XIAP and Ki-67: A Correlation between antiapoptotic and proliferative marker expression in benign and malignant tumours of salivary gland: An immunohistochemical study

Journal of Clinical and Diagnostic Research

Volumn 9, Issue 2, 2015, Pages EC01-EC04

  Bagulkar, Bhupesh Bhayyaji ^a   Gawande, Madhuri ^b   Chaudhary, Minal ^b   Gadbail, Amol Ramchandra ^b   Patil, Swati ^b   Bagulkar, Smita ^a  

^a Sri Aurobindo College of Dentistry   (India)

^b DATTA MEGHE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Apoptosis; Benign and malignant salivary gland tumours; Inhibitor of apoptotic protein (IAP); Ki 67; X linked inhibitor of apoptotic protein (XIAP)

Indexed keywords

KI 67 ANTIGEN; TUMOR MARKER; X LINKED INHIBITOR OF APOPTOSIS;

ACINAR CELL CARCINOMA; ADENOID CYSTIC CARCINOMA; ADENOSQUAMOUS CARCINOMA; ARTICLE; BENIGN SALIVARY GLAND TUMOR; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALIGNANT SALIVARY GLAND TUMOR; PLEOMORPHIC ADENOMA; PROTEIN EXPRESSION; SALIVARY GLAND TUMOR; WARTHIN TUMOR;

EID: 84922260308     PISSN: 2249782X     EISSN: 0973709X     Source Type: Journal    
DOI: 10.7860/JCDR/2015/11690.5604     Document Type: Article

References (30)

