Effects of Silybum marianum (L.) Gaertn. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: A randomized, triple-blind, placebo-controlled clinical trial

Phytomedicine

Volumn 22, Issue 2, 2015, Pages 290-296

  Ebrahimpour Koujan, Soraiya ^a   Gargari, Bahram Pourghassem ^a   Mobasseri, Majid ^b   Valizadeh, Hadi ^c   Asghari Jafarabadi, Mohammad ^a  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF TABRIZ   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antioxidants; Diabetes mellitus; Malondialdehyde; Silymarin hs CRP

Indexed keywords

ANTIOXIDANT; C REACTIVE PROTEIN; GLIBENCLAMIDE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; METFORMIN; PLACEBO; SILYBUM MARIANUM EXTRACT; SUPEROXIDE DISMUTASE; ANTIINFLAMMATORY AGENT; SILYMARIN;

ABSENCE OF SIDE EFFECTS; ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD SAMPLING; BODY HEIGHT; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CLINICAL ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; FEMALE; FOOD INTAKE; HUMAN; IRAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PARALLEL DESIGN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SILYBUM MARIANUM; TREATMENT DURATION; TRIPLE BLIND PROCEDURE; WAIST CIRCUMFERENCE; WEIGHT CHANGE; CHEMISTRY; DRUG EFFECTS; INFLAMMATION; METABOLISM; MIDDLE AGED; ORAL DRUG ADMINISTRATION;

SILYBUM MARIANUM;

ADMINISTRATION, ORAL; ADULT; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; C-REACTIVE PROTEIN; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; FEMALE; GLUTATHIONE PEROXIDASE; HUMANS; INFLAMMATION; MALE; MALONDIALDEHYDE; MIDDLE AGED; MILK THISTLE; OXIDATIVE STRESS; SILYMARIN; SUPEROXIDE DISMUTASE;

EID: 84922256837     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.12.010     Document Type: Article

References (28)

