Hedgehog pathway blockade with the cancer drug LDE225 disrupts taste organs and taste sensation

Journal of Neurophysiology

Volumn 113, Issue 3, 2015, Pages 1034-1040

  Kumari, Archana ^a   Ermilov, Alexandre N ^b   Allen, Benjamin L ^b   Bradley, Robert M ^a,b   Dlugosz, Andrzej A ^b   Mistretta, Charlotte M ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Cancer drugs and taste ensation; Chorda tympani nerve responses; Hedgehog pathway inhibitors; Hedgehog signaling and taste; Taste bud and fungiform papillae

Indexed keywords

CYTOKERATIN 8; NEUROFILAMENT PROTEIN; PURINERGIC P2X3 RECEPTOR; SONIDEGIB; ANTINEOPLASTIC AGENT; BIPHENYL DERIVATIVE; PYRIDINE DERIVATIVE; SONIC HEDGEHOG PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHORDA TYMPANI; COLD; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HEDGEHOG PATHWAY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TASTE; TASTE BUD; TOUCH; ANIMAL; DRUG EFFECTS; METABOLISM; PHYSIOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; BIPHENYL COMPOUNDS; FEMALE; HEDGEHOG PROTEINS; MICE; PYRIDINES; SIGNAL TRANSDUCTION; TASTE; TASTE BUDS; TOUCH;

EID: 84922265238     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00822.2014     Document Type: Article

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