1. Fàbio A Alves, Daniel EC Perez, Osley P Almeida, Márcio A Lopes, Luiz P Kowalski. Pleomorphic Adenoma of the Submandibular Gland Clinicopathological and Immunohistochemical Features of 60 Cases in Brazil. Arch Otolaryngol Head Neck Surg. 2002;128:1400-03.
2. Johns ME, Goldsmith MM. Incidence, diagnosis, and classification of salivary gland tumours. Part 1. Oncology (Huntingt). 1989;3(2):47-56.
3. Carlos G Ferreira, Paul van der Valk, Simone W Span, Inge Ludwig, Egbert F Smit, Frank AE Kruyt, et al. Expression of X-linked Inhibitor of Apoptosis as a Novel Prognostic Marker in Radically Resected Non-Small Cell Lung Cancer Patients. Clin Cancer Res. 2001;7:2468-74.
4. Ramp U, Krieg T, Caliskan E, Mahotka C, Ebert T, Willers R, Gabbert HE, Gerharz CD. XIAP expression is an independent prognostic marker in clear-cell renal carcinomas. Hum Pathol. 2004;35(8):1022-28.
5. LaCasse EC, Baird S, Korneluk RG, MacKenzie AE. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene. 1998;17:3247-59.
6. Schimmer AD, Dalili S, Batey RA, Riedl SJ. Targeting XIAP for the treatment of malignancy. Cell Death Differ. 2006;13:179- 88.
7. Holcik M, Gibson H, Korneluk RG. XIAP: apoptotic brake and promising therapeutic target. Apoptosis. 2001;6:253-61.
8. Lewis JE, Olsen KD, Sebo TJ. Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. Hum Pathol. 2001;32:596-604.
9. Freitas LL, Araujo VC, Martins MT, et al. Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation. Int J Surg Pathol. 2005;13:337-42.
10. DiPalma SD, Skalova A, Vanieek T, et al. Non-invasive (intracapsular) carcinoma ex pleomorphic adenoma: recognition of focal carcinoma by HER-2/neu and MIB1 immunohistochemistry. Histopathology. 2005;46:144-52.
11. Ohtake S, Cheng J, Ida H, et al. Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma by P53 immunohistochemistry. J Oral Pathol Med. 2002;31:590-97.
12. Altemani A, Martins MT, Freitas L, et al. Cacinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression. Histopathology. 2005;46:635-41.
13. Foschini MP, Gaiba A, Cocchi R, et al. p63 expression in salivary gland tumours: role of delta Np73L in neoplastic transformation. Int J Surg Pathol. 2005;13:329-35.
14. Benjamin L Hoch, Maoxin Wu, Michael Lewis, Li Gan, David E. Burstei. An immunohistochemical study of XIAP expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma. J Oral Pathol Med. 2008;37:634-38.
15. Muris JJ, Cillessen SA, Vos W, van Houdt IS, Kummer JA, van Krieken J, et al. Immunohistochemical profiling of caspase signalling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood. 2005;105:2916-23.
16. Tamm I, Richter S, Scholz F, Schmelz K, Oltersdorf D, Karawajew L, et al. XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis. Hematol J. 2004;5:489-95.
17. Tamm I, Richter S, Oltersdorf D, Creutzig U, Harbott J, Scholz F, et al. High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia. Clin Cancer Res. 2004;10:3737- 44.
18. Schluter C, Duchrow M, Wohlengerg C, Becker MHG, Key G, Flad HD, et al. The Cell Proliferation-associated Antigen of Antibody Ki-67: A Very Large, Ubiquitous Nuclear Protein with Numerous Repeated Elements, Representing a New Kind of Cell Cycle-Maintaining Proteins. The Journal of Cell Biology. 1993;123(3): 513-22.
19. Vargas PA, Cheng Y, Barrett AW, Craig GT, Speight PM. Expression of Mcm-2, Ki- 67 and geminin in benign and malignant salivary gland tumours. J Oral Pathol Med. 2008;37(5):309-18.
20. Ide F, Suka N, Kitada M, Sakashita H, Kusama K, Isikawa T. Skin and salivary gland carcinogenicity of 7, 12-dimethylbenz [a] anthracene is equivalent in the presence or absence of aryl hydrocarbon receptor. Cancer Lett. 2004; 214(8): 35-41.
21. Azuma M, Tamatani T, Kasai Y, Sato M. Immortalization of normal human salivary gland cells with duct-, myoepithelial-, acinar-, or squamous phenotype by transfection with SV40 ori-mutant deoxyribonucleic acid. Lab Invest. 1993;69: 24-42.
22. Espinal EG. Uvios AM, Cabrini RL. Salivary gland tumours induced by 32 P. J Oral Pathol. 1984;13:686-91.
23. Hockenbery DM, Giedt CD, O'Neill JW, et al. Mitochondria and apoptosis: new therapeutic targets. Adv Cancer Res. 2002;85:203-42.
24. Deveraux QL, Reed JC. IAP family proteins-suppressors of apoptosis. Genes Dev. 1999;13:239-52.
25. Brown DC, Gatter KC. Ki-67 protein: the immaculate deception? Histopathology. 2002;40:2-11.
26. Lazzaro B, Cleveland D. P53 and Ki-67 antigen expression in small oral biopsy specimens of salivary gland tumours. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(5):613-17.
27. Alves FA, Pires FR, de Almeida OP, Lopes MA, Kowalski LP. PCNA, Ki-67 and p53 expression in submandibular salivary gland tumours. Int J Oral Maxillofac Surg. 2004;33:593-97.
28. Aoki T, Tsukinoki K, Karakida K, Ota Y, Otsuru M, Kaneko A. Expression of cyclooxygenase-2, Bcl-2 and Ki-67 in pleomorphic adenoma with special reference to tumor proliferation and apoptosis. Oral Oncology. 2004;40:954-59.
29. Chandandeep Nagi, MD, Guang-Qing Xiao, MD, Gan Li, PhD, Eric Genden, MD, David E. Burstein, MD. Immunohistochemical detection of X-linked inhibitor of apoptosis in head and neck squamous cell carcinoma. Annals of Diagnostic Pathology. 2007;11:402-06.
30. Bannerji R, Kitada S, Flinn IW, et al. Apoptotic-regulatory and complement-protecting protein expression in chronic lymphocytic leukemia: relationship to in vivo rituximab resistance. J Clin Oncol. 2003;21:1466-71.