Neurological soft signs in the clinical course of schizophrenia: Results of a meta-analysis

Frontiers in Psychiatry

Volumn 5, Issue DEC, 2014, Pages

  Bachmann, Silke ^a,b   Degen, Christina ^c   Geider, Franz Josef ^c   Schröder, Johannes ^c  

^a Clienia Littenheid AG   (Switzerland)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Chronicity; Course; NSS; Outcome; Schizophrenia

Indexed keywords

CLINICAL FEATURE; DATA ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; MENTAL DISEASE; META ANALYSIS (TOPIC); NEUROLOGICAL SOFT SIGN; OUTCOME ASSESSMENT; PSYCHOLOGICAL RATING SCALE; REVIEW; RISK ASSESSMENT; RISK FACTOR; SCHIZOPHRENIA; SCORING SYSTEM;

EID: 84922245267     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2014.00185     Document Type: Review

References (31)

1. Manschreck TC, Ames D. Neurologic features and psychopathology in schizophrenic disorders. Biol Psychiatry (1984) 19:703-19.
2. Heinrichs DW, Buchanan RW. Significance and meaning of neurological signs in schizophrenia. Am J Psychiatry (1988) 145:11-8.
3. Schröder J, Niethammer R, Geider F-J, Reitz C, Binkert M, Jauss M, et al. Neurological soft signs in schizophrenia. Schizophr Res (1992) 6:25-30. doi: 10.1016/0920-9964(91)90017-L
4. Niethammer R, Weisbrod M, Schiesser S, Grothe J, Maier S, Peter U, et al. Genetic Influence on laterality in schizophrenia? A twin study of neurological soft signs. Am J Psychiatry (2000) 157:272-4. doi:10.1176/appi.ajp.157.2.272
5. Torrey EF, Taylor EH, Bracha HS, Bowler AE, McNeil TF, Rawlings RR, et al. Prenatal origin of schizophrenia in a subgroup of discordant monozygotic twins. Schizophr Bull (1994) 20:423-32. doi:10.1093/schbul/20.3.423
6. Rossi A, De Cataldo S, Di Michele V, Manna V, Ceccoli S, Stratta P, et al. Neurological soft signs in schizophrenia. Br J Psychiatry (1990) 157:735-9. doi:10.1192/bjp.157.5.735
7. Torrey EF. Neurological abnormalities in schizophrenic patients. Biol Psychiatry (1980) 15:381-9.
8. Schröder J, Tittel A, Stockert A, Karr M. Memory deficits in subsyndromes of chronic schizophrenia. Schizophr Res (1996) 21:19-26. doi:10.1016/0920-9964(96)00027-8
9. Schröder J, Silvestri S, Bubeck B, Karr M, Demisch S, Scherrer S, et al. D2 Dopamine receptor up-regulation, treatment response, neurological soft signs, and extrapyramidal side effects in schizophrenia: a follow-up study with 123I-iodobenzamide single photon emission computed tomography in the drug-naïve state and after neuroleptic treatment. Biol Psychiatry (1998) 43: 660-5.
10. Bachmann S, Bottmer C, Schröder S. Neurological soft signs in first-episode schizophrenia: a follow-up study. Am J Psychiatry (2005) 162:2337-43. doi:10.1176/appi.ajp.162.12.2337
11. Prikryl R, Ceskova E, Kasparek T, Kucerova H. Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia. Eur Psychiatry (2007) 22:449-504. doi:10.1016/j.eurpsy.2007.03.012
12. Prikryl R, Ceskova E, Tronerova S, Kasparek T, Prikrylova Kucerova H, Ustohal L, et al. Dynamics of neurological soft signs and its relationship to clinical course in patients with first-episode schizophrenia. Psychiatry Res (2012) 200:67-72. doi:10.1016/j.psychres.2012.03.008
13. Bachmann S, Schröder J. Neurological soft signs in schizophrenia: a review on the state- versus trait-perspective.
14. Emsley R, Turner HJ, Oosthuizen PP, Carr J. Neurological abnormalities in first-episode schizophrenia: temporal stability and clinical and outcome correlates. Schizophr Res (2005) 75:35-44. doi:10.1016/j.schres.2004.06.014
15. Chen EYH, Shapleske J, Luque R, McKenna PJ, Hodges JR, Calloway SP, et al. The Cambridge Neurological Inventory: a clinical instrument for assessment of soft neurological signs in psychiatric patients. Psychiatry Res (1995) 56:183-204. doi:10.1016/0165-1781(95)02535-2
