Myoid Gonadal Stromal Tumor: A Clinicopathologic Study of Three Cases of a Distinctive Testicular Tumor

American Journal of Clinical Pathology

Volumn 142, Issue 5, 2014, Pages 675-682

  Kao, Chia Sui ^a   Ulbright, Thomas M ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Immunohistochemistry; Myoid gonadal stromal tumor; Testis

Indexed keywords

CALRETININ; INHIBIN; PROTEIN S 100; SMOOTH MUSCLE ACTIN; STEROIDOGENIC FACTOR 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXL2; UNCLASSIFIED DRUG; WT1 PROTEIN; TUMOR MARKER;

ADULT; ARTICLE; CANCER PATIENT; CANCER SURGERY; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE DISSECTION; MALE; MIDDLE AGED; ORCHIECTOMY; PRIORITY JOURNAL; RETE TESTIS; SEX CORD TUMOR; SPINDLE CELL; SPINDLE CELL CARCINOMA; TESTICULAR MYOID GONADAL STROMAL TUMOR; TESTIS TUMOR; TUMOR DIFFERENTIATION; TUMOR VOLUME; DIFFERENTIAL DIAGNOSIS; IMMUNOHISTOCHEMISTRY; METABOLISM; NEOPLASMS, GONADAL TISSUE; PATHOLOGY; STROMA CELL; TESTICULAR NEOPLASMS; TESTIS; TREATMENT OUTCOME;

ADULT; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASMS, GONADAL TISSUE; STROMAL CELLS; TESTICULAR NEOPLASMS; TESTIS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84922232644     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCPGSCD1DGNZ0QO     Document Type: Article

References (34)