1. Alarcon C.; Martin M.J.; Marhuenda E. Gastric anti-ulcer activity of silymarin, a lipoxygenase inhibitor in rats J. Pharm. Pharmacol. 44(11) 1992 929 931
2. Al-Jassabi S.; Saad A.; Azirun M.A.; Al-Omari A. The role of silymarin in prevention of alloxan-induced diabetes mellitus in Balb/C mice Am-Euras. J. Toxicol. Sci. 3 2011 172 176
3. Bosisio E.; Benelli C.; Pirola O. Effect of the flavolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes Pharmacol. Res. 27 1992 147 154
4. Consultation, W. 1999. Definition, diagnosis and classification of diabetes mellitus and its complications, Part 1: diagnosis and classification of diabetes mellitus
5. Garcia C.; Feve B.; Ferré P.; Halimi S.; Baizri H.; Bordier L.; Guiu G.; Dupuy O.; Bauduceau B.; Mayaudon H. Diabetes and inflammation: Fundamental aspects and clinical implications Diabet. Meta. 36 2010 327 338
6. Gharagozloo M.; Velardi E.; Bruscoli S.; Agostini M.; Di Sante M.; Donato V.; Amirghofran Z.; Riccardi C. Silymarin suppress CD4+ T cell activation and proliferation: Effects on NF-kB activity and IL-2 production Pharma. Res. 61 2010 405 409
7. Gupta O.P.; Sing S.; Bani S.; Sharma N.; Malhotra S.; Gupta B.D.; Banerjee S.K.; Handa S.S. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase Phytomedicine 7 1999 21 24
8. Henriksen E.J.; Diamond-Stanic M.K.; Marchionne E.M. Oxidative stress and the etiology of insulin resistance and type 2 diabetes Free Radical Bio. Med. 51 5 2011 993 999
9. Huseini H.F.; Larijani B.; Heshmat R.; Fakhrzadeh H.; Radjabipour B.; Toliat T.; Raza M. The efficacy of Silybum marianum (L.) Gaertn.(silymarin) in the treatment of type II diabetes: A randomized, doubleblind, placebocontrolled, clinical trial Phytotherap. Res. 20 12 2006 1036 1039
10. IDF diabetes atlas-fifth edition (2011) International Diabetes Federation. www.idf.org/diabetesatlas/papers
11. Kang J.S.; Jeon Y.J.; Park S.; Yang K.; Kim H.M. Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1β and prostaglandin E2 synthesis by silymarin Biochem. Pharma. 67 2004 175 181
12. Khan, M.; Siddiqui, M.; 2010. Do supplements of Silybum marianum significantly lower fasting blood glucose (FBG) in patients with Type II Diabetes Mellitus? - A suggested protocol. www.medi.philica.com
13. Koca K.; Yurttas Y.; Cayci T.; Bilgic S.; Kaldirim U.; Durusu M.; Cekli Y.; Ozkan H.; Hanci V.; Purtuloglu T.; Akgul E.O.; Oguz E.; Yildiz C.; Basbozkurt M. The role of preconditioning and N-acetylcysteine on oxidative stress resulting from tourniquet-induced ischemia-reperfusion in arthroscopic knee surgery J. Trauma Acute Care Surg. 70 2011 717 723
14. Mandegary A.; Saeedi A.; Eftekhari A.; Montazeri V.; Sharif E. Hepatoprotective effect of silyamarin in individuals chronically exposed to hydrogen sulfide; modulating influence of TNF-α cytokine genetic polymorphism DARU J. Pharma. Sci. 21 1 2013 28
15. Manna S.K.; Mukhopadhyay A.; Van N.T.; Aggarwal B.B. Silymarin suppresses TNF-induced activation of NF-kB, c-Jun N-terminal kinase, and apoptosis J. Immunol. 163 1999 6800 6809
16. Miller N.J.; Rice-Evans C.; Davies M.J.; Gopinathan V.; Milner A. A novel method for measuring antioxidant capacity and its application for monitoring the antioxidant status in premature neonates Clin. Sci. 84 1993 407 412
17. Murata M.I.; Mika I.S.; Shosuke K. Metal-mediated DNA damage induced by diabetogenic alloxan in the presence of NADH Free Radical Bio. Med. 25 1998 586 595
18. Pooya S.h.; Jalali M.D.; Jazayery A.D.; Saedisomeolia A.; RezaEshraghian M.; Toorang F. The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients Nutr. Meta. Cardiovas. Dis. 20 2010 326 331
19. Rains J.L.; Jain S.K. Oxidative stress, insulin signaling, and diabetes Free Radical Bio. Med. 50 2011 567 575
20. Richard M.J.; Portal B.; Meo J.; Coudray C.; Hadjian A.; Favier A. Malondialdehyde kit evaluated for determining plasma and lipoprotein fractions that react with thiobarbituric acid Clin. Chem. 38 1992 704 709
21. Roozbeh J.; Shahriyari B.; Akmali M.; Vessal G.; Pakfetrat M.; Raees Jalali G.A.; Afshariani R.; Hasheminasab M.; Ghahramani N. Comparative effects of silymarin and vitamin E supplementation on oxidative stress markers, and hemoglobin levels among patients on hemodialysis Renal Failure 33 2011 118 123
22. Russell Sh. Silymarin induces recovery of pancreatic function after alloxan damage in rats Life Sci. 75 2004 2167 2180
23. Saghaei M. Random allocation software for parallel group randomized trials BMC 4 26 2004 1 6
24. Soto C.P.; Perez B.L.; Favari L.P.; Reyes J.L. Prevention of alloxan-induced diabetes mellitus in the rat by silymarin Comp. Biochem. Physiol. 119 1998 125 129
25. Soto C.; Recoba R.; Barróna H.; Alvareza C.; Favarib L. Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas Toxicol. Pharmacol. 136 2003 205 212
26. Soto C.; Pérez J.; García V.; Uría E.; Vadillo M.; Rayac L. Effect of silymarin on kidneys of rats suffering from alloxan-induced diabetes mellitus Phytomedicine 17 2010 1090 1094
27. Turgut F.; Bayrak O.; Catal F.; Akbas A.; Unal D. Antioxidant and protective effects of silymarin on ischemia and reperfusion injury in the kidney tissues of rat Int. Urol. Nephrol. 40 2008 453 460
28. Wellington K.; Harvis B. Silymarin: A review of its clinical properties in the management of hepatic disorders Biodrugs 15 2001 465 489