Association between vitamin D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms (rs10735810, rs1544410, rs7975232, rs731236)

Gene

Volumn 559, Issue 1, 2015, Pages 73-76

  Laczmanski, Lukasz ^a   Lwow, Felicja ^b   Mossakowska, Malgorzata ^c   Puzianowska Kuznicka, Monika ^d,e   Szwed, Małgorzata ^d   Kolackov, Katarzyna ^a   Krzyzanowska Swiniarska, Barbara ^f   Bar Andziak, Ewa ^g   Chudek, Jerzy ^h   Sloka, Natalia ^a   Milewicz, Andrzej ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b UNIVERSITY SCHOOL OF PHYSICAL EDUCATION   (Poland)

^c INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

^d MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^e MEDICAL CENTER FOR POSTGRADUATE EDUCATION   (Poland)

^f POMERANIAN MEDICAL UNIVERSITY   (Poland)

^g MEDICAL UNIVERSITY OF WARSAW   (Poland)

^h MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Aging; FAI; Testosterone level; VDR polymorphism; Vitamin D level

Indexed keywords

ESTRADIOL; SEX HORMONE; SEX HORMONE BINDING PROTEIN; TESTOSTERONE; VITAMIN D; CALCITRIOL RECEPTOR; ESTROGEN; VDR PROTEIN, HUMAN;

AGED; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; ESTRADIOL BLOOD LEVEL; FEMALE; FREE ANDROGEN INDEX; FREE ESTROGEN INDEX; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; POLISH CITIZEN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR GENE; SEX DIFFERENCE; TESTOSTERONE BLOOD LEVEL; VERY ELDERLY; VITAMIN BLOOD LEVEL; VITAMIN D RECEPTOR GENE; BLOOD; CLINICAL TRIAL; GENETIC POLYMORPHISM; GENETICS; MULTICENTER STUDY; POLAND; RANDOMIZED CONTROLLED TRIAL;

AGED; AGED, 80 AND OVER; ESTROGENS; FEMALE; HETEROZYGOTE; HUMANS; MALE; POLAND; POLYMORPHISM, GENETIC; RECEPTORS, CALCITRIOL; TESTOSTERONE; VITAMIN D;

EID: 84922247518     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2015.01.022     Document Type: Article

References (18)

1. Baker A.R., McDonnell D.P., Hughes M., et al. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc. Natl. Acad. Sci. U. S. A. 1988, 85:3294-3298.
2. Bledowski P., Mossakowska M., Chudek J., et al. Medical, psychological and socioeconomic aspects of aging in Poland: assumptions and objectives of the PolSenior project. Exp. Gerontol. 2011, 46:1003-1009.
3. Howard G., Nguyen T., Morrison N., et al. Genetic influences on bone density: physiological correlates of vitamin D receptor gene alleles in premenopausal women. J. Clin. Endocrinol. Metab. 1995, 80:2800-2805.
4. Janowsky Jeri, Oviatt S., Shelia K., et al. Testosterone influences spatial cognition in older men. Behav. Neurosci. 1994, 108:325-332.
5. Jurutka P.W., Remus L.S., Whitfield G.K., et al. The polymorphic N terminus in human vitamin D receptor isoforms influences transcriptional activity by modulating interaction with transcription factor IIB. Mol. Endocrinol. 2000, 14:401-420.
6. Laczmanska I., Pesz K., Laczmanski L. Application of selected methods based on the polymerase chain reaction in medical molecular diagnostics. Adv. Clin. Exp. Med. 2009, 18:85-92.
7. Laczmanski L., Milewicz A., Puzianowska-Kuznicka M., et al. Interrelation between genotypes of the vitamin D receptor gene and serum sex hormone concentrations in the Polish elderly population: the PolSenior study. Exp. Gerontol. 2014, 57:188-190.
8. Lins T.C., Nogueira L.R., Lima R.M., Gentil P., et al. A multiplex single-base extension protocol for genotyping Cdx2, FokI, BsmI, ApaI, and TaqI polymorphisms of the vitamin D receptor gene. Genet. Mol. Res. 2007, 6:316-324.
9. Miller S.A., Dykes D.D., Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988, 16:1215.
10. Morrison N.A., Qi J.C., Tokita A., Kelly P.J., et al. Prediction of bone density from vitamin D receptor alleles. Nature 1994, 367:284-287.
11. Norman A.W., Mizwicki M.T., Norman D.P. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat. Rev. Drug Discov. 2004, 3:27-41.
12. Parikh G., Varadinova M., Suwandhi P. Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells. Horm. Metab. Res. 2010, 42:754-757.
13. Pilz S., Frisch S., Koertke H., Kuhn J., et al. Effect of vitamin D supplementation on testosterone levels in men. Horm. Metab. Res. 2011, 43:223-225.
14. Protiva Petr, Cross Heide S., et al. Chemoprevention of colorectal neoplasia by estrogen: potential role of vitamin D activity. Cancer Prev. Res. 2009, 2:43-51.
15. Tang S., Han H., Bajic V.B. ERGDB: Estrogen Responsive Genes Database. Nucleic Acids Res. 2004, 32:533-536.
16. Uitterlinden A., Fang Y., Van Meurs J., et al. Genetics and biology of vitamin D receptor polymorphisms. Gene 2004, 338:143-156.
17. Wehr E., Pilz S., Boehm B.O., et al. Association of vitamin D status with serum androgen levels in men. Clin. Endocrinol. 2010, 73:243-248.
18. Wolf Oliver T., Kirschbaum Clemens Endogenous estradiol and testosterone levels are associated with cognitive performance in older women and men. Horm. Behav. 2002, 41:259-266.