1. Evans HL. Unusual gonadal stromal tumor of the testis: case report with ultrastructural observations. Arch Pathol Lab Med. 1977;101:317-320.
2. Greco MA, Feiner HD, Theil KS, et al. Testicular stromal tumor with myofilaments: ultrastructural comparison with normal gonadal stroma. Hum Pathol. 1984;15:238-243.
3. Weidner N. Myoid gonadal stromal tumor with epithelial differentiation (? testicular myoepithelioma). Ultrastruct Pathol. 1991;15:409-416.
4. Du S, Powell J, Hii A, et al. Myoid gonadal stromal tumor: a distinct testicular tumor with peritubular myoid cell differentiation. Hum Pathol. 2012;43:144-149.
5. Renshaw AA, Gordon M, Corless CL. Immunohistochemistry of unclassified sex cord-stromal tumors of the testis with a predominance of spindle cells. Mod Pathol. 1997;10:693-700.
6. Sasano H, Nakashima N, Matsuzaki O, et al. Testicular sex cord-stromal lesions: immunohistochemical analysis of cytokeratin, vimentin and steroidogenic enzymes. Virchows Arch A Pathol Anat Histopathol. 1992;421:163-169.
7. McCluggage WG, Shanks JH, Whiteside C, et al. Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. Am J Surg Pathol. 1998;22:615-619.
8. Iczkowski KA, Bostwick DG, Roche PC, et al. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod Pathol. 1998;11:774-779.
9. Tanaka Y, Carney JA, Ijiri R, et al. Utility of immunostaining for S-100 protein subunits in gonadal sex cord-stromal tumors, with emphasis on the large-cell calcifying Sertoli cell tumor of the testis. Hum Pathol. 2002;33:285-289.
10. Emerson RE, Ulbright TM. The use of immunohistochemistry in the differential diagnosis of tumors of the testis and paratestis. Semin Diagn Pathol. 2005;22:33-50.
11. Kalfa N, Fellous M, Boizet-Bonhoure B, et al. Aberrant expression of ovary determining gene FOXL2 in the testis and juvenile granulosa cell tumor in children. J Urol. 2008;180:1810-1813.
12. Hes O, Vanecek T, Petersson F, et al. Mutational analysis (c.402C>G) of the FOXL2 gene and immunohistochemical expression of the FOXL2 protein in testicular adult type granulosa cell tumors and incompletely differentiated sex cord stromal tumors. Appl Immunohistochem Mol Morphol. 2011;19:347-351.
13. Buell-Gutbrod R, Ivanovic M, Montag A, et al. FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas. Pediatr Dev Pathol. 2011;14:391-395.
14. Lima JF, Jin L, de Araujo AR, et al. FOXL2 mutations in granulosa cell tumors occurring in males. Arch Pathol Lab Med. 2012;136:825-828.
15. Sangoi AR, McKenney JK, Brooks JD, et al. Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases. Appl Immunohistochem Mol Morphol. 2013;21:318-321.
16. Gabrilove JL, Nicolis GL, Mitty HA, et al. Feminizing interstitial cell tumor of the testis: personal observations and a review of the literature. Cancer. 1975;35:1184-1202.
17. Perez C, Novoa J, Alcaniz J, et al. Leydig cell tumour of the testis with gynaecomastia and elevated oestrogen, progesterone and prolactin levels: case report. Clin Endocrinol (Oxf). 1980;13:409-412.
18. Bercovici JP, Nahoul K, Tater D, et al. Hormonal profile of Leydig cell tumors with gynecomastia. J Clin Endocrinol Metab. 1984;59:625-630.
19. Czernobilsky H, Czernobilsky B, Schneider HG, et al. Characterization of a feminizing testicular Leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture. Cancer. 1985;56:1667-1676.
20. Wilson DM, Pitts WC, Hintz RL, et al. Testicular tumors with Peutz-Jeghers syndrome. Cancer. 1986;57:2238-2240.
21. Mineur P, De Cooman S, Hustin J, et al. Feminizing testicular Leydig cell tumor: hormonal profile before and after unilateral orchidectomy. J Clin Endocrinol Metab. 1987;64:686-691.
22. Carney JA. Carney complex: the complex of myxomas, spotty pigmentation, endocrine overactivity, and schwannomas. Semin Dermatol. 1995;14:90-98.
23. Young S, Gooneratne S, Straus FH II, et al. Feminizing Sertoli cell tumors in boys with Peutz-Jeghers syndrome. Am J Surg Pathol. 1995;19:50-58.
24. Mostofi FK. Proceedings: testicular tumors: epidemiologic, etiologic, and pathologic features. Cancer. 1973;32:1186-1201.
25. Young RH, Talerman A. Testicular tumors other than germ cell tumors. Semin Diagn Pathol. 1987;4:342-360.
26. Scully RE. Testicular tumors with endocrine manifestations. In: LJ D, ed. Endocrinology. Philadelphia, PA: WB Saunders; 1995:2442-2448.
27. Fawcett D, Burgos MH. Studies of the fine structure of the mammalian testis, II: the human interstitial tissue. Am J Anat. 1960;107:245.
28. Vilar O. Histology of the human testis from neonatal period to adolescence. Adv Exp Med Biol. 1970;10:95.
29. Maekawa M, Kamimura K, Nagano T. Peritubular myoid cells in the testis: their structure and function. Arch Histol Cytol. 1996;59:1-13.
30. Zhang M, Kao CS, Ulbright TM, et al. Testicular fibrothecoma: a morphologic and immunohistochemical study of 16 cases. Am J Surg Pathol. 2013;37:1208-1214.
31. Miettinen M, Salo J, Virtanen I. Testicular stromal tumor: ultrastructural, immunohistochemical, and gel electrophoretic evidence of epithelial differentiation. Ultrastruct Pathol. 1986;10:515-528.
32. Kim I, Young RH, Scully RE. Leydig cell tumors of the testis: a clinicopathological analysis of 40 cases and review of the literature. Am J Surg Pathol. 1985;9:177-192.
33. Young RH, Koelliker DD, Scully RE. Sertoli cell tumors of the testis, not otherwise specified: a clinicopathologic analysis of 60 cases. Am J Surg Pathol. 1998;22:709-721.
34. Henley JD, Young RH, Ulbright TM. Malignant Sertoli cell tumors of the testis: a study of 13 examples of a neoplasm frequently misinterpreted as seminoma. Am J Surg Pathol. 2002;26:541-550.