16. Mayoral M, Bombin I, Zabala A, Robes O, Moreno D, Parellada M, et al. Neurological soft signs in adolescents with first-episode psychosis: two-year followup. Psychiatry Res (2008) 161:344-8. doi:10.1016/j.psychres.2007.07.013
17. Mayoral M, Bombin I, Castro-Fornieles J, Gonzales-Pinto A, Otero S, Parellada M, et al. Longitudinal study of neurological soft signs in first-episode early-onset psychosis. J Child Psychol Psychiatry (2012) 53:323-31. doi:10.1111/j.1469-7610.2011.02475.x
18. Boks MPM, Selten JP, Leask S, Van den Bosch RJ. The 2-year stability of neurological soft signs after a first episode of non-affective psychosis. Eur Psychiatry (2006) 21:288-90. doi:10.1016/j.eurpsy.2005.09.004
19. Buchanan RW, Koeppl P, Breier A. Stability of neurological signs with clozapine treatment. Biol Psychiatry (1994) 36:198-200. doi:10.1016/0006-3223(94)91225-4
20. Chen EYH, Hui CLM, Chan RCK, Dunn ELW, Miao MYK, Yeung WS, et al. A 3-year prospective study of neurological soft signs in first episode schizophrenia. Schizophr Res (2005) 75:45-54. doi:10.1016/j.schres.2004.09.002
21. Cuesta MJ, Jalon EG, Campos MS, Peralta V. Cognitive effectiveness of olanzapine and risperidone in first episode psychosis. Br J Psychiatry (2009) 194:439-45. doi:10.1192/bjp.bp.108.055137
22. Mangot AG, Sawant NS. First episode schizophrenia: neurological abnormalities and prognosis. German J Psychiatry. Reprinted from the German Journal of Psychiatry. Available from: http://www.gjpsy.uni-goettingen.de
23. Mittal VA, Hasenkamp W, Sanfilipo M, Wieland S, Angrist B, Rotrosen J, et al. Relation of neurological soft signs to psychiatric symptoms in schizophrenia. Schizophr Res (2007) 94:37-44. doi:10.1016/j.schres.2007.04.017
24. Sevincok L, Topaloglu B. Neurological soft signs and positive treatment response to olanzapine in chronic schizophrenia. Prog Neuropsychoph (2006) 30:141-3. doi:10.1016/j.pnpbp.2005.06.012
25. Whitty P, Clarke M, Browne S, McTique O, Kamali M, Feeney L, et al. Prospective evaluation of neurological soft signs in first-episode schizophrenia in relation to psychopathology: state versus trait phenomena. Psychol Med (2003) 33:1479-84. doi:10.1017/S0033291703008225
26. Jahn T, Hubmann W, Karr M, Mohr F, Schlenker R, Heidenreich T, et al. Motoric neurological soft signs and psychopathological symptoms in schizophrenic psychoses. Psychiatr Res (2006) 142:191-9. doi:10.1016/j.psychres.2002.12.003
27. Chen EYH, Kwok CL, Au JWY, Chen RYL, Lau BST. Progressive deterioration of soft neurological signs in chronic schizophrenic patients. Acta Psychiatr Scand (2000) 102:342-9. doi:10.1034/j.1600-0447.2000.102005342.x
28. Chan RCK, Xu T, Heinrichs RW, Yu Y, Wang Y. Neurological soft signs in schizophrenia: a meta-analysis. Schizophr Bull (2009) 36:1089-104. doi:10.1093/schbul/sbp011
29. Kong L, Bachmann S, Thomann PA, Essig M, Schröder J. Neurological soft signs and gray matter changes: a longitudinal analysis in first-episode schizophrenia. Schizophr Res (2012) 134:27-32. doi:10.1016/j.schres.2011.09.015
30. Browne S, Clarke M, Gervin M, Lane A, Waddington JL, Larkin C, et al. Determinants of neurological dysfunction in first episode schizophrenia. Psychol Med (2000) 30:1433-41. doi:10.1017/S003329179900286X
31. Keshavan MS, Sanders RD, Sweeney JA, Diwadkar VA, Goldstein G, Pettegrew JW, et al. Diagnostic specificity and neuroanatomical validity of neurological abnormalities in first-episode psychosis. Am J Psychiatry (2003) 160:1298-304. doi:10.1176/appi.ajp.160.7.1298