; MALE; MIDDLE AGED; MULTIPLE MYELOMA;

EID: 84922277045     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2014.208     Document Type: Letter

References (15)

1. Hemminki K, Li X, Försti A, Sundquist J, Sundquist K. Incidence and survival in non-hereditary amyloidosis in Sweden. BMC Public Health 2012; 12: 974. DOI: 10.1186/1471-2458-12-974
2. Merlini G, Seldin DC, Gertz MA. Amyloidosis: pathogenesis and new therapeutic options. J Clin Oncol 2011; 29: 1924–1933. DOI: 10.1200/JCO.2010.32.2271
3. Kyle RA, Rajkumar SV. Epidemiology of the plasma-cell disorders. Best Pract Res Clin Haematol 2007; 20: 637–664. DOI: 10.1016/j.beha.2007.08.001
4. Morgan GJ, Johnson DC, Weinhold N, Goldschmidt H, Landgren O, Lynch HT et al. Inherited genetic susceptibility to multiple myeloma. Leukemia 2014; 28: 518–524. DOI: 10.1038/leu.2013.344
5. Bochtler T, Hegenbart U, Heiss C, Benner A, Moos M, Seckinger A et al. Hyperdiploidy is less frequent inAL amyloidosis compared with monoclonal gammopathy of undetermined significance and inversely associated with translocation t(11;14). Blood 2011; 117: 3809–3815. DOI: 10.1182/blood-2010-02-268987
6. Broderick P, Chubb D, Johnson DC, Weinhold N, Försti A, Lloyd A et al. Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk. Nat Genet 2012; 44: 58–61. DOI: 10.1038/ng.993
7. Chubb D, Weinhold N, Broderick P, Chen B, Johnson DC, Försti A et al. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nat Genet 2013; 45: 1221–1225. DOI: 10.1038/ng.2733
8. Weinhold N, Johnson DC, Rawstron AC, Försti A, Doughty C, Vijayakrishnan J et al. Inherited genetic susceptibility to monoclonal gammopathy of unknown significance. Blood 2014; 123: 2513–2517. DOI: 10.1182/blood-2013-10-532283
9. Weinhold N, Johnson DC, Chubb D, Chen B, Försti A, Hosking FJ et al. The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Nat Genet 2013; 45: 522–525. DOI: 10.1038/ng.2583
10. Schoenland SO, Hegenbart U, Bochtler T, Mangatter A, Hansberg M, Ho AD et al. Immunohistochemistry in the classification of systemic forms of amyloidosis: a systematic investigation of 117 patients. Blood 2012; 119: 488–493. DOI: 10.1182/blood-2011-06-358507
11. Kourelis TV, Kumar SK, Gertz Ma, Lacy MQ, Buadi FK, Hayman SR et al. Coexistent multiple myeloma or increased bone marrow plasma cells define equally high-risk populations in patients with immunoglobulin light chain amyloidosis. J Clin Oncol 2013; 31: 4319–4324. DOI: 10.1200/JCO.2013.50.8499
12. Knudsen KE, Diehl JA, Haiman CA, Knudsen ES. Cyclin D1: polymorphism, aberrant splicing and cancer risk. Oncogene 2006; 25: 1620–1628. DOI: 10.1038/sj.onc.1209371
13. Li Z, Jiao X, Wang C, Shirley LA, Elsaleh H, Dahl O et al. Alternative cyclin D1 splice forms differentially regulate the DNA damage response. Cancer Res 2010; 70: 8802–8811. DOI: 10.1158/0008-5472.CAN-10-0312
14. Jirawatnotai S, Hu Y, Michowski W, Elias JE, Becks L, Bienvenu F et al. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 2011; 474: 230–234. DOI: 10.1038/nature10155
15. Hemminki K, Musak L, Vymetalkova V, Smerhovsky Z, Halasova E, Osina O et al. Cyclin D1 splice site variant triggers chromosomal aberrations in healthy humans. Leukemia 2014; 28: 721–722. DOI: 10.1038/leu.2013.353